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1,243 Results Found

  • Article
  • Open Access
1 Citations
1,896 Views
13 Pages

4 March 2024

Flip-flow vibrating screens (FFVSs) effectively tackle the challenges posed by the dry deep-screening of wet, fine, low-grade bituminous coal, thereby facilitating advancements in the thermal coal preparation process. The tensile lengths of the scree...

  • Article
  • Open Access
1,315 Views
16 Pages

9 October 2023

Structural breaks are often encountered in empirical studies with large panels. This paper considers the estimation of multiple breaks in the mean of panel data model based on a modified screening and ranking algorithm. This algorithm satisfies symme...

  • Article
  • Open Access
999 Views
14 Pages

CFTR Variant Frequencies and Newborn Screening Panel Performance in the Diverse CF Population Receiving Care in the State of Georgia

  • Eileen Barr,
  • Brittany Truitt,
  • Andrew Jergel,
  • Shasha Bai,
  • Kathleen McKie,
  • Rossana Sanchez Russo,
  • Kathryn E. Oliver and
  • Rachel W. Linnemann

Cystic fibrosis (CF) newborn screening (NBS) aims to improve outcomes through early diagnosis, yet disparities in time to diagnosis remain. This study examines CFTR allele frequencies and variant panel performance among a diverse CF population in Geo...

  • Feature Paper
  • Article
  • Open Access
6 Citations
6,047 Views
14 Pages

13 April 2023

Human-relevant systems that mimic the 3D tumor microenvironment (TME), particularly the complex mechanisms of immuno-modulation in the tumor stroma, in a reproducible and scalable format are of high interest for the drug discovery industry. Here, we...

  • Article
  • Open Access
5 Citations
2,341 Views
9 Pages

Counting Conditions on Newborn Bloodspot Screening Panels in Australia and New Zealand

  • Natasha Heather,
  • Ronda F. Greaves,
  • Kaustuv Bhattacharya,
  • Lawrence Greed,
  • James Pitt,
  • Carol Wai-Kwan Siu,
  • Mark de Hora,
  • Ricky Price,
  • Enzo Ranieri and
  • Tiffany Wotton
  • + 1 author

A greater number of screened conditions is often considered to equate to better screening, whereas it may be due to conditions being counted differently. This manuscript describes a harmonised Australasian approach to listing target conditions found...

  • Letter
  • Open Access
4 Citations
5,169 Views
10 Pages

Capacitive Heart-Rate Sensing on Touch Screen Panel with Laterally Interspaced Electrodes

  • Junhyung Kim,
  • Wonho Song,
  • Sungchul Jung,
  • Yuna Kim,
  • Wonsang Park,
  • Bonghyun You and
  • Kibog Park

17 July 2020

It is demonstrated that the heart-rate can be sensed capacitively on a touch screen panel (TSP) together with touch signals. The existing heart-rate sensing systems measure blood pulses by tracing the amount of light reflected from blood vessels duri...

  • Communication
  • Open Access
1 Citations
3,236 Views
13 Pages

6 April 2023

This paper presents a fully-differential touch screen panel (TSP) self-capacitance sensing (SCS) system with a self-capacitance mismatch calibration technique. Due to the self-capacitance mismatch of TSP, the analog front-end (AFE) of the receiver (R...

  • Article
  • Open Access
9 Citations
6,272 Views
10 Pages

ITO/SiO2/ITO Structure on a Sapphire Substrate Using the Oxidation of Ultra-Thin Si Films as an Insulating Layer for One-Glass-Solution Capacitive Touch-Screen Panels

  • Shin Yong Joo,
  • Chadrasekhar Loka,
  • Young Woong Jo,
  • Maddipatla Reddyprakash,
  • Sung Whan Moon,
  • YiSik Choi,
  • Seong Eui Lee,
  • Gue Serb Cho and
  • Kee-Sun Lee

3 February 2020

The SiO2 generated by low-temperature oxidation of ultra-thin metallic silicon (thickness = 50 nm) film was evaluated for implementation in one-glass-solution capacitive touch-screen panels (OGS-TSPs) on sapphire-based substrates. Our results show th...

  • Editorial
  • Open Access
10 Citations
2,507 Views
3 Pages

It has recently been announced that the Secretary of the U.S. Department of Health and Human Services has approved the recommendation by the Advisory Committee on Heritable Disorders in Newborns and Children (ACHDNC) to add mucopolysaccharidosis type...

  • Article
  • Open Access
1 Citations
1,493 Views
12 Pages

A Four-Gene Panel in Rectal Swab Samples as a Biomarker for Colorectal Cancer Screening

  • Lui Ng,
  • Sunny Kit-Man Wong,
  • Hung-Sing Li,
  • Ryan Wai-Yan Sin,
  • Johnny Hon-Wai Man,
  • Oswens Siu-Hung Lo,
  • Roberta Wen-Chi Pang,
  • Dominic Chi-Chung Foo and
  • Wai-Lun Law

28 May 2024

Background: The dysregulation of gene expression is one of the key molecular features of colorectal cancer (CRC) development. This study aimed to investigate whether such dysregulation is reflected in rectal swab specimens of CRC patients and to eval...

  • Article
  • Open Access
31 Citations
4,987 Views
14 Pages

Supporting the Sensory Panel to Grade Virgin Olive Oils: An In-House-Validated Screening Tool by Volatile Fingerprinting and Chemometrics

  • Beatriz Quintanilla-Casas,
  • Marco Marin,
  • Francesc Guardiola,
  • Diego Luis García-González,
  • Sara Barbieri,
  • Alessandra Bendini,
  • Tullia Gallina Toschi,
  • Stefania Vichi and
  • Alba Tres

21 October 2020

The commercial category of virgin olive oil is currently assigned on the basis of chemical-physical and sensory parameters following official methods. Considering the limited number of samples that can be analysed daily by a sensory panel, an instrum...

  • Article
  • Open Access
24 Citations
3,184 Views
18 Pages

Protein Panel of Serum-Derived Small Extracellular Vesicles for the Screening and Diagnosis of Epithelial Ovarian Cancer

  • Huiling Lai,
  • Yunyun Guo,
  • Liming Tian,
  • Linxiang Wu,
  • Xiaohui Li,
  • Zunxian Yang,
  • Shuqin Chen,
  • Yufeng Ren,
  • Shasha He and
  • Weipeng He
  • + 1 author

30 July 2022

Although ovarian cancer, a gynecological malignancy, has the highest fatality rate, it still lacks highly specific biomarkers, and the differential diagnosis of ovarian masses remains difficult to determine for gynecologists. Our study aimed to obtai...

  • Article
  • Open Access
47 Citations
8,137 Views
15 Pages

An HS-GC-IMS Method for the Quality Classification of Virgin Olive Oils as Screening Support for the Panel Test

  • Enrico Valli,
  • Filippo Panni,
  • Enrico Casadei,
  • Sara Barbieri,
  • Chiara Cevoli,
  • Alessandra Bendini,
  • Diego L. García-González and
  • Tullia Gallina Toschi

20 May 2020

Sensory evaluation, carried out by panel tests, is essential for quality classification of virgin olive oils (VOOs), but is time consuming and costly when many samples need to be assessed; sensory evaluation could be assisted by the application of sc...

  • Article
  • Open Access
2 Citations
3,127 Views
21 Pages

17 November 2024

This study presents a rapid and comprehensive method for screening mushroom extracts for the putative discovery of bioactive molecules, including those exhibiting antimicrobial activity. This approach utilizes a panel of bioluminescent bacteria, whos...

  • Article
  • Open Access
2 Citations
2,756 Views
12 Pages

Prospects for Expansion of Universal Newborn Screening in Bulgaria: A Survey among Medical Professionals

  • Georgi Iskrov,
  • Vyara Angelova,
  • Boyan Bochev,
  • Vaska Valchinova,
  • Teodora Gencheva,
  • Desislava Dzhuleva,
  • Julian Dichev,
  • Tanya Nedkova,
  • Mariya Palkova and
  • Anelia Tyutyukova
  • + 3 authors

Determining the scope of a newborn screening program is a challenging health policy issue. Our study aimed to explore the attitudes of specialists in pediatrics, neonatology, medical genetics, and biochemistry regarding the prospects for expanding th...

  • Article
  • Open Access
10 Citations
6,606 Views
11 Pages

Galactosaemia has been included in various newborn screening programs since 1963. Several methods are used for screening; however, the predominant methods used today are based on the determination of either galactose-1-phosphate uridyltransferase (GA...

  • Editorial
  • Open Access
14 Citations
3,368 Views
5 Pages

Neonatal screening programmes have been introduced in almost all European countries. In practice there are large differences, especially in the panel of conditions that are screened for, often without clear reasons. Policy making on a European level...

  • Article
  • Open Access
323 Views
22 Pages

The goal of newborn screening (NBS) has remained the same despite its significant expansion from its inception as a public health initiative. This goal is to identify infants that are at risk for a set list of conditions and to implement a care plan...

  • Article
  • Open Access
2,803 Views
21 Pages

Advancing Non-Invasive Prenatal Screening: A Targeted 1069-Gene Panel for Comprehensive Detection of Monogenic Disorders and Copy Number Variations

  • Roberto Sirica,
  • Alessandro Ottaiano,
  • Luigi D’Amore,
  • Monica Ianniello,
  • Nadia Petrillo,
  • Raffaella Ruggiero,
  • Rosa Castiello,
  • Alessio Mori,
  • Eloisa Evangelista and
  • Luigia De Falco
  • + 4 authors

2 April 2025

We introduce an innovative, non-invasive prenatal screening approach for detecting fetal monogenic alterations and copy number variations (CNVs) from maternal blood. Method: Circulating free DNA (cfDNA) was extracted from maternal peripheral blood an...

  • Article
  • Open Access
11 Citations
7,525 Views
8 Pages

Transparent Conducting Film Fabricated by Metal Mesh Method with Ag and Cu@Ag Mixture Nanoparticle Pastes

  • Hyun Min Nam,
  • Duck Min Seo,
  • Hyung Duk Yun,
  • Gurunathan Thangavel,
  • Lee Soon Park and
  • Su Yong Nam

16 May 2017

Transparent conducting electrode film is highly desirable for application in touch screen panels (TSPs), flexible and wearable displays, sensors, and actuators. A sputtered film of indium tin oxide (ITO) shows high transmittance (90%) at low sheet re...

  • Article
  • Open Access
10 Citations
2,979 Views
11 Pages

NBSTRN Tools to Advance Newborn Screening Research and Support Newborn Screening Stakeholders

  • Kee Chan,
  • Zhanzhi Hu,
  • Lynn W. Bush,
  • Heidi Cope,
  • Ingrid A. Holm,
  • Stephen F. Kingsmore,
  • Kevin Wilhelm,
  • Curt Scharfe and
  • Amy Brower

Rapid advances in the screening, diagnosis, and treatment of genetic disorders have increased the number of conditions that can be detected through universal newborn screening (NBS). However, the addition of conditions to the Recommended Uniform Scre...

  • Article
  • Open Access
2 Citations
2,929 Views
11 Pages

7 March 2019

In order to expand the range of pot materials for induction cookers, a kind of sandwich structural composite ceramic panel that consists of an Al2O3 ceramic substrate, magnetic heating interlayer, and ZrO2 ceramic substrate was developed by combining...

  • Article
  • Open Access
7 Citations
5,594 Views
19 Pages

14 October 2019

This study investigated the potential of using a nonuniform woven panel with nonuniform strips—thick sticks and thin battens—as an external solar shading screen that addressed daylighting, shading, and mechanical performance factors. The...

  • Article
  • Open Access
4 Citations
3,943 Views
15 Pages

Screening a Targeted Panel of Genes by Next-Generation Sequencing Improves Risk Stratification in Real World Patients with Acute Myeloid Leukemia

  • Sónia Matos,
  • Paulo Bernardo,
  • Susana Esteves,
  • Aida Botelho de Sousa,
  • Marcos Lemos,
  • Patrícia Ribeiro,
  • Madalena Silva,
  • Albertina Nunes,
  • Joana Lobato and
  • Maria de Jesus Frade
  • + 11 authors

30 June 2022

Although mutation profiling of defined genes is recommended for classification of acute myeloid leukemia (AML) patients, screening of targeted gene panels using next-generation sequencing (NGS) is not always routinely used as standard of care. The ob...

  • Review
  • Open Access
20 Citations
5,916 Views
25 Pages

Developments in Genetics: Better Management of Ovarian Cancer Patients

  • Ovidiu-Virgil Maioru,
  • Viorica-Elena Radoi,
  • Madalin-Codrut Coman,
  • Iulian-Andrei Hotinceanu,
  • Andra Dan,
  • Anca-Elena Eftenoiu,
  • Livia-Mălina Burtavel,
  • Laurentiu-Camil Bohiltea and
  • Emilia-Maria Severin

5 November 2023

The purpose of this article is to highlight the new advancements in molecular and diagnostic genetic testing and to properly classify all ovarian cancers. In this article, we address statistics, histopathological classification, molecular pathways im...

  • Article
  • Open Access
21 Citations
8,522 Views
13 Pages

Mutual Capacitive Sensing Touch Screen Controller for Ultrathin Display with Extended Signal Passband Using Negative Capacitance

  • Chang-Ju Lee,
  • Jong Kang Park,
  • Canxing Piao,
  • Han-Eol Seo,
  • Jaehyuk Choi and
  • Jung-Hoon Chun

26 October 2018

Flexible and thin displays for smart devices have a large coupling capacitance between the sensor electrode of the touch screen panel (TSP) and the display electrode. This increased coupling capacitance limits the signal passband to less than 100 kHz...

  • Article
  • Open Access
3 Citations
3,701 Views
17 Pages

8 June 2022

This paper proposes a low-computing-complexity touch signal detection method and analog front-end (AFE) circuits based on cross-correlation technology for large mutual capacitance touch screen panels (TSPs). To solve the traditional touch signal dete...

  • Article
  • Open Access
4 Citations
2,650 Views
15 Pages

28 November 2022

New methods and demonstrations of feasibility guide future implementation of genomic population health screening programs. This is the first report of genomic population screening in a primary care, non-research setting using existing large carrier a...

  • Article
  • Open Access
4 Citations
4,668 Views
13 Pages

31 July 2021

This paper presents a mutual capacitance touch readout IC architecture for 120 Hz high-refresh-rate AMOLED displays. In high-refresh-rate AMOLED panels, whole pixels in a horizontal line should be updated without any time-sharing with each other, lea...

  • Article
  • Open Access
1 Citations
1,152 Views
17 Pages

11 February 2025

In-cell touch and display integrated panels, along with their integrated readout systems, are widely adopted in mobile devices for their cost-effectiveness and compact design. This paper proposes an analog Gaussian-shaped filter and a current mode co...

  • Article
  • Open Access
5 Citations
3,064 Views
18 Pages

Graduate students often seek hands-on experiences in the international development field. Given that Multilateral Development Banks (MDBs) provide hundreds of billions of dollars in aid each year, we expected that reviewing the design, implementation...

  • Article
  • Open Access
6 Citations
2,042 Views
20 Pages

Identification of a Novel Biomarker Panel for Breast Cancer Screening

  • Maria Vaida,
  • Kamala K. Arumalla,
  • Pavan Kumar Tatikonda,
  • Bharadwaj Popuri,
  • Rashid A. Bux,
  • Paramjit S. Tappia,
  • Guoyu Huang,
  • Jean-François Haince and
  • W. Randolph Ford

4 November 2024

Breast cancer remains a major public health concern, and early detection is crucial for improving survival rates. Metabolomics offers the potential to develop non-invasive screening and diagnostic tools based on metabolic biomarkers. However, the inh...

  • Article
  • Open Access
16 Citations
5,934 Views
19 Pages

Screening for Preterm Birth: Potential for a Metabolomics Biomarker Panel

  • Elizabeth C. Considine,
  • Ali S. Khashan and
  • Louise C. Kenny

The aim of this preliminary study was to investigate the potential of maternal serum to provide metabolomic biomarker candidates for the prediction of spontaneous preterm birth (SPTB) in asymptomatic pregnant women at 15 and/or 20 weeks’ gestat...

  • Article
  • Open Access
31 Citations
6,534 Views
18 Pages

Sorting Rare ALS Genetic Variants by Targeted Re-Sequencing Panel in Italian Patients: OPTN, VCP, and SQSTM1 Variants Account for 3% of Rare Genetic Forms

  • Viviana Pensato,
  • Stefania Magri,
  • Eleonora Dalla Bella,
  • Pierpaola Tannorella,
  • Enrica Bersano,
  • Gianni Sorarù,
  • Marta Gatti,
  • Nicola Ticozzi,
  • Franco Taroni and
  • Giuseppe Lauria
  • + 2 authors

3 February 2020

Amyotrophic lateral sclerosis (ALS) is an adult-onset progressive neurodegenerative disease due to motor neuron loss variably associated with frontotemporal dementia (FTD). Next generation sequencing technology revealed an increasing number of rare a...

  • Article
  • Open Access
2 Citations
9,535 Views
17 Pages

Fully Differential Touch Screen Controller with Wide Input Dynamic Range for Thin Displays

  • Chang-Ju Lee,
  • Jong Kang Park,
  • Han-Eol Seo,
  • Junho Huh and
  • Jung-Hoon Chun

4 February 2020

As today’s smartphone displays become thinner, the coupling capacitance between the display electrodes and touch screen panel (TSP) electrodes is increasing significantly. The increased capacitance easily introduces time-varying display signals...

  • Article
  • Open Access
15 Citations
7,306 Views
21 Pages

11 March 2022

Globally, 70 million people are annually affected by TBI. A significant proportion of all TBI cases are actually mild TBI (concussion, 70–85%), which is considerably more difficult to diagnose due to the absence of apparent symptoms. Current cl...

  • Article
  • Open Access
1 Citations
2,038 Views
21 Pages

Impact of Methylated Cyclodextrin KLEPTOSE® CRYSMEB on Inflammatory Responses in Human In Vitro Models

  • Damien Truffin,
  • Flora Marchand,
  • Mathias Chatelais,
  • Gérald Chêne,
  • Laure Saias,
  • Frauke Herbst,
  • Justin Lipner and
  • Alastair J. King

9 September 2024

KLEPTOSE® CRYSMEB methylated cyclodextrin derivative displays less methylated group substitution than randomly methylated cyclodextrin. It has demonstrated an impact on atherosclerosis and neurological diseases, linked in part to cholesterol comp...

  • Article
  • Open Access
4 Citations
1,452 Views
18 Pages

A Novel Kinematics Model of Flip-Flow Screen Panel: Inclined Catenary Model

  • Jingfeng Fan,
  • Zhanshu He,
  • Yifei Zhang and
  • Mingli Wang

25 April 2023

A flip-flow screen can effectively screen viscous particles, and its kinematic characteristics determine its screening performance. Since previous kinematic models have errors, a novel kinematics model of the flip-flow screen panel, namely the inclin...

  • Article
  • Open Access
11 Citations
7 Pages

Tapping panel dryness (TPD) syndrome is one of the latex yield affecting factors in the rubber tree (Hevea brasiliensis Mull. Arg.). Therefore, identification of a DNA marker will be highly useful for screening progenies in breeding programs. The maj...

  • Article
  • Open Access
42 Citations
3,394 Views
21 Pages

Screening a Panel of Topical Ophthalmic Medications against MMP-2 and MMP-9 to Investigate Their Potential in Keratoconus Management

  • Amany Belal,
  • Mohamed A. Elanany,
  • Eman Y. Santali,
  • Ahmed A. Al-Karmalawy,
  • Moustafa O. Aboelez,
  • Ali H. Amin,
  • Magda H. Abdellattif,
  • Ahmed B. M. Mehany and
  • Hazem Elkady

Keratoconus (KC) is a serious disease that can affect people of any race or nationality, although the exact etiology and pathogenic mechanism are still unknown. In this study, thirty-two FDA-approved ophthalmic drugs were exposed to virtual screening...

  • Article
  • Open Access
3 Citations
4,514 Views
8 Pages

Genetic Screening of a Large Panel of Genes Associated with Cardiac Disease in a Spanish Heart Transplanted Cohort

  • Elías Cuesta-Llavona,
  • Rebeca Lorca,
  • Beatriz Díaz-Molina,
  • José L. Lambert-Rodríguez,
  • Julián R. Reguero,
  • Sara Iglesias,
  • Belén Alonso,
  • Alejandro Junco-Vicente,
  • Vanesa Alonso and
  • Eliecer Coto
  • + 1 author

In this study we performed a next generation sequencing of 210 genes in 140 patients with cardiac failure requiring a heart transplantation. We identified a total of 48 candidate variants in 47 patients. Forty-three patients (90%) presented a single...

  • Article
  • Open Access
11 Citations
5,786 Views
14 Pages

A Machine Learning Approach to Screen for Otitis Media Using Digital Otoscope Images Labelled by an Expert Panel

  • Josefin Sandström,
  • Hermanus Myburgh,
  • Claude Laurent,
  • De Wet Swanepoel and
  • Thorbjörn Lundberg

Background: Otitis media includes several common inflammatory conditions of the middle ear that can have severe complications if left untreated. Correctly identifying otitis media can be difficult and a screening system supported by machine learning...

  • Article
  • Open Access
3,179 Views
10 Pages

Panel Sequencing for Clinically Oriented Variant Screening and Copy Number Detection in Chronic Lymphocytic Leukemia Patients

  • Mariam Ibáñez,
  • Esperanza Such,
  • Alessandro Liquori,
  • Gayane Avestisyan,
  • Rafael Andreu,
  • Ana Vicente,
  • María José Macián,
  • Mari Carmen Melendez,
  • Mireya Morote-Faubel and
  • Pedro Asensi
  • + 15 authors

According to current guidelines, in chronic lymphocytic leukemia (CLL), only the TP53 molecular status must be evaluated prior to every treatment’s initiation. However, additional heterogeneous genetic events are known to confer a proliferative...

  • Article
  • Open Access
7 Citations
2,819 Views
20 Pages

Screening of Comprehensive Panel of Cultivated and Wild Vigna Species for Resistance to Pulse Beetle, Callosobruchus chinensis L.

  • Prince Sahu,
  • Mahendra Singh,
  • Rakesh Pandey,
  • Mukesh Kumar Mishra,
  • Akhilesh Kumar Singh,
  • Bhupendra Kumar Singh,
  • Surendra Kumar Singh,
  • Ashutosh Rai,
  • Vishal Chugh and
  • Gaurav Shukla
  • + 4 authors

27 May 2023

Pulses are a key source of dietary proteins in human nutrition. Despite several efforts to increase the production, various constraints, such as biotic and abiotic factors, threaten pulse production by various means. Bruchids (Callosobruchus spp.) ar...

  • Article
  • Open Access
1,173 Views
32 Pages

2 July 2025

PAN-gastrointestinal cancers (PAN-GI cancers), including the oral, esophageal, gastric, hepatocellular, pancreatic=, and colorectal cancers, are the leading cause of cancer-related mortality. Despite recent advances in identifying the molecular mecha...

  • Communication
  • Open Access
2 Citations
2,596 Views
13 Pages

Immunohistochemistry Screening of Different Tyrosine Kinase Receptors in Canine Solid Tumors—Part I: Proposal of a Receptor Panel to Predict Therapies

  • Denner Santos Dos Anjos,
  • Patrick Antônio Sonaglio Civa,
  • Juliana Werner,
  • Igor Simões Tiagua Vicente and
  • Carlos Eduardo Fonseca-Alves

The use of tyrosine kinase inhibitors (TKI) has been growing in veterinary oncology and in the past few years several TKI have been tested in dogs. However, different from human medicine, we lack strategies to select patients to be treated with each...

  • Article
  • Open Access
6 Citations
2,643 Views
11 Pages

22 May 2023

Broomrape (Orobanche crenata Forsk.) is a serious problem causing important losses to lentil (Lens culinaris Medik.) production and productivity in Mediterranean countries. Despite intensive breeding activities, no resistance sources against O. crena...

  • Guidelines
  • Open Access
1 Citations
2,694 Views
10 Pages

ISNS General Guidelines for Neonatal Bloodspot Screening 2025

  • Dianne Webster,
  • Amy Gaviglio,
  • Aysha Habib Khan,
  • Mei Baker,
  • David Cheillan,
  • Layachi Chabraoui,
  • Ghassan Abdoh,
  • Juan Cabello,
  • Roberto Giugliani and
  • Dimitris Platis
  • + 4 authors

Part of the vision of the ISNS is ‘to enhance the quality of neonatal screening and medical services through dissemination of information, guidelines and best practices.’ Although newborn screening encompasses testing in the newborn perio...

  • Review
  • Open Access
8 Citations
5,188 Views
10 Pages

Understanding False Negative in Prenatal Testing

  • Mark I. Evans,
  • Ming Chen and
  • David W. Britt

A false negative can happen in many kinds of medical tests, regardless of whether they are screening or diagnostic in nature. However, it inevitably poses serious concerns especially in a prenatal setting because its sequelae can mark the birth of an...

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