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Advances in Clinical Anesthesia and Analgesia: Novel Approaches for Optimal Patient Safety and Comfort

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Anesthesiology".

Deadline for manuscript submissions: 25 October 2025 | Viewed by 321

Special Issue Editors


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Guest Editor
Department of Surgical, Oncological and Oral Science (Di.Chir.On.S.), Section of Anesthesia, Analgesia, Intensive Care and Emergency, Policlinico Paolo Giaccone, University of Palermo, Via del Vespro 129, 90127 Palermo, Italy
Interests: analgosedation management; general anesthesia; anesthesiology; respiratory medicine

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Guest Editor
Responsabile Unità Operativa Analgesia e Chirurgia Percutanea, Fondazione Istituto G. Giglio, Cefalù, Italy
Interests: anesthesiology; pain management; neuromodulation; pain medicine; chronic pain management; interventional pain procedures

Special Issue Information

Dear Colleagues,

Ensuring optimal patient safety and comfort has always been a principal focus in the field of clinical anesthesia and analgesia. Over the past few years, significant progress has been made in developing novel technologies, pharmacological agents, and multimodal approaches for perioperative care. From refined regional anesthesia techniques and enhanced recovery pathways to personalized pain management and cutting-edge patient monitoring systems, the scope of modern anesthesiology continues to expand. These innovations have led not only to better intra- and postoperative outcomes but also to improved patient experiences and reduced healthcare costs.

In this Special Issue, we invite researchers and clinicians to contribute original research review and articles that highlight breakthroughs in clinical anesthesia and analgesia. Topics may include (but are not limited to) advancements in regional anesthesia, opioid-sparing techniques, patient-centered analgesic strategies, individualized sedation protocols, innovative monitoring and safety systems, and the intersection of anesthesia with emerging fields such as neuromodulation and telemedicine. By sharing knowledge and insights in these areas, we aim to foster collaboration and drive further progress toward safer and more comfortable patient care.

We look forward to your contributions and to advancing the field together.

Dr. Cesare Gregoretti
Dr. Giuliano Lo Bianco
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pain management
  • pain medicine
  • anesthesia
  • analgesia
  • anesthesiology

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Published Papers (1 paper)

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21 pages, 2319 KiB  
Systematic Review
The Effect of Thermal-Softened Endotracheal Tubes on Postoperative Sore Throat and Other Complications—A Systematic Review and Meta-Analysis
by Hui-Zen Hee, Chen-Hsi Chiu and Cheng-Wei Lu
J. Clin. Med. 2025, 14(11), 3620; https://doi.org/10.3390/jcm14113620 - 22 May 2025
Viewed by 145
Abstract
Background: Endotracheal tube (ETT) intubation during general anesthesia (GA) is commonly associated with postoperative sore throat. This study aimed to evaluate whether thermal-softened ETTs reduce the postoperative sore throat incidence in patients undergoing elective surgery under GA. Methods: We conducted a [...] Read more.
Background: Endotracheal tube (ETT) intubation during general anesthesia (GA) is commonly associated with postoperative sore throat. This study aimed to evaluate whether thermal-softened ETTs reduce the postoperative sore throat incidence in patients undergoing elective surgery under GA. Methods: We conducted a comprehensive search of the literature across PubMed, Cochrane Library, and EMBASE to identify randomized controlled trials (RCTs) evaluating the effect of thermal-softened ETTs on postoperative sore throat in patients undergoing elective surgeries under GA. The primary outcome was postoperative sore throat incidence, while secondary outcomes included hoarseness, vocal cord lesions, and time to intubation. Data were extracted independently by two authors, and the risk of bias was assessed using the Revised Cochrane risk of bias tool (version 2.0). A meta-analysis was then performed using the random-effects model, with the results expressed as risk ratios (RRs) and mean difference (MDs). Results: Eight studies, with a total of 970 participants, were included. Thermal-softened ETTs significantly reduced postoperative sore throat incidence (RR: 0.60, 95% CI: 0.44 to 0.82, p = 0.001). Subgroup analysis showed no difference for single-lumen tubes (RR: 0.76, 95% CI: 0.45 to 1.26, p = 0.28), but remained significant for double-lumen tubes (RR: 0.5, 95% CI: 0.39 to 0.65, p < 0.00001). No significant difference was found in hoarseness (RR: 0.86, 95% CI: 0.64 to 1.17, p = 0.34), but a lower incidence of vocal cord lesions (RR: 0.52, 95% CI: 0.40 to 0.68, p < 0.00001) was observed. No difference was found in the time to intubation (MD: −6.51, 95% CI: −20.04 to 7.02, p = 0.35). Conclusions: Thermal-softened ETTs may reduce the incidence of postoperative sore throat and vocal cord lesions but have no significant effect on hoarseness or intubation time. Full article
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