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Cardiovascular Imaging: Opportunities and Challenges in Clinical Application: 3rd Edition
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Cardiovascular Imaging: Opportunities and Challenges in Clinical Application: 3rd Edition

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiology".

Deadline for manuscript submissions: closed (20 January 2026) | Viewed by 10911

Special Issue Editors

Dr. Kana Fujikura

E-Mail Website
Guest Editor
Department of Radiology, Division of Cardiology, NYU School of Medicine, NYU Langone Health Center for Biomedical Imaging, New York, NY 10016, USA
Interests: echocardiography; cardiovascular magnetic resonance imaging; cardiovascular computed tomography imaging; nuclear cardiology imaging; stress test with imaging; multimodality cardiovascular imaging; cardiomyopathy; coronary artery disease; microvascular disease; valvular heart disease
Special Issues, Collections and Topics in MDPI journals
Dr. Panagiota Christia

E-Mail Website
Guest Editor
Department of Radiology, Division of Cardiology, NYU School of Medicine, New York, NY 10016, USA
Interests: multimodality imaging; preventative cardiology; women's cardiovascular disease

Special Issue Information

Dear Colleagues,

At the end of 2020, the first volume of the Special Issue “Cardiovascular Imaging: Opportunities and Challenges in Clinical Application” was released in JCM. Since then, we have received many excellent papers; the full text can be accessed via the links below.

Cardiovascular Imaging: Opportunities and Challenges in Clinical Application: https://www.mdpi.com/journal/jcm/special_issues/Cardiovascular_Imaging_Application

Cardiovascular Imaging: Opportunities and Challenges in Clinical Application: 2nd Edition: https://www.mdpi.com/journal/jcm/special_issues/01TGFKP2P6

Imaging has long been, and will continue to be, an integral part of clinical cardiovascular medicine. The depth of information that can be obtained from non-invasive cardiovascular imaging continues to expand. Increasing numbers of clinical decisions are being made without intervention, given the various non-invasive cardiovascular imaging methods available. Each imaging modality assesses cardiovascular conditions from a particular perspective. The relatively new multimodality approach offers multiple perspectives and, thus, the possibility of a better understanding of disease status and processes.

This volume will collect manuscripts that discuss the role of all non-invasive cardiovascular imaging modalities in critical clinical decision making, as well as articles on recent advancements in non-invasive cardiovascular imaging. The imaging methods include, but are not limited to, echocardiography (TTE and TEE), cardiac magnetic resonance imaging (CMR), cardiovascular computed tomography imaging (CCT), nuclear cardiology, and stress tests with imaging. We welcome the submission of research articles and review articles on non-invasive cardiovascular imaging.

Dr. Kana Fujikura
Dr. Panagiota Christia
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • echocardiography
  • cardiovascular magnetic resonance imaging
  • cardiovascular computed tomography imaging
  • nuclear cardiology imaging
  • stress test with imaging
  • multimodality cardiovascular imaging
  • cardiomyopathy
  • coronary artery disease
  • microvascular disease
  • valvular heart disease

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Further information on MDPI's Special Issue policies can be found here.

Related Special Issues

Published Papers (5 papers)

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Review

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14 pages, 1750 KB  
Review
The Role of Imaging Modalities in Estimating Myocardial Viability: A Narrative Review
by Vishakha Modak, Vikyath Satish, Maisha Maliha, Sriram S. Kumar and Panagiota Christia
J. Clin. Med. 2025, 14(15), 5529; https://doi.org/10.3390/jcm14155529 - 6 Aug 2025
Cited by 1 | Viewed by 2263
Abstract
Myocardial viability assessment plays a critical role in the clinical management of patients with ischemic heart disease, particularly in guiding revascularization decisions. Various non-invasive imaging modalities have been developed and refined to evaluate viable myocardium, each offering unique insights into myocardial perfusion, metabolism, [...] Read more.
Myocardial viability assessment plays a critical role in the clinical management of patients with ischemic heart disease, particularly in guiding revascularization decisions. Various non-invasive imaging modalities have been developed and refined to evaluate viable myocardium, each offering unique insights into myocardial perfusion, metabolism, and contractile function. This review examines the comparative strengths and limitations of key imaging techniques. Understanding the pathophysiological basis and diagnostic capabilities of these modalities enables clinicians to tailor viability assessments to individual patient profiles, ultimately enhancing decision-making and optimizing outcomes in ischemic cardiomyopathy. Full article
(This article belongs to the Special Issue Cardiovascular Imaging: Opportunities and Challenges in Clinical Application: 3rd Edition)
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18 pages, 6048 KB  
Review
Cardio-Oncology and Multi-Imaging Modalities
by Christine M. Park, Ben Lerman, Felipe Contreras Yametti, Mario Garcia, Leandro Slipczuk, Aldo L. Schenone, Lili Zhang and Carlos A. Gongora
J. Clin. Med. 2025, 14(12), 4353; https://doi.org/10.3390/jcm14124353 - 18 Jun 2025
Cited by 2 | Viewed by 1753
Abstract
Early detection and the rise of targeted cancer treatment have led to increased overall survival and decreased mortality among cancer patients. As the cancer survivor population ages, there is an increased risk for cardiovascular disease due to pre-existing comorbidities, deconditioning during therapy, or [...] Read more.
Early detection and the rise of targeted cancer treatment have led to increased overall survival and decreased mortality among cancer patients. As the cancer survivor population ages, there is an increased risk for cardiovascular disease due to pre-existing comorbidities, deconditioning during therapy, or the natural progression of aging. Furthermore, with emerging oncologic therapies, there is an increased recognition of their potential cardiovascular toxicities. Indeed, heart disease is the leading cause of death in cancer survivors, which may reflect upon both the success of novel oncologic therapies and their potential cardiovascular toxicities. This recognition has driven the development of cardio-oncology, a multi-disciplinary field that involves collaboration between hematologists, oncologists, and cardiologists to screen, prevent, and manage cardiovascular disease in cancer patients and cancer survivors. The field focuses on early cardiovascular detection and prevention for these patients before, during, and after their oncologic treatment. As oncologic therapies evolve and our knowledge of short- and long-term adverse cardiovascular effects grows, it is critical for physicians to identify those at risk for increased morbidity and mortality, while also balancing the importance of their oncologic treatment plan. Multimodality cardiac imaging is the crux of the diagnosis and surveillance of these patients within cardio-oncology, and includes echocardiography, nuclear, computed tomography (CT), and cardiac magnetic resonance (CMR). Cardiac imaging is essential to establish the baseline function and assess various cardiotoxicities, including left ventricular dysfunction, heart failure, atherosclerosis, vascular injury, and arrhythmias. This review will discuss common oncologic therapies and their cardiotoxic profiles, the cardiac multimodality imaging modalities used in cardio-oncology, and the various approaches for the diagnosis and surveillance of this population. Full article
(This article belongs to the Special Issue Cardiovascular Imaging: Opportunities and Challenges in Clinical Application: 3rd Edition)
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19 pages, 4643 KB  
Review
Multimodal Imaging of Immune Checkpoint Inhibitor Myocarditis
by Shreyans Patel, Kartikeya Dave, Mario J. Garcia, Carlos A. Gongora, Mark I. Travin and Lili Zhang
J. Clin. Med. 2025, 14(8), 2850; https://doi.org/10.3390/jcm14082850 - 21 Apr 2025
Cited by 2 | Viewed by 3282
Abstract
Immune checkpoint inhibitors (ICIs) have dramatically changed the landscape of cancer treatment and are increasingly used either as monotherapy or in combination with other ICIs, chemotherapy, and molecularly targeted agents. ICI myocarditis is a rare but potentially fatal irAE associated with the use [...] Read more.
Immune checkpoint inhibitors (ICIs) have dramatically changed the landscape of cancer treatment and are increasingly used either as monotherapy or in combination with other ICIs, chemotherapy, and molecularly targeted agents. ICI myocarditis is a rare but potentially fatal irAE associated with the use of ICI characterized by T-cell mediated cardiomyocyte death. Diagnosing ICI myocarditis can be intricate as its atypical presentations. Multimodal imaging plays a crucial role in the diagnosis and risk stratification of ICI myocarditis. Current management strategies for ICI myocarditis include corticosteroids and immunosuppressants. Multidisciplinary collaboration is vital in these cases—combining oncology expertise with cardiology insights. Full article
(This article belongs to the Special Issue Cardiovascular Imaging: Opportunities and Challenges in Clinical Application: 3rd Edition)
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20 pages, 14486 KB  
Review
A Practical Approach to Multimodality Imaging in Hypertrophic Cardiomyopathy
by Ankur K. Dalsania, Christine M. Park, Sanjana Nagraj, Daniel Lorenzatti, Annalisa Filtz, Adaya Weissler-Snir, Mario J. Garcia, Leandro Slipczuk and Aldo L. Schenone
J. Clin. Med. 2025, 14(8), 2606; https://doi.org/10.3390/jcm14082606 - 10 Apr 2025
Cited by 3 | Viewed by 2392
Abstract
Hypertrophic cardiomyopathy remains underdiagnosed despite a growing number of effective treatment interventions that can improve care. Multimodality imaging has become integral to diagnosing and managing hypertrophic cardiomyopathy, providing a comprehensive assessment of the disease. In particular, it enhances the diagnostic accuracy and deepens [...] Read more.
Hypertrophic cardiomyopathy remains underdiagnosed despite a growing number of effective treatment interventions that can improve care. Multimodality imaging has become integral to diagnosing and managing hypertrophic cardiomyopathy, providing a comprehensive assessment of the disease. In particular, it enhances the diagnostic accuracy and deepens the understanding of the mechanisms underlying patient symptoms, enabling targeted therapeutic approaches. Additionally, multimodality imaging allows for better risk stratification, assessment of therapy response, and guidance of interventions to deliver personalized medicine. The practical tools outlined in this review can help providers integrate multimodality imaging strategies to provide better care and improve the patient experience. Full article
(This article belongs to the Special Issue Cardiovascular Imaging: Opportunities and Challenges in Clinical Application: 3rd Edition)
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25 pages, 1792 KB  
Systematic Review
Systolic Versus Diastolic Echocardiographic Assessment of Epicardial Adipose Tissue for the Detection of Obstructive Coronary Artery Disease: A Systematic Review and Meta-Analysis
by Andrea Sonaglioni, Giulio Francesco Gramaglia, Gian Luigi Nicolosi, Massimo Baravelli and Michele Lombardo
J. Clin. Med. 2026, 15(2), 878; https://doi.org/10.3390/jcm15020878 - 21 Jan 2026
Viewed by 293
Abstract
Background: Epicardial adipose tissue (EAT) is a metabolically active visceral fat depot increasingly associated with the development and progression of coronary artery disease (CAD). Transthoracic echocardiography is the most widely used modality for EAT assessment; however, substantial heterogeneity exists regarding the timing [...] Read more.
Background: Epicardial adipose tissue (EAT) is a metabolically active visceral fat depot increasingly associated with the development and progression of coronary artery disease (CAD). Transthoracic echocardiography is the most widely used modality for EAT assessment; however, substantial heterogeneity exists regarding the timing of measurement within the cardiac cycle, with EAT thickness variably assessed during systole or diastole. Whether these measurements provide equivalent information for identifying obstructive CAD remains unclear. This systematic review and meta-analysis evaluated the association between echocardiographically measured EAT thickness and angiographically confirmed obstructive CAD, with specific focus on systolic versus diastolic assessments. Methods: PubMed, Scopus, and EMBASE were systematically searched through December 2025 for observational studies comparing EAT thickness in patients with and without obstructive CAD confirmed by invasive coronary angiography. Random-effects models were used to pool standardized mean differences (SMDs) for systolic and diastolic EAT thickness. Heterogeneity was assessed using the I2 statistic, publication bias by funnel plots and Egger’s regression test, and robustness by meta-regression and leave-one-out sensitivity analyses. Results: Twenty-two studies including more than 6500 patients were analyzed. Both systolic and diastolic EAT thickness were significantly greater in patients with obstructive CAD than in non-CAD controls. Systolic EAT showed a large, pooled effect size (SMD 1.27; 95% CI 0.96–1.59; p < 0.001), while diastolic EAT demonstrated a similarly strong association (SMD 1.59; 95% CI 1.10–2.07; p < 0.001). Heterogeneity was substantial (I2 > 90%), but the direction of effect was consistent across all studies. Meta-regression analyses indicated that demographic, clinical, metabolic, geographic, and methodological characteristics, including ultrasound software/vendor category and timing of EAT measurement, did not significantly moderate the association between EAT thickness and obstructive CAD. No significant publication bias was detected, and sensitivity analyses confirmed the robustness of the results. Conclusions: Echocardiographically measured EAT thickness is strongly and consistently associated with obstructive CAD, irrespective of whether measurements are obtained during systole or diastole. Although both approaches show robust discriminatory capacity at the population level, differences in effect magnitude suggest that they may not be fully interchangeable. Moreover, in the absence of standardized and broadly applicable cut-off values, the interpretation and clinical management of EAT measurements as individual risk predictors require further investigation. Full article
(This article belongs to the Special Issue Cardiovascular Imaging: Opportunities and Challenges in Clinical Application: 3rd Edition)
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