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310 Results Found

  • Article
  • Open Access
6 Citations
2,379 Views
15 Pages

20 November 2022

Hyperspectral observations are used to retrieve high-resolution horizontal distribution and vertical profiles of trace gases (O3, NO2, HCHO, and SO2), thereby playing a vital role in monitoring the spatio-temporal distribution and transportation of a...

  • Article
  • Open Access
6 Citations
2,408 Views
11 Pages

Limb Laterality Discrimination, Evoked Sensations and Somatosensory Behavior in Fibromyalgia Syndrome: A Cross-Sectional Study

  • Víctor Riquelme-Aguado,
  • Antonio Gil-Crujera,
  • Josué Fernández-Carnero,
  • Ferran Cuenca-Martínez and
  • Francisco Gómez Esquer

26 July 2022

The main objective of this study was to assess the status of body schema using limb laterality discrimination tasks and pain measurement variables of patients with FMS compared to healthy subjects. The secondary aim was to analyze the relationships b...

  • Article
  • Open Access
3 Citations
2,779 Views
15 Pages

Trajectory Modulation for Impact Reducing of Lower-Limb Exoskeletons

  • Long Zhang,
  • Guangkui Song,
  • Chaobin Zou,
  • Rui Huang,
  • Hong Cheng and
  • Dekun Hu

Lower-limb exoskeletons have received considerable attention because of their effectiveness in walking assistance and rehabilitation for paraplegic patients. Excessive foot–ground impacts during walking make patients uncomfortable and even lead...

  • Article
  • Open Access
1,654 Views
11 Pages

Load Modulation Affects Pediatric Lower Limb Joint Moments During a Step-Up Task

  • Vatsala Goyal,
  • Keith E. Gordon and
  • Theresa Sukal-Moulton

6 November 2024

Introduction: Performance in a single step has been suggested to be a sensitive measure of movement quality in pediatric clinical populations. Although there is less information available in children with typical development, researchers have postula...

  • Article
  • Open Access
3 Citations
3,178 Views
19 Pages

Modulation of Titin and Contraction-Regulating Proteins in a Rat Model of Heart Failure with Preserved Ejection Fraction: Limb vs. Diaphragmatic Muscle

  • Beatrice Vahle,
  • Leonard Heilmann,
  • Antje Schauer,
  • Antje Augstein,
  • Maria-Elisa Prieto Jarabo,
  • Peggy Barthel,
  • Norman Mangner,
  • Siegfried Labeit,
  • T. Scott Bowen and
  • Volker Adams
  • + 1 author

Heart failure with preserved ejection fraction (HFpEF) is characterized by biomechanically dysfunctional cardiomyocytes. Underlying cellular changes include perturbed myocardial titin expression and titin hypophosphorylation leading to titin filament...

  • Article
  • Open Access
10 Citations
5,210 Views
15 Pages

21 November 2019

Action observation (AO) and motor imagery (MI) are useful techniques in neurorehabilitation. Previous studies have reported that AO and MI facilitate corticospinal excitability only in those muscles that are active when actually performing the observ...

  • Article
  • Open Access
3 Citations
1,341 Views
11 Pages

How Does Conditioned Pain Modulation Influence Motor Imagery Processes in Women with Fibromyalgia Syndrome? A Cross-Sectional Study Secondary Analysis

  • Víctor Riquelme-Aguado,
  • Silvia Di-Bonaventura,
  • María Elena González-Álvarez,
  • Alazne Zabarte-Del Campo,
  • Josué Fernández-Carnero,
  • Antonio Gil-Crujera,
  • Francisco Gómez-Esquer and
  • Jorge Hugo Villafañe

2 December 2024

Background/Objectives: Fibromyalgia syndrome (FMS) is a multifactorial pain syndrome not only characterized by widespread pain as the primary symptom but also accompanied by physical, psychological, and cognitive manifestations. Impairments in condit...

  • Article
  • Open Access
6 Citations
5,025 Views
13 Pages

Timing and Modulation of Activity in the Lower Limb Muscles During Indoor Rowing: What Are the Key Muscles to Target in FES-Rowing Protocols?

  • Taian M. Vieira,
  • Giacinto Luigi Cerone,
  • Costanza Stocchi,
  • Morgana Lalli,
  • Brian Andrews and
  • Marco Gazzoni

17 March 2020

The transcutaneous stimulation of lower limb muscles during indoor rowing (FES Rowing) has led to a new sport and recreation and significantly increased health benefits in paraplegia. Stimulation is often delivered to quadriceps and hamstrings; this...

  • Article
  • Open Access
18 Citations
3,202 Views
15 Pages

Limb Remote Ischemic Conditioning Promotes Neurogenesis after Cerebral Ischemia by Modulating miR-449b/Notch1 Pathway in Mice

  • Sijie Li,
  • Yong Yang,
  • Ning Li,
  • Haiyan Li,
  • Jiali Xu,
  • Wenbo Zhao,
  • Xiaojie Wang,
  • Linqing Ma,
  • Chen Gao and
  • Changhong Ren
  • + 2 authors

18 August 2022

Neurogenesis plays an important role in the prognosis of stroke patients and is known to be promoted by the activation of the Notch1 signaling pathway. Studies on the airway epithelium have shown that miR-449b represses the Notch pathway. The study a...

  • Review
  • Open Access
33 Citations
6,408 Views
31 Pages

Modulation of Mesenchymal Stem Cells for Enhanced Therapeutic Utility in Ischemic Vascular Diseases

  • Sally L. Elshaer,
  • Salma H. Bahram,
  • Pranav Rajashekar,
  • Rajashekhar Gangaraju and
  • Azza B. El-Remessy

27 December 2021

Mesenchymal stem cells are multipotent stem cells isolated from various tissue sources, including but not limited to bone marrow, adipose, umbilical cord, and Wharton Jelly. Although cell-mediated mechanisms have been reported, the therapeutic effect...

  • Article
  • Open Access
2 Citations
2,354 Views
26 Pages

28 November 2024

Decoding lower-limb motor imagery (MI) is highly important in brain–computer interfaces (BCIs) and rehabilitation engineering. However, it is challenging to classify lower-limb MI from electroencephalogram (EEG) signals, because lower-limb moti...

  • Article
  • Open Access
10 Citations
5,587 Views
15 Pages

Design and Analysis of a Lower Limb Rehabilitation Training Component for Bedridden Stroke Patients

  • Xusheng Wang,
  • Yongfei Feng,
  • Jiazhong Zhang,
  • Yungui Li,
  • Jianye Niu,
  • Yandong Yang and
  • Hongbo Wang

30 September 2021

Carrying out the immediate rehabilitation interventional therapy will better improve the curative effect of rehabilitation therapy, after the condition of bedridden stroke patients becomes stable. A new lower limb rehabilitation training module, as a...

  • Article
  • Open Access
4 Citations
1,775 Views
20 Pages

An Assist-as-Needed Control Strategy Based on a Subjective Intention Decline Model

  • Hao Yan,
  • Fangcao Zhang,
  • Xingao Li,
  • Chenchen Zhang,
  • Yunjia Zhang and
  • Yongfei Feng

In the rehabilitation training process for stroke patients, the level of excitement in the patient’s physiological state has a positive impact on the efficacy of the training. In order to improve patients’ initiative during training and p...

  • Article
  • Open Access
1,321 Views
14 Pages

Acute Effects of Complex Hand Proprioceptive Task on Low-Frequency Hand Rest Tremor

  • Francesca Di Rocco,
  • Emanuel Festino,
  • Olga Papale,
  • Marianna De Maio,
  • Cristina Cortis and
  • Andrea Fusco

21 October 2025

Resting hand tremor is a low-frequency, involuntary oscillation influenced by mechanical and neural factors, often manifesting as inter-limb asymmetry. Therefore, the aim of this study was to investigate whether a single complex hand proprioceptive t...

  • Article
  • Open Access
12 Citations
2,826 Views
19 Pages

25 March 2024

The implementation of a progressive rehabilitation training model to promote patients’ motivation efforts can greatly restore damaged central nervous system function in patients. Patients’ active engagement can be effectively stimulated b...

  • Article
  • Open Access
9 Citations
4,134 Views
18 Pages

Modular Robotic Limbs for Astronaut Activities Assistance

  • Sikai Zhao,
  • Jie Zhao,
  • Dongbao Sui,
  • Tianshuo Wang,
  • Tianjiao Zheng,
  • Chuanwu Zhao and
  • Yanhe Zhu

21 September 2021

In order to meet the assist requirements of extravehicular activity (EVA) for astronauts, such as moving outside the international space station (ISS) or performing on-orbit tasks by a single astronaut, this paper proposes an astronaut robotic limbs...

  • Article
  • Open Access
5 Citations
3,507 Views
14 Pages

Parasympathetic Effect Induces Cell Cycle Activation in Upper Limbs of Paraplegic Patients with Spinal Cord Injury

  • Ahreum Baek,
  • Ji Cheol Shin,
  • Min-Young Lee,
  • Sung Hoon Kim,
  • Jiyong Kim and
  • Sung-Rae Cho

27 November 2019

The present study aimed to investigate gene expression changes related to cell cycle activation in patients with spinal cord injury (SCI) and to further evaluate the difference between the upper and lower limbs of SCI patients. Fibroblasts were obtai...

  • Article
  • Open Access
8 Citations
2,090 Views
19 Pages

24 January 2025

The estimation of multijoint angles is of great significance in the fields of lower limb rehabilitation, motion control, and exoskeleton robotics. Accurate joint angle estimation helps assess joint function, assist in rehabilitation training, and opt...

  • Article
  • Open Access
7 Citations
2,692 Views
22 Pages

25 May 2024

As important auxiliary equipment, rehabilitation robots are widely used in rehabilitation treatment and daily life assistance. The rehabilitation robot proposed in this paper is mainly composed of an omnidirectional mobile platform module, a lower li...

  • Article
  • Open Access
47 Citations
10,155 Views
17 Pages

Wearable Physiological Monitoring System Based on Electrocardiography and Electromyography for Upper Limb Rehabilitation Training

  • Shumi Zhao,
  • Jianxun Liu,
  • Zidan Gong,
  • Yisong Lei,
  • Xia OuYang,
  • Chi Chiu Chan and
  • Shuangchen Ruan

28 August 2020

Secondary injuries are common during upper limb rehabilitation training because of uncontrollable physical force and overexciting activities, and long-time training may cause fatigue and reduce the training effect. This study proposes a wearable moni...

  • Article
  • Open Access
9 Citations
2,973 Views
14 Pages

Spinal muscular atrophy (SMA) is an autosomal recessive disorder caused by the deletion or/and mutation in the survival motor neuron 1 (SMN1) gene on chromosome 5. Until now, only a few articles investigating the relationship between upper limb funct...

  • Article
  • Open Access
906 Views
13 Pages

Differential Effects of Low-Frequency TMS of the Motor Cortex on Voluntary and Non-Voluntary Rhythmic Arm Movements

  • Irina A. Solopova,
  • Victor A. Selionov,
  • Irina Y. Dolinskaya,
  • Germana Cappellini and
  • Yury Ivanenko

6 June 2025

Given the cervical spinal cord’s role in locomotor and rhythmic upper limb tasks, its neuromodulation has emerged as an important area of study for understanding human spinal rhythmogenesis. We previously demonstrated that, under unloading cond...

  • Article
  • Open Access
8 Citations
4,288 Views
19 Pages

A Novel Mine Cage Safety Monitoring Algorithm Utilizing Visible Light

  • Xu Yang,
  • Mingzhi Pang,
  • Peihao Li,
  • Pengpeng Chen and
  • Qiang Niu

14 July 2020

The mine cage has an important role in the production of coal mines. It has many safety problems in the transportation of people, such as overloading of personnel and illegal outreach of human limbs. However, the harsh mine environment makes it very...

  • Article
  • Open Access
217 Views
22 Pages

Most pediatric exoskeletons for cerebral palsy (CP) focus on lower-limb assistance and neglect trunk control, limiting rehabilitation outcomes. This study presents a self-aligning trunk–limb exoskeleton that integrates trunk stabilization with...

  • Article
  • Open Access
4 Citations
5,022 Views
10 Pages

30 September 2019

Equine athletes can incur musculoskeletal injuries due to repetitive loading during training and competition. Prior to signs of lameness, horse trainers and veterinarians may observe swelling in the distal limbs, where injuries most frequently occur....

  • Article
  • Open Access
2 Citations
2,398 Views
20 Pages

The Middleware for an Exoskeleton Assisting Upper Limb Movement

  • Przemyslaw Strzelczyk,
  • Krzysztof Tomczewski and
  • Krzysztof Wrobel

13 April 2022

This article presents the possibilities of newly developed middleware dedicated for distributed and modular control systems. The software enables the exchange of information locally, within one control module, and globally, between many modules. The...

  • Article
  • Open Access
520 Views
20 Pages

4 December 2025

Uphill wheelchair propulsion requires considerable upper-limb effort and often leads to rapid fatigue, limiting user mobility and independence. Therefore, mechanical solutions that enhance propulsion safety and efficiency are essential. This study ai...

  • Article
  • Open Access
3,337 Views
13 Pages

Eccentric Exercise-Induced Muscle Damage Is Independent of Limb Dominance in Young Women

  • Natalia Prokopiou,
  • Dimitris Mandalidis,
  • Gerasimos Terzis and
  • Vassilis Paschalis

26 September 2025

Unaccustomed eccentric exercise is well established to induce exercise-induced muscle damage (EIMD), characterized by transient strength loss, delayed onset muscle soreness (DOMS), reduced range of motion, and proprioceptive disturbances. While limb...

  • Article
  • Open Access
13 Citations
4,168 Views
18 Pages

31 December 2021

Both Type 1 diabetes mellitus (DM1) and type 2 diabetes mellitus (DM2) are associated with an increased risk of limb amputation in peripheral arterial disease (PAD). How diabetes contributes to poor PAD outcomes is poorly understood but may occur thr...

  • Article
  • Open Access
2 Citations
3,668 Views
11 Pages

Expression and Functional Characterization of c-Fos Gene in Chinese Fire-Bellied Newt Cynops orientalis

  • Gang Ye,
  • Yalong Feng,
  • Zhaoxiang Mi,
  • Du Wang,
  • Shuai Lin,
  • Fulin Chen,
  • Jihong Cui and
  • Yuan Yu

30 January 2021

c-Fos is an immediate-early gene that modulates cellular responses to a wide variety of stimuli and also plays an important role in tissue regeneration. However, the sequence and functions of c-Fos are still poorly understood in newts. This study des...

  • Article
  • Open Access
5 Citations
2,866 Views
17 Pages

Bionic Design of a Novel Portable Hand-Elbow Coordinate Exoskeleton for Activities of Daily Living

  • Qingyun Meng,
  • Guanxin Liu,
  • Qiaoling Meng,
  • Xin Xu,
  • Liang Qin and
  • Hongliu Yu

This paper presents the mechanical design and test of a portable hand-elbow combination linkage upper limb rehabilitation robot, which can realize the joint movement of the hand joint and elbow joint and reproduce the complete grasping action. The jo...

  • Article
  • Open Access
6 Citations
3,483 Views
15 Pages

Efficacy of REAC Neurobiological Optimization Treatments in Post-Polio Syndrome: A Manual Muscle Testing Evaluation

  • Monalisa Pereira Motta,
  • Acary Souza Bulle Oliveira,
  • Jeyce Adrielly André Nogueira,
  • Alcione Aparecida Vieira de Souza Moscardi,
  • Vanessa Manchim Favaro,
  • Amanda Orasmo Simcsik,
  • Chiara Rinaldi,
  • Vania Fontani and
  • Salvatore Rinaldi

24 September 2024

Background: This study evaluated the effectiveness of radio electric asymmetric conveyer (REAC) neurobiological optimization treatments on muscle strength (MS) in individuals with post-polio syndrome (PPS), a condition causing new muscle weakness in...

  • Article
  • Open Access
10 Citations
3,475 Views
10 Pages

Slow Walking in Individuals with Chronic Post-Stroke Hemiparesis: Speed Mediated Effects of Gait Kinetics and Ankle Kinematics

  • Jing Nong Liang,
  • Kai-Yu Ho,
  • Yun-Ju Lee,
  • Corey Ackley,
  • Kiley Aki,
  • Joshua Arias and
  • Jassie Trinh

Post-stroke rehabilitation often aims to increase walking speeds, as faster walking is associated with improved functional status and quality of life. However, for successful community ambulation, ability to modulate (increase and decrease) walking s...

  • Article
  • Open Access
2,836 Views
28 Pages

1 February 2024

This paper presents the structure and model of a hybrid modular structure of a robotic system for lower limb rehabilitation. It is made of two modules identical in structure, including an active 3-PRRR manipulator for moving the patient’s foot...

  • Article
  • Open Access
330 Views
18 Pages

Normative Data of Neuromuscular Function in Upper Limb and Its Correlation with Superficial Fascia and Body Mass Composition

  • Oriol Casasayas-Cos,
  • Noé Labata-Lezaun,
  • Luis Llurda-Almuzara,
  • Sara Ortiz-Miguel,
  • Johke Smit,
  • Carlos López-de-Celis and
  • Albert Pérez-Bellmunt

3 February 2026

Background/Objectives: Neuromuscular functions (NMFs) encompass biomechanical and viscoelastic properties that are essential for coordinated movement and muscular control. While NMFs have been extensively investigated in the lower limb, normative dat...

  • Article
  • Open Access
12 Citations
3,729 Views
24 Pages

10 August 2022

An innovative wearable upper-limb power-assist exoskeleton system (UPES) was designed for laborers to improve work efficiency and reduce the risk of musculoskeletal disorders. This novel wearable UPES consists of four joints, each comprising a single...

  • Article
  • Open Access
5 Citations
4,911 Views
14 Pages

Treatment of the Paretic Hand with a Robotic Glove Combined with Physiotherapy in a Patient Suffering from Traumatic Tetraparesis: A Case Report

  • Federica Bressi,
  • Laura Cricenti,
  • Marco Bravi,
  • Fabiana Pannunzio,
  • Francesca Cordella,
  • Martina Lapresa,
  • Sandra Miccinilli,
  • Fabio Santacaterina,
  • Loredana Zollo and
  • Benedetta Campagnola
  • + 1 author

27 March 2023

Background: cervical spinal cord injury leads to loss of upper limb functionality, which causes a decrease in autonomy to perform activities of daily living. The use of robotic technologies in rehabilitation could contribute to improving upper limb f...

  • Article
  • Open Access
246 Views
14 Pages

The Relationship Between Emotion Processing and Flexor Afferent Responses in Upper Limbs

  • Gianluca Isoardo,
  • Rita B. Ardito,
  • Stefano Ciullo,
  • Elena Fontana,
  • Ilaria Stura,
  • Giuseppe Migliaretti,
  • Paolo Titolo,
  • Enrico Matteoni,
  • Andrea Calvo and
  • Mauro Adenzato
  • + 2 authors

14 January 2026

Background: This study investigates the influence of emotional processing on flexor reflex responses in the upper limbs, focusing on cutaneomuscular reflexes (CMRs) and the cutaneous silent period (CSP) in patients with chronic neuropathic pain. The...

  • Article
  • Open Access
4 Citations
3,652 Views
15 Pages

Trunk positioning and unexpected perturbations are high-risk conditions at the time of anterior cruciate ligament injury. The influence of trunk positioning on motor control responses to perturbation during dynamic performance is not known. We tested...

  • Article
  • Open Access
35 Citations
5,055 Views
16 Pages

Manipulating the Perceived Shape and Color of a Virtual Limb Can Modulate Pain Responses

  • Marta Matamala-Gomez,
  • Birgit Nierula,
  • Tony Donegan,
  • Mel Slater and
  • Maria V. Sanchez-Vives

21 January 2020

Changes in body representation may affect pain perception. The effect of a distorted body image, such as the telescoping effect in amputee patients, on pain perception, is unclear. This study aimed to investigate whether distorting an embodied virtua...

  • Article
  • Open Access
13 Citations
4,095 Views
35 Pages

31 December 2022

This paper proposed a novel design using a torsion spring mechanism with a single fluidic muscle actuator (FMA) to drive a joint with one degree-of-freedom (DOF) through a steel wire and a proportional pressure regulating valve (PRV). We developed a...

  • Review
  • Open Access
17 Citations
8,641 Views
14 Pages

Stroke remains a global leading cause of disability. Novel treatment approaches are required to alleviate impairment and promote greater functional recovery. One potential candidate is transcranial direct current stimulation (tDCS), which is thought...

  • Article
  • Open Access
4 Citations
3,030 Views
13 Pages

Propulsive Force Modulation Drives Split-Belt Treadmill Adaptation in People with Multiple Sclerosis

  • Andrew C. Hagen,
  • Christopher M. Patrick,
  • Isaac E. Bast and
  • Brett W. Fling

6 February 2024

Most people with multiple sclerosis (PwMS) experience significant gait asymmetries between their legs during walking, leading to an increased risk of falls. Split-belt treadmill training, where the speed of each limb is controlled independently, alte...

  • Article
  • Open Access
199 Views
11 Pages

Examining the Cross-Education Phenomenon in Lower Limbs: Insights from the Force–Velocity Profile

  • Jessica Rial-Vázquez,
  • Juan Fariñas,
  • María Rúa-Alonso,
  • Iván Nine,
  • Manuel Avelino Giráldez-García and
  • Eliseo Iglesias-Soler

3 February 2026

This study explored whether the cross-education (CE) phenomenon could be examined through the force–velocity (FV) profile obtained from unilateral leg extension. Nineteen participants completed 5 weeks of unilateral knee extension interventions...

  • Article
  • Open Access
17 Citations
2,688 Views
16 Pages

Gait recognition has received widespread attention due to its non-intrusive recognition mechanism. Currently, most gait recognition methods use appearance-based recognition methods, and such methods are easily affected by occlusions when facing compl...

  • Article
  • Open Access
1 Citations
1,542 Views
10 Pages

Altitudinal Variation of Limb Size of a High-Altitude Frog

  • Xueyan Liu,
  • Hongzhou Chen,
  • Yanfang Wu,
  • Huan Xiong,
  • Song Liu,
  • Huafan Ling and
  • Wei Chen

22 January 2025

Geographical variation in morphological traits represents a significant ecological phenomenon. According to Allen’s rule, animals inhabiting cooler environments typically exhibit shorter extremities compared to those in warmer regions. While Al...

  • Article
  • Open Access
3 Citations
2,745 Views
17 Pages

31 December 2022

Considering the importance of programmed cell death in the formation of the skeleton during embryonic development, the aim of the present study was to analyze whether regulated cell degeneration also accompanies the differentiation of embryonic limb...

  • Article
  • Open Access
6 Citations
5,518 Views
22 Pages

This comprehensive study presents a pioneering approach to limb lengthening, leveraging the advancements in wireless technology to enhance orthopedic healthcare. Historically, limb lengthening has been a response to discrepancies caused by fractures,...

  • Article
  • Open Access
2 Citations
2,431 Views
16 Pages

26 July 2024

Skeleton-based action recognition, renowned for its computational efficiency and indifference to lighting variations, has become a focal point in the realm of motion analysis. However, most current methods typically only extract global skeleton featu...

  • Article
  • Open Access
22 Citations
4,343 Views
17 Pages

8 November 2022

The muscle synergy approach is used to evaluate motor control and to quantitatively determine the number and structure of the modules underlying movement. In experimental studies regarding the upper limb, typically 8 to 16 EMG probes are used dependi...

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