Real-World Visual and Refractive Results of Two Different Presbyopia Correcting Intraocular Lenses

Hinterberger, Sarah; Artmayr, Cornelia; Multani, Karanpreet; Riaz, Kamran M.; Pantanelli, Seth M.; Kaiser, Klemens P.; Langenbucher, Achim; Bolz, Matthias; Wendelstein, Jascha A.

doi:10.3390/jcm14228259

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Open AccessArticle

Real-World Visual and Refractive Results of Two Different Presbyopia Correcting Intraocular Lenses

by

Sarah Hinterberger

^1,2,†,

Cornelia Artmayr

^1,2,†,

Karanpreet Multani

³

,

Kamran M. Riaz

³

,

Seth M. Pantanelli

⁴

,

Klemens P. Kaiser

⁵

,

Achim Langenbucher

⁶,

Matthias Bolz

^1,2 and

Jascha A. Wendelstein

^6,7,8,*

¹

Medical Faculty, Johannes Kepler University Linz, Altenberger Strasse 69, 4040 Linz, Austria

²

Department for Ophthalmology and Optometry, Kepler University Hospital GmbH, Krankenhausstrasse 9, 4020 Linz, Austria

³

Dean McGee Eye Institute, University of Oklahoma, Oklahoma City, OK 73019, USA

⁴

Department of Ophthalmology, Penn State College of Medicine, Hershey, PA 17033, USA

⁵

Department of Ophthalmology, Goethe-University Frankfurt, 60590 Frankfurt, Germany

⁶

Institute of Experimental Ophthalmology, Saarland University, Kirrberger Str. 100/22, 66424 Homburg, Germany

⁷

Department of Ophthalmology, Ludwig-Maximilians-Universität, 80336 Munich, Germany

⁸

Institut für Refraktive und Ophthalmo-Chirurgie (IROC), 8002 Zurich, Switzerland

^*

Author to whom correspondence should be addressed.

^†

These authors contributed equally to this work.

J. Clin. Med. 2025, 14(22), 8259; https://doi.org/10.3390/jcm14228259 (registering DOI)

Submission received: 10 October 2025 / Revised: 10 November 2025 / Accepted: 17 November 2025 / Published: 20 November 2025

(This article belongs to the Special Issue Clinical Advancements in Intraocular Lens Power Calculation Methods)

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Abstract

Background/Objectives: To investigate visual acuity, refractive outcomes and the predictive accuracy of modern intraocular lens (IOL) power calculation formulas in eyes implanted with two presbyopia-correcting IOLs: trifocal Zeiss AT LISA TRI and the nondiffractive EDOF Teleon Comfort. Methods: This retrospective consecutive chart review included 115 patients who underwent uncomplicated bilateral cataract surgery and received either the LISA TRI (n = 56) or Comfort (n = 59). Biometric measurements were obtained preoperatively, and refractive outcomes were assessed 1, 3, and 6 months postoperatively. Postoperative spherical equivalent (SEQ) was compared to predicted SEQ using the ESCRS calculator and IOLCON platform. Outcome measures included mean prediction error and mean absolute error (MAE). Distance-corrected visual acuity (VA), uncorrected VA, defocus curves, preferred viewing distances, contrast sensitivity, and photopic reading speed were also analyzed. Results: All formulas performed better in the LISA TRI group, with significantly lower MAE and higher proportions of eyes within ±0.50 diopters (D). Systematic prediction error offsets were observed for three formulas (K6, Castrop, Hoffer QST) in the LISA TRI group and for all five formulas in the MF15 group. Refractive stability was achieved by 3 months for the LISA TRI, while 20% of Comfort eyes continued to show SEQ shifts >0.50 D at 3 months. Defocus equivalent (DEQ) had lower proportions of eyes within ±0.50 D than SEQ. Conclusions: The LISA TRI demonstrated superior predictive accuracy, faster refractive stabilization, and stronger near performance than the Comfort. These findings support the importance of IOL-specific constant optimization and highlight the need for incorporating DEQ into routine refractive outcome evaluation.

Keywords: cataract surgery; biometry; presbyopia-correcting IOL; refractive outcomes

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MDPI and ACS Style

Hinterberger, S.; Artmayr, C.; Multani, K.; Riaz, K.M.; Pantanelli, S.M.; Kaiser, K.P.; Langenbucher, A.; Bolz, M.; Wendelstein, J.A. Real-World Visual and Refractive Results of Two Different Presbyopia Correcting Intraocular Lenses. J. Clin. Med. 2025, 14, 8259. https://doi.org/10.3390/jcm14228259

AMA Style

Hinterberger S, Artmayr C, Multani K, Riaz KM, Pantanelli SM, Kaiser KP, Langenbucher A, Bolz M, Wendelstein JA. Real-World Visual and Refractive Results of Two Different Presbyopia Correcting Intraocular Lenses. Journal of Clinical Medicine. 2025; 14(22):8259. https://doi.org/10.3390/jcm14228259

Chicago/Turabian Style

Hinterberger, Sarah, Cornelia Artmayr, Karanpreet Multani, Kamran M. Riaz, Seth M. Pantanelli, Klemens P. Kaiser, Achim Langenbucher, Matthias Bolz, and Jascha A. Wendelstein. 2025. "Real-World Visual and Refractive Results of Two Different Presbyopia Correcting Intraocular Lenses" Journal of Clinical Medicine 14, no. 22: 8259. https://doi.org/10.3390/jcm14228259

APA Style

Hinterberger, S., Artmayr, C., Multani, K., Riaz, K. M., Pantanelli, S. M., Kaiser, K. P., Langenbucher, A., Bolz, M., & Wendelstein, J. A. (2025). Real-World Visual and Refractive Results of Two Different Presbyopia Correcting Intraocular Lenses. Journal of Clinical Medicine, 14(22), 8259. https://doi.org/10.3390/jcm14228259

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Real-World Visual and Refractive Results of Two Different Presbyopia Correcting Intraocular Lenses

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