2026 August - 84 articles
Machine learning (ML) integrated with metabolomics has emerged as a promising strategy to advance precision pharmacotherapy, enabling data-driven prediction of drug response. This review provides an overview of commonly applied ML methodologies in me...
Background: Wampee (Clausena lansium (Lour.) Skeels) is an understudied Rutaceae crop native to southern China, whose fruit features a complex aroma profile with simultaneous sour, sweet, bitter and astringent notes. Although bioactive compounds incl...
Background: Mammalian arachidonic acid lipoxygenases (ALOXs) are non-heme iron-containing enzymes that oxygenate polyunsaturated fatty acids (PUFAs) with at least two isolated double bonds to hydroperoxy derivatives. The patho-physiological roles of...
Nicotinamide adenine dinucleotide (NAD+) is a fundamental metabolic cofactor and signaling molecule that supports redox reactions, DNA repair, chromatin regulation, stress adaptation, inflammation, and neuronal maintenance. Age-associated NAD+ declin...
Background/Objectives: Ciliary neurotrophic factor (CNTF), a pleiotropic cytokine with central and peripheral actions, has been implicated in obesity, insulin resistance, and aging, yet its role in skeletal muscle and cardiometabolic health remains u...
Background/Objectives: Gestational diabetes mellitus (GDM) is one of the most common metabolic disorders during pregnancy and is associated with adverse maternal and neonatal outcomes. Xenopsin-Related Peptide-1 (XRP-1) has recently emerged as a pote...
Background: Recovering from COVID-19 does not always lead to complete recovery, and many patients report symptoms of anxiety and depression. One potential mechanism behind these disorders is dysbiosis. The aim of this study was to evaluate the impact...
Background/Objectives: This 12-week randomized controlled trial investigated whether progressive resistance training combined with vitamin D supplementation produces enhanced combined improvements in cardiometabolic profiles and functional capacities...
Background/Objectives: Inflammatory bowel disease (IBD) is a chronic gastrointestinal disorder influenced by environmental factors including cold stress. While cold exposure exacerbates intestinal inflammation, the specific microbial metabolites link...
Background: Peganum harmala L. stem ethanolic extract (PHL) has been scarcely evaluated as a ruminant feed component. We evaluated its effects on serum inflammatory and antioxidant biomarkers and duodenal and hepatic molecular responses in Hu sh...
Background/Objective: Maternal diet is an important determinant of gut microbiota composition in dams and offspring. This study investigated whether HDCA supplementation during maternal high-fat diet (HFD) exposure was associated with gut microbiota...
Background/Objectives: Myasthenia gravis (MG) is an immune-mediated neuromuscular disorder for which antibody-based assays have limited sensitivity, particularly in double-seronegative MG (dsNMG), highlighting the need for complementary biomarkers. G...
Background: Large yellow tea (LYT), a distinctive variety made from mature leaves, has recently gained attention for its remarkable health benefits. However, whether these benefits can be transmitted from mother to offspring remains unexplored. Purpo...
Background/Objectives: Acute liver failure (ALF) rapidly induces hepatic encephalopathy (HE), a severe neurological syndrome associated with astrocytic dysfunction and glutamatergic dysregulation. Guanosine (GUO), an endogenous guanine-based nucleosi...
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a leading cause of chronic liver disease, and its progressive inflammatory phenotype, metabolic dysfunction-associated steatohepatitis (MASH), is characterized by hepatocellular inju...
Spectral-library matching is a widely used approach for compound annotation in mass spectrometry (MS)-based metabolomics, yet annotation performance is influenced by spectrum preprocessing, parameter selection, and similarity-measure choice. We prese...
Background/Objectives: Vonoprazan is a potassium-competitive acid blocker with potential for the treatment of equine gastric ulcer syndrome. Vonoprazan metabolic pathways in horses have not been characterized. This study aimed to identify vonoprazan...
Background/Objectives: Magnesium (Mg) deficiency has been linked to various adverse health outcomes; however, its association with metabolic dysfunction-associated steatotic liver disease (MASLD) has not been fully elucidated. This study examined the...
Microbial biostimulants and microbial plant protection products overlap in biological function, creating both R&D opportunities and regulatory challenges. In particular, multi-strain bacterial consortia may simultaneously affect nutrient mobilisa...
Background: Metabolomics data is inherently characterized by high dimensionality and small sample size. Existing multi-objective particle swarm optimization (MOPSO)-based feature selection algorithms suffer from two critical limitations: they general...
Background/Objectives: Health challenges associated with metabolic syndrome (MetS) have stimulated investigations into the effectiveness of nutraceutical interventions, including beetroot juice (BRJ), in mitigating MetS risk factors. Methods: This re...
Background: The relationship between Graves’ disease (GD) and thyroid carcinoma (TC) remains controversial, particularly regarding the predictive value of metabolic, hormonal, immunological, and ultrasound biomarkers. We performed a systematic...
Background/Objectives: Dietary inflammation may influence cardiometabolic health, yet the gut mycobiome and bacterial–fungal interactions remain unclear. Building upon our earlier findings and data from the TALENTs trial (Targeting Aging and Lo...
Background: AML cells can be defined by impairments in glycolytic metabolism, resulting in increased glucose uptake coupled with reduced glycolytic flux. Consequently, cells rely on alternative pathways such as glutamine metabolism to fuel mitochondr...
Medicinal fungi are important sources of natural medicines and are rich in a wide range of secondary metabolites with significant bioactivities, including terpenoids and alkaloids. As one of the core tools of systems biology, metabolomics has develop...
Background/Objective: Recurrent acute pancreatitis (RAP) can progress to chronic pancreatitis and ultimately pancreatic ductal adenocarcinoma; therefore, early identification of patients at high recurrence risk is clinically important. However, the h...
Background: Extensive prior work has established severe aortic stenosis as a whole-heart remodeling process involving chronic pressure overload, concentric hypertrophy, myocardial stiffness, and progressive ventricular fibrosis. However, direct paire...
Background/Objectives: Heracleum millefolium Diels (HMD) is a traditional Tibetan medicinal herb that has been reported to possess analgesic, anti-edematous, and anti-inflammatory activities. However, its chemical composition and anti-inflammatory me...
Background/Objectives: Garlic (Allium sativum) has long been valued for its rich constellation of organosulfur and phenolic compounds, molecules that underpin its many recognized biological activities. Despite its deep roots in traditional medicine,...
Background: Preeclampsia and fetal growth restriction (FGR) are major obstetric complications originating from abnormal placental development during early pregnancy. Early identification of pregnancies at increased risk remains challenging despite th...
Background/Objectives: DEFA3 and DEFA5 are alpha-defensins, which are small cationic antimicrobial peptides that are part of the innate immune system. DEFA3 encodes human neutrophil peptide-3 (HNP-3), primarily expressed in neutrophils, while DEFA5 e...
Background: Body mass index (BMI) is widely used to assess pediatric obesity but has limitations in distinguishing between fat and muscle mass. This study aimed to investigate the association between various body composition parameters and insulin re...
Background/Objectives: Loss of skeletal muscle mass is linked to functional decline and adverse health outcomes. Evidence on long-term associations between macronutrient-based dietary patterns and muscle mass decline remains limited. This study exami...
Background: Metabolic syndrome (MetS) is associated with increased cardiometabolic risk, although substantial metabolic abnormalities may also occur in individuals with normal body weight. This study compared anthropometric characteristics, body comp...
Microbiota, whether in the gut, skin, or other habitats, has a long history of co-evolution with the host, and plays vital physiological and pathological roles, such as mediating the metabolism, barrier function, immune balance, biological rhythm, an...
Background/Objectives: β-Glucosidases from lactic acid bacteria are valuable biocatalysts for carbohydrate conversion, flavour enhancement, and bioactive glycoside biotransformation. Although GH3 family enzymes have been characterized from sever...
Background/Objectives: Water deficit during the pod filling stage severely limits the productivity of common beans (Phaseolus vulgaris). Although the effects of water scarcity have been extensively studied in leaves and roots, the contribution of xyl...
Brassica crops, encompassing globally important vegetables and oilseeds, face severe threats from diverse biotic and abiotic stresses. Plant secondary metabolites constitute the chemical foundation of defence, and metabolomics has emerged as an effec...
Resting myokine abundance cannot distinguish adaptive signaling from compensation, tissue injury, altered receptor availability, or non-muscle contribution. We conducted a targeted narrative review of PubMed/MEDLINE, Embase, Web of Science Core Colle...
Background/Objectives: Clematis huchouensis Tamura, a genuine medicinal herb endemic to Huzhou, Zhejiang Province. However, its secondary metabolic profile and organ-specific distribution of bioactive constituents remain largely uncharacterized. This...
Background/Objectives: Conventional lipid parameters incompletely reflect coronary atherosclerotic burden, particularly in the setting of metabolic heterogeneity and residual cardiovascular risk. Composite indices such as the atherogenic index of pla...
Background/Objectives: Mesoporous silica nanoparticles (MSNs) are widely investigated as nanocarriers for drug delivery, gene transfer, and bioimaging. However, the mechanisms underlying their size-dependent cytotoxicity at the metabolic level remain...
Background/Objectives: Opiates comprise naturally occurring opium alkaloids and their semisynthetic derivatives. Routine urine drug screening relies on enzyme immunoassays (EIAs) to rapidly detect opiate exposure; however, EIAs provide limited insigh...
Background: Accurate preoperative prediction of lymph node metastasis (LNM) remains challenging in colon cancer. Ferroptosis, an iron-dependent regulated cell-death pathway, is implicated in tumor invasion and metastasis. Yet, the clinical value of r...
Background: Finger citron (Citrus medica L. var. sarcodactylis Swingle, CM) is an important edible and medicinal plant. Owing to its diverse pharmacological properties, its fruit has long served as a traditional Chinese medicine and has increasingly...
Osteosarcopenia—defined as the coexistence of sarcopenia and osteoporosis—is increasingly recognized as a clinically important geriatric syndrome associated with falls, fractures, frailty, disability, and mortality. Beyond the simple coex...
Background/Objectives: Perinatal asphyxia (PA) is a major cause of neonatal mortality and morbidity both in the short and in the long term. The identification of novel reliable biomarkers is essential in order to improve early diagnosis and allow for...
Background/Objectives: Ambient fine particulate matter (PM2.5) poses significant health risks to older adult populations, yet the specific contributions of its chemical constituents, particularly non-phthalate and non-organophosphate ester compounds,...
Background/Objectives: Date seeds contain a wide range of biologically active constituents and have been associated with multiple health benefits. Our study aimed to evaluate the utility of biphasic aqueous methanol/chloroform extraction for separati...
Background/Objectives: Mushroom poisoning is a leading cause of death from foodborne illness, and α-amanitin is its most potent toxin. However, the mechanisms and biomarkers of α-amanitin-induced hepatorenal injury remain inadequately und...
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