Nutrients, Volume 14, Issue 2
2022 January-2 - 168 articles
Cover Story: Several studies relate Mediterranean diet and virgin olive oils (VOO) intake with lower risk of several chronic diseases, including breast cancer. Many of them described antitumor properties of isolated minor compounds present in VOO, but beneficial properties of VOO arise from the effects of all its compounds acting together. The aim of the present study was to test the antitumor effects of two minor compounds from VOO (hydroxytyrosol (HT) and squalene (SQ)) on highly metastatic human breast tumor cells when acting in combination. Both molecules separately have no antitumour activity but when they act in combination, they inhibit cell proliferation, and promote apoptosis and DNA damage in metastatic breast cancer cells. Therefore, our results suggest that the health-promoting properties of VOO may be due, at least in part, to the combined action of these two minor compounds. View this paper - Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
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