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Marine Drugs, Volume 20, Issue 5

May 2022 - 66 articles

Cover Story: The overexpression of efflux pumps is one of the multidrug resistance mechanisms in bacteria. The search for efflux inhibitors has been prolific, despite none being clinically approved. In this study, we explored the potential of marine-inspired chalcones, dihydrochalcones, and diarylpropanes as Gram-positive efflux pump inhibitors. For promising compounds, their effect on the formation of a biofilm was also investigated, as efflux pumps are related to this resistance mechanism. Structure-activity relationships were established and show the potential of this scaffold in the reversal of antimicrobial resistance, emphasizing the importance of the marine environment as a source of templates for new drugs. View this paper
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Articles (66)

  • Article
  • Open Access
12 Citations
3,777 Views
14 Pages

Brasilterpenes A–E, Bergamotane Sesquiterpenoid Derivatives with Hypoglycemic Activity from the Deep Sea-Derived Fungus Paraconiothyrium brasiliense HDN15-135

  • Wenxue Wang,
  • Yeqin Shi,
  • Yuanyuan Liu,
  • Yundong Zhang,
  • Jiajin Wu,
  • Guojian Zhang,
  • Qian Che,
  • Tianjiao Zhu,
  • Mingyu Li and
  • Dehai Li

23 May 2022

Five bergamotane sesquiterpenoid derivatives, brasilterpenes A–E (1–5), bearing an unreported spiral 6/4/5 tricyclic ring system, were isolated from the deep sea-derived ascomycete fungus Paraconiothyrium brasiliense HDN15-135. Their stru...

  • Review
  • Open Access
8 Citations
4,254 Views
18 Pages

Secondary Metabolites Isolated from Chilean Marine Algae: A Review

  • Dioni Arrieche,
  • Héctor Carrasco,
  • Andrés F. Olea,
  • Luis Espinoza,
  • Aurelio San-Martín and
  • Lautaro Taborga

23 May 2022

Chile is in the extreme southwestern part of America, and it has an extreme length, of approximately 4300 km that increases to 8000 km considering the Chilean Antarctic Territory. Despite the large extent of its coastal territory and the diversity of...

  • Review
  • Open Access
133 Citations
10,201 Views
43 Pages

21 May 2022

Microalgae and cyanobacteria are photosynthetic organisms that can produce/accumulate biomolecules with industrial interest. Among these molecules, EPSs are macromolecular polysaccharidic compounds that present biological activities and physico-chemi...

  • Review
  • Open Access
132 Citations
12,659 Views
42 Pages

Multiple Roles of Chitosan in Mucosal Drug Delivery: An Updated Review

  • Paola Mura,
  • Francesca Maestrelli,
  • Marzia Cirri and
  • Natascia Mennini

20 May 2022

Chitosan (CS) is a linear polysaccharide obtained by the deacetylation of chitin, which, after cellulose, is the second biopolymer most abundant in nature, being the primary component of the exoskeleton of crustaceans and insects. Since joining the p...

  • Article
  • Open Access
8 Citations
3,621 Views
16 Pages

19 May 2022

With the increasingly serious antimicrobial resistance, discovering novel antibiotics has grown impendency. The Antarctic abundant microbial resources, especially fungi, can produce unique bioactive compounds for adapting to the hostile environment....

  • Review
  • Open Access
14 Citations
5,406 Views
28 Pages

Approaches to Configuration Determinations of Flexible Marine Natural Products: Advances and Prospects

  • Zong-Qing Huo,
  • Feng Zhu,
  • Xing-Wang Zhang,
  • Xiao Zhang,
  • Hong-Bao Liang,
  • Jing-Chun Yao,
  • Zhong Liu,
  • Gui-Min Zhang,
  • Qing-Qiang Yao and
  • Guo-Fei Qin

19 May 2022

Flexible marine natural products (MNPs), such as eribulin and bryostatin, play an important role in the development of modern marine drugs. However, due to the multiple chiral centers and geometrical uncertainty of flexible systems, configuration det...

  • Feature Paper
  • Article
  • Open Access
20 Citations
4,037 Views
17 Pages

Ferroptosis Related Immunomodulatory Effect of a Novel Extracellular Polysaccharides from Marine Fungus Aureobasidium melanogenum

  • Yuqi Lin,
  • Jiajia Yang,
  • Lianxiang Luo,
  • Xiaoyong Zhang,
  • Shengyu Deng,
  • Xiaodan Chen,
  • Yiyang Li,
  • Alaa El-Din A. Bekhit,
  • Baojun Xu and
  • Riming Huang

19 May 2022

Marine fungi represent an important and sustainable resource, from which the search for novel biological substances for application in the pharmacy or food industry offers great potential. In our research, novel polysaccharide (AUM-1) was obtained fr...

  • Article
  • Open Access
21 Citations
3,600 Views
16 Pages

Cyclodepsipeptides: Isolation from Endophytic Fungi of Sarcophyton ehrenbergi and Verification of Their Larvicidal Activity via In-Vitro and In-Silico Studies

  • Abdel Nasser B. Singab,
  • Nada M. Mostafa,
  • Yasmin A. Elkhawas,
  • Eman Al-Sayed,
  • Mokhtar M. Bishr,
  • Ahmed M. Elissawy,
  • Mohamed S. Elnaggar,
  • Iten M. Fawzy,
  • Osama M. Salama and
  • Yi-Hong Tsai
  • + 1 author

18 May 2022

Culex pipiens mosquitoes are vectors to many viruses and can transmit diseases such as filariasis and avian malaria. The present study evaluated the larvicidal activity of marine-derived endophytic fungi Aspergillus nomius and Aspergillus flavus from...

  • Review
  • Open Access
16 Citations
18,069 Views
23 Pages

The Role of Seawater and Saline Solutions in Treatment of Upper Respiratory Conditions

  • Danijela Štanfel,
  • Livije Kalogjera,
  • Sergej V. Ryazantsev,
  • Kristina Hlača,
  • Elena Y. Radtsig,
  • Rashidov Teimuraz and
  • Pero Hrabač

17 May 2022

The history of saline nasal irrigation (SNI) is indeed a long one, beginning from the ancient Ayurvedic practices and gaining a foothold in the west at the beginning of the 20th century. Today, there is a growing number of papers covering the effects...

  • Review
  • Open Access
20 Citations
8,992 Views
27 Pages

17 May 2022

Ipomoea pes-caprae (Linn.) R. Br. (Convolvulaceae) is a halophytic plant that favorably grows in tropical and subtropical countries in Asia, America, Africa, and Australia. Even though this plant is considered a pan-tropical plant, I. pes-caprae has...

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Mar. Drugs - ISSN 1660-3397