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  • Feature Paper
  • Review
  • Open Access
64 Citations
11,067 Views
14 Pages

Bacteriophages in the Dairy Environment: From Enemies to Allies

  • Lucía Fernández,
  • Susana Escobedo,
  • Diana Gutiérrez,
  • Silvia Portilla,
  • Beatriz Martínez,
  • Pilar García and
  • Ana Rodríguez

The history of dairy farming goes back thousands of years, evolving from a traditional small-scale production to the industrialized manufacturing of fermented dairy products. Commercialization of milk and its derived products has been very important...

  • Review
  • Open Access
17 Citations
6,284 Views
22 Pages

29 March 2022

In the last few decades, a dramatic increase in the global prevalence of allergic diseases and asthma was observed. It was hypothesized that diet may be an important immunomodulatory factor influencing susceptibility to allergic diseases. Fermented f...

  • Article
  • Open Access
11 Citations
5,777 Views
18 Pages

Developing a High-Umami, Low-Salt Soy Sauce through Accelerated Moromi Fermentation with Corynebacterium and Lactiplantibacillus Strains

  • Li-Hao Wang,
  • Wen-Hui Qu,
  • Ya-Nan Xu,
  • Song-Gang Xia,
  • Qian-Qian Xue,
  • Xiao-Ming Jiang,
  • Hong-Ying Liu,
  • Chang-Hu Xue and
  • Yun-Qi Wen

30 April 2024

The traditional fermentation process of soy sauce employs a hyperhaline model and has a long fermentation period. A hyperhaline model can improve fermentation speed, but easily leads to the contamination of miscellaneous bacteria and fermentation fai...

  • Article
  • Open Access
18 Citations
3,723 Views
13 Pages

Conversion of Food Waste into 2,3-Butanediol via Thermophilic Fermentation: Effects of Carbohydrate Content and Nutrient Supplementation

  • Dajun Yu,
  • Joshua O’Hair,
  • Nicholas Poe,
  • Qing Jin,
  • Sophia Pinton,
  • Yanhong He and
  • Haibo Huang

10 January 2022

Fermentation of food waste into 2,3-butanediol (2,3-BDO), a high-value chemical, is environmentally sustainable and an inexpensive method to recycle waste. Compared to traditional mesophilic fermentation, thermophilic fermentation can inhibit the gro...

  • Review
  • Open Access
9 Citations
4,883 Views
19 Pages

Fermented Vegetables and Legumes vs. Lifestyle Diseases: Microbiota and More

  • Eliza Knez,
  • Kornelia Kadac-Czapska and
  • Małgorzata Grembecka

19 April 2023

Silages may be preventive against lifestyle diseases, including obesity, diabetes mellitus, or metabolic syndrome. Fermented vegetables and legumes are characterized by pleiotropic health effects, such as probiotic or antioxidant potential. That is m...

  • Article
  • Open Access
3 Citations
1,017 Views
16 Pages

Predictive Fermentation Control of Lactiplantibacillus plantarum Using Deep Learning Convolutional Neural Networks

  • Chien-Chang Wu,
  • Jung-Sheng Chen,
  • Yu-Ching Lu,
  • Jain-Shing Wu,
  • Yu-Fen Huang and
  • Chien-Sen Liao

The fermentation of Lactiplantibacillus plantarum is a complex bioprocess due to the nonlinear and dynamic nature of microbial growth. Traditional monitoring methods often fail to provide early and actionable insights into fermentation outcomes. This...

  • Article
  • Open Access
6 Citations
3,017 Views
21 Pages

29 June 2023

This paper introduces a novel soft sensor modeling method based on BDA-IPSO-LSSVM designed to address the issue of model failure caused by varying fermentation data distributions resulting from different operating conditions during the fermentation o...

  • Article
  • Open Access
11 Citations
3,578 Views
9 Pages

16 May 2019

Lactococcus lactis is one of the most important bacteria in dairy fermentations, being used in the production of cheese and buttermilk. The processes are vulnerable to phage attacks, and undefined mixtures of lactococcal strains are often used to red...

  • Article
  • Open Access
4 Citations
4,137 Views
12 Pages

The Challenge of Bacteremia Treatment due to Non-Fermenting Gram-Negative Bacteria

  • Svetlana Sadyrbaeva-Dolgova,
  • María del Mar Sánchez-Suárez,
  • Juan Antonio Reguera Márquez and
  • Carmen Hidalgo-Tenorio

Nosocomial infections caused by non-fermenting Gram-negative bacteria are a real challenge for clinicians, especially concerning the accuracy of empirical treatment. This study aimed to describe the clinical characteristic, empirical antibiotic thera...

  • Review
  • Open Access
21 Citations
10,648 Views
21 Pages

12 December 2024

As natural parasites of bacteria, phages have greatly contributed to bacterial evolution owing to their persistent threat. Diverse phage resistance systems have been developed in bacteria during the coevolutionary process with phages. Conversely, pha...

  • Review
  • Open Access
8 Citations
3,718 Views
14 Pages

In wine technology, the on-line measurement of redox potential is a fast, accurate, and reliable measurement that provides insight into the metabolism of Saccharomyces cerevisiae, its microbial activity, and the oxidation and reduction state of wine,...

  • Article
  • Open Access
1 Citations
2,351 Views
13 Pages

22 December 2023

In the context of the mysterious Balkan endemic nephropathy of the 1900s, and the discovery in the 1960s of the potent mycotoxin ochratoxin A, experimental research projects sought to explore any inter-relationship. Experimental lifetime administrati...

  • Review
  • Open Access
21 Citations
6,220 Views
23 Pages

Flavour is a key driver of consumer preferences and acceptability of foods, and the food industry has made food aroma compounds a crucial area of research. At present, about 80% of food aroma compounds are produced by chemical synthesis; however, alt...

  • Article
  • Open Access
58 Citations
6,921 Views
16 Pages

The Synergic Effects of FDM 3D Printing Parameters on Mechanical Behaviors of Bronze Poly Lactic Acid Composites

  • Mahmoud Moradi,
  • Mojtaba Karami Moghadam,
  • Mahmoud Shamsborhan and
  • Mahdi Bodaghi

3 February 2020

In this paper, the influence of layer thickness (LT), infill percentage (IP), and extruder temperature (ET) on the maximum failure load, thickness, and build time of bronze polylactic acid (Br-PLA) composites 3D printed by the fused deposition modeli...

  • Communication
  • Open Access
2 Citations
2,263 Views
9 Pages

17 April 2023

Ochratoxin A is historically the most notable secondary metabolite of Aspergillus ochraceus on account of its toxicity to animals and fish. Currently, over 150 compounds of diverse structure and biosynthesis is a challenge to predict the array for an...

  • Review
  • Open Access
17 Citations
6,636 Views
17 Pages

Short-Chain Fatty Acids and Their Metabolic Interactions in Heart Failure

  • Laura Chulenbayeva,
  • Argul Issilbayeva,
  • Aliya Sailybayeva,
  • Makhabbat Bekbossynova,
  • Samat Kozhakhmetov and
  • Almagul Kushugulova

Short-chain fatty acids (SCFAs), produced through fermentation of dietary fibers by gut bacteria, play a central role in modulating cardiovascular function and heart failure (HF) development. The progression of HF is influenced by intestinal barrier...

  • Review
  • Open Access
447 Views
32 Pages

Nutritional Disorders and Metabolic Adaptations in Dromedary Camels: Insights into Foregut Fermentation and Mineral Balance

  • Muhammad Mahboob Ali Hamid,
  • Mohamed Tharwat,
  • Tarek A. Ebeid and
  • Fahad A. Alshanbari

23 February 2026

Dromedary camels possess unique anatomical, physiological, and metabolic adaptations that enable survival in arid environments; however, these same adaptations make them highly sensitive to nutritional imbalance under modern feeding conditions. This...

  • Article
  • Open Access
38 Citations
3,978 Views
13 Pages

13 August 2020

Due to the rapid increase of antimicrobial resistance with ensuring therapeutic failures, the purpose of this study was to identify novel synthetic molecules as alternatives to conventional available, but presently ineffective antibiotics. Variously...

  • Article
  • Open Access
15 Citations
4,068 Views
13 Pages

The Modulation Effect of a Fermented Bee Pollen Postbiotic on Cardiovascular Microbiota and Therapeutic Perspectives

  • Laura-Dorina Dinu,
  • Florentina Gatea,
  • Florentina Roaming Israel,
  • Milena Lakicevic,
  • Nebojša Dedović and
  • Emanuel Vamanu

Hypertension is a frequent comorbidity in patients with heart failure; therefore, blood pressure management for these patients is widely recommended in medical guidelines. Bee pollen and postbiotics that contain inactivated probiotic cells and their...

  • Review
  • Open Access
8 Citations
6,977 Views
16 Pages

15 September 2023

Until recently, it was widely accepted that bacteria participate in caries pathogenesis mainly through carbohydrate fermentation and acid production, which promote the dissolution of tooth components. Neutrophils, on the other hand, were considered w...

  • Article
  • Open Access
6 Citations
3,933 Views
13 Pages

A Lactococcal Phage Protein Promotes Viral Propagation and Alters the Host Proteomic Response During Infection

  • Marie-Laurence Lemay,
  • Sandra Maaß,
  • Andreas Otto,
  • Jérémie Hamel,
  • Pier-Luc Plante,
  • Geneviève M. Rousseau,
  • Denise M. Tremblay,
  • Rong Shi,
  • Jacques Corbeil and
  • Sylvain Moineau
  • + 2 authors

24 July 2020

The lactococcal virulent phage p2 is a model for studying the Skunavirus genus, the most prevalent group of phages causing milk fermentation failures in cheese factories worldwide. This siphophage infects Lactococcus lactis MG1363, a model strain use...

  • Review
  • Open Access
115 Citations
12,279 Views
14 Pages

Fermentation of Agri-Food Waste: A Promising Route for the Production of Aroma Compounds

  • Jasmine Hadj Saadoun,
  • Gaia Bertani,
  • Alessia Levante,
  • Fabio Vezzosi,
  • Annalisa Ricci,
  • Valentina Bernini and
  • Camilla Lazzi

26 March 2021

Food waste and byproducts are generated along the entire food processing and storage chain. The large amount of waste deriving from the whole process represents not only a great economic loss but also an important ethical and environmental issue in t...

  • Article
  • Open Access
25 Citations
4,023 Views
14 Pages

Ventilator-Associated Pneumonia in COVID-19 Patients Admitted in Intensive Care Units: Relapse, Therapeutic Failure and Attributable Mortality—A Multicentric Observational Study from the OutcomeRea Network

  • Paul-Henri Wicky,
  • Claire Dupuis,
  • Charles Cerf,
  • Shidasp Siami,
  • Yves Cohen,
  • Virginie Laurent,
  • Bruno Mourvillier,
  • Jean Reignier,
  • Dany Goldgran-Toledano and
  • Jean-François Timsit
  • + 4 authors

6 February 2023

Introduction: Ventilator-associated pneumonia (VAP) incidence is high among critically ill COVID-19 patients. Its attributable mortality remains underestimated, especially for unresolved episodes. Indeed, the impact of therapeutic failures and the de...

  • Article
  • Open Access
1,053 Views
22 Pages

Dark fermentation (DF) has gained increasing interest over the past two decades as a sustainable route for biohydrogen production; however, understanding how reproducible the process can be, both from macro- and microbiological perspectives, remains...

  • Review
  • Open Access
6 Citations
5,672 Views
42 Pages

The Invisible Threat of Antibiotic Resistance in Food

  • Gabriella Kiskó,
  • Belma Bajramović,
  • Fatma Elzhraa,
  • Patrícia Erdei-Tombor,
  • Viktória Dobó,
  • Csilla Mohácsi-Farkas,
  • Andrea Taczman-Brückner and
  • Ágnes Belák

The continued and improper use of antibiotics has resulted in the emergence of antibiotic resistance (AR). The dissemination of antibiotic-resistant microorganisms occurs via a multitude of pathways, including the food supply. The failure to comply w...

  • Review
  • Open Access
171 Citations
30,897 Views
37 Pages

Avermectin Derivatives, Pharmacokinetics, Therapeutic and Toxic Dosages, Mechanism of Action, and Their Biological Effects

  • Gaber El-Saber Batiha,
  • Ali Alqahtani,
  • Omotayo B. Ilesanmi,
  • Abdullah A. Saati,
  • Amany El-Mleeh,
  • Helal F. Hetta and
  • Amany Magdy Beshbishy

17 August 2020

Avermectins are a group of drugs that occurs naturally as a product of fermenting Streptomyces avermitilis, an actinomycetes, isolated from the soil. Eight different structures, including ivermectin, abamectin, doramectin, eprinomectin, moxidectin, a...

  • Article
  • Open Access
7 Citations
2,526 Views
12 Pages

Performance Assessment of Three Similar Dental Restorative Composite Materials via Raman Spectroscopy Supported by Complementary Methods Such as Hardness and Density Measurements

  • Stefan-Marian Iordache,
  • Ana-Maria Iordache,
  • Dina Ilinca Gatin,
  • Cristiana Eugenia Ana Grigorescu,
  • Roxana Romanita Ilici,
  • Catalin-Romeo Luculescu and
  • Eduard Gatin

7 February 2024

(1) Background: A widespread problem in oral health is cavities produced by cariogenic bacteria that consume fermentable carbohydrates and lower pH to 5.5–6.5, thus extracting Ca2+ and phosphate ions (PO43−) from teeth. Dental restorative...

  • Article
  • Open Access
578 Views
39 Pages

29 December 2025

Shale gas extraction is underway in the Karoo Basin. Previous oil and gas explorers abandoned several wells, and the abandonment statuses of these wells are unknown. Critically, improperly abandoned wells can provide a pathway for the leakage of stra...

  • Review
  • Open Access
247 Views
14 Pages

Pre-, Pro-, Post- and Synbiotics in Pediatric Short Bowel Syndrome: A Narrative Review of Current Evidence

  • Roberta Giusy Ruiz,
  • Annalisa Morelli,
  • Rosangela Grieco,
  • Sabrina Cardile,
  • Teresa Capriati,
  • Chiara Maria Trovato,
  • Giulia Bolasco,
  • Daniela Knafelz,
  • Fiammetta Bracci and
  • Antonella Diamanti
  • + 1 author

28 February 2026

Background: Pediatric Short bowel syndrome (SBS) is the leading cause of intestinal failure and is characterized by persistent dysbiosis that negatively impacts intestinal adaptation and growth. Although microbiota modulation via pre-, pro-, and synb...

  • Review
  • Open Access
82 Citations
6,547 Views
15 Pages

8 November 2022

Cardiovascular disease (CVD) is the number one cause of death worldwide. Recent evidence has demonstrated an association between the gut microbiota and CVD, including heart failure, cerebrovascular illness, hypertension, and stroke. Marine algal poly...

  • Article
  • Open Access
2 Citations
2,890 Views
14 Pages

2 December 2021

The products of a batch process have high economic value. Meanwhile, a batch process involves complex chemicals and equipment. The variability of its operation leads to a high failure rate. Therefore, early fault diagnosis of batch processes is of gr...

  • Review
  • Open Access
107 Citations
16,326 Views
28 Pages

Microbial Interactions within the Cheese Ecosystem and Their Application to Improve Quality and Safety

  • Baltasar Mayo,
  • Javier Rodríguez,
  • Lucía Vázquez and
  • Ana Belén Flórez

12 March 2021

The cheese microbiota comprises a consortium of prokaryotic, eukaryotic and viral populations, among which lactic acid bacteria (LAB) are majority components with a prominent role during manufacturing and ripening. The assortment, numbers and proport...

  • Communication
  • Open Access
3 Citations
3,375 Views
11 Pages

Impacts of Subchronic and Mild Social Defeat Stress on Plasma Putrefactive Metabolites and Cardiovascular Structure in Male Mice

  • Atsushi Toyoda,
  • Kina Kawakami,
  • Yuto Amano,
  • Hideaki Nishizawa,
  • Shin-ichi Nakamura,
  • Takahiro Kawase,
  • Yuta Yoshida,
  • Hodaka Suzuki and
  • Takamitsu Tsukahara

Psychosocial stress precipitates mental illnesses, such as depression, and increases the risk of other health problems, including cardiovascular diseases. In this study, we observed the effects of psychosocial stress on the histopathological features...

  • Review
  • Open Access
1,797 Views
28 Pages

Duration Matters: Tailoring Antibiotic Therapy for Ventilator-Associated Pneumonia

  • Tim Rahmel,
  • Isabella Traut,
  • Lars Bergmann,
  • Maria Panagiota Almyroudi,
  • Barbara Tamowicz,
  • Priyam Varma,
  • Despoina Koulenti and
  • Antonios Katsounas

Ventilator-associated pneumonia (VAP) remains the most frequent ICU-acquired infection and a major driver of antimicrobial exposure. Historically, clinicians treated patients for 10–14 days or longer, particularly when multidrug-resistant organ...

  • Article
  • Open Access
7 Citations
2,288 Views
15 Pages

Infectious Foci, Comorbidities and Its Influence on the Outcomes of Septic Critically Ill Patients

  • Ana Maria Oliveira,
  • André Oliveira,
  • Raquel Vidal and
  • João Gonçalves-Pereira

Sepsis is among the most frequent diagnoses on admission to the intensive care unit (ICU). A systemic inflammatory response, activated by uncontrolled infection, fosters hypoperfusion and multiorgan failure and often leads to septic shock and mortali...

  • Review
  • Open Access
9 Citations
2,742 Views
22 Pages

8 September 2025

Chronic kidney disease (CKD) is a progressive disorder that is characterized by the gradual loss of kidney function, often leading to end-stage renal failure. Recent research has highlighted the role of gut dysbiosis and its metabolic byproducts in t...

  • Article
  • Open Access
26 Citations
5,118 Views
18 Pages

Effect of Cobalt, Nickel, and Selenium/Tungsten Deficiency on Mesophilic Anaerobic Digestion of Chemically Defined Soluble Organic Compounds

  • Luka Šafarič,
  • Sepehr Shakeri Yekta,
  • Bo H. Svensson,
  • Anna Schnürer,
  • David Bastviken and
  • Annika Björn

Trace elements (TEs) are vital for anaerobic digestion (AD), due to their role as cofactors in many key enzymes. The aim of this study was to evaluate the effects of specific TE deficiencies on mixed microbial communities during AD of soluble polymer...

  • Article
  • Open Access
2 Citations
1,543 Views
13 Pages

Clinical Characteristics of Patients with Intra-Abdominal Infection Caused by Stenotrophomonas maltophilia

  • Chien-Liang Chen,
  • Chun-Chou Tsai,
  • Wei-Ping Chen,
  • Feng-Yee Chang,
  • Ching-Mei Yu,
  • Hung-Sheng Shang,
  • Leung-Kei Siu,
  • Ya-Sung Yang,
  • Jung-Chung Lin and
  • Ching-Hsun Wang

4 June 2025

Background: Intra-abdominal infections (IAIs) caused by Stenotrophomonas maltophilia have rarely been reported. This study aimed to describe the clinical characteristics and risk factors for mortality among patients with S. maltophilia IAIs. Methods:...

  • Article
  • Open Access
1 Citations
1,415 Views
17 Pages

A Plasmid-Encoded Surface Polysaccharide Partly Blocks Ceduovirus Infection in Lactococci

  • Claudia Rendueles,
  • Javier Nicolás Garay-Novillo,
  • Martin Holm Rau,
  • Paula Gaspar,
  • José Ángel Ruiz-Masó,
  • Jennifer Mahony,
  • Ana Rodríguez,
  • José Luis Barra,
  • Gloria del Solar and
  • Beatriz Martínez

Bacteriophages (or phages) remain the leading cause of failure in dairy fermentations. Thereby, phage-resistant Lactococcus lactis and Lactococcus cremoris dairy starters are in continuous demand. In this work, our goal was to identify phage defense...

  • Review
  • Open Access
32 Citations
10,099 Views
30 Pages

18 November 2022

Plastic production worldwide has doubled in the last two decades and is expected to reach a four-fold increase by 2050. The durability of plastic makes them a perfect material for many applications, but it is also a key limitation to their end-of-lif...

  • Article
  • Open Access
4 Citations
7,659 Views
19 Pages

Investigation on the Quality of Commercially Available GABA Tea in Taiwan

  • Mu-Chen Wu,
  • Shih-Lun Liu,
  • Bo-Kang Liou,
  • Chun-Yeh Chen and
  • Yuh-Shuen Chen

28 August 2023

This study collected 220 commercially available samples of γ-Aminobutyric acid (GABA) tea produced in Taiwan from 2016 to 2021. The 220 tea samples were categorized into five types of GABA tea, including 108 GABA Oolong tea, 71 GABA Black tea,...

  • Article
  • Open Access
3 Citations
3,354 Views
20 Pages

Microbial and Physico-Chemical Characterization of Cold Smoked Sea Bass (Dicentrarchus labrax), a New Product of Fishery

  • Michela Pellegrini,
  • Lucilla Iacumin,
  • Jelka Pleadin,
  • Greta Krešić,
  • Elisabetta Orecchia,
  • Andrea Colautti,
  • Ana Vulić,
  • Nina Kudumija,
  • Cristian Bernardi and
  • Giuseppe Comi

12 July 2023

The aim of this study was to investigate the microbial and physico-chemical characteristics of cold smoked sea bass (CSSB), a novel italian fish product. The microbiological analyses showed the presence of bacterial contamination from the raw materia...

  • Article
  • Open Access
2 Citations
3,023 Views
23 Pages

Enhancing Oxygen-Dissolving Capacity of Rotary Drum Food Waste Composting: Tumbling Process Optimization and Experimental Validation with Discrete and Finite Element Methods

  • Jufei Wang,
  • Xueru Zhu,
  • Zhenming Zhu,
  • Chao Li,
  • Xuesong Peng,
  • Shilong Qiu,
  • Jinbo Ren,
  • Xinhui Wu,
  • Samuel Mbugua Nyambura and
  • Shuhe Zheng
  • + 1 author

9 November 2024

An optimized tumbling process can significantly improve the oxygen dissolving capacity of composting and fertilizer quality: by increasing the fluffiness of the lower layer of the pile, localized anaerobic fermentation can be avoided, thereby enhanci...

  • Article
  • Open Access
77 Citations
8,209 Views
20 Pages

The Short-Chain Fatty Acid Butyrate Attenuates Pulmonary Vascular Remodeling and Inflammation in Hypoxia-Induced Pulmonary Hypertension

  • Vijaya Karoor,
  • Derek Strassheim,
  • Timothy Sullivan,
  • Alexander Verin,
  • Nagavedi S. Umapathy,
  • Edward C. Dempsey,
  • Daniel N. Frank,
  • Kurt R. Stenmark and
  • Evgenia Gerasimovskaya

14 September 2021

Pulmonary hypertension (PH) is a progressive cardiovascular disorder in which local vascular inflammation leads to increased pulmonary vascular remodeling and ultimately to right heart failure. The HDAC inhibitor butyrate, a product of microbial ferm...

  • Review
  • Open Access
148 Citations
28,585 Views
20 Pages

Nutritional Physiology and Biochemistry of Dairy Cattle under the Influence of Heat Stress: Consequences and Opportunities

  • Abdul Sammad,
  • Ya Jing Wang,
  • Saqib Umer,
  • Hu Lirong,
  • Imran Khan,
  • Adnan Khan,
  • Baseer Ahmad and
  • Yachun Wang

3 May 2020

Higher milk yield and prolificacy of the modern dairy cattle requires high metabolism activities to support them. It causes high heat production by the body, which coupled with increasing environmental temperatures results in heat stress (HS). Produc...