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Journal of Clinical Medicine, Volume 15, Issue 6

2026 March-2 - 377 articles

Cover Story: Non-invasive mechanical ventilation is now a mainstay in the management of acute, chronic, and acute-on-chronic hypoxemic and hypercapnic respiratory failure from diverse etiologies. While NIV offers an effective approach to avoid invasive mechanical ventilation with its inherent risks of lung injury and sedation-related harms, it is a complex modality that requires a nuanced approach to management. As the use of NIV has become ubiquitous, complex challenges arise in the initiation, management, and discontinuation of the treatment. We review complex clinical scenarios that present during liberation from non-invasive mechanical ventilation and discuss an approach to successful weaning and liberation in these patient populations. View this paper
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Articles (377)

  • Case Report
  • Open Access
1,265 Views
22 Pages

Time Is Kidney: A Case Study and Literature Review of Bilateral Renal Compartment Syndrome After Blunt Trauma, a Rare Complication

  • Luis Fernandez,
  • Ahmad Jalal Kanawati,
  • Mohamed Abdelgawad,
  • Diana Wu,
  • Brittany Wagner,
  • Andrew Navetta,
  • Marc Mathews,
  • Sarah Kamel,
  • Andrew Armanyous and
  • David Villareal

23 March 2026

Background: Acute compartment syndrome (ACS), a condition characterized by elevated pressure within an enclosed compartment, leads to ischemia and organ failure, and is hence a surgical emergency. Renal compartment syndrome (RCS) is a disease in whic...

(This article belongs to the Section General Surgery)
  • Article
  • Open Access
936 Views
20 Pages

Perceived Usability as a Factor Associated with Clinical Outcomes in Mobile Health Diabetes Management: A Bayesian Mediation and Equity Analysis

  • Oscar Eduardo Rodríguez Montes,
  • María del Carmen Gogeascoechea-Trejo and
  • Clara Bermúdez-Tamayo

23 March 2026

Background: While mobile health (mHealth) interventions show promise for type 2 diabetes management, mechanisms linking user experience to clinical outcomes remain poorly understood. We hypothesized that perceived usability may mediate associations b...

(This article belongs to the Special Issue Clinical Management for Metabolic Syndrome and Obesity)
  • Article
  • Open Access
1 Citations
1,266 Views
14 Pages

23 March 2026

Background/Objectives: Early recurrence after complete initial transurethral resection of bladder tumor (TUR-BT) may indicate biologically aggressive non-muscle-invasive bladder cancer (NMIBC). This study aimed to identify clinicopathological predict...

(This article belongs to the Special Issue Bladder Cancer: Diagnosis and Treatments)
  • Review
  • Open Access
2 Citations
2,540 Views
11 Pages

23 March 2026

Background/Objectives: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are increasingly prescribed for type 2 diabetes in addition to other conditions such as obesity. As their use expands, understanding potential ocular safety signals is impor...

(This article belongs to the Section Ophthalmology)
  • Systematic Review
  • Open Access
1,177 Views
17 Pages

23 March 2026

Background/Objectives: Effective wound closure in breast surgery achieves a compromise between safety and aesthetic outcomes. This systematic review evaluates the effect of 2-octyl cyanoacrylate (2-OCA) tissue adhesive (Dermabond) as a primary means...

(This article belongs to the Special Issue Plastic and Reconstructive Surgery: Clinical Advances and Future Opportunities)
  • Review
  • Open Access
1 Citations
2,223 Views
29 Pages

Ocular Color Doppler Ultrasound (OCDUS) in Diagnosis and Monitoring of Ophthalmological, Cerebrovascular and Systemic Diseases: A Narrative Review

  • Massimo Venturini,
  • Silvia Malnati,
  • Noemi Teresa Catania,
  • Andrea Coppola,
  • Chiara Recaldini,
  • Aroa Gnesutta,
  • Marianna Ciani,
  • Silvia Tamietti,
  • Emilio Simonini and
  • Federico Fontana
  • + 3 authors

23 March 2026

Ocular Color Doppler ultrasound (OCDUS) has been underutilized in the past as a diagnostic technique, although several OCDUS-based studies were performed in the last 30 years for diagnosis or monitoring of some ophthalmological, cerebrovascular or sy...

(This article belongs to the Special Issue Technological Advancements and Clinical Innovations in Diagnostic and Interventional Radiology: 2nd Edition)
  • Article
  • Open Access
1 Citations
1,048 Views
32 Pages

First-Trimester Gestational Diabetes Mellitus Risk Prediction with Machine Learning Techniques: Results from the BORN2020 Cohort Study

  • Nikolaos Pazaras,
  • Antonios Siargkas,
  • Antigoni Tranidou,
  • Aikaterini Apostolopoulou,
  • Ioannis Tsakiridis,
  • Panagiotis D. Bamidis,
  • Sofoklis Stavros,
  • Anastasios Potiris,
  • Michail Chourdakis and
  • Themistoklis Dagklis

23 March 2026

Background: Gestational diabetes mellitus (GDM) affects many pregnancies worldwide and is associated with adverse maternal and fetal outcomes. Current screening at 24–28 weeks limits opportunities for early intervention. We evaluated whether ma...

(This article belongs to the Special Issue Navigating Pregnancy and Its Complications: Challenges and Innovations in Maternal–Fetal Medicine)
  • Review
  • Open Access
1 Citations
1,717 Views
24 Pages

High-Frame-Rate Echocardiography: A New Frontier in Noninvasive Functional Assessment

  • Fatemeh Mashayekhi,
  • Fatemeh Shahbazi,
  • Andressa Araujo Andrade Sousa,
  • Miaomiao Liu,
  • Jens-Uwe Voigt,
  • Annette Caenen and
  • Jan D’hooge

23 March 2026

High-frame-rate (HFR) ultrasound imaging enables the acquisition of up to several thousand frames per second, substantially improving the temporal resolution of echocardiography. This technical advancement allows visualization of rapid mechanical and...

(This article belongs to the Section Cardiology)
  • Article
  • Open Access
787 Views
13 Pages

Incidental Hepatic Findings in Cardiac Magnetic Resonance Imaging Examinations in Patients with Congenital Heart Disease: A Pilot Study

  • Gretha Hecke,
  • Bianca Haase,
  • Nikolaus Clodi,
  • Karolin Hauptvogel,
  • David Plajer,
  • Jakob Spogis,
  • Anja Hanser,
  • Jürgen F. Schäfer,
  • Konstantin Nikolaou and
  • Sarah Nordmeyer
  • + 1 author

23 March 2026

Objectives: During cardiac magnetic resonance imaging (cMRI) exams in patients with congenital heart disease (CHD), incidental liver abnormalities are increasingly found. However, no systematic data exist on the incidence of liver lesions in patients...

(This article belongs to the Section Cardiovascular Medicine)
  • Systematic Review
  • Open Access
3,140 Views
19 Pages

Constraint-Induced Movement Therapy in the Rehabilitation of Adults After Stroke: An Umbrella Review

  • José Conchillo-Liria,
  • Iván Cavero-Redondo,
  • Alicia Saz-Lara,
  • Nerea Moreno-Herraiz,
  • Candela Calvo-Utrilla,
  • Ana González-Collado and
  • Iris Otero-Luis

23 March 2026

Background/Objectives: Stroke is among the leading causes of disability in adults, as hemiparesis affects motor function and daily activities. Constraint-induced movement therapy (CIMT) has proven effective in functional recovery through intensive us...

(This article belongs to the Special Issue Enhancing and Rehabilitation of Gait and Mobility in Chronic Stroke)
  • Article
  • Open Access
723 Views
17 Pages

Evaluation of Gingival Sulcus Width Gain After Nd: YAG Laser and Astringent Retraction Paste Using Intraoral and Laboratory STL Analysis: A Pilot Split-Mouth Study

  • Edwin Sever Bechir,
  • Andrei-Mario Bădărău-Șuster,
  • Mircea Suciu,
  • Anca-Georgiana Zamfir,
  • Zsuzsanna Bardocz-Veres and
  • Farah Bechir

23 March 2026

Background/Objectives: Advancements in digital dentistry have led to new approaches for soft tissue management aimed at improving impression accuracy. This pilot split-mouth study included a single 39-year-old male patient with 19 abutment teeth (114...

(This article belongs to the Special Issue Oral Health and Dental Care: Current Advances and Future Options)
  • Article
  • Open Access
1 Citations
1,545 Views
13 Pages

23 March 2026

Background/Objectives: In exercise science and sports medicine, the potential use of large language models for generating personalized exercise programs is being explored. However, the practical applicability of AI-generated exercise prescriptions ha...

(This article belongs to the Special Issue Artificial Intelligence in Exercise, Rehabilitation and Health Promotion: A Clinical Perspective)
  • Article
  • Open Access
2 Citations
878 Views
11 Pages

23 March 2026

Background/Objectives: Contrast-associated acute kidney injury (CA-AKI) remains an important cause of morbidity and mortality in patients undergoing procedures that require intravascular contrast administration. Therefore, the early identification of...

(This article belongs to the Section Cardiology)
  • Review
  • Open Access
753 Views
12 Pages

Reporting Standards and Quality Assurance Methods for Pancreatoduodenectomy in Randomised Controlled Trials: A Structured Narrative Review

  • Abdullah K. Malik,
  • Bishow B. Karki,
  • Balaji Mahendran,
  • John A. G. Moir,
  • Shailesh V. Shrikhande,
  • Andrew M. Smith,
  • Deborah D. Stocken,
  • Natalie S. Blencowe and
  • Samir Pathak

23 March 2026

Background: Surgical interventions are complex and comprise multiple components, creating difficulties when considering how they might be described, standardised, and monitored (i.e., quality assurance) within randomised controlled trials (RCTs). Con...

(This article belongs to the Special Issue The Current Status and Future Directions of Pancreatoduodenectomy and Pancreatectomy)
  • Article
  • Open Access
1 Citations
1,578 Views
11 Pages

23 March 2026

Background/Objectives: Half of diagnosed unilateral maxillary sinusitis may have odontogenic origin, and root canal treatment (RCT) can be beneficial as a single-mode treatment for full resolution of maxillary sinusitis of endodontic origin (MSEO) sy...

(This article belongs to the Special Issue Oral Health and Systemic Diseases: Clinical Insights)
  • Systematic Review
  • Open Access
1,341 Views
18 Pages

Artificial Intelligence in the Diagnosis of Odontogenous Cysts and Ameloblastomas—A Systematic Review and Meta-Analysis

  • Anna Takács,
  • Dalma Tábi,
  • Bianca Golzio Navarro Cavalcante,
  • Bence Szabó,
  • Alexander Schulze Wenning,
  • Gábor Gerber,
  • Péter Hermann,
  • Gábor Varga,
  • Péter Hegyi and
  • Márton Kivovics

23 March 2026

Background/Objectives: Odontogenic cysts and ameloblastomas (AB) are mostly asymptomatic, often discovered later due to severe symptoms, and only histopathological examination provides definitive diagnosis. AI-assisted diagnostics offer a fast, nonin...

(This article belongs to the Special Issue Oral Surgery: Recent Advances and Future Perspectives)
  • Review
  • Open Access
1 Citations
915 Views
16 Pages

Oncofertility in Women with Renal Cell Carcinoma in the Immune Checkpoint Inhibitors Era: A Multidisciplinary Perspective

  • Michele Miscia,
  • Antonio Raffone,
  • Veronica Mollica,
  • Pietro Piazza,
  • Linda Cipriani,
  • Manuela Maletta,
  • Stefano Ferla,
  • Maria Perucci,
  • Federica Cortese and
  • Diego Raimondo
  • + 4 authors

23 March 2026

Background/Objectives: Renal cell carcinoma (RCC) care has been reshaped by immune checkpoint inhibitors (ICIs), now used across adjuvant and metastatic settings as PD-1/PD-L1 blockade alone, combined with anti-CTLA-4 agents, or in combination with v...

(This article belongs to the Section Oncology)
  • Article
  • Open Access
1 Citations
1,286 Views
15 Pages

Cardiac Syncope: An Underestimated Cause of Unexplained Syncope in the Elderly-Data from a Single High-Volume Syncope Unit

  • Stefanos Archontakis,
  • Evangelos Oikonomou,
  • Nikias Milaras,
  • Panagiotis Dourvas,
  • Tzonatan Klogkeri,
  • Dimitrios Kalantzis,
  • Anastasios Markakos,
  • Michail Ampeliotis,
  • Artemis Papadima and
  • Skevos Sideris
  • + 3 authors

23 March 2026

Background/Objectives: Syncope remains a common problem in the elderly, adversely affecting quality of life, morbidity and mortality. Diagnosis is challenging due to the atypical presentation, multifactorial aetiology, overlap with non-syncoptic fall...

(This article belongs to the Special Issue Cardiovascular Disease in the Elderly: Cardiogeriatric Assessment, Prevention, Treatment Outcomes and Perspectives)
  • Article
  • Open Access
982 Views
20 Pages

23 March 2026

Objectives: To clarify the characteristics of Basosquamous cell carcinoma (BSC), this study compares demographic, clinical, therapeutic, histological, and outcome findings of BSCs with those of basal cell carcinoma (BCC) and squamous cell carcinoma (...

(This article belongs to the Special Issue Skin Cancers: Update on Clinical Treatment and Management)
  • Article
  • Open Access
1,972 Views
14 Pages

23 March 2026

Background: Lipomas are common benign subcutaneous neoplasms treated surgically for cosmetic or symptomatic reasons. The minimal one-third incision and four-step (MOTIF) technique provides reliable excision with minimal scarring, but smaller proporti...

(This article belongs to the Special Issue New Insights into Skin Tumors: From Pathogenesis to Therapy)
  • Article
  • Open Access
1,073 Views
12 Pages

Safety Profile and Tumor Response of EGFR-TKIs in Clinical Practice: A Real-World Study in Thailand

  • Pattama Jainan,
  • Chayanat Pongsathabordee,
  • Kamala Sadabpod,
  • Titima Junkrut,
  • Thanakorn Jerasirichot,
  • Oran Phetchuensakun,
  • Taniya Paiboonvong and
  • Saranporn Srithonrat

23 March 2026

Background: Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are the first-line treatment for patients with non-small cell lung cancer (NSCLC) harboring EGFR mutations. Although EGFR-TKIs can cause various adverse events (AEs),...

(This article belongs to the Section Oncology)
  • Review
  • Open Access
1 Citations
1,951 Views
18 Pages

The Current Landscape of Artificial Intelligence in Positron Emission Tomography (PET) Imaging Across the Cancer Continuum

  • Wut Yee The Zar,
  • Mi Rim Kim,
  • Aruni Ghose,
  • Sola Adeleke,
  • Manoj Gupta,
  • Partha S. Choudhary,
  • Anirudh Shankar,
  • Srishti Mohapatra,
  • Stergios Boussios and
  • Akash Maniam

23 March 2026

PET scans have long been used in oncology imaging to provide molecular and metabolic information about diseases. The use of artificial intelligence (AI) in PET scans in oncology theranostics has the potential to optimise PET modality and overcome the...

(This article belongs to the Section Oncology)
  • Article
  • Open Access
1 Citations
768 Views
12 Pages

Long-Term Clinical and Biological Outcomes of Biologic Therapy in Severe Asthma: 24-Month Real-World Cohort Study from Romania

  • Corina Mărginean,
  • Andreea Cristina Safta,
  • Dragoș Huțanu,
  • Corina Eugenia Budin,
  • Maria Beatrice Ianosi,
  • Gabriela Jimborean and
  • Edith-Simona Ianosi

23 March 2026

Background: Severe asthma remains associated with substantial morbidity despite optimized inhaled therapy. Biologic agents targeting type 2 inflammation improve clinical outcomes; however, real-world evidence regarding the durability of these effects...

(This article belongs to the Section Respiratory Medicine)
  • Review
  • Open Access
2 Citations
1,744 Views
17 Pages

Artificial Intelligence in Asthma and COPD: Current Status and Future Potential

  • Federica Marrelli,
  • Chiara Lupia,
  • Saverio Nucera,
  • Daniela Pastore,
  • Paolo Zaffino,
  • Carolina Muscoli,
  • Girolamo Pelaia and
  • Corrado Pelaia

23 March 2026

Interest in artificial intelligence (AI) is rapidly growing. In healthcare, especially through machine learning and deep learning, AI is emerging as a promising tool to support the diagnosis, management, and prevention of lung diseases and to advance...

(This article belongs to the Special Issue Moving Forward to New Trends in Pulmonary Diseases)
  • Editorial
  • Open Access
999 Views
3 Pages

23 March 2026

Over the past decade, the therapeutic landscape of cystic fibrosis (CF) has undergone a historic transformation; once considered a progressive, life-limiting multisystem disease treated exclusively with symptomatic therapies, CF has entered the era o...

(This article belongs to the Special Issue Cystic Fibrosis: Novel Strategies of Diagnosis and Treatments)
  • Article
  • Open Access
812 Views
11 Pages

Patient-Specific Restoration of Constitutional Alignment Within Predefined Safety Boundaries Using Three-Dimensional Navigation in Primary Total Knee Arthroplasty: One-Year Clinical and Radiographic Outcomes

  • Maximilian F. Kasparek,
  • Tobias Scheidl,
  • Oliver Haider,
  • Gyula Kiss,
  • Anna Jungwirth-Weinberger,
  • Maximilian Muellner,
  • Valerie Ladstaetter and
  • Thomas Muellner

23 March 2026

Background/Objectives: This study investigates a surgical concept that restores constitutional bony alignment within predefined safety boundaries in primary total knee arthroplasty (TKA) using modern 3D navigation. The technique combines a standard k...

(This article belongs to the Special Issue New Insights in Joint Arthroplasty—2nd Edition)
  • Article
  • Open Access
846 Views
14 Pages

Identification of High-Risk Individuals for Osteoporosis and Fragility Fractures in Cushing’s Syndrome: A Promising Predictive Approach

  • Enes Ucgul,
  • Burak Menekse,
  • Ogulcan Boz,
  • Huseyin Demirci,
  • Bekir Ucan,
  • Erman Cakal,
  • Takako Araki and
  • Muhammed Kizilgul

23 March 2026

Background: Cushing’s syndrome (CS) causes excessive cortisol exposure, leading to significant skeletal complications. However, there is no validated, CS-specific model to predict osteoporosis and fracture risk. This study aimed to identify ind...

(This article belongs to the Section Endocrinology & Metabolism)
  • Article
  • Open Access
711 Views
11 Pages

23 March 2026

Background/Objectives: Adults with congenital heart disease (CHD) have a substantially higher risk of ischemic stroke than the general population. Circulating biomarkers such as N-terminal pro B-type natriuretic peptide (NT-pro-BNP), high-sensitivity...

(This article belongs to the Special Issue Current Challenges in Adult Congenital Heart Diseases)
  • Article
  • Open Access
1 Citations
1,094 Views
22 Pages

Risk Factors for Mortality in Critically Ill Patients with Diabetes Admitted to the ICU: A Single-Center Retrospective Observational Study

  • Mădălina Diana Daina (Fehér),
  • Codrin Dan Nicolae Ilea,
  • Cosmin Mihai Vesa,
  • Alina Cristiana Venter,
  • Simona Daciana Birsan,
  • Timea Claudia Ghitea,
  • László Fehér and
  • Cristian Marius Daina

23 March 2026

Background and Objectives: Diabetes mellitus (DM) is a highly prevalent comorbidity among critically ill patients and may significantly influence intensive care unit (ICU) outcomes through metabolic, immune, and cardiovascular mechanisms. This study...

(This article belongs to the Section Intensive Care)
  • Article
  • Open Access
749 Views
13 Pages

Comparative Diagnostic Accuracy of EUS-Guided Fine-Needle Biopsy Versus Aspiration for Pancreatic Serous Cystic Neoplasms: A Retrospective Cohort Study

  • Alan Chuncharunee,
  • Kazuo Hara,
  • Shin Haba,
  • Takamichi Kuwahara,
  • Nozomi Okuno,
  • Shimpei Matsumoto,
  • Hiroki Koda and
  • Tomoki Ogata

22 March 2026

Background: Serous cystic neoplasm (SCN) is a common benign pancreatic lesion frequently encountered in practice. However, diagnostic confirmation by Endoscopic ultrasound (EUS)-guided fine needle aspiration (FNA) is often limited by inadequate tissu...

(This article belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
  • Article
  • Open Access
1 Citations
1,163 Views
12 Pages

Bioinductive Collagen Augmentation in Arthroscopic Rotator Cuff Repair: 24-Month MRI and Clinical Outcomes

  • Daniele De Amicis,
  • Aurelio Picchi,
  • Luca Andriollo,
  • Francesco Calafiore,
  • Michela Saracco,
  • Riccardo Fabiani,
  • Andrea Fidanza,
  • Giandomenico Logroscino and
  • Francesco Raffelini

22 March 2026

Background/Objectives: Rotator cuff repair (RCR) is a common orthopedic procedure, with healing outcomes strongly influenced by patient-specific factors such as tissue quality, tear characteristics, and biological healing potential. Bioinductive coll...

(This article belongs to the Section Orthopedics)
  • Article
  • Open Access
1 Citations
593 Views
12 Pages

Reliability and Validity of the Serbian Version of the Hidradenitis Suppurativa Quality of Life Questionnaire (HSQoL-24)

  • Milana Marinkovic,
  • Milan Stojičić,
  • Marko S. Jović,
  • Jelena Rakocevic,
  • Zoran Bukumirić,
  • Milana Jurišić,
  • Milan D. Jovanović,
  • Jelena Jeremić,
  • Aleksandar M. Vlahovic and
  • Nataša Maksimović
  • + 1 author

22 March 2026

Background: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized by painful nodules, abscesses, and sinus tracts in apocrine gland-rich areas, leading to significant impairment in patients’ quality of life (QoL). P...

(This article belongs to the Section Dermatology)
  • Systematic Review
  • Open Access
965 Views
19 Pages

The Effects of Periodontal Treatment on Psoriasis: A Systematic Review of Limited Clinical and Preclinical Evidence

  • Daniela Cornelia Condor,
  • Ana-Maria Copaciu-Condor,
  • Andreea Kui,
  • Marius Negucioiu,
  • Smaranda Buduru and
  • Ondine Patricia Lucaciu

22 March 2026

Background/Objectives: Psoriasis and periodontitis share inflammatory pathways. Current evidence suggests a bidirectional non-causal relation. However, the evidence on the effects of periodontal treatment on psoriasis outcomes (severity, inflammatory...

(This article belongs to the Special Issue Emerging Therapies: Clinical Trials and Insights in Psoriasis)
  • Article
  • Open Access
842 Views
10 Pages

Is There a Reliable, Rapid, and Economic Diagnostic Approach for SLCO2A1-Related Chronic Enteropathy?

  • Rongbei Liu,
  • Yujuan Fu,
  • Jie Mao,
  • Zhinong Jiang,
  • Qian Cao and
  • Lingna Ye

22 March 2026

Background: Chronic enteropathy associated with SLCO2A1 (CEAS) is a rare genetic disorder that is prone to misdiagnosis and characterized by significant challenges in achieving an early diagnosis. Current diagnosis relies on clinical manifestation co...

(This article belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
  • Article
  • Open Access
1 Citations
973 Views
16 Pages

22 March 2026

Background: Red blood cell distribution width (RDW) is an accessible prognostic biomarker in cardiovascular disease, but its independent association with clinical outcomes in patients with acute myocardial infarction (AMI) undergoing percutaneous cor...

(This article belongs to the Section Cardiology)
  • Article
  • Open Access
831 Views
14 Pages

The Safety of Two Different Oral Misoprostol Dosing Strategies for Labor Preinduction at Term: A Single-Center Retrospective Cohort Study

  • Magdalena Adamczyk,
  • Witold Włodzimierz Kędzia,
  • Julia Rogalska,
  • Paulina Mularczyk and
  • Małgorzata Kędzia

22 March 2026

Background/Objectives: Preinduction of labor is commonly performed in women with unfavorable cervical conditions at term. Oral misoprostol is increasingly used due to its ease of administration and effectiveness; however, optimal dosing regimens rema...

(This article belongs to the Section Obstetrics & Gynecology)
  • Feature Paper
  • Article
  • Open Access
1 Citations
832 Views
14 Pages

Outcomes of Percutaneous Coronary Intervention in Patients with Inflammatory Bowel Disease

  • Umesh Bhagat,
  • Akshat Banga,
  • Ankit Agrawal,
  • Prabhat Kumar,
  • Aro Daniela Arockiam,
  • Akiva Rosenzveig,
  • Danial Nasif,
  • Heba Wassif and
  • Jean-Paul Achkar

22 March 2026

Background: Inflammatory bowel disease (IBD), comprising Crohn’s disease (CD) and ulcerative colitis (UC), has been associated with elevated cardiovascular risks. However, the impact of IBD on outcomes following percutaneous coronary intervention (PC...

(This article belongs to the Special Issue Patient-Reported Outcomes (PROs) in Inflammatory Bowel Disease (IBD) Around the World—2nd Edition)
  • Article
  • Open Access
801 Views
14 Pages

22 March 2026

Background/Objectives: Recent guidelines have emphasized the importance of early mobilization and rehabilitation of patients following cardiac surgery. However, studies on the optimal targets and prescription methods for phase I cardiac rehabilitatio...

(This article belongs to the Section Clinical Rehabilitation)
  • Systematic Review
  • Open Access
2 Citations
1,563 Views
26 Pages

Non-Invasive Radiofrequency Therapy for Musculoskeletal, Neurological, and Vascular Conditions of the Lower Limb: A Systematic Review and Meta-Analysis

  • Maria Jesus Vinolo-Gil,
  • María José Estebanez-Pérez,
  • Francisco Jose Vera-Serrano,
  • Jorge Góngora-Rodríguez,
  • Carlos Manuel Perez-Perez,
  • Francisco Javier Martin-Vega and
  • Ismael García-Campanario

22 March 2026

Background/Objectives: Non-invasive radiofrequency (NIRF) therapy is increasingly used in physical rehabilitation. However, its efficacy across different lower limb pathologies remains unclear. This study aimed to evaluate the effects of NIRF on pain...

(This article belongs to the Section Clinical Rehabilitation)
  • Review
  • Open Access
2,078 Views
21 Pages

Restoration of Muscle Function Following Distal Biceps Tendon Reinsertion: A Narrative Review

  • Michał Harasymczuk,
  • Ewa Bręborowicz,
  • Aleksandra Bartkowiak-Graczyk,
  • Anna Madziewicz,
  • Tomasz Balcerek and
  • Leszek Romanowski

22 March 2026

Background/Objectives: Distal biceps tendon rupture (DBTR) significantly impairs upper-limb function, particularly in movements requiring elbow flexion and forearm supination. This condition continues to attract clinical interest due to its complex b...

(This article belongs to the Special Issue Shoulder and Elbow Surgery: Clinical Updates and Perspectives)
  • Article
  • Open Access
648 Views
19 Pages

Temporal Dissociation Between Intravascular Albumin Mass and Transcapillary Escape Dynamics in Sepsis: A Longitudinal Characterization of Albumin Homeostasis Using Routine Laboratory Parameters

  • Gianni Turcato,
  • Arian Zaboli,
  • Lucia Filippi,
  • Michael Maggi,
  • Alessandra Eugenia Bionda,
  • Fabrizio Lucente,
  • Alberto Caregnato,
  • Daniela Milazzo,
  • Paolo Ferretto and
  • Christian J. Wiedermann
  • + 1 author

22 March 2026

Background: In sepsis, albumin homeostasis is altered by capillary leak and recovery mechanisms (synthesis and interstitial–lymphatic return), which are difficult to capture clinically. A joint evaluation of ratio-based escape dynamics and mass...

(This article belongs to the Section Emergency Medicine)
  • Article
  • Open Access
647 Views
11 Pages

22 March 2026

Background: Cardiac troponin testing is central to evaluating suspected acute coronary syndromes, yet its expanding use may increase resource utilization in low-risk emergency department populations. Methods: We conducted a multicenter retrospective...

(This article belongs to the Section Cardiology)
  • Article
  • Open Access
1 Citations
638 Views
10 Pages

Safety of Simultaneous Robot-Assisted Resection of Colorectal Malignancy and Synchronous Liver Metastases

  • Miha Petrič,
  • Boštjan Plešnik,
  • Jurij Aleš Košir,
  • Blaž Trotovšek and
  • Jan Grosek

22 March 2026

Introduction: Simultaneous resection of primary colorectal malignancies and liver metastases resulted in outcomes comparable to those achieved through a two-stage procedure, while offering the advantage of a single surgical intervention. The role of...

(This article belongs to the Special Issue Clinical Advances in Risk Minimization Through Robot-Assisted Surgery)
  • Case Report
  • Open Access
894 Views
8 Pages

22 March 2026

Background/Objectives: Fully robotic pancreatic resections using the Hugo™ RAS platform have not yet been described in the literature. Methods: A 72-year-old male with a cystic lesion in the pancreatic tail underwent a fully robotic distal panc...

(This article belongs to the Special Issue Challenges and Opportunities in Application of Laparoscopic, Robotic and Other Technological Advances in Gastrointestinal Surgery)
  • Article
  • Open Access
1 Citations
800 Views
18 Pages

Psycho-Socio-Cultural Determinants of Delayed Presentation for Specialized Burn Care and Their Clinical Consequences: A Mixed Observational Study

  • Bogdan Oprita,
  • Georgeta Burlacu,
  • Vlad-Mircea Ispas,
  • Cristina Virag-Iorga,
  • Alice-Elena Diaconu and
  • Ruxandra Oprita

21 March 2026

Background: Burn injuries have both physical and psychological impacts on patients. Factors such as personal beliefs, prior experiences, and geographic, economic, or cultural barriers, as well as fear of hospitals, can contribute to delays in seeking...

(This article belongs to the Section Emergency Medicine)
  • Article
  • Open Access
1,022 Views
12 Pages

Hepatitis B Virus, Helicobacter pylori and High-Risk Events of Gastric Cancer Development: An Observational Study (SIGES)

  • Jin-Chen Zou,
  • Mao-Yao Wen,
  • Yuan Yang,
  • Zhuo-Yu Li,
  • Yan Huang,
  • Xin-Zu Chen and
  • SIGES Research Group

21 March 2026

Background: Hepatitis B virus (HBV) is an infection proven to increase the risk of gastric cancer, especially among hepatitis B virus surface antigen (HBsAg) seropositive patients. However, the route through which HBV injures gastric mucosa and its m...

(This article belongs to the Section Epidemiology & Public Health)
  • Article
  • Open Access
3 Citations
800 Views
12 Pages

Open vs. Laparoscopic Surgery for Rectal Cancer: Impact on Identification and Preservation of Pelvic Autonomic Nerves and Effects on Urinary and Sexual Function and Quality of Life

  • Ivan Dimitrijevic,
  • Marko Miladinov,
  • Jelenko Jelenkovic,
  • Predrag Gavrilovic,
  • Aleksandar Sekulic,
  • Goran Barisic and
  • Jovana Rosic Stojkovic

21 March 2026

Background/Objectives: With advances in surgical techniques for rectal cancer—particularly laparoscopic and robotic-assisted approaches—the choice of operative method may influence not only oncological but also functional outcomes. This s...

(This article belongs to the Section General Surgery)
  • Article
  • Open Access
666 Views
14 Pages

21 March 2026

Background/Objectives: Racial and ethnic disparities in cesarean birth and labor management persist in the United States, including among individuals considered low risk. Understanding variation in labor progression and cesarean indications within lo...

(This article belongs to the Section Obstetrics & Gynecology)
  • Article
  • Open Access
1 Citations
1,109 Views
18 Pages

Relevance of Reversible Causes of Out-of-Hospital Cardiac Arrest: The “REBECCA” Interactive Checklist

  • Martina Hermann,
  • Arthur Stoiber,
  • Andreas Schmid,
  • Thomas Hamp,
  • Angelika De Abreu Santos,
  • Daniel Grassmann,
  • Mario Krammel,
  • Josef M. Lintschinger,
  • Stefan Ulbing and
  • Christina Hafner
  • + 1 author

21 March 2026

Background/Objectives: Adequate cardiopulmonary resuscitation (CPR), defibrillation, and treatment of reversible causes are essential for improving the survival of patients suffering from out-of-hospital cardiac arrests (OHCAs). The Advanced Life Sup...

(This article belongs to the Special Issue Current Challenges and Innovations in Emergency Medicine: From Prehospital Care to Critical Decision-Making in the Emergency Department)
  • Article
  • Open Access
1 Citations
1,562 Views
15 Pages

Long-Term Neurodevelopmental Outcomes and Prognostic Factors in Neonates with Hypoxic–Ischemic Encephalopathy

  • Ramazan Keçeci,
  • Melek Büyükeren,
  • Fatma Hilal Yılmaz,
  • Beyza Özcan,
  • Ümmügülsüm Pamukçu,
  • Şambaz Yılmaz,
  • Halil Çelik and
  • Ümmügülsüm Esenkaya

21 March 2026

Background: Hypoxic–ischemic encephalopathy (HIE) remains a major cause of neonatal mortality and long-term neurodevelopmental impairment despite advances in perinatal care and the widespread use of therapeutic hypothermia. Reliable early progn...

(This article belongs to the Special Issue Clinical Advances in Child Neurology)

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J. Clin. Med. - ISSN 2077-0383