Topic Editors

Institute of Polymers, Composites and Biomaterials, National Research Council of Italy, 80125 Naples, Italy
Institute of Polymers, Composites and Biomaterials, National Research Council of Italy, V.le J.F. Kennedy 54, Mostra d’Oltremare Pad. 20, 80125 Naples, Italy
Institute of Polymers, Composites and Biomaterials, National Research Council of Italy, V. le J. F. Kennedy 54, Mostra d\'Oltremare, Pad. 20, 80125 Naples, Italy

Advanced Biomaterials: Processing and Applications

Abstract submission deadline
31 March 2025
Manuscript submission deadline
31 May 2025
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Topic Information

Dear Colleagues,

The progress of biomaterial science and engineering has allowed the creation of increasingly advanced and innovative interfaces with biological systems capable of performing multiple functions aimed at supporting the growth of new tissue during healing/regeneration processes. To achieve this aim, an accurate design study of the material properties is required to guarantee a controlled structure and the dynamic functionality capable of adapting/integrating with the biological complexity of tissues and organs. In this context, the transition from inert to bioactive materials has been consolidated, leading to the development of new strategies in chemistry and nanotechnologies capable of responding to the growing needs in terms of promotion and control of biological phenomena in vitro and in vivo. In this perspective, this topic issue aims to review recent achievements in the field of hard and soft biomaterials with a specific emphasis on micro and nanotechnology advances which have showed the potential of controlling morphology and static/dynamic functionalities at micro/sub micrometer scale, including tailoring of biomechanical/sensing properties for the creation of bio-complex materials that might be used ad hoc in challenging applications of biomedicine and biotechnology. Research on the potential impact of recent technological developments, including safety laws and toxicology for large scale applications, will also be considered.

Dr. Vincenzo Guarino
Dr. Roberto De Santis
Dr. Ugo D'Amora
Topic Editors

Keywords

  • electro fluid dynamics
  • 3D/4D printing
  • nanomedicine
  • regenerative medicine
  • tissue engineering

Participating Journals

Journal Name Impact Factor CiteScore Launched Year First Decision (median) APC
Chemistry
chemistry
2.4 3.2 2019 13.4 Days CHF 1800 Submit
Materials
materials
3.1 5.8 2008 15.5 Days CHF 2600 Submit
Molecules
molecules
4.2 7.4 1996 15.1 Days CHF 2700 Submit
Polymers
polymers
4.7 8.0 2009 14.5 Days CHF 2700 Submit
Pharmaceutics
pharmaceutics
4.9 7.9 2009 14.9 Days CHF 2900 Submit

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Published Papers (2 papers)

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26 pages, 5993 KiB  
Article
Unveiling the Impact of Eco-Friendly Synthesized Nanoparticles on Vegetative Growth and Gene Expression in Pelargonium graveolens and Sinapis alba L.
by Maha M. Kamel, Abdelfattah Badr, Dalal Hussien M. Alkhalifah, Rehab Mahmoud, Yasser GadelHak and Wael N. Hozzein
Molecules 2024, 29(14), 3394; https://doi.org/10.3390/molecules29143394 - 19 Jul 2024
Viewed by 224
Abstract
Nanoscale geranium waste (GW) and magnesium nanoparticle/GW nanocomposites (Mg NP/GW) were prepared using green synthesis. The Mg NP/GW samples were subjected to characterization using X-ray diffraction (XRD) and Fourier-transform infrared spectroscopy (FTIR-FT). The surface morphology of the materials was examined using a scanning [...] Read more.
Nanoscale geranium waste (GW) and magnesium nanoparticle/GW nanocomposites (Mg NP/GW) were prepared using green synthesis. The Mg NP/GW samples were subjected to characterization using X-ray diffraction (XRD) and Fourier-transform infrared spectroscopy (FTIR-FT). The surface morphology of the materials was examined using a scanning electron microscope (SEM), and their thermal stability was assessed through thermal gravimetric analysis (TG). The BET-specific surface area, pore volume, and pore size distribution of the prepared materials were determined using the N2 adsorption–desorption method. Additionally, the particle size and zeta potentials of the materials were also measured. The influence of the prepared nanomaterials on seed germination was intensively investigated. The results revealed an increase in seed germination percent at low concentrations of Mg NP/GWs. Upon treatment with Mg NP/GW nanoparticles, a reduction in the mitotic index (MI) was observed, indicating a decrease in cell division. Additionally, an increase in chromosomal abnormalities was detected. The efficacy of GW and Mg NP/GW nanoparticles as new elicitors was evaluated by studying their impact on the expression levels of the farnesyl diphosphate synthase (FPPS1) and geranylgeranyl pyrophosphate (GPPS1) genes. These genes play a crucial role in the terpenoid biosynthesis pathway in Sinapis alba (S. alba) and Pelargonium graveolens (P. graveolens) plants. The expression levels were analyzed using reverse transcription–quantitative polymerase chain reaction (RT-qPCR) analysis. The qRT-PCR analysis of FPPS and GPPS gene expression was performed. The outputs of FPPS1 gene expression demonstrated high levels of mRNA in both S. alba and P. graveolens with fold changes of 25.24 and 21.68, respectively. In contrast, the minimum expression levels were observed for the GPPS1 gene, with fold changes of 11.28 and 6.48 in S. alba and P. graveolens, respectively. Thus, this study offers the employment of medicinal plants as an alternative to fertilizer usage resulting in promoting environmental preservation, optimal waste utilization, reducing water consumption, and cost reduction. Full article
(This article belongs to the Topic Advanced Biomaterials: Processing and Applications)
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17 pages, 3385 KiB  
Article
Multifunctional Hydrogel with 3D Printability, Fluorescence, Biodegradability, and Biocompatibility for Biomedical Microrobots
by Gang Wang, Sisi Wang, Tao Hu and Famin Shi
Molecules 2024, 29(14), 3351; https://doi.org/10.3390/molecules29143351 - 17 Jul 2024
Viewed by 274
Abstract
As micron-sized objects, mobile microrobots have shown significant potential for future biomedical applications, such as targeted drug delivery and minimally invasive surgery. However, to make these microrobots viable for clinical applications, several crucial aspects should be implemented, including customizability, motion-controllability, imageability, biodegradability, and [...] Read more.
As micron-sized objects, mobile microrobots have shown significant potential for future biomedical applications, such as targeted drug delivery and minimally invasive surgery. However, to make these microrobots viable for clinical applications, several crucial aspects should be implemented, including customizability, motion-controllability, imageability, biodegradability, and biocompatibility. Developing materials to meet these requirements is of utmost importance. Here, a gelatin methacryloyl (GelMA) and (2-(4-vinylphenyl)ethene-1,1,2-triyl)tribenzene (TPEMA)-based multifunctional hydrogel with 3D printability, fluorescence imageability, biodegradability, and biocompatibility is demonstrated. By using 3D direct laser writing method, the hydrogel exhibits its versatility in the customization and fabrication of 3D microstructures. Spherical hydrogel microrobots were fabricated and decorated with magnetic nanoparticles on their surface to render them magnetically responsive, and have demonstrated excellent movement performance and motion controllability. The hydrogel microstructures also represented excellent drug loading/release capacity and degradability by using collagenase, along with stable fluorescence properties. Moreover, cytotoxicity assays showed that the hydrogel was non-toxic, as well as able to support cell attachment and growth, indicating excellent biocompatibility of the hydrogel. The developed multifunctional hydrogel exhibits great potential for biomedical microrobots that are integrated with customizability, 3D printability, motion controllability, drug delivery capacity, fluorescence imageability, degradability, and biocompatibility, thus being able to realize the real in vivo biomedical applications of microrobots. Full article
(This article belongs to the Topic Advanced Biomaterials: Processing and Applications)
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