Pharmacopeia monographs are not intended to establish biosimilarity. However, the US Food and Drug Administration (FDA) has stopped the US Pharmacopeia (USP) from creating monographs for biological drugs due to the need for side-by-side comparisons w...
Gray mold caused by Botrytis cinerea poses a major threat to tomato production worldwide. This study investigated the antifungal efficacy and defense-inducing potential of Agricultural Jiaosu (AJ), a fermented bioproduct derived from agricultural res...
The development of food products implies ensuring the optimal composition and ratio of the basic components, as well as their technological compatibility. A priori, the quality of raw materials, the optimal formula of the product and the efficiency o...
Definitions of biological medicinal products (BMPs) vary depending on the source. BMPs are manufactured using complex biological/biotechnological processes involving living cell lines, tissues and organisms such as microorganisms, plants, humans and...
In this paper, we present an updated review on the mathematical modeling of different biological methods of hydrogen production. The presented mathematical modeling and methods range from inception to the current state-of-the-art developments in hydr...
Nanofiltration (NF) membranes, which can consistently offer safe and reliable water quality, have become increasingly popular in drinking water treatment. In this study, the conventional (coagulation-sedimentation-sand filtration) and ozonation-biolo...
Mycobacteria can be one of the main contaminants of biological products, and their presence can have serious consequences on patients’ health. For this reason, the European Pharmacopoeia mandates the specific testing of biological products for...
Existing research on integrated innovation primarily focuses on the integration of product functions or technologies in the engineering field, with limited exploration of cross-domain integration of biological knowledge. Various organisms exhibit var...
Bacterial canker, caused by Pseudomonas syringae pv. syringae and pv. morsprunorum, is one of the most important diseases of stone fruit trees (Prunus spp.). The pathogen infects buds, flowers, fruitlets, leaves and shoots, from which the disease spr...
Recently, cyanobacteria have become one of the most attractive hosts for biochemical production due to its high proliferative ability and ease of genetic manipulation. Several researches aimed at biological production using modified cyanobacteria hav...
In this paper, the inhibitory effects of added hydrogen in reactor headspace on fermentative hydrogen production from acidogenesis of glucose by a bacterium, Clostridium acetobutylicum, was investigated experimentally in a batch reactor. It was obser...
The functional gene is a product of functional information expression methods inspired by biological genes. Product innovation design is essentially a process of functional problem-solving, which has an intrinsic connection with biological gene expre...
Developing sustainable agriculture by identifying non-chemical alternative Plant Protection Products (PPP) is a cornerstone in achieving long-sought environmental friendliness. Despite significant legislative and political efforts to promote biocontr...
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Biological hazards in products of animal origin pose a significant threat to human health. In Cambodia, there are few comprehensive data and information on the causes of foodborne diseases or risks. To date, there has been no known published study si...
Toxic shock caused by the discharge of biocide-contaminated fecal sludge (FS) from chemical toilets to conventional wastewater treatment plants (WWTP) can be a major problem in activated sludge operation. It is necessary to develop new environmental...
Phenazine natural products are a class of colored nitrogen-containing heterocycles produced by various microorganisms mainly originating from marine and terrestrial sources. The tricyclic ring molecules show various chemical structures and the decora...
Natural product-derived drugs represent a cornerstone of modern pharmacotherapy, with many serving as essential therapeutic agents across diverse medical conditions. Recent advances in structural biology have provided unprecedented insights into the...
Tetrahydroisoquinolines are the framework of numerous natural products predominantly alkaloids, an important and one of the most wide spread families of naturally occurring compounds in the plant kingdom. Tetrahydroisoquinolines are commonly construc...
Artificial Intelligence (AI) has the disruptive potential to transform patients’ lives via innovations in pharmaceutical sciences, drug development, clinical trials, and manufacturing. However, it presents significant challenges, ethical concer...
Pleurotus ostreatus is among the most widely cultivated mushroom species on a global scale, valued for its relative ease of cultivation, excellent organoleptic qualities, and notable nutraceutical properties. P. ostreatus could use a wide range of by...
Glaucoma is an age-related neurodegenerative disease characterized by progressive optic nerve damage. Accelerated biological aging, assessed using predicted age derived from fundus images, may serve as a biomarker for glaucoma progression. This study...
To evaluate the agro-biological traits and select the promising populations of alfalfa under pedoclimatic conditions, field experiments were carried out in two locations of the Lithuanian Research Centre for Agriculture and Forestry (western Lithuani...
Dialyzable leukocyte extracts are clinically used under different commercial names (IMMUNEPOTENT CRP®, IMMODIN®, Transferon®) to modulate the immune response altered by pathological conditions such as cancer, inflammation, and viral infections. The p...
Water purification by ultrafiltration (UF) requires regular membrane cleaning via backwashing. In the case of chemically enhanced backwashing (CEB), it can result in the formation of unwanted by-product precursors due to reactions with organic matter...
Yellow eels were sampled by electrofishing in 1979, 1980, and 1981 in Vester Vedsted Stream, Denmark, which has as its outlet to the North Sea. Yellow eels were aged by burning the otoliths. The gender of the eels was not specified, and they varied f...
Melanin produced in melanocytes contributes to photoprotection, oxidative stress reduction, immune regulation, and epidermal homeostasis, while its dysregulation underlies diverse pigmentary disorders. Natural products modulate melanogenesis by regul...
We conducted 24-h real-time monitoring of temperature, salinity, dissolved oxygen, and nutrients in the near-shore (M4-1), front (M4-8), and offshore (M4-13) regions of the 31° N section of the Changjiang (Yangtze) River estuary plume in summer. Carb...
Olive anthracnose is the most important fungal disease of the olive fruit worldwide, with the fungus Colletotrichum acutatum as the main cause of the disease in Greece. A total of 11 commercial biological plant protection products (bioPPPs) (Amylo-X&...
Teriparatide is an anabolic peptide drug indicated for the treatment of osteoporosis. Recombinant teriparatide was first approved in 2002 and has since been followed by patent-free alternatives under biosimilar or hybrid regulatory application. The a...
Products enriched with probiotic microorganisms have proven to possess immunomodulatory, antioxidant, hypo-cholesterolemic, hypotensive, and antimicrobial properties. Biologically active substances, which are by-products of microbial fermentation, ha...
The excessive H2S presence in water and wastewater can lead to corrosion, toxicity, and biological processes inhibition—i.e., anaerobic digestion. Production of H2S can occur in psychrophilic conditions. Biological removal of HS− by addition of NO3−...
Hylocereus spp. present two varieties of commercial interest due to their color, organoleptic characteristics, and nutritional contribution, such as Hylocerous polyrhizus and Selenicerus undatus. The fruit recognized as dragon fruit or Pitahaya is an...
The quality of equine colostrum is typically defined by refractometry or the concentration of maternal antibodies. However, the activity of other equine colostral bioactive molecules has not yet been investigated. This study analyzed whether the admi...
Insect trap studies were carried out to determine the presence of entomopathogenic nematodes (EPN) from the family Steinernematidae in the soils of Poland and to compare the biological activities of field nematode isolates with nematodes from commerc...
Natural products are substances found in nature that have not been significantly modified by humans [...]
Natural products obtained from marine organisms continue to be a rich source of novel structural architecture and of importance in drug discovery, medicine, and health. However, the success of such endeavors depends on the exact structural elucidatio...
The key trends driving the global dairy market are shelf-life extension and generating consumer demand for new products. Healthy diets and special foods meet the criteria based on the protein digestibility-corrected amino acid score, while other fact...
The mounting global population and the challenges posed by climate change underline the need for sustainable food production systems. This review synthesizes evidence for a dual-track bioeconomy, green (terrestrial plants and insects) and blue (aquat...
The six Dioscorea species, D. brevipetiolata, D. bulbifera, D. depauperata (Dd), D. glabra (Dg), D. pyrifolia and D. hamiltonii were analyzed for phytochemicals, toxicity in PBMCs, and biological activity in two cancer cell lines by MTT and comet ass...
Lactobionic acid, widely used in the pharmaceutical, cosmetic, and food industries, is produced through chemical and biological methods, each with distinct advantages and challenges. This review examines the key approaches to its production, highligh...
Essential oil (EO) extraction is a widespread practice generating huge amounts of solid plant by-products a potential source of bioactive compounds, on the one hand, and a detrimental risk for the environment that needs to be carefully considered on...
The aim of this study was to apply the combined thermomechanical–biological treatment for corn processing by-product (CPBP) valorization to added-value food and feed material. The mechanical–thermal pre-treatment was performed by applying...
Severe virus outbreaks are occurring more often and spreading faster and further than ever. Preparedness plans based on lessons learned from past epidemics can guide behavioral and pharmacological interventions to contain and treat emergent diseases....
C. brachyspora, a widespread dematiaceous fungus, was evaluated in this study to optimize the production of exopolysaccharides (CB-EPS). Optimization was performed using response surface methodology, and the best production yielded 75.05% of total su...
Glucosinolates (GLS) were extracted and purified from Lepidium meyenii (Maca) root. Purified GLS were analyzed without desulfation by UPLC–ESI–MS. Glucosinolates were decomposed into benzyl isothiocyanate (BITC) by thioglucosidase. DPPH r...
The soil used for the field experiment was PLb-g4 Endohipogleyic Eutric Planasol. The research aimed to investigate the effects of different nitrogen fertilisation rates and biological preparations on yield structure elements and partial factor produ...
Food products in the United States (U.S.), including dietary supplements, may contain live microorganisms and can be promoted for general health, nutritional, or structure/function claims. In contrast, such preparations used with the intention of hav...
Extremophilic fungi have been found to develop unique defences to survive extremes of pressure, temperature, salinity, desiccation, and pH, leading to the biosynthesis of novel natural products with diverse biological activities. The present review f...
The islands of the South Pacific Ocean have been in the limelight for natural product biodiscovery, due to their unique and pristine tropical waters and environment. The Kingdom of Tonga is an archipelago in the central Indo-Pacific Ocean, consisting...
Bees are important pollinators worldwide, promoting sustainability in agriculture and natural ecosystems. Moreover, honey bees produce a variety of honey bee products (beehive products). Honey is the main edible bee product. The consumption of pollen...
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