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  • Review
  • Open Access
8 Citations
5,547 Views
14 Pages

Coherent Diffraction Imaging in Transmission Electron Microscopy for Atomic Resolution Quantitative Studies of the Matter

  • Elvio Carlino,
  • Francesco Scattarella,
  • Liberato De Caro,
  • Cinzia Giannini,
  • Dritan Siliqi,
  • Alessandro Colombo and
  • Davide Emilio Galli

19 November 2018

The paper focuses on the development of electron coherent diffraction imaging in transmission electron microscopy, made in the, approximately, last ten years in our collaborative research group, to study the properties of materials at atomic resoluti...

  • Article
  • Open Access
14 Citations
4,796 Views
19 Pages

20 March 2020

In this paper, for the first time it is shown how in-line holography in Transmission Electron Microscopy (TEM) enables the study of radiation-sensitive nanoparticles of organic and inorganic materials providing high-contrast holograms of single nanop...

  • Article
  • Open Access
4 Citations
3,406 Views
9 Pages

Atomic-Resolution Imaging of Micron-Sized Samples Realized by High Magnetic Field Scanning Tunneling Microscopy

  • Weixuan Li,
  • Jihao Wang,
  • Jing Zhang,
  • Wenjie Meng,
  • Caihong Xie,
  • Yubin Hou,
  • Zhigang Xia and
  • Qingyou Lu

22 January 2023

Scanning tunneling microscopy (STM) can image material surfaces with atomic resolution, making it a useful tool in the areas of physics and materials. Many materials are synthesized at micron size, especially few-layer materials. Limited by their com...

  • Article
  • Open Access
5 Citations
1,868 Views
11 Pages

Toward Real Real-Space Refinement of Atomic Models

  • Alexandre G. Urzhumtsev and
  • Vladimir Y. Lunin

11 October 2022

High-quality atomic models providing structural information are the results of their refinement versus diffraction data (reciprocal-space refinement), or versus experimental or experimentally based maps (real-space refinement). A proper real-space re...

  • Article
  • Open Access
7 Citations
3,739 Views
10 Pages

A Novel Atomically Resolved Scanning Tunneling Microscope Capable of Working in Cryogen-Free Superconducting Magnet

  • Tao Geng,
  • Jihao Wang,
  • Wenjie Meng,
  • Jing Zhang,
  • Qiyuan Feng,
  • Yubin Hou and
  • Qingyou Lu

11 March 2023

We present a novel homebuilt scanning tunneling microscope (STM) with atomic resolution integrated into a cryogen-free superconducting magnet system with a variable temperature insert. The STM head is designed as a nested structure of double piezoele...

  • Article
  • Open Access
1 Citations
2,638 Views
14 Pages

Direct Imaging of Radiation-Sensitive Organic Polymer-Based Nanocrystals at Sub-Ångström Resolution

  • Elvio Carlino,
  • Antonietta Taurino,
  • Dritan Hasa,
  • Dejan-Krešimir Bučar,
  • Maurizio Polentarutti,
  • Lidia E. Chinchilla and
  • Josè J. Calvino Gamez

Seeing the atomic configuration of single organic nanoparticles at a sub-Å spatial resolution by transmission electron microscopy has been so far prevented by the high sensitivity of soft matter to radiation damage. This difficulty is related t...

  • Review
  • Open Access
1 Citations
1,503 Views
33 Pages

Nanoscale Imaging of Biological Tissues: Techniques, Challenges and Emerging Frontiers

  • Rohit Kajla,
  • Rebecca Leija-Cardenas,
  • Meghraj Magadi Shivalingaiah,
  • Muhammad Waqas Shabbir and
  • Zihao Ou

22 November 2025

Nanoscale characterization of biological tissues bridges molecular identity with structural, mechanical, and chemical organization, enabling high-resolution insights into intact specimens. This review provides a comprehensive overview of the principa...

  • Feature Paper
  • Review
  • Open Access
15 Citations
9,285 Views
37 Pages

Yeast Nanobiotechnology

  • Ronnie Willaert,
  • Sandor Kasas,
  • Bart Devreese and
  • Giovanni Dietler

Yeast nanobiotechnology is a recent field where nanotechniques are used to manipulate and analyse yeast cells and cell constituents at the nanoscale. The aim of this review is to give an overview and discuss nanobiotechnological analysis and manipula...

  • Article
  • Open Access
6 Citations
6,365 Views
11 Pages

6 October 2020

The exit wave is the state of a uniform plane incident electron wave exiting immediately after passing through a specimen and before the atomic-resolution transmission electron microscopy (ARTEM) image is modified by the aberration of the optical sys...

  • Review
  • Open Access
33 Citations
13,912 Views
48 Pages

Current Progress in Femtosecond Laser Ablation/Ionisation Time-of-Flight Mass Spectrometry

  • Marek Tulej,
  • Niels F.W. Ligterink,
  • Coenraad de Koning,
  • Valentine Grimaudo,
  • Rustam Lukmanov,
  • Peter Keresztes Schmidt,
  • Andreas Riedo and
  • Peter Wurz

12 March 2021

The last decade witnessed considerable progress in the development of laser ablation/ionisation time-of-flight mass spectrometry (LI-TOFMS). The improvement of both the laser ablation ion sources employing femtosecond lasers and the method of ion cou...

  • Review
  • Open Access
11 Citations
3,676 Views
14 Pages

19 June 2023

Transmission electron microscope (TEM) is thought as one powerful tool to imaging the atomic-level structure of organic inorganic hybrid perovskite (OIHP) materials, which provides valuable and essential guidance toward high performance OIHP-related...

  • Article
  • Open Access
17 Citations
1,971 Views
10 Pages

Atomic Force Microscopy as a Tool for the Investigation of Living Cells

  • Inga Morkvėnaitė-Vilkončienė,
  • Almira Ramanavičienė and
  • Arūnas Ramanavičius

Atomic force microscopy is a valuable and useful tool for the imaging and investigation of living cells in their natural environment at high resolution. Procedures applied to living cell preparation before measurements should be adapted individually...

  • Review
  • Open Access
37 Citations
11,344 Views
28 Pages

Current Status of Single Particle Imaging with X-ray Lasers

  • Zhibin Sun,
  • Jiadong Fan,
  • Haoyuan Li and
  • Huaidong Jiang

22 January 2018

The advent of ultrafast X-ray free-electron lasers (XFELs) opens the tantalizing possibility of the atomic-resolution imaging of reproducible objects such as viruses, nanoparticles, single molecules, clusters, and perhaps biological cells, achieving...

  • Article
  • Open Access
7 Citations
4,417 Views
11 Pages

A Non-Destructive, Tuneable Method to Isolate Live Cells for High-Speed AFM Analysis

  • Christopher T. Evans,
  • Sara J. Baldock,
  • John G. Hardy,
  • Oliver Payton,
  • Loren Picco and
  • Michael J. Allen

Suitable immobilisation of microorganisms and single cells is key for high-resolution topographical imaging and study of mechanical properties with atomic force microscopy (AFM) under physiologically relevant conditions. Sample preparation techniques...

  • Article
  • Open Access
2 Citations
1,818 Views
10 Pages

Unsupervised Learning for the Automatic Counting of Grains in Nanocrystals and Image Segmentation at the Atomic Resolution

  • Woonbae Sohn,
  • Taekyung Kim,
  • Cheon Woo Moon,
  • Dongbin Shin,
  • Yeji Park,
  • Haneul Jin and
  • Hionsuck Baik

10 October 2024

Identifying the grain distribution and grain boundaries of nanoparticles is important for predicting their properties. Experimental methods for identifying the crystallographic distribution, such as precession electron diffraction, are limited by the...

  • Article
  • Open Access
4 Citations
2,578 Views
15 Pages

6 February 2024

Neutrons interact with the magnetic moment of the atomic shell of an atom, as is common for X-rays, but mainly they interact directly with the nucleus. Therefore, the atomic number and the related number of electrons does not play a role in the stren...

  • Article
  • Open Access
6 Citations
5,256 Views
12 Pages

X-ray Assisted Scanning Tunneling Microscopy and Its Applications for Materials Science: The First Results on Cu Doped ZrTe3

  • Hui Yan,
  • Nozomi Shirato,
  • Xiangde Zhu,
  • Daniel Rosenmann,
  • Xiao Tong,
  • Weihe Xu,
  • Cedomir Petrovic,
  • Volker Rose and
  • Evgeny Nazaretski

9 November 2019

Synchrotron X-ray Scanning Tunneling Microscopy (SX-STM) is a novel imaging technique capable of providing real space chemically specific mapping with a potential of reaching atomic resolution. Determination of chemical composition along with ultra-h...

  • Article
  • Open Access
4 Citations
2,465 Views
9 Pages

Atomic Force Microscopy’s Application for Surface Structure Investigation of Materials Synthesized by Laser Powder Bed Fusion

  • Ivan A. Pelevin,
  • Tatiana P. Kaminskaya,
  • Stanislav V. Chernyshikhin,
  • Kirill B. Larionov and
  • Ella L. Dzidziguri

13 September 2024

Article presents a comparison of surface structure study methods, such as atomic force microscopy, scanning and transition electron microscopy in terms of metallic materials 3D-printed using the laser powder bed fusion technique. The main features, a...

  • Feature Paper
  • Article
  • Open Access
5 Citations
5,587 Views
13 Pages

14 August 2021

High-resolution scanning transmission electron microscopy (STEM) images of human tooth enamel crystals, mainly in the high-angle annular dark-field (STEM-HAADF) mode, are presented in this work along the [1000], [10-11]. and [1-210] directions. These...

  • Article
  • Open Access
12 Citations
4,760 Views
12 Pages

16 February 2023

There is a growing trend towards the development of high resolution and multiplexing metasurface holograms. In this paper, we propose the reconstruction of polarization multiplexing terahertz (THz) holographic images based on transmissive metasurface...

  • Article
  • Open Access
4 Citations
1,671 Views
10 Pages

26 July 2023

The structural change in Pt networks composed of multiple chain connections among grains was observed in air at 1 atm using atomic-resolution environmental cell scanning transmission electron microscopy. An aberration-corrected incident electron prob...

  • Article
  • Open Access
9 Citations
6,321 Views
16 Pages

27 May 2021

Point defects play a fundamental role in the discovery of new materials due to their strong influence on material properties and behavior. At present, imaging techniques based on transmission electron microscopy (TEM) are widely employed for characte...

  • Article
  • Open Access
3 Citations
2,967 Views
11 Pages

17 January 2024

Simulation of atomic force microscopy (AFM) computationally emulates experimental scanning of a biomolecular structure to produce topographic images that can be correlated with measured images. Its application to the enormous amount of available high...

  • Article
  • Open Access
8 Citations
3,029 Views
10 Pages

28 July 2021

Near-field interactions between metallic surfaces and single molecules play an essential role in the application of metamaterials. To reveal the near-field around a photo-irradiated single molecule on the metallic surface, high-resolution photo-assis...

  • Article
  • Open Access
2 Citations
5,065 Views
10 Pages

Magnetic Resonance Lithography with Nanometer Resolution

  • Fahad AlGhannam,
  • Philip Hemmer,
  • Zeyang Liao and
  • M. Suhail Zubairy

We propose an approach for super-resolution optical lithography which is based on the inverse of magnetic resonance imaging (MRI). The technique uses atomic coherence in an ensemble of spin systems whose final state population can be optically detect...

  • Article
  • Open Access
2,027 Views
13 Pages

Low-Photon Counts Coherent Modulation Imaging via Generalized Alternating Projection Algorithm

  • Meng Sun,
  • Tao Liu,
  • George Barbastathis,
  • Yincheng Qi and
  • Fucai Zhang

11 November 2022

Phase contrast imaging is advantageous for mitigating radiation damage to samples, such as biological specimens. For imaging at nanometer or atomic resolution, the required flux on samples increases dramatically and can easily exceed the sample damag...

  • Review
  • Open Access
9 Citations
7,908 Views
14 Pages

21 March 2022

Obtaining an understanding of the mechanism underlying the interrelations between the structure and function of HIV-1 is of pivotal importance. In previous decades, this mechanism was addressed extensively in a variety of studies using conventional a...

  • Article
  • Open Access
8 Citations
9,061 Views
19 Pages

Atomic Resolution Structure of the Oncolytic Parvovirus LuIII by Electron Microscopy and 3D Image Reconstruction

  • Nikéa Pittman,
  • Adam Misseldine,
  • Lorena Geilen,
  • Sujata Halder,
  • J. Kennon Smith,
  • Justin Kurian,
  • Paul Chipman,
  • Mandy Janssen,
  • Robert Mckenna and
  • Mavis Agbandje-McKenna
  • + 4 authors

30 October 2017

LuIII, a protoparvovirus pathogenic to rodents, replicates in human mitotic cells, making it applicable for use to kill cancer cells. This virus group includes H-1 parvovirus (H-1PV) and minute virus of mice (MVM). However, LuIII displays enhanced on...

  • Article
  • Open Access
63 Citations
14,212 Views
21 Pages

28 April 2017

Individual, luminescent point defects in solids, so-called color centers, are atomic-sized quantum systems enabling sensing and imaging with nanoscale spatial resolution. In this overview, we introduce nanoscale sensing based on individual nitrogen v...

  • Feature Paper
  • Review
  • Open Access
23 Citations
10,679 Views
35 Pages

Atom Probe Tomography for Catalysis Applications: A Review

  • Cédric Barroo,
  • Austin J. Akey and
  • David C. Bell

5 July 2019

Atom probe tomography is a well-established analytical instrument for imaging the 3D structure and composition of materials with high mass resolution, sub-nanometer spatial resolution and ppm elemental sensitivity. Thanks to recent hardware developme...

  • Review
  • Open Access
37 Citations
14,136 Views
24 Pages

21 August 2015

A major challenge in molecular investigations at surfaces has been to image individual molecules, and the assemblies they form, with single-bond resolution. Scanning probe microscopy, with its exceptionally high resolution, is ideally suited to this...

  • Article
  • Open Access
4 Citations
4,052 Views
9 Pages

31 July 2020

We studied the O2 dissociated state under the different O2 exposed temperatures with atomic resolution by scanning probe microscopy (SPM) and imaged the O adatom by simultaneous atomic force microscopy (AFM)/scanning tunneling microscopy (STM). The e...

  • Article
  • Open Access
2 Citations
2,754 Views
19 Pages

Design of an FPGA-Based Controller for Fast Scanning Probe Microscopy

  • Leonardo Gregorat,
  • Marco Cautero,
  • Sergio Carrato,
  • Dario Giuressi,
  • Mirco Panighel,
  • Giuseppe Cautero and
  • Friedrich Esch

21 September 2024

Atomic-scale imaging using scanning probe microscopy is a pivotal method for investigating the morphology and physico-chemical properties of nanostructured surfaces. Time resolution represents a significant limitation of this technique, as typical im...

  • Article
  • Open Access
52 Citations
12,429 Views
21 Pages

Microscopic Analysis of Current and Mechanical Properties of Nafion® Studied by Atomic Force Microscopy

  • Renate Hiesgen,
  • Stefan Helmly,
  • Ines Galm,
  • Tobias Morawietz,
  • Michael Handl and
  • K. Andreas Friedrich

16 November 2012

The conductivity of fuel cell membranes as well as their mechanical properties at the nanometer scale were characterized using advanced tapping mode atomic force microscopy (AFM) techniques. AFM produces high-resolution images under continuous curren...

  • Feature Paper
  • Review
  • Open Access
14 Citations
6,960 Views
10 Pages

In Situ Room Temperature Electron-Beam Driven Graphene Growth from Hydrocarbon Contamination in a Transmission Electron Microscope

  • Mark H Rummeli,
  • Yumo Pan,
  • Liang Zhao,
  • Jing Gao,
  • Huy Q Ta,
  • Ignacio G. Martinez,
  • Rafael G. Mendes,
  • Thomas Gemming,
  • Lei Fu and
  • Zhongfan Liu
  • + 1 author

26 May 2018

The excitement of graphene (as well as 2D materials in general) has generated numerous procedures for the fabrication of graphene. Here we present a mini-review on a rather less known, but attractive, in situ means to fabricate graphene inside a tran...

  • Article
  • Open Access
1 Citations
1,758 Views
15 Pages

Atomic Depth Image Transfer of Large-Area Optical Quartz Materials Based on Pulsed Ion Beam

  • Shuyang Ran,
  • Kefan Wen,
  • Lingbo Xie,
  • Xingyu Zhou,
  • Ye Tian,
  • Shuo Qiao,
  • Feng Shi and
  • Xing Peng

15 July 2024

The high-efficiency preparation of large-area microstructures of optical materials and precision graphic etching technology is one of the most important application directions in the atomic and near-atomic-scale manufacturing industry. Traditional fo...

  • Article
  • Open Access
3 Citations
3,524 Views
19 Pages

31 October 2024

Chemical and physical properties of nanoparticles (NPs) are strongly influenced not only by the crystal structure of the respective material, including crystal structure defects but also by the NP size and shape. Contemporary transmission electron mi...

  • Communication
  • Open Access
2,140 Views
9 Pages

Reconstructed Cd(0001) Surface Induced by Adsorption of Triphenyl Bismuth

  • Mengmeng Bai,
  • Zuo Li,
  • Mingxia Shi,
  • Minlong Tao,
  • Kai Sun,
  • Xiaotian Yang,
  • Yufeng Zhang and
  • Junzhong Wang

8 February 2023

Largish molecules on metal surfaces may act as not only the building blocks of 2D self-assemblies, but also as the template to reshape the metal surfaces. Here, we report the molecular adsorption-induced formation of the periodic nanostripe arrays of...

  • Article
  • Open Access
1,715 Views
22 Pages

Our understanding of molecules has stagnated at a single quantum system, with atoms as Newtonian particles and electrons as quantum particles. Here, however, we reveal that both atoms and electrons in a molecule are quantum particles, and their quant...

  • Article
  • Open Access
1 Citations
1,374 Views
13 Pages

Adaptive Drive as a Control Strategy for Fast Scanning in Dynamic Mode Atomic Force Microscopy

  • Matilde Gelli,
  • Bruno Tiribilli,
  • Faiza Abdul Salam,
  • Massimo Vassalli and
  • Michele Basso

31 January 2025

Atomic Force Microscopy (AFM) is an advanced imaging technique which features nanoscale resolution and the ability to work under physiological conditions on soft samples. Modern AFM systems offer easy access to Dynamic Mode imaging which reduces the...

  • Article
  • Open Access
5 Citations
2,840 Views
10 Pages

24 December 2020

High resolution dense lines patterned by focused electron beam-induced deposition (FEBID) have been demonstrated to be promising for lithography. One of the challenges is the presence of interconnecting material, which is often carbonaceous, between...

  • Article
  • Open Access
6 Citations
6,583 Views
16 Pages

Sparse Reconstruction for Temperature Distribution Using DTS Fiber Optic Sensors with Applications in Electrical Generator Stator Monitoring

  • João Paulo Bazzo,
  • Daniel Rodrigues Pipa,
  • Erlon Vagner Da Silva,
  • Cicero Martelli and
  • Jean Carlos Cardozo da Silva

7 September 2016

This paper presents an image reconstruction method to monitor the temperature distribution of electric generator stators. The main objective is to identify insulation failures that may arise as hotspots in the structure. The method is based on temper...

  • Article
  • Open Access
14 Citations
9,279 Views
11 Pages

Atomic Force Microscopy Sidewall Imaging with a Quartz Tuning Fork Force Sensor

  • Danish Hussain,
  • Yongbing Wen,
  • Hao Zhang,
  • Jianmin Song and
  • Hui Xie

1 January 2018

Sidewall roughness measurement is becoming increasingly important in the micro-electromechanical systems and nanoelectronics devices. Atomic force microscopy (AFM) is an emerging technique for sidewall scanning and roughness measurement due to its hi...

  • Article
  • Open Access
1,099 Views
15 Pages

Growth and Atomic-Scale Characterization of 2D Gallium Selenide Crystals via STEM and EELS

  • Antonio Serra,
  • Letizia Meleleo,
  • Alessandro Buccolieri,
  • Lucio Calcagnile and
  • Daniela Manno

20 September 2025

The advent of graphene has catalyzed extensive exploration into two-dimensional (2D) materials, among which gallium selenide (GaSe)—a layered semiconductor—stands out for its promise in optoelectronic and nanoscale device applications. To...

  • Article
  • Open Access
9 Citations
3,760 Views
18 Pages

24 January 2024

This paper introduces a method for high-resolution lattice image reconstruction and dislocation analysis based on diffraction extinction. The approach primarily involves locating extinction spots in the Fourier transform spectrum (reciprocal space) a...

  • Review
  • Open Access
57 Citations
10,581 Views
21 Pages

Photon-Counting Computed Tomography (PCCT): Technical Background and Cardio-Vascular Applications

  • Antonella Meloni,
  • Francesca Frijia,
  • Daniele Panetta,
  • Giulia Degiorgi,
  • Carmelo De Gori,
  • Erica Maffei,
  • Alberto Clemente,
  • Vincenzo Positano and
  • Filippo Cademartiri

Photon-counting computed tomography (PCCT) is a new advanced imaging technique that is going to transform the standard clinical use of computed tomography (CT) imaging. Photon-counting detectors resolve the number of photons and the incident X-ray en...

  • Review
  • Open Access
25 Citations
7,513 Views
28 Pages

Application of VCSEL in Bio-Sensing Atomic Magnetometers

  • Peng Zhou,
  • Wei Quan,
  • Kai Wei,
  • Zihua Liang,
  • Jinsheng Hu,
  • Lu Liu,
  • Gen Hu,
  • Ankang Wang and
  • Mao Ye

30 November 2022

Recent years have seen rapid development of chip-scale atomic devices due to their great potential in the field of biomedical imaging, namely chip-scale atomic magnetometers that enable high resolution magnetocardiography (MCG) and magnetoencephalogr...

  • Article
  • Open Access
18 Citations
3,729 Views
24 Pages

14 May 2022

Digital images are used in various technological, financial, economic, and social processes. Huge datasets of high-resolution images require protected storage and low resource-intensive processing, especially when applying edge computing (EC) for des...

  • Article
  • Open Access
23 Citations
18,837 Views
18 Pages

STM, SECPM, AFM and Electrochemistry on Single Crystalline Surfaces

  • Holger Wolfschmidt,
  • Claudia Baier,
  • Stefan Gsell,
  • Martin Fischer,
  • Matthias Schreck and
  • Ulrich Stimming

5 August 2010

Scanning probe microscopy (SPM) techniques have had a great impact on research fields of surface science and nanotechnology during the last decades. They are used to investigate surfaces with scanning ranges between several 100 mm down to atomic reso...

  • Article
  • Open Access
33 Citations
6,253 Views
22 Pages

A Deep Learning Approach for Molecular Classification Based on AFM Images

  • Jaime Carracedo-Cosme,
  • Carlos Romero-Muñiz and
  • Rubén Pérez

24 June 2021

In spite of the unprecedented resolution provided by non-contact atomic force microscopy (AFM) with CO-functionalized and advances in the interpretation of the observed contrast, the unambiguous identification of molecular systems solely based on AFM...

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