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Organosulfur and Organoselenium Chemistry II

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 3621

Special Issue Editor


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Guest Editor
School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China
Interests: organic chemistry; organic synthesis methodology; organosulfur chemistry; asymmetric catalysis
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Special Issue Information

Dear Colleagues,

Sulfur- and selenium-containing compounds are important in organic synthesis. These sulfur- and selenium-containing molecules are not only widely applied in pharmaceuticals, materials, natural products, biology, etc., but they are also useful building blocks in organic synthesis. Additionally, sulfur and selenium show divergent functions and potencies in different oxidative states, which has led to the rich chemistry of sulfur and selenium in organic synthesis. The diversified oxidation states enable sulfur and selenium to acquire significant functions for pharmacokinetics and pharmacodynamics in the development of pharmaceuticals. The unique optical and electronic properties of sulfur and selenium also make this element indispensable in organic photoconducting materials and batteries.

Molecules plans to publish a Special Issue comprising high-quality contributions by top researchers in the fields of organosulfur and organoselenium chemistry. This Special Issue invites original papers and reviews reporting on recent progress in the development of novel organosulfur and organoselenium chemistry. In this Special Issue, we hope to offer insights into different research areas of organosulfur and organoselenium chemistry by active researchers in the relevant field. The topics include the synthesis and transformation of sulfur- and selenium-containing compounds and their application in polymers, organic semiconductors, pharmaceuticals, and agrochemical and food chemistry.

Prof. Dr. Ming Wang
Guest Editor

Manuscript Submission Information

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Keywords

  • organosulfur
  • organoselenium
  • synthesis
  • transformation
  • application

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Related Special Issue

Published Papers (3 papers)

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Research

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9 pages, 1485 KiB  
Article
Sulfide Oxidation to Sulfone Using Sodium Chlorite and Hydrochloric Acid in Organic Solvents
by Yuki Itabashi, Shuto Ogata, Tsuyoshi Inoue, Haruyasu Asahara and Kei Ohkubo
Molecules 2025, 30(9), 1912; https://doi.org/10.3390/molecules30091912 - 25 Apr 2025
Viewed by 143
Abstract
Organosulfur compounds are appealing owing to the diverse oxidation states accessible by sulfur, allowing the precise adjustment of their properties. In this study, we report a practical oxidation method that converts sulfides to sulfones by generating chlorine dioxide in situ from sodium chlorite [...] Read more.
Organosulfur compounds are appealing owing to the diverse oxidation states accessible by sulfur, allowing the precise adjustment of their properties. In this study, we report a practical oxidation method that converts sulfides to sulfones by generating chlorine dioxide in situ from sodium chlorite (NaClO2) and hydrochloric acid (HCl) in organic solvents. Diphenyl sulfide was effectively oxidized to diphenyl sulfone in yields of up to 96% under optimized conditions, with high selectivity in ethyl acetate and acetonitrile solvents. The method is compatible with a wide range of substrates, including various aryl, benzyl, and alkyl sulfides, although reactivity diminishes with sterically hindered or electron-rich substrates. This scalable and environmentally friendly process overcomes challenges associated with aqueous oxidants, such as substrate solubility and side reactions, providing a robust alternative for sulfone synthesis. Full article
(This article belongs to the Special Issue Organosulfur and Organoselenium Chemistry II)
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17 pages, 1282 KiB  
Article
Static and Dynamic Assessments of a Sulfur-Triglyceride Composite for Antimicrobial Surface Applications
by Shalini K. Wijeyatunga, Perla Y. Sauceda-Oloño, Nawoda L. Kapuge Dona, Bárbara G. S. Guinati, Katelyn M. Derr, Katelyn A. Tisdale, Ashlyn D. Smith, Andrew G. Tennyson and Rhett C. Smith
Molecules 2025, 30(7), 1614; https://doi.org/10.3390/molecules30071614 - 4 Apr 2025
Viewed by 320
Abstract
Over 80 MT of elemental sulfur, a byproduct of fossil fuel desulfurization, are generated annually. This has spurred the development of high sulfur content materials (HSMs) via inverse vulcanization as a productive pathway towards sulfur utilization. In this study, we evaluate the antimicrobial [...] Read more.
Over 80 MT of elemental sulfur, a byproduct of fossil fuel desulfurization, are generated annually. This has spurred the development of high sulfur content materials (HSMs) via inverse vulcanization as a productive pathway towards sulfur utilization. In this study, we evaluate the antimicrobial performance of SunBG90, an HSM made from brown grease and sulfur, as tiles or infused into fabric squares. The static antimicrobial activity of SunBG90 tiles was assessed, revealing excellent efficacy against Gram-positive bacteria, with reductions of 96.84% for Staphylococcus aureus and 91.52% for Listeria monocytogenes. The tiles also exhibited strong antifungal activity, reducing Candida auris by 96.20% and mold (fumigatus) by 83.77%. In contrast, efficacy against Gram-negative bacteria was more variable, with moderate reductions for Escherichia coli (61.10%) and Salmonella enteritidis (62.15%), lower activity against Campylobacter jejuni and Salmonella typhi, and no effect on Clostridium perfringens. Under dynamic conditions, SunBG90-infused fabrics achieved a near-complete inhibition of L. monocytogenes (99.91%) and high reduction of E. coli (98.49%), along with a 96.24% inhibition of Candida auris. These results highlight the potential and limitations of SunBG90 for antimicrobial applications, emphasizing the need for further optimization to achieve consistent broad-spectrum activity. Full article
(This article belongs to the Special Issue Organosulfur and Organoselenium Chemistry II)
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Review

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22 pages, 2936 KiB  
Review
Effects and Impact of Selenium on Human Health, A Review
by Song Bai, Miaohe Zhang, Shouying Tang, Miao Li, Rong Wu, Suran Wan, Lijun Chen, Xian Wei and Shuang Feng
Molecules 2025, 30(1), 50; https://doi.org/10.3390/molecules30010050 - 26 Dec 2024
Cited by 3 | Viewed by 2776
Abstract
Selenium (Se) is an essential trace element that is crucial for human health. As a key component of various enzymes and proteins, selenium primarily exerts its biological functions in the form of selenoproteins within the body. Currently, over 30 types of selenoproteins have [...] Read more.
Selenium (Se) is an essential trace element that is crucial for human health. As a key component of various enzymes and proteins, selenium primarily exerts its biological functions in the form of selenoproteins within the body. Currently, over 30 types of selenoproteins have been identified, with more than 20 of them containing selenocysteine residues. Among these, glutathione peroxidases (GPXs), thioredoxin reductases (TrxRs), and iodothyronine deiodinases (DIOs) have been widely studied. Selenium boasts numerous biological functions, including antioxidant properties, immune system enhancement, thyroid function regulation, anti-cancer effects, cardiovascular protection, reproductive capability improvement, and anti-inflammatory activity. Despite its critical importance to human health, the range between selenium’s nutritional and toxic doses is very narrow. Insufficient daily selenium intake can lead to selenium deficiency, while excessive intake carries the risk of selenium toxicity. Therefore, selenium intake must be controlled within a relatively precise range. This article reviews the distribution and intake of selenium, as well as its absorption and metabolism mechanisms in the human body. It also explores the multiple biological functions and mechanisms of selenium in maintaining human health. The aim is to provide new insights and evidence for further elucidating the role of selenium and selenoproteins in health maintenance, as well as for future nutritional guidelines and public health policies. Full article
(This article belongs to the Special Issue Organosulfur and Organoselenium Chemistry II)
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