Interaction between Dietary Fat Intake and Metabolic Genetic Risk Score on 25-Hydroxyvitamin D Concentrations in a Turkish Adult Population

Isgin-Atici, Kubra; Alathari, Buthaina E.; Turan-Demirci, Busra; Sendur, Suleyman Nahit; Lay, Incilay; Ellahi, Basma; Alikasifoglu, Mehmet; Erbas, Tomris; Buyuktuncer, Zehra; Vimaleswaran, Karani Santhanakrishnan

doi:10.3390/nu14020382

Submit to this Journal Review for this Journal Edit a Special Issue

Article Menu

...

Open AccessArticle

Interaction between Dietary Fat Intake and Metabolic Genetic Risk Score on 25-Hydroxyvitamin D Concentrations in a Turkish Adult Population

Kubra Isgin-Atici

^1,2,†

Buthaina E. Alathari

^3,4,†,

Busra Turan-Demirci

Suleyman Nahit Sendur

⁵,

^6,7

⁸,

^9,10,

⁵

^1,*,† and

Karani Santhanakrishnan Vimaleswaran

^3,11,*,†

Department of Nutrition and Dietetics, Faculty of Health Sciences, Hacettepe University, Ankara 06230, Turkey

Department of Nutrition and Dietetics, Faculty of Health Sciences, Amasya University, Amasya 05000, Turkey

Hugh Sinclair Unit of Human Nutrition, Department of Food and Nutritional Sciences, University of Reading, Reading RG6 6DZ, UK

⁴

Department of Food Science and Nutrition, Faculty of Health Sciences, The Public Authority for Applied Education and Training, AlFaiha 72853, Kuwait

⁵

Department of Endocrinology and Metabolism, School of Medicine, Hacettepe University, Ankara 06230, Turkey

⁶

Department of Medical Biochemistry, Faculty of Medicine, Hacettepe University, Ankara 06230, Turkey

⁷

Clinical Pathology Laboratory, Hacettepe University Hospitals, Ankara 06230, Turkey

⁸

Faculty of Health and Social Care, University of Chester, Chester CH1 4DS, UK

⁹

Department of Medical Genetics, School of Medicine, Hacettepe University, Ankara 06230, Turkey

¹⁰

Genetics Diagnostic Centre, DAMAGEN, Ankara 06230, Turkey

¹¹

Institute for Food, Nutrition, and Health, University of Reading, Reading RG6 6AH, UK

Show full affiliation list

Hide full affiliation list

Authors to whom correspondence should be addressed.

^†

These authors contributed equally to this work.

Academic Editors: Giovanni Passeri, Sandro Giannini and Carsten Carlberg

Nutrients 2022, 14(2), 382; https://doi.org/10.3390/nu14020382

Received: 10 October 2021 / Revised: 10 January 2022 / Accepted: 14 January 2022 / Published: 17 January 2022

(This article belongs to the Special Issue Benefits of Vitamin D in Health and Diseases)

View Full-Text Download PDF

Browse Figures

Citation Export

Abstract

Previous studies have pointed out a link between vitamin D status and metabolic traits, however, consistent evidence has not been provided yet. This cross-sectional study has used a nutrigenetic approach to investigate the interaction between metabolic-genetic risk score (GRS) and dietary intake on serum 25-hydroxyvitamin D [25(OH)D] concentrations in 396 unrelated Turkish adults, aged 24–50 years. Serum 25(OH)D concentration was significantly lower in those with a metabolic-GRS ≥ 1 risk allele than those with a metabolic-GRS < 1 risk allele (p = 0.020). A significant interaction between metabolic-GRS and dietary fat intake (energy%) on serum 25(OH)D levels was identified (P_interaction = 0.040). Participants carrying a metabolic-GRS ≥ 1 risk allele and consuming a high fat diet (≥38% of energy = 122.3 ± 52.51 g/day) had significantly lower serum 25(OH)D concentration (p = 0.006) in comparison to those consuming a low-fat diet (<38% of energy = 82.5 ± 37.36 g/d). In conclusion, our study suggests a novel interaction between metabolic-GRS and dietary fat intake on serum 25(OH)D level, which emphasises that following the current dietary fat intake recommendation (<35% total fat) could be important in reducing the prevalence of vitamin D deficiency in this Turkish population. Nevertheless, further larger studies are needed to verify this interaction, before implementing personalized dietary recommendations for the maintenance of optimal vitamin D status. View Full-Text

Keywords: vitamin D; TCF7L2; MC4R; genetic risk score; fat intake; metabolic traits

▼ Show Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

Supplementary Material

Supplementary File 1:
ZIP-Document (ZIP, 161 KiB)

Share and Cite

MDPI and ACS Style

Isgin-Atici, K.; Alathari, B.E.; Turan-Demirci, B.; Sendur, S.N.; Lay, I.; Ellahi, B.; Alikasifoglu, M.; Erbas, T.; Buyuktuncer, Z.; Vimaleswaran, K.S. Interaction between Dietary Fat Intake and Metabolic Genetic Risk Score on 25-Hydroxyvitamin D Concentrations in a Turkish Adult Population. Nutrients 2022, 14, 382. https://doi.org/10.3390/nu14020382

AMA Style

Isgin-Atici K, Alathari BE, Turan-Demirci B, Sendur SN, Lay I, Ellahi B, Alikasifoglu M, Erbas T, Buyuktuncer Z, Vimaleswaran KS. Interaction between Dietary Fat Intake and Metabolic Genetic Risk Score on 25-Hydroxyvitamin D Concentrations in a Turkish Adult Population. Nutrients. 2022; 14(2):382. https://doi.org/10.3390/nu14020382

Chicago/Turabian Style

Isgin-Atici, Kubra, Buthaina E. Alathari, Busra Turan-Demirci, Suleyman N. Sendur, Incilay Lay, Basma Ellahi, Mehmet Alikasifoglu, Tomris Erbas, Zehra Buyuktuncer, and Karani S. Vimaleswaran. 2022. "Interaction between Dietary Fat Intake and Metabolic Genetic Risk Score on 25-Hydroxyvitamin D Concentrations in a Turkish Adult Population" Nutrients 14, no. 2: 382. https://doi.org/10.3390/nu14020382

Find Other Styles

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Metrics

Abstract views Pdf views Html views

Article Menu

Interaction between Dietary Fat Intake and Metabolic Genetic Risk Score on 25-Hydroxyvitamin D Concentrations in a Turkish Adult Population

Abstract

Supplementary Material

Share and Cite

Article Metrics

Article Access Statistics

Article Access Map by Country/Region

Author Biographies

Further Information

Guidelines

MDPI Initiatives

Follow MDPI