The proper functioning of the endoplasmic reticulum (ER) is crucial for multiple cellular activities and survival. Disturbances in the normal ER functions lead to the accumulation and aggregation of unfolded proteins, which initiates an adaptive resp...
Modern agriculture is being challenged by deteriorating edaphoclimatic conditions and increasing anthropogenic pressure. This necessitates the development of innovative crop production systems that can sustainably meet the demands of a growing world...
Reinforced concrete interfaces, either cracks within monolithic elements or joints between concretes cast at different times may become critical under cyclic actions, due to stiffness and interface resistance degradation. Among the numerous parameter...
Hybrid rice parental lines with better combining abilities provide an efficient tool to increase rice production. In the current study, twenty hybrid combinations were generated from five aromatic cytoplasmic male sterile (CMS) lines and four restore...
This work aimed to identify the chemical compounds of Cinnamomum burmannii leaf essential oil (CBLEO) and to unravel the antibacterial mechanism of CBLEO at the molecular level for developing antimicrobials. CBLEO had 37 volatile compounds with abund...
High temperature is a major environmental stress that devastatingly affects wheat production. Thenceforth, developing heat-tolerant and high-yielding wheat genotypes has become more critical to sustaining wheat production particularly under abrupt cl...
The lightweight floor system (LFS) with a heating coil is one of many types of radiant heating systems. It differs from most of the others, as it has a much higher thermal efficiency at low flow temperature. To verify whether adhesive mortars can saf...
The group III two-component hybrid histidine kinase MoHik1p in the filamentous fungus Magnaporthe oryzae is known to be a sensor for external osmotic stress and essential for the fungicidal activity of the phenylpyrrole fludioxonil. The mode of actio...
The durability of subsea tunnels under the coupled action of stress and chloride ions was analyzed to estimate the service life and provide a theoretical foundation for durability design. The influence coefficient of the stress on chloride ion transm...
Erythropoietin (EPO) regulation of red blood cell production and its induction at reduced oxygen tension provides for the important erythropoietic response to ischemic stress. The cloning and production of recombinant human EPO has led to its clinica...
Estrogens are among important contributing factors to many sex differences in neuroendocrine regulation of energy homeostasis induced by stress. Research in this field is warranted since chronic stress-related psychiatric and metabolic disturbances c...
Oxidative stress, characterized by an imbalance between the production of reactive oxygen species (ROS) and the body’s antioxidant defenses, significantly affects cellular function and viability. It plays a pivotal role in modulating membrane p...
Polyamines (PAs) are found in all living organisms and serve many vital physiological processes. In plants, PAs are ubiquitous in plant growth, physiology, reproduction, and yield. In the last decades, PAs have been studied widely for exploring their...
We present the first study in the literature that has aimed to determine Depression Anxiety Stress Scale (DASS) levels by analyzing facial expressions using Facial Action Coding System (FACS) by means of a unique noninvasive architecture on three lay...
As sessile species, plants have to deal with the rapidly changing environment. In response to these environmental conditions, plants employ a plethora of response mechanisms that provide broad phenotypic plasticity to allow the fine-tuning of the ext...
Preeclampsia (PE) is a gestational hypertensive disease characterized by endothelial dysfunction. Epigallocatechin-3-gallate (EGCG), the main compound in green tea, is a promising therapeutic target for the disease. By activating eNOS, EGCG increased...
Benzo[a]pyrene (BaP) is a polycyclic aromatic hydrocarbon (PAH) primarily formed by burning of fossil fuels, wood and other organic materials. BaP as group I carcinogen shows mutagenic and carcinogenic effects. One of the important mechanisms of acti...
A bimodular material is a kind of material that presents two elastic moduli in tension and compression. In classical thermoelasticity, however, the bimodular material is rarely considered due to its complexity in analysis. In fact, almost all materia...
The antiproliferative G-quadruplex aptamers are a promising and challenging subject in the framework of the anticancer therapeutic oligonucleotides research field. Although several antiproliferative G-quadruplex aptamers have been identified and prov...
Dysregulated redox balance is involved in the pathogenesis of type 2 diabetes. While the benefit of antioxidants in neutralizing oxidative stress is well characterized, the potential harm of antioxidant-induced reductive stress is unclear. The aim of...
In recent years, epidemiological studies have identified a relationship between diet and cerebro–cardiovascular disease (CVD). In this regard, there is a promising dietary group for cardiovascular protection are polyphenols, especially anthocyanins....
This study aims to investigate the mechanical response of a submarine concrete pipeline under wave action in shallow waters, taking into account factors such as the compressibility of pores and the permeability of the seabed. The control equation of...
Stress has become an increasingly serious problem in the current society, threatening mankind’s well-beings. With the ubiquitous deployment of video cameras in surroundings, detecting stress based on the contact-free camera sensors becomes a co...
Multidimensional models of perfectionism postulate the existence of various perfectionism traits, with different effects on mental health. In order to suggest parsimonious targets in psychological interventions for university students, this study aim...
Increasing seed yield, fatty acids, and essential oil content are the main objectives in breeding coriander. However, in order to achieve this, there is a need to understand the nature of gene action and quantify the heterosis and inbreeding depressi...
Reactive oxygen species (ROS) are implicated in various pathological conditions due to their ability to induce oxidative damage to cellular components. In this study, we investigated the antioxidant properties of a peptide isolated from the hydrolysa...
Post-Traumatic Stress Disorder (PTSD) can be seen as the result of dysfunctional beliefs that associate stimuli with a danger or a threat leading to anxious reactions. Exposure therapy is so far considered to be the most effective treatment, and rese...
End concrete cover separation is one of the most common failure modes for RC beams strengthened with external FRP reinforcement. The premature failure mode significantly restricts the application of FRP materials and could incur serious safety proble...
Based on their proven anti-inflammatory and antioxidant effects, recent studies have examined the therapeutic potential of the sodium-glucose cotransporter 2 (SGLT2) inhibitors in neurodevelopmental disorders such as autism spectrum disorder (ASD). T...
Natural melanocortins (MCs) have been used in the successful development of drugs with neuroprotective properties. Here, we studied the behavioral effects and molecular genetic mechanisms of two synthetic MC derivatives-ACTH(4–7)PGP (Semax) and ACTH(...
23 August 2022
(1) Background: We aimed to explore Young medical researchers (YMR) normative beliefs and perceived causes of distress and burnout, prior and during the financial crisis in Greece, and to assess their views on Participatory Action Research (PAR) inte...
Cerebral dopamine neurotrophic factor (CDNF) is a neurotrophic factor that has beneficial effects on dopamine neurons in both in vitro and in vivo models of Parkinson’s disease (PD). CDNF was recently tested in phase I-II clinical trials for th...
15 February 2019
Climate change increases the risks of heat stress, especially in urban areas where urban heat islands can develop. This literature review aims to describe how severe heat can occur and be identified in urban indoor environments, and what actions can...
The time when plant biostimulants were considered as “snake oil” is erstwhile and the skepticism regarding their agricultural benefits has significantly faded, as solid scientific evidences of their positive effects are continuously provi...
Cisplatin (CDDP), carboplatin (CP), and oxaliplatin (OXP) are three platinating agents clinically approved worldwide for use against a variety of cancers. They are canonically known as DNA damage inducers; however, that is only one of their mechanism...
The use of chemical herbicides could not only potentially induce negative impacts on the environment, animals, and human health, but also increase the weed resistance to herbicides. In this context, the use of plant extracts could be an interesting a...
This paper introduces a new formability test based on double-action radial extrusion to characterize material formability in the three-dimensional to plane-stress material flow transitions that are found in bulk metal-formed parts. The presentation d...
Water deficit is a pivotal abiotic stress that detrimentally constrains rice growth and production. Thereupon, the development of high-yielding and drought-tolerant rice genotypes is imperative in order to sustain rice production and ensure global fo...
Salinity is one of the most common abiotic stress factors affecting different biochemical and physiological processes in plants, inhibiting plant growth, and greatly reducing productivity. During the last decade, silicon (Si) supplementation was inte...
With the increasing development of civil engineering in large cities, more and more excavations and surcharge loadings are being constructed or planned adjacent to existing building piles in crowded urban areas. Previous study on pile deformation has...
Obesity is frequently associated with metabolic alterations like hypercholesterolemia and hyperinsulinemia and represents a major risk factor for several diseases, including breast cancer (BC). Insulin signaling, as well as the frequent overexpressio...
Excessive flow turbulence poses a threat to the development of drifting fish eggs, leading to mortality or developmental malformations and ultimately depleting early fish resources. Currently, there is a scarcity of quantitative studies investigating...
Xestoquinone derivatives isolated from marine sponges exhibit a range of bioactivities, including the inhibition of HIF signaling, mitochondrial function, and tumor cell proliferation. Mechanistic investigation suggested that 14-hydroxymethylxestoqui...
Coriander (Coriander sativum L.) is an annual herb mainly cultivated for its seed characteristics. Drought stress is a major problem which affects coriander behaviour through biochemical responses. This study aimed to determine the nature and magnitu...
Kiwifruit is a significant fruit crop species for many countries around the world. Due to climate change, it undergoes significant heat stress during the summer months in the Mediterranean area. Heat stress, along with high irradiance, generally impo...
The article presents the results of research on a lightweight floor system (LFS) with a heat diffuser made of metal lamellae. It differs from traditional layered floors in the absence of a screed layer, which reduces thermal inertia and predisposes i...
Major depressive disorder is one of the most common mental illnesses that highly impairs quality of life. Pharmacological interventions are mainly focused on altered monoamine neurotransmission, which is considered the primary event underlying the di...
Natural compounds have shown good potential for the discovery of new chemotherapeutics for the treatment of Chagas’ disease. Recently, our group reported the effective trypanocidal activity of (−)-elatol, extracted from the red macroalgae Laurencia d...
“Extracellular” Heat Shock Protein-90 (Hsp90) was initially reported in the 1970s but was not formally recognized until 2008 at the 4th International Conference on The Hsp90 Chaperone Machine (Monastery Seeon, Germany). Studies presented...
The realm of antimicrobial proteins in plants is extensive but remains relatively uncharted. Understanding the mechanisms underlying the action of plant antifungal proteins (AFPs) holds promise for antifungal strategies. This study aimed to bridge th...
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