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90 Results Found

  • Article
  • Open Access
4 Citations
2,225 Views
16 Pages

An Extended Investigation of Unexpected Helicoverpa zea (Boddie) Survival and Ear Injury on a Transgenic Maize Hybrid Expressing Cry1A/Cry2A/Vip3A Toxins

  • Fangneng Huang,
  • Ying Niu,
  • Tiago Silva,
  • Sebe Brown,
  • Tyler Towles,
  • Dawson Kerns,
  • Juan Luis Jurat-Fuentes,
  • Graham P. Head,
  • Matthew Carroll and
  • Shucong Lin
  • + 1 author

22 July 2023

The wide occurrence of resistance to Cry1A and Cry2A insecticidal toxins from Bacillus thuringiensis (Bt) in the corn earworm/bollworm Helicoverpa zea (Boddie) leaves the Vip3A toxin produced during the vegetative stage of Bt as the only fully active...

  • Article
  • Open Access
3 Citations
3,098 Views
17 Pages

Indeterminacy of the Diagnosis of Sudden Infant Death Syndrome Leading to Problems with the Validity of Data

  • Ivana Olecká,
  • Martin Dobiáš,
  • Adéla Lemrová,
  • Kateřina Ivanová,
  • Tomáš Fürst,
  • Jan Krajsa and
  • Petr Handlos

The validity of infant mortality data is essential in assessing health care quality and in the setting of preventive measures. This study explores different diagnostic procedures used to determine the cause of death across forensic settings and thus...

  • Article
  • Open Access
386 Views
16 Pages

Psychiatric hospitals present occupational hazards, with patients’ unexpected behaviors constituting a unique factor that makes the safety climate crucial for preventing injuries and ensuring a healthy work environment. In this context, this st...

  • Case Report
  • Open Access
4 Citations
2,778 Views
7 Pages

An Atypical Case of Rhabdomyolysis Following an Atypical Antidepressant Overdose

  • Raluca Ungureanu,
  • Ana-Maria Dumitriu,
  • Cristian Cobilinschi,
  • Rǎzvan Ene,
  • Mihaela Buiuc,
  • Ioana Marina Grințescu and
  • Liliana Mirea

6 January 2025

Background: Bupropion, an atypical antidepressant and smoking cessation aid, is known for its potential to cause seizures, cardiotoxicity and neurotoxicity in overdose scenarios. However, overdoses may present variably, and muscular and renal complic...

  • Article
  • Open Access
5 Citations
3,342 Views
11 Pages

Clinical Relevance of Unexpected Findings of Post-Mortem Computed Tomography in Hospitalized Patients: An Observational Study

  • Max G. Mentink,
  • Bartholomeus G. H. Latten,
  • Frans C. H. Bakers,
  • Casper Mihl,
  • Roger J. M. W. Rennenberg,
  • Bela Kubat and
  • Paul A. M. Hofman

Background and objective: The current literature describing the use of minimally invasive autopsy in clinical care is mainly focused on the cause of death. However, the identification of unexpected findings is equally important for the evaluation and...

  • Review
  • Open Access
2 Citations
2,688 Views
14 Pages

The Impact of Microbiota on Musculoskeletal Injuries

  • Giada La Placa,
  • Marcello Covino,
  • Marcello Candelli,
  • Antonio Gasbarrini,
  • Francesco Franceschi and
  • Giuseppe Merra

7 April 2025

Musculoskeletal injuries comprise a wide range of physical conditions impacting the coordination of bones, muscles, and joints. Estimations suggest that close to one-third of the world’s population will experience a musculoskeletal or non-muscu...

  • Feature Paper
  • Article
  • Open Access
2 Citations
5,536 Views
5 Pages

Lessons Learned from Implementing a Programme of Home Modifications to Prevent Falls amongst the General Population

  • Michael D. Keall,
  • Philippa Howden-Chapman,
  • Nevil Pierse,
  • Chris W. Cunningham and
  • Michael G. Baker

20 June 2018

Home fall injuries amongst the general population are common and costly. In the Home Injury Prevention Intervention (HIPI) trial, we showed that 26% of medically treated home fall injuries could be prevented by a package of home modifications underta...

  • Article
  • Open Access
10 Citations
3,834 Views
11 Pages

The tasks performed by police officers are unique, varied and can be performed in unexpected situations. Initial police college training is used to prepare new police officers to conduct these tasks and is known to be a time when police trainees are...

  • Article
  • Open Access
2 Citations
3,414 Views
12 Pages

Terrain Perception Using Wearable Parrot-Inspired Companion Robot, KiliRo

  • Jaishankar Bharatharaj,
  • Loulin Huang,
  • Ahmed M. Al-Jumaily,
  • Senthil Kumar Sasthan Kutty and
  • Chris Krägeloh

Research indicates that deaths due to fall incidents are the second leading cause of unintentional injury deaths in the world. Death by fall due to a person texting or talking on mobile phones while walking, impaired vision, unexpected terrain change...

  • Review
  • Open Access
6 Citations
2,757 Views
11 Pages

12 December 2023

The introduction of transcatheter aortic valve replacement (TAVR) has undeniably changed the landscape of valvular heart disease management over the last two decades. A reduction in complications through improvements in techniques, experience, and te...

  • Proceeding Paper
  • Open Access
6 Citations
5,054 Views
6 Pages

In competitive association football, wearing electronic performance and tracking system (EPTS) devices was approved in 2015. Safety concerns regarding their use have been raised; however, research and understanding is limited. Recently, FIFA has take...

  • Review
  • Open Access
14 Citations
8,663 Views
12 Pages

Background: Polytrauma is understood as significant injuries, occurring at the same time, to two or more anatomical regions (the ISS regions) or organ systems, with at least one of the injuries considered as posing a threat to life. Trauma is the mai...

  • Study Protocol
  • Open Access
1,151 Views
19 Pages

24 October 2025

Background: The majority of injuries among older adults occur due to unexpected and sudden incidents in the home environment. This study aimed to develop a protocol for the design of the health belief model-based program for preventing unintentional...

  • Article
  • Open Access
4 Citations
3,631 Views
15 Pages

Trunk positioning and unexpected perturbations are high-risk conditions at the time of anterior cruciate ligament injury. The influence of trunk positioning on motor control responses to perturbation during dynamic performance is not known. We tested...

  • Review
  • Open Access
127 Views
11 Pages

Ureteral and Vascular Events During Robotic Post-Chemotherapy Retroperitoneal Lymph Node Dissection: Technical Insights and Management Considerations

  • Manuel Saavedra Centeno,
  • Eduardo Albers Acosta,
  • Clara Velasco Balanza,
  • Lira Pelari Mici,
  • Carlos Márquez Güemez,
  • Marta Pérez Pérez,
  • Ana Sánchez Ramírez and
  • Luis Alberto San José Manso

Robotic retroperitoneal lymph node dissection (R-RPLND) represents an evolution in the surgical management of testicular germ cell tumors, offering reduced morbidity compared with open approaches. However, this procedure remains technically challengi...

  • Review
  • Open Access
3 Citations
4,680 Views
19 Pages

Critical Review of Gaps in the Diagnosis and Management of Drug-Induced Liver Injury Associated with Severe Cutaneous Adverse Reactions

  • Marina Villanueva-Paz,
  • Hao Niu,
  • Antonio Segovia-Zafra,
  • Inmaculada Medina-Caliz,
  • Judith Sanabria-Cabrera,
  • M. Isabel Lucena,
  • Raúl J. Andrade and
  • Ismael Alvarez-Alvarez

15 November 2021

Drug-induced liver injury (DILI) encompasses the unexpected damage that drugs can cause to the liver. DILI may develop in the context of an immunoallergic syndrome with cutaneous manifestations, which are sometimes severe (SCARs). Nevirapine, allopur...

  • Article
  • Open Access
5 Citations
5,482 Views
12 Pages

The purpose of this pilot study was to explore and interpret the way that individuals with acquired brain injury, admitted to inpatient neurorehabilitation with severe eating difficulties, experienced eating nine to fifteen months after discharge. Fo...

  • Review
  • Open Access
17 Citations
19,181 Views
18 Pages

Ultrasound Imaging of Facial Vascular Neural Structures and Relevance to Aesthetic Injections: A Pictorial Essay

  • Wei-Ting Wu,
  • Ke-Vin Chang,
  • Hsiang-Chi Chang,
  • Chen-Hsiang Kuan,
  • Lan-Rong Chen,
  • Kamal Mezian,
  • Vincenzo Ricci and
  • Levent Özçakar

The facial and submental regions are supplied by complicated neurovascular networks; therefore, facial aesthetic injections may be associated with serious adverse events such as skin necrosis and blindness. Pre-injection localization of neurovascular...

  • Feature Paper
  • Article
  • Open Access
21 Citations
4,473 Views
15 Pages

Closing the Wearable Gap—Part III: Use of Stretch Sensors in Detecting Ankle Joint Kinematics During Unexpected and Expected Slip and Trip Perturbations

  • Harish Chander,
  • Ethan Stewart,
  • David Saucier,
  • Phuoc Nguyen,
  • Tony Luczak,
  • John E. Ball,
  • Adam C. Knight,
  • Brian K. Smith,
  • Reuben F. Burch V and
  • R. K. Prabhu

24 September 2019

Background: An induced loss of balance resulting from a postural perturbation has been reported as the primary source for postural instability leading to falls. Hence; early detection of postural instability with novel wearable sensor-based measures...

  • Article
  • Open Access
5 Citations
4,989 Views
16 Pages

Analysis of Occupational Accidents in Tree Climbers

  • Luboš Staněk,
  • Ondřej Augustin and
  • Jindřich Neruda

19 September 2022

The work of tree climbers is a hazardous activity during which many risks of occupational accidents must be faced. Numerous injuries happen during the performance of this professional activity. This is why our research was conducted, and the principl...

  • Proceeding Paper
  • Open Access
2 Citations
3,039 Views
7 Pages

Non-professional runners make extensive use of consumer-available wearable devices and smartphone apps to monitor training sessions, health, and physical performance. Despite the popularity of these products, they usually neglect subjective factors,...

  • Case Report
  • Open Access
4 Citations
3,204 Views
8 Pages

Native Aortic Valve Endocarditis Complicated by Splenic Infarction and Giant Mitral-Aortic Intervalvular Fibrosa Pseudoaneurysm—A Case Report and Brief Review of the Literature

  • Andreea Varga,
  • Ioan Tilea,
  • Cristina Maria Tatar,
  • Dragos Gabriel Iancu,
  • Maria Andrada Jiga,
  • Robert Adrian Dumbrava,
  • Marian Pop and
  • Horatiu Suciu

Background: Pseudoaneurysm of the mitral-aortic intervalvular fibrosa (P-MAIVF) is an unusual complication related to various injuries or conditions which involve the mitro-aortic region; it communicates with the left ventricular outflow tract and is...

  • Review
  • Open Access
6 Citations
4,893 Views
16 Pages

24 March 2023

The present review aims to provide a critical appraisal of the sonographic diagnosis and follow-up and to evaluate the optimal clinical management of monochorionic twin pregnancies where one of the twins is complicated by selective fetal growth restr...

  • Article
  • Open Access
21 Citations
5,596 Views
30 Pages

18 June 2022

Making rapid and proper compensatory postural adjustments is vital to prevent falls and fall-related injuries. This study aimed to investigate how, especially how rapidly, the multiple lower-limb muscles and joints would respond to the unexpected sta...

  • Article
  • Open Access
22 Citations
9,843 Views
11 Pages

Causes of Needlestick and Sharps Injuries When Using Devices with and without Safety Features

  • Madeleine Dulon,
  • Johanna Stranzinger,
  • Dana Wendeler and
  • Albert Nienhaus

Safety-engineered devices (SEDs) have been developed to protect healthcare personnel (HCP) from needlestick and sharps injuries (NSIs). The aim of this study was to analyze NSIs associated with SEDs and non-SEDs among HCP in hospitals, medical office...

  • Case Report
  • Open Access
5 Citations
300 Views
5 Pages

Periorbital injury can present with various permutations of bone trauma, soft-tissue edema, and hematomas that might involve proptosis and restricted motility. We report a case of a 32-year-old patient who sustained a traumatic orbital compartment sy...

  • Case Report
  • Open Access
4 Citations
8,330 Views
4 Pages

Corticosteroid-Induced Liver Injury in Adult-Onset Still’s Disease

  • Chin-Chi Lee,
  • Yi-Jen Peng,
  • Chun-Chi Lu,
  • Hsiang-Cheng Chen and
  • Fu-Chiang Yeh

27 January 2022

Background and Objectives: Adult-onset Still’s disease (AOSD) is a rheumatic disease characterized by systemic inflammatory symptoms, including intermittent spiking fever, polyarthritis and a distinctive salmon-colored rash. Corticosteroids are...

  • Feature Paper
  • Review
  • Open Access
7 Citations
9,797 Views
26 Pages

Seizure Detection Devices

  • Christoph Baumgartner,
  • Jakob Baumgartner,
  • Clemens Lang,
  • Tamara Lisy and
  • Johannes P. Koren

28 January 2025

Goals of automated detection of epileptic seizures using wearable devices include objective documentation of seizures, prevention of sudden unexpected death in epilepsy (SUDEP) and seizure-related injuries, obviating both the unpredictability of seiz...

  • Review
  • Open Access
17 Citations
5,387 Views
34 Pages

Alternative Targets for Modulators of Mitochondrial Potassium Channels

  • Antoni Wrzosek,
  • Shur Gałecka,
  • Monika Żochowska,
  • Anna Olszewska and
  • Bogusz Kulawiak

4 January 2022

Mitochondrial potassium channels control potassium influx into the mitochondrial matrix and thus regulate mitochondrial membrane potential, volume, respiration, and synthesis of reactive oxygen species (ROS). It has been found that pharmacological ac...

  • Article
  • Open Access
1,200 Views
13 Pages

Incidence of Unapparent Preoperative Deep Vein Thrombosis in Patients with Traumatic Intraarticular Tibial Plateau Fracture

  • Henriette Hermel,
  • Simon Yacoub,
  • Firas Souleiman,
  • Friederike Kohlmann,
  • Andreas Kühnapfel,
  • Christian Kleber,
  • Katja S. Mühlberg and
  • Ralf Henkelmann

16 May 2025

Objective: In patients with leg injuries, typical symptoms of thrombosis such as painful swelling may be misinterpreted as a consequence of the trauma. This has the potential to result in an unexpected embolism, especially during the perioperative pe...

  • Review
  • Open Access
3 Citations
2,160 Views
14 Pages

Energy Metabolism and Metformin: Effects on Ischemia-Reperfusion Injury in Kidney Transplantation

  • Denise V. Nemeth,
  • Leonardo Iannelli,
  • Elena Gangitano,
  • Vito D’Andrea and
  • Maria Irene Bellini

Metformin (MTF) is the only biguanide included in the World Health Organization’s list of essential medicines; representing a widespread drug in the management of diabetes mellitus. With its accessibility and affordability being one of its bigg...

  • Review
  • Open Access
45 Citations
9,216 Views
20 Pages

Macrophages were first described as phagocytic immune cells responsible for maintaining tissue homeostasis by the removal of pathogens that disturb normal function. Historically, macrophages have been viewed as terminally differentiated monocyte-deri...

  • Article
  • Open Access
52 Citations
7,092 Views
16 Pages

Fostering Safety Communication among Construction Workers: Role of Safety Climate and Crew-Level Cohesion

  • Bhavana Pandit,
  • Alex Albert,
  • Yashwardhan Patil and
  • Ahmed Jalil Al-Bayati

Safety communication among construction workers is fundamental to effective safety management. However, evidence suggests that poor safety communication is a common problem in construction workplaces. In fact, previous research has unveiled a number...

  • Article
  • Open Access
8 Citations
5,943 Views
14 Pages

At a cellular level, nutrients are sensed by the mechanistic Target of Rapamycin (mTOR). The response of cells to hypoxia is regulated via action of the oxygen sensor Hypoxia-Inducible Factor 1 (HIF-1). During development, injury and disease, tissues...

  • Proceeding Paper
  • Open Access
479 Views
8 Pages

3 November 2025

This study aims to enhance safety within the Budapest tram network by developing methods to assess and manage tram drivers’ cognitive workload. While defensive driving reduces accident risk, it becomes less effective when drivers are mentally o...

  • Feature Paper
  • Article
  • Open Access
1,759 Views
16 Pages

Ankle Joint Kinematics in Expected and Unexpected Trip Responses with Dual-Tasking and Physical Fatigue

  • Sachini N. K. Kodithuwakku Arachchige,
  • Harish Chander and
  • Adam C. Knight

Concurrent cognitive tasks, such as avoiding visual, auditory, chemical, and electrical hazards, and concurrent motor tasks, such as load carriage, are prevalent in ergonomic settings. Trips are extremely common in the workplace, leading to fatal and...

  • Feature Paper
  • Article
  • Open Access
32 Citations
4,080 Views
15 Pages

Azilsartan Modulates HMGB1/NF-κB/p38/ERK1/2/JNK and Apoptosis Pathways during Renal Ischemia Reperfusion Injury

  • Rania Alaaeldin,
  • Sally M. Bakkar,
  • Reham H. Mohyeldin,
  • Fares E. M. Ali,
  • Nehad M. Reda Abdel-Maqsoud and
  • Moustafa Fathy

2 January 2023

Renal ischemia/reperfusion (IR) injury is characterized by an unexpected impairment of blood flow to the kidney. Azilsartan is an angiotensin receptor blocker that is approved for the management of hypertension. The present study aimed to investigate...

  • Article
  • Open Access
4 Citations
2,805 Views
14 Pages

Design of a Mixed Reality System for Simulating Indoor Disaster Rescue

  • Yoon-Jae Chae,
  • Ho-Won Lee,
  • Jong-Hyuk Kim,
  • Se-Woong Hwang and
  • Yoon-Young Park

30 March 2023

Modern buildings are large and complex, and as more time is spent inside them, the risk of indoor disasters such as fires and gas leaks increases. In the event of such a disaster, the success of the rescue operation depends on the ability of the resc...

  • Article
  • Open Access
1,326 Views
21 Pages

Problems and Design of a Powered Mechanism-Based Car Child Restraint System

  • Luis Angel Guerrero-Hernández,
  • Marco Ceccarelli,
  • Christopher Rene Torres-SanMiguel and
  • Matteo Russo

29 January 2025

Vehicle collisions can cause serious injury or even death to passengers, especially children aged 1–12 years. Hence, child restraint systems are now subject to legislative requirements for the development of better solutions. This paper present...

  • Article
  • Open Access
17 Citations
3,900 Views
13 Pages

Characterization of Efficacy and Animal Safety across Four Caprine Disbudding Methodologies

  • Kelly M. Still Brooks,
  • Melissa N. Hempstead,
  • Jessica L. Anderson,
  • Rebecca L. Parsons,
  • Mhairi A. Sutherland,
  • Paul J. Plummer and
  • Suzanne T. Millman

7 February 2021

There is a strong industry demand for technically simple and highly efficacious alternatives to heat cautery disbudding in goat kids that can be performed as a stand-alone procedure without adjunct anesthesia, and that result in improved overall welf...

  • Review
  • Open Access
50 Citations
6,457 Views
30 Pages

Insights into the Molecular Mechanisms of NRF2 in Kidney Injury and Diseases

  • Da-Wei Lin,
  • Yung-Chien Hsu,
  • Cheng-Chih Chang,
  • Ching-Chuan Hsieh and
  • Chun-Liang Lin

Redox is a constant phenomenon in organisms. From the signaling pathway transduction to the oxidative stress during the inflammation and disease process, all are related to reduction-oxidation (redox). Nuclear factor erythroid 2-related factor 2 (NRF...

  • Article
  • Open Access
16 Citations
5,080 Views
12 Pages

Design of a Sensitive Balloon Sensor for Safe Human–Robot Interaction

  • Dongjin Kim,
  • Seungyong Han,
  • Taewi Kim,
  • Changhwan Kim,
  • Doohoe Lee,
  • Daeshik Kang and
  • Je-Sung Koh

19 March 2021

As the safety of a human body is the main priority while interacting with robots, the field of tactile sensors has expanded for acquiring tactile information and ensuring safe human–robot interaction (HRI). Existing lightweight and thin tactile senso...

  • Article
  • Open Access
12 Citations
5,508 Views
11 Pages

Effect of Core Balance Training on Muscle Tone and Balance Ability in Adult Men and Women

  • Sun-Ha Jo,
  • Hyuk-Jae Choi,
  • Hyeon-Seok Cho,
  • Jin-Hwan Yoon and
  • Won-Young Lee

(1) Background: The amount of physical activity most adults perform is less than the recommended amount, and the resulting decrease in physical strength makes them vulnerable to various diseases. A decrease in muscle size and strength due to damage c...

  • Article
  • Open Access
3 Citations
2,686 Views
18 Pages

24 April 2024

Self-assembled peptide-based nanobiomaterials exhibit promising prospects for drug delivery applications owing to their commendable biocompatibility and biodegradability, facile tissue uptake and utilization, and minimal or negligible unexpected toxi...

  • Article
  • Open Access
4 Citations
3,599 Views
10 Pages

Impact of COVID-19-Related Sports Activity Disruptions on the Physical Fitness of Japanese Adolescent Athletes

  • Hiromune Obayashi,
  • Yasunari Ikuta,
  • Naoki Nakashima,
  • Ryoko Yamamoto,
  • Hironori Fujishita,
  • Koki Fukuhara,
  • Tetsuhiko Sakamitsu,
  • Kai Ushio,
  • Hiroaki Kimura and
  • Nobuo Adachi

24 March 2022

We assessed whether the coronavirus disease 2019 (COVID-19) pandemic-related disruptions impacted the physical fitness of adolescent athletes. We reviewed the age-, sex-, and sports category-matched data of 78 adolescent athletes (divided into two gr...

  • Review
  • Open Access
3 Citations
7,800 Views
12 Pages

22 February 2023

Much research has been conducted in an attempt to decrease skeletal injuries in athletic horses. The objective of this literature review is to compile the findings of over three decades of research in this area, make practical recommendations, and de...

  • Article
  • Open Access
4 Citations
3,436 Views
8 Pages

Challenges in the Diagnosis and Management of Non-Severe Hemophilia

  • Estera Boeriu,
  • Teodora Smaranda Arghirescu,
  • Margit Serban,
  • Jenel Marian Patrascu,
  • Eugen Boia,
  • Cristian Jinca,
  • Wolfgang Schramm,
  • Adina Traila and
  • Cristina Emilia Ursu

9 June 2022

(1) Background: Mild and moderate hemophilia, synonymous with non-severe hemophilia (NSH), are of constant interest for the clinicians. Bleeding occurs usually after trauma, injury, surgery, or inhibitor development, sometimes leading to a shift of t...

  • Article
  • Open Access
17 Citations
3,586 Views
16 Pages

MSEDDI: Multi-Scale Embedding for Predicting Drug—Drug Interaction Events

  • Liyi Yu,
  • Zhaochun Xu,
  • Meiling Cheng,
  • Weizhong Lin,
  • Wangren Qiu and
  • Xuan Xiao

24 February 2023

A norm in modern medicine is to prescribe polypharmacy to treat disease. The core concern with the co-administration of drugs is that it may produce adverse drug—drug interaction (DDI), which can cause unexpected bodily injury. Therefore, it is...

  • Review
  • Open Access
2,470 Views
21 Pages

Unraveling the Mystery of Hemoglobin in Hypoxia-Accelerated Neurodegenerative Diseases

  • Zhengming Tian,
  • Feiyang Jin,
  • Zhuowen Geng,
  • Zirui Xu,
  • Qianqian Shao,
  • Guiyou Liu,
  • Xunming Ji and
  • Jia Liu

25 August 2025

Hypoxic stress is increasingly recognized as a convergent pathological factor in various age-related neurodegenerative diseases (NDDs), encompassing both acute events such as stroke and traumatic brain injury (TBI), and chronic disorders including Pa...

  • Article
  • Open Access
3 Citations
2,771 Views
10 Pages

Mediation of the Cardioprotective Effects of Mannitol Discovered, with Refutation of Common Protein Kinases

  • Carolin Torregroza,
  • Chiara O. Glashoerster,
  • Katharina Feige,
  • Martin Stroethoff,
  • Annika Raupach,
  • André Heinen,
  • Markus W. Hollmann and
  • Ragnar Huhn

19 November 2021

The osmodiuretic agent Mannitol exerts cardioprotection against ischemia and reperfusion (I/R) injury when applied as a pre- and/or postconditioning stimulus. Previously, we demonstrated that these properties are mediated via the activation of mitoch...

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