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1,625 Results Found

  • Article
  • Open Access
3 Citations
2,908 Views
13 Pages

4 March 2024

Flip-flow vibrating screens (FFVSs) effectively tackle the challenges posed by the dry deep-screening of wet, fine, low-grade bituminous coal, thereby facilitating advancements in the thermal coal preparation process. The tensile lengths of the scree...

(This article belongs to the Section Mineral Processing and Extractive Metallurgy)
  • Perspective
  • Open Access
1,077 Views
12 Pages

Background: Miscarriage is the most common complication of pregnancy. Current trends in medicine point to the increasing importance of evidence-based personalization in diagnostic and therapeutic processes. Purpose: The aim of this study was to devel...

(This article belongs to the Special Issue Dietary Antioxidants, Oxidative Stress, and Women’s Reproductive Health)
  • Article
  • Open Access
2 Citations
1,849 Views
16 Pages

9 October 2023

Structural breaks are often encountered in empirical studies with large panels. This paper considers the estimation of multiple breaks in the mean of panel data model based on a modified screening and ranking algorithm. This algorithm satisfies symme...

(This article belongs to the Special Issue Symmetry in Probability Theory and Statistics)
  • Article
  • Open Access
1 Citations
2,941 Views
14 Pages

CFTR Variant Frequencies and Newborn Screening Panel Performance in the Diverse CF Population Receiving Care in the State of Georgia

  • Eileen Barr,
  • Brittany Truitt,
  • Andrew Jergel,
  • Shasha Bai,
  • Kathleen McKie,
  • Rossana Sanchez Russo,
  • Kathryn E. Oliver and
  • Rachel W. Linnemann

Cystic fibrosis (CF) newborn screening (NBS) aims to improve outcomes through early diagnosis, yet disparities in time to diagnosis remain. This study examines CFTR allele frequencies and variant panel performance among a diverse CF population in Geo...

(This article belongs to the Special Issue Advances in Cystic Fibrosis Newborn Screening: From Laboratory Testing to Diagnosis)
  • Feature Paper
  • Article
  • Open Access
11 Citations
7,234 Views
14 Pages

13 April 2023

Human-relevant systems that mimic the 3D tumor microenvironment (TME), particularly the complex mechanisms of immuno-modulation in the tumor stroma, in a reproducible and scalable format are of high interest for the drug discovery industry. Here, we...

(This article belongs to the Collection Advances in 3D Cell Culture)
  • Article
  • Open Access
9 Citations
3,489 Views
9 Pages

Counting Conditions on Newborn Bloodspot Screening Panels in Australia and New Zealand

  • Natasha Heather,
  • Ronda F. Greaves,
  • Kaustuv Bhattacharya,
  • Lawrence Greed,
  • James Pitt,
  • Carol Wai-Kwan Siu,
  • Mark de Hora,
  • Ricky Price,
  • Enzo Ranieri and
  • Dianne Webster
  • + 1 author

A greater number of screened conditions is often considered to equate to better screening, whereas it may be due to conditions being counted differently. This manuscript describes a harmonised Australasian approach to listing target conditions found...

  • Letter
  • Open Access
4 Citations
5,875 Views
10 Pages

Capacitive Heart-Rate Sensing on Touch Screen Panel with Laterally Interspaced Electrodes

  • Junhyung Kim,
  • Wonho Song,
  • Sungchul Jung,
  • Yuna Kim,
  • Wonsang Park,
  • Bonghyun You and
  • Kibog Park

17 July 2020

It is demonstrated that the heart-rate can be sensed capacitively on a touch screen panel (TSP) together with touch signals. The existing heart-rate sensing systems measure blood pulses by tracing the amount of light reflected from blood vessels duri...

(This article belongs to the Section Physical Sensors)
  • Article
  • Open Access
1,090 Views
32 Pages

The Spanish Uniform Newborn Screening Panel (SUSP): A National Consensus Framework for Harmonized Newborn Screening

  • Judit García-Villoria,
  • Rosa María López-Galera,
  • Carmen Delgado-Pecellín,
  • Dolores Rausell Félix,
  • Cristóbal Colón,
  • Hugo Rocha,
  • Belén Pérez,
  • Antonia Ribes,
  • María Luz Couce and
  • Domingo González-Lamuño

Newborn screening (NBS) is a cornerstone of preventive medicine, enabling early diagnosis and treatment of severe congenital disorders. In Spain, despite the existence of a Basic Common Portfolio, the absence of a harmonized national panel has led to...

(This article belongs to the Special Issue Equity Issues in Newborn Screening)
  • Communication
  • Open Access
3 Citations
4,425 Views
13 Pages

6 April 2023

This paper presents a fully-differential touch screen panel (TSP) self-capacitance sensing (SCS) system with a self-capacitance mismatch calibration technique. Due to the self-capacitance mismatch of TSP, the analog front-end (AFE) of the receiver (R...

(This article belongs to the Special Issue Advanced CMOS Integrated Circuit Design and Application II)
  • Article
  • Open Access
10 Citations
8,057 Views
10 Pages

ITO/SiO2/ITO Structure on a Sapphire Substrate Using the Oxidation of Ultra-Thin Si Films as an Insulating Layer for One-Glass-Solution Capacitive Touch-Screen Panels

  • Shin Yong Joo,
  • Chadrasekhar Loka,
  • Young Woong Jo,
  • Maddipatla Reddyprakash,
  • Sung Whan Moon,
  • YiSik Choi,
  • Seong Eui Lee,
  • Gue Serb Cho and
  • Kee-Sun Lee

3 February 2020

The SiO2 generated by low-temperature oxidation of ultra-thin metallic silicon (thickness = 50 nm) film was evaluated for implementation in one-glass-solution capacitive touch-screen panels (OGS-TSPs) on sapphire-based substrates. Our results show th...

(This article belongs to the Section Thin Films)
  • Editorial
  • Open Access
14 Citations
3,590 Views
3 Pages

It has recently been announced that the Secretary of the U.S. Department of Health and Human Services has approved the recommendation by the Advisory Committee on Heritable Disorders in Newborns and Children (ACHDNC) to add mucopolysaccharidosis type...

  • Article
  • Open Access
2 Citations
2,076 Views
12 Pages

A Four-Gene Panel in Rectal Swab Samples as a Biomarker for Colorectal Cancer Screening

  • Lui Ng,
  • Sunny Kit-Man Wong,
  • Hung-Sing Li,
  • Ryan Wai-Yan Sin,
  • Johnny Hon-Wai Man,
  • Oswens Siu-Hung Lo,
  • Roberta Wen-Chi Pang,
  • Dominic Chi-Chung Foo and
  • Wai-Lun Law

28 May 2024

Background: The dysregulation of gene expression is one of the key molecular features of colorectal cancer (CRC) development. This study aimed to investigate whether such dysregulation is reflected in rectal swab specimens of CRC patients and to eval...

(This article belongs to the Section Cell Microenvironment)
  • Article
  • Open Access
27 Citations
3,974 Views
18 Pages

Protein Panel of Serum-Derived Small Extracellular Vesicles for the Screening and Diagnosis of Epithelial Ovarian Cancer

  • Huiling Lai,
  • Yunyun Guo,
  • Liming Tian,
  • Linxiang Wu,
  • Xiaohui Li,
  • Zunxian Yang,
  • Shuqin Chen,
  • Yufeng Ren,
  • Shasha He and
  • Guofen Yang
  • + 1 author

30 July 2022

Although ovarian cancer, a gynecological malignancy, has the highest fatality rate, it still lacks highly specific biomarkers, and the differential diagnosis of ovarian masses remains difficult to determine for gynecologists. Our study aimed to obtai...

(This article belongs to the Special Issue Challenge on Biomarkers and Treatment for Ovarian Cancer and Cervical Cancer)
  • Article
  • Open Access
32 Citations
5,650 Views
14 Pages

Supporting the Sensory Panel to Grade Virgin Olive Oils: An In-House-Validated Screening Tool by Volatile Fingerprinting and Chemometrics

  • Beatriz Quintanilla-Casas,
  • Marco Marin,
  • Francesc Guardiola,
  • Diego Luis García-González,
  • Sara Barbieri,
  • Alessandra Bendini,
  • Tullia Gallina Toschi,
  • Stefania Vichi and
  • Alba Tres

21 October 2020

The commercial category of virgin olive oil is currently assigned on the basis of chemical-physical and sensory parameters following official methods. Considering the limited number of samples that can be analysed daily by a sensory panel, an instrum...

(This article belongs to the Special Issue Novel Analytical Methods to Evaluate Quality and Authenticity of Edible Oils and Fats)
  • Article
  • Open Access
51 Citations
9,069 Views
15 Pages

An HS-GC-IMS Method for the Quality Classification of Virgin Olive Oils as Screening Support for the Panel Test

  • Enrico Valli,
  • Filippo Panni,
  • Enrico Casadei,
  • Sara Barbieri,
  • Chiara Cevoli,
  • Alessandra Bendini,
  • Diego L. García-González and
  • Tullia Gallina Toschi

20 May 2020

Sensory evaluation, carried out by panel tests, is essential for quality classification of virgin olive oils (VOOs), but is time consuming and costly when many samples need to be assessed; sensory evaluation could be assisted by the application of sc...

(This article belongs to the Special Issue Flavor and Aroma Analysis as a Tool for Quality Control of Foods)
  • Article
  • Open Access
8 Citations
5,169 Views
21 Pages

17 November 2024

This study presents a rapid and comprehensive method for screening mushroom extracts for the putative discovery of bioactive molecules, including those exhibiting antimicrobial activity. This approach utilizes a panel of bioluminescent bacteria, whos...

(This article belongs to the Section Biosensor and Bioelectronic Devices)
  • Article
  • Open Access
3 Citations
3,540 Views
12 Pages

Prospects for Expansion of Universal Newborn Screening in Bulgaria: A Survey among Medical Professionals

  • Georgi Iskrov,
  • Vyara Angelova,
  • Boyan Bochev,
  • Vaska Valchinova,
  • Teodora Gencheva,
  • Desislava Dzhuleva,
  • Julian Dichev,
  • Tanya Nedkova,
  • Mariya Palkova and
  • Rumen Stefanov
  • + 3 authors

Determining the scope of a newborn screening program is a challenging health policy issue. Our study aimed to explore the attitudes of specialists in pediatrics, neonatology, medical genetics, and biochemistry regarding the prospects for expanding th...

(This article belongs to the Special Issue Neonatal Screening in Europe: On the Brink of a New Era)
  • Article
  • Open Access
10 Citations
7,378 Views
11 Pages

Galactosaemia has been included in various newborn screening programs since 1963. Several methods are used for screening; however, the predominant methods used today are based on the determination of either galactose-1-phosphate uridyltransferase (GA...

(This article belongs to the Special Issue Selected Papers from 11th ISNS European Regional Meeting)
  • Article
  • Open Access
1,334 Views
9 Pages

A Survey of Current Australasian Practices in the Use of Residual Bloodspots for the Addition of a New Disorder to the Screening Panel

  • Lawrence Greed,
  • James Pitt,
  • Ronda F. Greaves,
  • Kate Coleman,
  • Gabrielle Crisp,
  • Enzo Ranieri,
  • Mark de Hora,
  • Dianne Webster and
  • Natasha Heather

Newborn screening (NBS) bloodspots are primarily used to test for a defined panel of conditions, yet screening expansion has necessitated the implementation of new tests. Integral to test implementation across all clinical laboratories is the need to...

  • Editorial
  • Open Access
14 Citations
3,638 Views
5 Pages

Neonatal screening programmes have been introduced in almost all European countries. In practice there are large differences, especially in the panel of conditions that are screened for, often without clear reasons. Policy making on a European level...

(This article belongs to the Special Issue Newborn Screening for Sickle Cell Disease and other Haemoglobinopathies)
  • Article
  • Open Access
1 Citations
2,468 Views
22 Pages

The goal of newborn screening (NBS) has remained the same despite its significant expansion from its inception as a public health initiative. This goal is to identify infants that are at risk for a set list of conditions and to implement a care plan...

  • Article
  • Open Access
1,286 Views
16 Pages

Wildfires that destroy residential infrastructure can generate chemically complex soil contamination; however, post-fire screening is often limited and does not directly reflect biological hazards. Herein, we integrated a multi-stress lux-based whole...

(This article belongs to the Special Issue Feature Papers in AppliedChem, 2nd Edition)
  • Article
  • Open Access
5 Citations
6,329 Views
21 Pages

Advancing Non-Invasive Prenatal Screening: A Targeted 1069-Gene Panel for Comprehensive Detection of Monogenic Disorders and Copy Number Variations

  • Roberto Sirica,
  • Alessandro Ottaiano,
  • Luigi D’Amore,
  • Monica Ianniello,
  • Nadia Petrillo,
  • Raffaella Ruggiero,
  • Rosa Castiello,
  • Alessio Mori,
  • Eloisa Evangelista and
  • Antonio Fico
  • + 4 authors

2 April 2025

We introduce an innovative, non-invasive prenatal screening approach for detecting fetal monogenic alterations and copy number variations (CNVs) from maternal blood. Method: Circulating free DNA (cfDNA) was extracted from maternal peripheral blood an...

(This article belongs to the Section Technologies and Resources for Genetics)
  • Article
  • Open Access
13 Citations
8,085 Views
8 Pages

Transparent Conducting Film Fabricated by Metal Mesh Method with Ag and Cu@Ag Mixture Nanoparticle Pastes

  • Hyun Min Nam,
  • Duck Min Seo,
  • Hyung Duk Yun,
  • Gurunathan Thangavel,
  • Lee Soon Park and
  • Su Yong Nam

16 May 2017

Transparent conducting electrode film is highly desirable for application in touch screen panels (TSPs), flexible and wearable displays, sensors, and actuators. A sputtered film of indium tin oxide (ITO) shows high transmittance (90%) at low sheet re...

(This article belongs to the Special Issue Metal Matrix Composites)
  • Article
  • Open Access
11 Citations
3,652 Views
11 Pages

NBSTRN Tools to Advance Newborn Screening Research and Support Newborn Screening Stakeholders

  • Kee Chan,
  • Zhanzhi Hu,
  • Lynn W. Bush,
  • Heidi Cope,
  • Ingrid A. Holm,
  • Stephen F. Kingsmore,
  • Kevin Wilhelm,
  • Curt Scharfe and
  • Amy Brower

Rapid advances in the screening, diagnosis, and treatment of genetic disorders have increased the number of conditions that can be detected through universal newborn screening (NBS). However, the addition of conditions to the Recommended Uniform Scre...

  • Article
  • Open Access
3 Citations
3,429 Views
11 Pages

7 March 2019

In order to expand the range of pot materials for induction cookers, a kind of sandwich structural composite ceramic panel that consists of an Al2O3 ceramic substrate, magnetic heating interlayer, and ZrO2 ceramic substrate was developed by combining...

(This article belongs to the Special Issue Ceramic Composites and Films)
  • Article
  • Open Access
6 Citations
4,705 Views
15 Pages

Screening a Targeted Panel of Genes by Next-Generation Sequencing Improves Risk Stratification in Real World Patients with Acute Myeloid Leukemia

  • Sónia Matos,
  • Paulo Bernardo,
  • Susana Esteves,
  • Aida Botelho de Sousa,
  • Marcos Lemos,
  • Patrícia Ribeiro,
  • Madalena Silva,
  • Albertina Nunes,
  • Joana Lobato and
  • Joana Desterro
  • + 11 authors

30 June 2022

Although mutation profiling of defined genes is recommended for classification of acute myeloid leukemia (AML) patients, screening of targeted gene panels using next-generation sequencing (NGS) is not always routinely used as standard of care. The ob...

(This article belongs to the Special Issue Feature Paper in Section "Cancer Biomarkers" in 2022)
  • Article
  • Open Access
8 Citations
6,783 Views
19 Pages

14 October 2019

This study investigated the potential of using a nonuniform woven panel with nonuniform strips—thick sticks and thin battens—as an external solar shading screen that addressed daylighting, shading, and mechanical performance factors. The...

(This article belongs to the Section Air, Climate Change and Sustainability)
  • Review
  • Open Access
25 Citations
7,321 Views
25 Pages

Developments in Genetics: Better Management of Ovarian Cancer Patients

  • Ovidiu-Virgil Maioru,
  • Viorica-Elena Radoi,
  • Madalin-Codrut Coman,
  • Iulian-Andrei Hotinceanu,
  • Andra Dan,
  • Anca-Elena Eftenoiu,
  • Livia-Mălina Burtavel,
  • Laurentiu-Camil Bohiltea and
  • Emilia-Maria Severin

5 November 2023

The purpose of this article is to highlight the new advancements in molecular and diagnostic genetic testing and to properly classify all ovarian cancers. In this article, we address statistics, histopathological classification, molecular pathways im...

(This article belongs to the Special Issue Ovarian Cancer: From Molecular Mechanisms to Targeted Therapy)
  • Article
  • Open Access
373 Views
25 Pages

HS-GC/MS-Based Targeted Blood VOC Panel for Canine Cancer Screening Using an Integrated Classification Framework in Retrospective Korea and Thailand Cohorts

  • Kyung-Geun Ahn,
  • Jin-Wook Chris Kim,
  • Soon Chul Gwak,
  • Eunkyung Oh,
  • Seyeon Lee,
  • Jedsada Siripoonsub,
  • Sirintra Sirivisoot,
  • Patharakrit Teewasutrakul,
  • Somporn Techangamsuwan and
  • Geon A Kim
  • + 5 authors

9 September 2026

Canine cancer screening has an important limitation in that organ-specific screening strategies used in human medicine cannot be directly applied across routine veterinary clinical practice. Blood-based volatile organic compound (VOC) profiling may p...

(This article belongs to the Special Issue Insights in Metabolomics: Chromatography and Mass Spectrometry Applications in Cancer Research)
  • Article
  • Open Access
23 Citations
9,974 Views
13 Pages

Mutual Capacitive Sensing Touch Screen Controller for Ultrathin Display with Extended Signal Passband Using Negative Capacitance

  • Chang-Ju Lee,
  • Jong Kang Park,
  • Canxing Piao,
  • Han-Eol Seo,
  • Jaehyuk Choi and
  • Jung-Hoon Chun

26 October 2018

Flexible and thin displays for smart devices have a large coupling capacitance between the sensor electrode of the touch screen panel (TSP) and the display electrode. This increased coupling capacitance limits the signal passband to less than 100 kHz...

(This article belongs to the Special Issue Tactile Sensors and Applications)
  • Article
  • Open Access
5 Citations
4,469 Views
17 Pages

8 June 2022

This paper proposes a low-computing-complexity touch signal detection method and analog front-end (AFE) circuits based on cross-correlation technology for large mutual capacitance touch screen panels (TSPs). To solve the traditional touch signal dete...

(This article belongs to the Section Electronic Sensors)
  • Article
  • Open Access
9 Citations
3,340 Views
15 Pages

28 November 2022

New methods and demonstrations of feasibility guide future implementation of genomic population health screening programs. This is the first report of genomic population screening in a primary care, non-research setting using existing large carrier a...

(This article belongs to the Special Issue Genomic Medicine Cohorts Based at U.S. Health Systems and Health Centers)
  • Article
  • Open Access
2 Citations
2,086 Views
17 Pages

11 February 2025

In-cell touch and display integrated panels, along with their integrated readout systems, are widely adopted in mobile devices for their cost-effectiveness and compact design. This paper proposes an analog Gaussian-shaped filter and a current mode co...

(This article belongs to the Section Electrical, Electronics and Communications Engineering)
  • Article
  • Open Access
6 Citations
5,983 Views
13 Pages

31 July 2021

This paper presents a mutual capacitance touch readout IC architecture for 120 Hz high-refresh-rate AMOLED displays. In high-refresh-rate AMOLED panels, whole pixels in a horizontal line should be updated without any time-sharing with each other, lea...

(This article belongs to the Section E: Engineering and Technology)
  • Article
  • Open Access
19 Citations
6,650 Views
19 Pages

Screening for Preterm Birth: Potential for a Metabolomics Biomarker Panel

  • Elizabeth C. Considine,
  • Ali S. Khashan and
  • Louise C. Kenny

The aim of this preliminary study was to investigate the potential of maternal serum to provide metabolomic biomarker candidates for the prediction of spontaneous preterm birth (SPTB) in asymptomatic pregnant women at 15 and/or 20 weeks’ gestat...

(This article belongs to the Special Issue Metabolomics of Complex Traits)
  • Article
  • Open Access
12 Citations
3,029 Views
20 Pages

Identification of a Novel Biomarker Panel for Breast Cancer Screening

  • Maria Vaida,
  • Kamala K. Arumalla,
  • Pavan Kumar Tatikonda,
  • Bharadwaj Popuri,
  • Rashid A. Bux,
  • Paramjit S. Tappia,
  • Guoyu Huang,
  • Jean-François Haince and
  • W. Randolph Ford

4 November 2024

Breast cancer remains a major public health concern, and early detection is crucial for improving survival rates. Metabolomics offers the potential to develop non-invasive screening and diagnostic tools based on metabolic biomarkers. However, the inh...

(This article belongs to the Special Issue Molecular Biomarkers in Cancers: Advances and Challenges)
  • Article
  • Open Access
5 Citations
3,732 Views
18 Pages

Graduate students often seek hands-on experiences in the international development field. Given that Multilateral Development Banks (MDBs) provide hundreds of billions of dollars in aid each year, we expected that reviewing the design, implementation...

(This article belongs to the Special Issue Innovative Pedagogies for Cultivating Leadership amidst the Climate Change Crisis)
  • Article
  • Open Access
34 Citations
8,040 Views
18 Pages

Sorting Rare ALS Genetic Variants by Targeted Re-Sequencing Panel in Italian Patients: OPTN, VCP, and SQSTM1 Variants Account for 3% of Rare Genetic Forms

  • Viviana Pensato,
  • Stefania Magri,
  • Eleonora Dalla Bella,
  • Pierpaola Tannorella,
  • Enrica Bersano,
  • Gianni Sorarù,
  • Marta Gatti,
  • Nicola Ticozzi,
  • Franco Taroni and
  • Cinzia Gellera
  • + 2 authors

3 February 2020

Amyotrophic lateral sclerosis (ALS) is an adult-onset progressive neurodegenerative disease due to motor neuron loss variably associated with frontotemporal dementia (FTD). Next generation sequencing technology revealed an increasing number of rare a...

(This article belongs to the Section Clinical Neurology)
  • Article
  • Open Access
3 Citations
10,578 Views
17 Pages

Fully Differential Touch Screen Controller with Wide Input Dynamic Range for Thin Displays

  • Chang-Ju Lee,
  • Jong Kang Park,
  • Han-Eol Seo,
  • Junho Huh and
  • Jung-Hoon Chun

4 February 2020

As today’s smartphone displays become thinner, the coupling capacitance between the display electrodes and touch screen panel (TSP) electrodes is increasing significantly. The increased capacitance easily introduces time-varying display signals...

(This article belongs to the Section Physical Sensors)
  • Article
  • Open Access
19 Citations
9,033 Views
21 Pages

11 March 2022

Globally, 70 million people are annually affected by TBI. A significant proportion of all TBI cases are actually mild TBI (concussion, 70–85%), which is considerably more difficult to diagnose due to the absence of apparent symptoms. Current cl...

(This article belongs to the Section Biosensors and Healthcare)
  • Article
  • Open Access
886 Views
19 Pages

30 June 2026

Climate change threatens global food security through shifts in temperature and precipitation regimes, greater frequency of extreme weather events, and cascading effects on agricultural input markets and institutional capacity. Policymakers require n...

  • Article
  • Open Access
2 Citations
2,830 Views
21 Pages

Impact of Methylated Cyclodextrin KLEPTOSE® CRYSMEB on Inflammatory Responses in Human In Vitro Models

  • Damien Truffin,
  • Flora Marchand,
  • Mathias Chatelais,
  • Gérald Chêne,
  • Laure Saias,
  • Frauke Herbst,
  • Justin Lipner and
  • Alastair J. King

9 September 2024

KLEPTOSE® CRYSMEB methylated cyclodextrin derivative displays less methylated group substitution than randomly methylated cyclodextrin. It has demonstrated an impact on atherosclerosis and neurological diseases, linked in part to cholesterol comp...

(This article belongs to the Special Issue Research on Cyclodextrin)
  • Article
  • Open Access
4 Citations
1,777 Views
18 Pages

A Novel Kinematics Model of Flip-Flow Screen Panel: Inclined Catenary Model

  • Jingfeng Fan,
  • Zhanshu He,
  • Yifei Zhang and
  • Mingli Wang

25 April 2023

A flip-flow screen can effectively screen viscous particles, and its kinematic characteristics determine its screening performance. Since previous kinematic models have errors, a novel kinematics model of the flip-flow screen panel, namely the inclin...

(This article belongs to the Special Issue Mathematical Modeling and Numerical Analysis for Applied Sciences)
  • Article
  • Open Access
11 Citations
7 Pages

Tapping panel dryness (TPD) syndrome is one of the latex yield affecting factors in the rubber tree (Hevea brasiliensis Mull. Arg.). Therefore, identification of a DNA marker will be highly useful for screening progenies in breeding programs. The maj...

  • Article
  • Open Access
55 Citations
4,103 Views
21 Pages

Screening a Panel of Topical Ophthalmic Medications against MMP-2 and MMP-9 to Investigate Their Potential in Keratoconus Management

  • Amany Belal,
  • Mohamed A. Elanany,
  • Eman Y. Santali,
  • Ahmed A. Al-Karmalawy,
  • Moustafa O. Aboelez,
  • Ali H. Amin,
  • Magda H. Abdellattif,
  • Ahmed B. M. Mehany and
  • Hazem Elkady

Keratoconus (KC) is a serious disease that can affect people of any race or nationality, although the exact etiology and pathogenic mechanism are still unknown. In this study, thirty-two FDA-approved ophthalmic drugs were exposed to virtual screening...

(This article belongs to the Special Issue Spectroscopic, Thermodynamic and Molecular Docking Studies on Molecular Mechanisms of Drug Binding to Proteins)
  • Article
  • Open Access
4 Citations
5,949 Views
8 Pages

Genetic Screening of a Large Panel of Genes Associated with Cardiac Disease in a Spanish Heart Transplanted Cohort

  • Elías Cuesta-Llavona,
  • Rebeca Lorca,
  • Beatriz Díaz-Molina,
  • José L. Lambert-Rodríguez,
  • Julián R. Reguero,
  • Sara Iglesias,
  • Belén Alonso,
  • Alejandro Junco-Vicente,
  • Vanesa Alonso and
  • Juan Gómez
  • + 1 author

In this study we performed a next generation sequencing of 210 genes in 140 patients with cardiac failure requiring a heart transplantation. We identified a total of 48 candidate variants in 47 patients. Forty-three patients (90%) presented a single...

(This article belongs to the Special Issue Cardiogenetics: Feature Papers 2021)
  • Article
  • Open Access
20 Citations
7,481 Views
14 Pages

A Machine Learning Approach to Screen for Otitis Media Using Digital Otoscope Images Labelled by an Expert Panel

  • Josefin Sandström,
  • Hermanus Myburgh,
  • Claude Laurent,
  • De Wet Swanepoel and
  • Thorbjörn Lundberg

Background: Otitis media includes several common inflammatory conditions of the middle ear that can have severe complications if left untreated. Correctly identifying otitis media can be difficult and a screening system supported by machine learning...

(This article belongs to the Special Issue Advances in Diagnostics of Otology and Neurotology)
  • Article
  • Open Access
1 Citations
3,624 Views
10 Pages

Panel Sequencing for Clinically Oriented Variant Screening and Copy Number Detection in Chronic Lymphocytic Leukemia Patients

  • Mariam Ibáñez,
  • Esperanza Such,
  • Alessandro Liquori,
  • Gayane Avestisyan,
  • Rafael Andreu,
  • Ana Vicente,
  • María José Macián,
  • Mari Carmen Melendez,
  • Mireya Morote-Faubel and
  • Irene Luna
  • + 15 authors

According to current guidelines, in chronic lymphocytic leukemia (CLL), only the TP53 molecular status must be evaluated prior to every treatment’s initiation. However, additional heterogeneous genetic events are known to confer a proliferative...

(This article belongs to the Section Pathology and Molecular Diagnostics)
  • Article
  • Open Access
5 Citations
2,866 Views
32 Pages

2 July 2025

PAN-gastrointestinal cancers (PAN-GI cancers), including the oral, esophageal, gastric, hepatocellular, pancreatic=, and colorectal cancers, are the leading cause of cancer-related mortality. Despite recent advances in identifying the molecular mecha...

(This article belongs to the Special Issue Application of Bioinformatics to Unravel the Molecular Mechanisms of Cancer Biology)

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