Next Article in Journal
Metabolomic Laboratory-Developed Tests: Current Status and Perspectives
Next Article in Special Issue
Diversion of Acetyl CoA to 3-Methylglutaconic Acid Caused by Discrete Inborn Errors of Metabolism
Previous Article in Journal
Trehalose Reduces the Secreted Beta-Amyloid Levels in Primary Neurons Independently of Autophagy Induction
Previous Article in Special Issue
Mitochondria in Myelinating Oligodendrocytes: Slow and Out of Breath?
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Metabolites
Volume 11
Issue 7
10.3390/metabo11070422
metabolites-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Sigma-1 Receptor Promotes Mitochondrial Bioenergetics by Orchestrating ER Ca2+ Leak during Early ER Stress

by
Zhanat Koshenov
1,
Furkan E. Oflaz
1,
Martin Hirtl
1,
Johannes Pilic
1,
Olaf A. Bachkoenig
1,
Benjamin Gottschalk
1,
Corina T. Madreiter-Sokolowski
1,
Rene Rost
1,
Roland Malli
1,2 and
Wolfgang F. Graier
1,2,*
1
Molecular Biology and Biochemistry, Gottfried Schatz Research Center, Medical University of Graz, Neue Stiftingtalstraße 6/6, 8010 Graz, Austria
2
BioTechMed Graz, Mozartgasse 12/II, 8010 Graz, Austria
*
Author to whom correspondence should be addressed.
Metabolites 2021, 11(7), 422; https://doi.org/10.3390/metabo11070422
Submission received: 17 May 2021 / Revised: 11 June 2021 / Accepted: 24 June 2021 / Published: 26 June 2021
(This article belongs to the Special Issue Mitochondrial Energy Metabolism in Health and Disease)
Browse Figures
Versions Notes

Abstract

The endoplasmic reticulum (ER) is a complex, multifunctional organelle of eukaryotic cells and responsible for the trafficking and processing of nearly 30% of all human proteins. Any disturbance to these processes can cause ER stress, which initiates an adaptive mechanism called unfolded protein response (UPR) to restore ER functions and homeostasis. Mitochondrial ATP production is necessary to meet the high energy demand of the UPR, while the molecular mechanisms of ER to mitochondria crosstalk under such stress conditions remain mainly enigmatic. Thus, better understanding the regulation of mitochondrial bioenergetics during ER stress is essential to combat many pathologies involving ER stress, the UPR, and mitochondria. This article investigates the role of Sigma-1 Receptor (S1R), an ER chaperone, has in enhancing mitochondrial bioenergetics during early ER stress using human neuroblastoma cell lines. Our results show that inducing ER stress with tunicamycin, a known ER stressor, greatly enhances mitochondrial bioenergetics in a time- and S1R-dependent manner. This is achieved by enhanced ER Ca2+ leak directed towards mitochondria by S1R during the early phase of ER stress. Our data point to the importance of S1R in promoting mitochondrial bioenergetics and maintaining balanced H2O2 metabolism during early ER stress.
Keywords: sigma-1 receptor; mitochondrial bioenergetics; ER stress; UPR; ER Ca2+ leak; mitochondrial Ca2+; mitochondrial metabolism sigma-1 receptor; mitochondrial bioenergetics; ER stress; UPR; ER Ca2+ leak; mitochondrial Ca2+; mitochondrial metabolism
Graphical Abstract

Share and Cite

MDPI and ACS Style

Koshenov, Z.; Oflaz, F.E.; Hirtl, M.; Pilic, J.; Bachkoenig, O.A.; Gottschalk, B.; Madreiter-Sokolowski, C.T.; Rost, R.; Malli, R.; Graier, W.F. Sigma-1 Receptor Promotes Mitochondrial Bioenergetics by Orchestrating ER Ca2+ Leak during Early ER Stress. Metabolites 2021, 11, 422. https://doi.org/10.3390/metabo11070422

AMA Style

Koshenov Z, Oflaz FE, Hirtl M, Pilic J, Bachkoenig OA, Gottschalk B, Madreiter-Sokolowski CT, Rost R, Malli R, Graier WF. Sigma-1 Receptor Promotes Mitochondrial Bioenergetics by Orchestrating ER Ca2+ Leak during Early ER Stress. Metabolites. 2021; 11(7):422. https://doi.org/10.3390/metabo11070422

Chicago/Turabian Style

Koshenov, Zhanat, Furkan E. Oflaz, Martin Hirtl, Johannes Pilic, Olaf A. Bachkoenig, Benjamin Gottschalk, Corina T. Madreiter-Sokolowski, Rene Rost, Roland Malli, and Wolfgang F. Graier. 2021. "Sigma-1 Receptor Promotes Mitochondrial Bioenergetics by Orchestrating ER Ca2+ Leak during Early ER Stress" Metabolites 11, no. 7: 422. https://doi.org/10.3390/metabo11070422

APA Style

Koshenov, Z., Oflaz, F. E., Hirtl, M., Pilic, J., Bachkoenig, O. A., Gottschalk, B., Madreiter-Sokolowski, C. T., Rost, R., Malli, R., & Graier, W. F. (2021). Sigma-1 Receptor Promotes Mitochondrial Bioenergetics by Orchestrating ER Ca2+ Leak during Early ER Stress. Metabolites, 11(7), 422. https://doi.org/10.3390/metabo11070422

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop