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Journal of Clinical Medicine, Volume 14, Issue 22

November-2 2025 - 369 articles

Cover Story: Topical tretinoin is a first-generation retinoid with well-established efficacy in acne and photoaging. Its pleiotropic actions on epidermal differentiation, inflammation, pigmentation and collagen remodeling support a broad range of dermatologic uses. This review summarizes evidence from clinical trials and prospective studies published between 2000 and 2025, including FDA-approved indications and expanding off-label applications. Beyond acne and photoaging, tretinoin shows potential benefits in melasma, post-inflammatory hyperpigmentation, acanthosis nigricans, striae distensae, scarring, flat warts, alopecia, actinic keratosis and field cancerization. Overall, tretinoin remains a versatile, well-tolerated therapy with growing relevance in modern dermatology. View this paper
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Articles (369)

  • Article
  • Open Access
269 Views
14 Pages

Effects of Subcutaneous Administration of Glucocorticoids by Pellets on a Mouse Model of Ligature-Induced Periodontal Disease

  • Rintaro Kato,
  • Takuma Sato,
  • Shunsuke Kako,
  • Masako Tabuchi,
  • Yuki Aoki,
  • Kai Kataoka,
  • Sho Okuni,
  • Yoshihiko Sugita,
  • Hatsuhiko Maeda and
  • Ken Miyazawa

20 November 2025

Background/Objective: Glucocorticoids (GC) have anti-inflammatory effects, but long-term use can suppress bone formation and cause osteoporosis. The impact of inflammatory environments, such as periodontitis, on alveolar bone metabolism remains insuf...

  • Article
  • Open Access
555 Views
16 Pages

20 November 2025

Background: Primary Biliary Cholangitis (PBC) is a chronic autoimmune liver disease, characterized by cholestasis and fibrosis. Ursodeoxycholic acid (UDCA) is the first-line treatment for normalizing markers, slowing progression, and improving outcom...

  • Article
  • Open Access
385 Views
21 Pages

Early Detection of Acute Kidney Injury After Congenital Heart Surgery—Using Urine Proteomics to Identify New Biomarker Candidates: A Prospective Clinical Study

  • Raphael Seiler,
  • Alexa Leona Herre,
  • Marieluise Kirchner,
  • Matthias Ziehm,
  • Philipp Mertins,
  • Felix Berger,
  • Joachim Photiadis,
  • Giang Tong,
  • Liliya Brankova and
  • Katharina R. L. Schmitt
  • + 1 author

20 November 2025

Background: Acute kidney injury (AKI) is a frequent complication following congenital heart surgery and is associated with increased morbidity and mortality. Early recognition is crucial, yet standard clinical biomarkers result in delayed detection....

  • Article
  • Open Access
399 Views
20 Pages

20 November 2025

Background/Objectives: The increasing number and complexity of cardiac and neurosurgical procedures underscore the importance of effective perioperative care. One of the most serious postoperative complications is delirium, which prolongs hospitaliza...

  • Feature Paper
  • Article
  • Open Access
463 Views
12 Pages

Ultrasound-Guided Supraclavicular Nerves Block for Acute Pain Management in Clavicular Fractures—A Pragmatic Randomized Trial

  • Eckehart Schöll,
  • Mark Ulrich Gerbershagen,
  • Werner Vach,
  • Maria Rösli and
  • Rainer Jürgen Litz

20 November 2025

Background/Objectives: This pragmatic randomized controlled trial evaluated the efficacy of ultrasound-guided supraclavicular nerve (SCLN) block compared to standard pain management in patients with acute displaced clavicle fractures (CFs) in an emer...

  • Article
  • Open Access
317 Views
13 Pages

Artificial Intelligence-Based Evaluation of Post-Procedural Electrocardiographic Parameters to Identify Patients at Risk of Atrial Fibrillation Recurrence After Transcatheter Ablation

  • Gennaro De Rosa,
  • Marco Giuggia,
  • Mattia Peyracchia,
  • Martina Peddis,
  • Roberto Di Summa,
  • Elisa Pelissero,
  • Giuseppe Trapani,
  • Davide De Los Rios,
  • Fabio Ugliano and
  • Plinio Cirillo
  • + 1 author

20 November 2025

Background/Objectives: Arrhythmic recurrence is a common issue affecting a significant percentage of patients undergoing transcatheter ablation (TCA) of Atrial Fibrillation (AF). The use of artificial intelligence (AI) for the identification of elect...

  • Review
  • Open Access
551 Views
12 Pages

Projected Augmented Reality in Surgery: History, Validation, and Future Applications

  • Nikhil Dipak Shah,
  • Lohrasb Sayadi,
  • Peyman Kassani and
  • Raj Vyas

20 November 2025

Background/Objectives: Projected augmented reality (PAR) enables real-time projection of digital surgical information directly onto the operative field. This offers a hands-free, headset-free platform that is universally visible to all members of the...

  • Article
  • Open Access
249 Views
12 Pages

Comparative Evaluation of Sagittal Alignment in Total Knee Arthroplasty: Robot Sensor Versus Surgeon’s Eye and Influencing Factors

  • Dong Nyoung Lee,
  • Chang Hyun Nam,
  • Ji-Hoon Baek,
  • Suengryol Ryu,
  • Juneyoung Heo,
  • Ji Hyun Kim,
  • Su Chan Lee and
  • Sang Won Lee

20 November 2025

Background: Postoperative sagittal imbalance, including hyperextension and flexion contracture after total knee arthroplasty (TKA), adversely affects long-term outcomes. Conventional techniques depend on surgeons’ visual estimation, which may v...

  • Article
  • Open Access
249 Views
15 Pages

20 November 2025

Background/Objectives: Radiotherapy (RT) induces oxidative stress and structural damage in solid tissues, including the liver. This study aimed to investigate the histological and immunohistochemical effects of dexmedetomidine (DEX) and amifostine on...

  • Article
  • Open Access
379 Views
13 Pages

Diagnostic Pitfalls of CT in Malignant Superior Cerebellar Artery Infarction: Implications for Treatment Decisions and Future Management Strategies

  • Maria Gollwitzer,
  • Baran Atli,
  • Vanessa Seiter,
  • Tobias Rossmann,
  • Eva Horner,
  • Anna Hauser,
  • Gracija Sardi,
  • Verena Sölva,
  • Andreas Gruber and
  • Kathrin Aufschnaiter-Hiessböck

20 November 2025

Background/Objectives: Superior cerebellar artery (SCA) infarction is a rare but clinically significant subtype of posterior circulation stroke. Extensive swelling in the SCA territory may cause downward brainstem compression and appear as brainstem...

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J. Clin. Med. - ISSN 2077-0383