You are currently viewing a new version of our website. To view the old version click .

Journal of Clinical Medicine, Volume 14, Issue 12

June-2 2025 - 376 articles

Cover Story: Alcohol use disorder (AUD) in patients with heroin use disorder (HUD) represents a major clinical challenge. While methadone is effective for HUD, many patients fail to respond to approved anti-craving agents for AUD. Sodium oxybate (SMO), a GHB salt approved for alcohol relapse prevention in Europe, may represent the closest option to substitution therapy for AUD. This retrospective study compared treatment outcomes in patients receiving methadone plus SMO either as detoxification only or as ongoing maintenance. Our aim was to assess the six-month efficacy of SMO co-maintenance in reducing alcohol use and improving treatment retention among patients with co-occurring HUD and AUD. View this paper
  • Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
  • You may sign up for email alerts to receive table of contents of newly released issues.
  • PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.

Articles (376)

  • Systematic Review
  • Open Access
2,256 Views
18 Pages

19 June 2025

Background: One of the major contributors to homeostasis at the level of the central nervous system, specifically the brain, is the glymphatic system, which is described as an exchange occurring at the level of and between the interstitial fluid and...

  • Article
  • Open Access
2 Citations
1,589 Views
14 Pages

Efficacy and Safety of Fosfomycin Disodium in Patients with Bacterial Infections: A Single-Center, Real-Life Clinical Study

  • Fabio Luciano,
  • Lorenzo Bertolino,
  • Fabian Patauner,
  • Filomena Boccia,
  • Raffaella Gallo,
  • Pino Sommese,
  • Anna Maria Carolina Peluso,
  • Oriana Infante,
  • Silvia Mercadante and
  • Augusto Delle Femine
  • + 4 authors

19 June 2025

Objectives: Fosfomycin is an old antibiotic that has recently gained attention owing to its preserved activity against multidrug-resistant (MDR) bacteria. Data on its use in real life are limited. Thus, we evaluated the efficacy and safety of fosfomy...

  • Article
  • Open Access
668 Views
11 Pages

Understanding the Perioperative Perception of Pain in Patients with Crohn’s Disease: Epidural Versus Non-Epidural Analgesia

  • Regina Pistorius,
  • Anna Widder,
  • Marleen Sabisch,
  • Christian Markus,
  • Michael Meir,
  • Imad Maatouk,
  • Christoph-Thomas Germer,
  • Patrick Meybohm,
  • Nicolas Schlegel and
  • Matthias Kelm
  • + 1 author

19 June 2025

Background: Patients with Crohn’s disease (CD) suffer from a relevant burden of abdominal pain and psychological distress that can aggravate postoperatively. While systematic strategies for postoperative pain management are lacking, the potenti...

  • Systematic Review
  • Open Access
730 Views
12 Pages

Recurrence Pattern of Left Upper Lobectomies and Trisegmentectomies: Systematic Review and Meta-Analysis

  • Borja Aguinagalde,
  • Juan A. Ferrer-Bonsoms,
  • Iker López,
  • Jon Ander Lizarbe,
  • Arantza Fernandez-Monge,
  • Maria Mainer,
  • Raul Embun and
  • Jon Zabaleta

19 June 2025

Background: Surgical resection remains the standard treatment for early-stage non-small-cell lung cancer (NSCLC). Traditionally, lobectomy has been considered the procedure of choice; however, emerging evidence suggests that trisegmentectomy may offe...

  • Article
  • Open Access
1,760 Views
19 Pages

A Multicentre, Double-Blind, Randomised, Non-Inferiority Trial of a Novel Single-Injection Intra-Articular HMDA-Cross-Linked Hyaluronate Gel for Knee Osteoarthritis

  • Kang-Il Kim,
  • Yong In,
  • Hyung-Suk Choi,
  • Ju-Hong Lee,
  • Jae-Ang Sim,
  • Han-Jun Lee,
  • Young-Wan Moon,
  • Oog-Jin Shon,
  • Jong-Keun Seon and
  • Young-Mo Kim
  • + 3 authors

19 June 2025

Background/Objectives: This Phase 3, randomised, double-blind, multicentre trial evaluated the efficacy and safety of a novel hyaluronic acid hydrogel cross-linked with hexamethylenediamine (HMDA-HA) compared to a conventional 1,4-butanediol diglycid...

  • Article
  • Open Access
783 Views
11 Pages

19 June 2025

Objectives: This study aimed to present our single-center experience on the efficacy of endovascular treatment for the dysfunction of hemodialysis arteriovenous fistulas (AVF). Methods: This retrospective study analyzed 110 patients with hemodialysis...

  • Article
  • Open Access
937 Views
16 Pages

19 June 2025

Objective: In recent years, a significant increase in the incidence of both total hip arthroplasty and acetabular revision surgery has been observed. A substantial proportion of patients requiring these revision procedures present with major bone def...

  • Article
  • Open Access
2 Citations
979 Views
13 Pages

The Relationship Between Neuromuscular Block Depth and Airway Retroglossal Area: A Prospective, Nonrandomized, Observational Clinical Trial

  • László Asztalos,
  • Mena Boktor,
  • Miklós Kukuly,
  • Dorka Sólyom,
  • Adrienn Pongrácz,
  • Sorin J. Brull and
  • Béla Fülesdi

19 June 2025

Background: Tracheal intubation and mechanical ventilation are facilitated by neuromuscular blocking agents. We investigated the effectiveness of subjective clinical evaluation of neuromuscular function on retroglossal area size, since it determines...

  • Systematic Review
  • Open Access
1 Citations
3,001 Views
23 Pages

Oral Findings Linked to Chronic Kidney Disease: A Comprehensive Systematic Review

  • Paula García-Rios,
  • Francisco Javier Rodríguez-Lozano and
  • Nuria Pérez-Guzmán

19 June 2025

Background\Objectives: Chronic kidney disease (CKD) is defined as a clinical syndrome secondary to a permanent change in kidney function or structure, making it irreversible. Most patients at the onset of the disease are asymptomatic or present nonsp...

  • Review
  • Open Access
1,940 Views
16 Pages

Enhancing Patient Education for Colonoscopy Preparation: Strategies, Tools, and Best Practices

  • Roba Ganayem,
  • Osama Alamour,
  • Daniel L. Cohen,
  • Nour Ealiwa and
  • Naim Abu-Freha

19 June 2025

Background: Colonoscopy is an important and essential diagnostic and screening tool for colorectal cancer and other pathologies in the colon. High-quality bowel preparation (BP) is a key quality measure of colonoscopy and is critical for maximizing i...

of 38

Get Alerted

Add your email address to receive forthcoming issues of this journal.

XFacebookLinkedIn
J. Clin. Med. - ISSN 2077-0383