Molecules, Volume 30, Issue 7

Diorganotin(IV) compounds of types RR′Sn(SeCH₂CH₂pz)₂ [R = R′ = ⁿBu (2), Ph (3); R = 2-(Me₂NCH₂)C₆H₄, R′ = Me (4), ⁿBu (5), Ph (6)], and RR′SnX(SeCH₂CH₂pz) [R = 2-(Me₂NCH₂)C₆H₄, R′ = ⁿBu, X = Cl (7), R′ = Me, X = S...

The use of different nanoparticles (NPs) is increasing in a wide variety of everyday products. Nevertheless, most studies concerning NP risk assessment have evaluated exposure scenarios involving a single kind of NP. A stepwise study distinguishing b...

The thiazole heterocycle is one of the most common moieties found in various drugs. Using 2-aminothiazole as the core structure, the amino group was functionalized with an amide. As a result, 30 trisubstituted 2-amino-4, 5-diarylthiazole derivatives...

Squalene is an important bioactive substance widely used in the food, pharmaceutical, and cosmetic industries. Microbial production of squalene has gained prominence in recent years due to its sustainability, safety, and environmental friendliness. I...

Oleacein (Olea) and Oleocanthal (Oleo) are two phenolic compounds found in olive oil. Cell and animal studies have shown these two compounds can modulate inflammation, cancer, and neurodegenerative diseases. Unfortunately, the study of the pharmacoki...

This study describes the synthesis, interaction with DNA, and transfection efficacy of eight lipidated compounds based on a recently published non-lipidated parent molecule, an octamer of 2,3-l-Dap, carrying the guanidine group on its side chain. The...

It is well established that certain carboxylic acid compounds can effectively inhibit tyrosinase activity. This study investigated the mechanisms by which four carboxylic acid compounds—3-phenyllactic acid, lactic acid, L-pyroglutamic acid, and...

This study employed an integrated in silico approach to identify and characterize anticancer peptides (ACPs) derived from Arca species. Using a comprehensive bioinformatics pipeline (BIOPEP, ToxinPred, ProtParam, ChemDraw, SwissTargetPrediction, and...

Converting pesticides into ionic liquids by designing counterions can modulate their physicochemical properties, thus improving their efficacy and environmental safety. In this study, eight prochloraz-based ionic liquids (PILs) were synthesized using...

The production of formic acid (FA) from lignocellulose and its derived sugars represents a pivotal upgrading reaction in biorefinery. This work prepared a Mn-Mo doped carbon nanotube composite catalyst for the catalytic oxidation of glucose into FA i...

In the present study, the extraction of volatile terpenes from A. annua with supercritical CO₂ (sc-CO₂) was optimized by a full factorial design procedure and compared with conventional distillation. The influence of pressure (100–220 bar) and...

Attention Deficit Hyperactivity Disorder (ADHD) is a prevalent neurodevelopmental disorder that significantly impacts learning, daily functioning, and personal development. Astaxanthin (ASTA), a naturally occurring antioxidant, has garnered interest...

Current breast cancer therapies are unable to positively impact the lives of a significant proportion of diagnosed patients (24% based on 10-year survival rate). Breast cancer relapse and metastasis, the leading cause of breast cancer-associated deat...

This study was conducted to identify the optimal conditions and evaluate the feasibility of deep eutectic solvent (DES)-based ultrasound-assisted extraction (UAE) for utilizing maca (Lepidium meyenii) leaves, an agricultural by-product, as functional...

Apple pomace pectins, extracted using various methods (water, cellulase, arabinase, and arabinase with mannanase), and commercial apple pectin were studied, analyzing their morphology and chemical structure. The microscopic analysis revealed morpholo...

Pomegranate is recognized for its health benefits, primarily due to its polyphenols and metabolites, such as urolithins (Uro-A), produced via colonic fermentation of ellagic acid (EA). These compounds make pomegranate a functional food with the poten...

One pair of novel enantiomers, gigantdioxin A (+)-1 and B (−)-1, with a skeleton of benzo[d][1,3]dioxin; a new acetophenone gigantone A (3); a known 3-chlorogentisyl alcohol (2), which is the bioprecursor of 1; acetophenone (4); and chromone de...

Rapid functional soft tissue restoration has shown considerable promise as a framework for stability and coordination in the human body. Inspired by the anisotropic arrangement of structures with soft and hard phases in biological tissues, such as te...

Organic solar cells (OSCs) have witnessed significant advancements in recent years, largely propelled by innovations in material design and device engineering. Among the emerging materials, dimerized small-molecule acceptors (DSMAs) have garnered con...

Recent advancements in mRNA technology, utilized in vaccines, immunotherapies, protein replacement therapies, and genome editing, have emerged as promising and increasingly viable treatments. The rapid, potent, and transient properties of mRNA-encode...

In this study, nine neo-clerodane-type diterpenoids (1–9) were isolated from the dichloromethane extract of Salvia guevarae Bedolla & Zamudio leaves. Compounds 1–6 were new natural products, and 7–9 were acetone artifacts. In ad...

Caigua (Cyclanthera pedata (L.) Schrad.) is a traditional herbal remedy traditionally used in Latin America for its health benefits and to treat metabolic disorders, including diabetes. Despite interest in its herbal use, the phytochemical properties...

α-Pinene is a very valuable natural raw material for organic syntheses, which is of increasing interest to scientists due to its renewability and relatively low price. This work presents the studies on the oxidation of α-pinene in the pre...

MXene is widely used in the fields of microwave absorption and electromagnetic shielding to balance electromagnetic pollution with the development of communication technologies and human health, due to its excellent surface functional groups and tuna...

Bacterial infections caused by resistant strains have emerged as one of the most significant life-threatening challenges. Developing alternatives to conventional antibiotic formulations is crucial to overcoming these challenges. Vancomycin HCl (VCM)...

Fluorescent proteins (FPs) are widely used as optical probes in molecular and cell biology. tKeima is a tetrameric, large Stokes shift red fluorescent protein and the ancestral protein of mt-Keima, which is widely applied as a pH-sensitive fluorescen...

In this study, α-cellulose was extracted from lignocellulosic simpor leaf residue as a sustainable alternative to conventional cellulose sources. The extraction process involved the removal of hemicellulose, lignin, and other phytocompounds usi...

Co-inoculation with Saccharomyces cerevisiae and non-Saccharomyces yeasts is an effective method to improve the flavor of cider. Wickerhamomyces anomalus, known for its high ester production capacity, was evaluated in combination with S. cerevisiae t...

This work aims to develop an insecticidal biofilm based on Calothrixin A, collagen, and chitosan for the protection of pea seeds. The main objective is to improve the ingredient concentrations maximizing the insecticidal activity of the biofilm and t...

Unlike many biopolymers, α-1,3-glucan (α-1,3-GLU) is water-insoluble, making it a promising candidate for the production of moisture-resistant films with applications in biodegradable packaging, biomedicine, and cosmetics. This study aimed to charact...

Plumbagin is an important naphthoquinone with potent anticancer properties besides multitudinous uses in healthcare. It is produced in a limited number of species and families but mostly in the roots of Plumbaginaceae family members. The biosynthetic...

This study introduces a traceless linker strategy for pentadehydro-Diels–Alder (PDDA) cyclization, in which the sulfide/sulfone linker is strategically repurposed as a diene surrogate. As excellent electron-donating dienes, these linkers react...

The synthesis and characterization of the tripodal phosphines RSi(CH₂CH₂PPh₂)₃ (R = Me, OMe, OEt) (1–3) is described. The ¹H NMR spectra of all phosphines display virtual coupling patterns. The ligands form the corresponding trinuclear Pd compl...

This is a broad look at the history of phosphorus—from the element through its inorganic and organic compounds to the applications of organophosphates. In addition to commercial and peaceful applications, they were used as chemical warfare agen...

Over 80 MT of elemental sulfur, a byproduct of fossil fuel desulfurization, are generated annually. This has spurred the development of high sulfur content materials (HSMs) via inverse vulcanization as a productive pathway towards sulfur utilization....

Designing supramolecular gelators with targeted properties is very difficult and mainly relies on structural modifications of known gelator molecules. However, very often, even minor modifications can result in the complete loss of gelation capabilit...

Purine-1,4,7,10-tetraazacyclododecane (cyclen) conjugate was designed to study its Cu²⁺ ions complexation capability. Several synthetic approaches were tested to achieve the target compound. The optimal approach involved stepwise modifications of pur...

Antimicrobial resistance (AMR) is one of the most urgent public health problems worldwide; multidrug resistance (MDR) is also of concern. In an effort to find new classes of antibiotics, recent studies have found that coordination compounds of noble...

Cellulose ethers (CEs), synthesized through the etherification of cellulose, have emerged as indispensable “green additives” in our modern industries, earning the moniker of industrial “monosodium glutamate” due to their unpar...

Microplastics (MPs), ubiquitous environmental pollutants, pose substantial threats to aquatic ecosystems and organisms, including the model species Daphnia magna. This study examined the effects of polyethylene (PE) and polystyrene (PS) MPs on D. mag...

The inhibitory effects of two novel lophine derivatives were unexpectedly discovered during the development of a chemiluminescent monoacylglycerol lipase (MAGL) assay. The proposed lophine derivatives were found to exhibit concentration-dependent inh...

Sample pretreatment is one of the most important steps in guaranteeing the success of a chromatographic analysis. The selected methodology must ensure simultaneously that a sample is “clean” enough for analysis and that the target analyte...

Carbon capture and sequestration (CCS) is an essential strategy for mitigating greenhouse gas emissions and addressing climate change. In this study, the biochar of bamboo and orange peel (BB and OPB) are synthesized and appraised as potential CO₂ ad...

The removal of methylene blue (MB) cationic dye from aqueous solutions was investigated by applying magnesium molybdate (β-MgMoO₄) as a nanosorbent. The β-MgMoO₄ was synthesized through a simple, rapid, and efficient method. The MB dye remo...

Chloromethane (CH₃Cl) is a key chlorinated organic compound not only in atmospheric chemistry, but also in the field of molecular astrophysics and a possible biosignature in exoplanetary atmospheres. While the spectroscopic characterization of the ma...

Goutweed (Aegopodium podagraria L.) is a species of medicinal perennial in the celery family (Apiaceae), also considered an edible plant with medicinal effects and high nutritional value. In traditional folk medicine, it was known as a remedy for gou...

The metabolic cycle of L-proline plays a crucial role in cancer cell survival, proliferation, and metastasis. A key intermediate in the biosynthesis and degradation of proline is 3,4-dihydro-2H-pyrrole-2-carboxylic acid. A direct route for synthesizi...

Natural rutile is a widely available titanium mineral which shows great potential as a photocatalyst for environmental remediation when processed correctly. Industries invest large sums in the transformation of the rutile mineral into pure, synthetic...

The Touriga Nacional grape variety is renowned in Portuguese red wines for its intense color and aromatic complexity, largely attributed to its rich phenolic composition. Several factors influence the phenolic profile of wines, including edapho-clima...

CO₂ is a greenhouse gas and a nontoxic, easily available and renewable C₁ feedstock. H₂ is a clean and cheap reductant that can be obtained from renewable energy. Olefins are platform chemicals that can be produced from a variety of raw materials suc...