30 September 2026
Objectives: To estimate the incidence of reported retinal detachment (RD) after primary anti-vascular endothelial growth factor (anti-VEGF) treatment for retinopathy of prematurity (ROP) and to explore study-level factors associated with RD incidence...
30 September 2026
Background: Posterior component separation with transversus abdominis release (TAR) enables tension-free reconstruction of large midline incisional hernias but, when performed as a complete bilateral release, may expose selected patients to extensive...
Background/Objectives: Sodium-glucose cotransporter 2 (SGLT2) inhibitors are increasingly used for heart failure and chronic kidney disease beyond type 2 diabetes, increasing exposure among people without diabetes. Ketoacidosis is a recognized compli...
Background/Objectives: This scoping review mapped how hyaluronic acid (HA) molecular weight has been defined and investigated in direct clinical comparisons for temporomandibular disorders (TMDs), including formulations, populations, procedures, outc...
Background/Objectives: Diffuse large B-cell lymphoma (DLBCL) is an aggressive hematologic malignancy with a defined, first-line (1L) standard of care (SOC). Several novel agents have been approved for the treatment of relapsed/refractory (R/R) diseas...
Background/Objectives: Immune checkpoint inhibitors have become a standard treatment option for advanced/metastatic non-small cell lung cancer (NSCLC); however, considerable heterogeneity exists among patients regarding treatment response and surviva...
Introduction: The safety assessment of tattoo removal procedures rests on the assumption that the treatment substrate corresponds to the ink composition declared by the manufacturer. This assumption has rarely been verified. Methods: A structured, co...
Introduction: The purpose of this study was to determine the prevalence of fibromyalgia (FM) syndrome in those with idiopathic granulomatous mastitis (IGM) and to assess the correlations between anxiety, depression, fatigue, sleep quality, and overal...
Background: Esophagectomy carries substantial morbidity and mortality with advanced age being a known risk factor. This study aims to evaluate the outcome of esophagectomy in octogenarians in the context of increasing adoption of minimally invasive e...
Background/Objectives: Prehospital quick Sequential Organ Failure Assessment (qSOFA) screens poorly for sepsis, but an already-recorded field score may still inform the receiving physician. We asked whether it is associated with 30-day mortality with...
Background/Objectives: A cancer diagnosis and its subsequent treatment constitute one of the most psychologically demanding experiences a patient can face, and decades of psycho-oncology research have documented an elevated burden of depression, anxi...
Background: Implantable cardioverter defibrillators (ICDs) are essential for the primary prevention of sudden cardiac death in heart failure (HF); however, appropriate shocks increase mortality and impair quality of life. The electrical risk score (E...
Recent advances in digital dentistry have transformed occlusal analysis through the introduction of new digital workflows for recording static and dynamic occlusal contacts. This clinical study aimed to evaluate the reliability and concordance of two...
Background/Objectives: To evaluate the concordance of three general-purpose large language models (LLMs), ChatGPT, Claude, and Gemini, with an adjudicated expert consensus classification of Stage, Grade, and Extent in Stage III–IV periodontitis...
Background/Objectives: Type 2 myocardial infarction (T2MI) results from a myocardial oxygen supply–demand imbalance without acute coronary atherothrombosis, and the role of invasive coronary angiography in its management is undefined. Prior lit...
Background: The deep-intronic variant 3849+10kbC>T preserves residual CFTR function and is recurrently associated with pancreatic sufficiency, normal or borderline sweat chloride and diagnosis beyond early childhood. A co-occurring poly-T 5T allel...
Oral piercing is an increasingly popular form of body modification, particularly among adolescents and young adults. Despite its aesthetic and cultural appeal, growing evidence indicates that oral piercings have been associated with a range of oral a...
Historically, beta-blockers have long represented a cornerstone of secondary prevention after acute myocardial infarction (AMI). However, the transition to the modern era of early reperfusion and potent pharmacotherapy has questioned their universal...
Background/Objectives: Gestational diabetes mellitus (GDM) is associated with increased short- and long-term risks for both mother and child. Screening and treatment between 24 and 30 weeks’ gestation reduces adverse pregnancy outcomes, while e...
Background: Vascular ultrasound enables non-invasive assessment of lower-limb arterial morphology and hemodynamics and may identify vascular abnormalities associated with type 2 diabetes mellitus (T2DM). This study aimed to determine whether ultrasou...
Background/Objectives: Surgical access and one-lung ventilation (OLV) may generate distinct systemic and local inflammatory responses after lung resection. We compared perioperative cytokine profiles in serum, pleural fluid, and bronchoalveolar lavag...
29 September 2026
Background: Pulmonary epithelioid trophoblastic tumor (ETT) without demonstrable uterine involvement is an exceedingly rare form of gestational trophoblastic neoplasia. Its non-specific presentation often results in misdiagnosis, commonly as ectopic...
Background: Mutations of the FLT3 gene, particularly internal tandem duplication (FLT3-ITD), define a biologically aggressive AML subtype with historically poor outcomes. Here we retrospectively assessed the clinical performance and tolerability of s...
Background/Objectives: Postoperative atrial fibrillation (POAF) is a common complication of coronary artery bypass grafting (CABG) and may recur during cardiac rehabilitation (CR); its long-term prognostic value remains unclear. We evaluated the impa...
Background/Objectives: Human papillomavirus (HPV) is one of the most widespread sexually transmitted infections (STIs) worldwide. The aim of the present study was to evaluate the prevalence and genotype distribution of HPV in Türkiye and Norther...
Background/Objectives: Catheter-appropriateness audits report a single rate without a measure of its reliability. We measured how far an emergency department (ED) estimate depends on the clinician applying the checklist, and which items carry that de...
Background/Objectives: Immune checkpoint inhibitor-related hepatitis (ICI-H) can resemble classical autoimmune hepatitis (AIH), but comparative multidomain data remain limited. We compared their clinical, biochemical, and serological profiles and des...
Background/Objectives: Modifiable lifestyle factors are established determinants of venous thromboembolism risk, but their relationship with the severity and early course of acute pulmonary embolism (PE) is poorly characterized, and no validated Roma...
Background: Anti-Müllerian hormone (AMH) is a key biomarker of ovarian reserve, reflecting the quantity of the remaining follicular pool. While chronological age is the primary determinant of AMH concentrations, emerging evidence suggests that v...
Background/Objectives: Multiple organ dysfunction syndrome (MODS) results from dynamic inter-organ interactions rather than isolated organ failures. Among these, kidney–lung crosstalk is a key determinant of outcomes in critically ill patients....
Background/Objectives: Sodium-glucose cotransporter-2 inhibitors (SGLT2i) are foundational therapy for heart failure with reduced ejection fraction (HFrEF), irrespective of diabetes. We evaluated recorded SGLT2i adoption and diabetes-related differen...
Background/Objectives: Dry eye disease (DED) affects daily visual functioning and vision-related quality of life in addition to tear film stability and ocular surface integrity. In a previously published prospective cohort, lyophilized amniotic membr...
Background/Objectives: The CRP–albumin–lymphocyte (CALLY) index is promoted both as a marker of postoperative morbidity and as a prognostic factor for survival. These claims are rarely tested together, thresholds usually come from the dat...
Background/Objectives: Antiseizure medications (ASMs) are widely used in the management of epilepsy; however, their effects on male reproductive function in humans remain incompletely characterized. This study aimed to evaluate drug-specific associat...
Background/Objectives: Premixed calcium silicate putties are used in vital pulp therapy, but direct comparisons with powder–liquid MTA from the same manufacturer remain scarce. This exploratory study compared the short-term combined clinical an...
Background: Breast cancer is the most common malignancy among women. The HER2-low subgroup represents one of its prevalent subtypes; however, due to its unique characteristics, it presents challenges in diagnosis and treatment, complicating clinical...
Pregnancy is characterized by progressive hemostatic adaptation: increased fibrinogen synthesis, enhanced thrombin generation, and reduced fibrinolytic potential together prepare the maternal circulation for delivery-related blood loss. A fall in fib...
Objective: To compare two lipid-lowering therapy strategies involving Ezetimibe and Alirocumab on the vulnerability of atherosclerotic plaque (AP) in patients with acute coronary syndrome (ACS) not achieving the LDL-cholesterol target while on intens...
Background/Objectives: Disability in chronic low back pain (CLBP) is multifactorial, yet the independent associations of pain, fear-avoidance beliefs, and comorbidity burden with self-reported disability and performance-based walking capacity remain...
Background/Objectives: Noonan syndrome (NS) is characterized by marked phenotypic variability. Although the classical phenotype includes short stature, craniofacial dysmorphism, skeletal abnormalities, and congenital heart defects, some patients pres...
Background: Preoperative perforator mapping is widely used to guide perforator selection in deep inferior epigastric perforator (DIEP) flap breast reconstruction. However, the impact of different imaging modalities on operative variables and postoper...
Background/Objectives: Chronic venous disease significantly impairs health-related quality of life (HRQoL). Although the Chronic Venous Insufficiency Questionnaire (CIVIQ-20) is widely used internationally, a validated Arabic version is lacking. The...
Objectives: Clusterin (CLU) has been implicated in cell survival and treatment resistance, but its relationship with pathological response to neoadjuvant chemotherapy in breast cancer remains unclear. We evaluated CLU expression in routine diagnostic...
Background/Objectives: Coronary artery disease coexists with severe aortic stenosis in about half of patients. Surgical aortic valve replacement with coronary artery bypass grafting (SAVR+CABG) is guideline-recommended, but transcatheter aortic valve...
Background: The C-reactive protein–albumin–lymphocyte (CALLY) index integrates systemic inflammation, nutritional status, and immune function. This study evaluated changes in the CALLY index after sleeve gastrectomy and their associations...
Background/Objectives: Pulse pressure (PP), an indirect hemodynamic marker reflecting the pulsatile component of blood pressure, has been linked to adverse outcomes in dialysis patients. Whether 24 h PP (24 h PP) derived from ambulatory BP monitoring...
We read with interest the study by Akkaya et al [...]
We read with great interest the recent case report describing acute kidney injury (AKI) requiring temporary haemodialysis following intraureteral indocyanine green (ICG) instillation during laparoscopic endometrioma excision [...]
Background: Neuropeptide Y is a highly conserved neuropeptide involved in several physiological processes, including stress regulation, appetite control, and cognitive functioning. Emerging evidence suggests that alterations in neuropeptide Y signali...
