You are currently viewing a new version of our website. To view the old version click .

5,056 Results Found

  • Article
  • Open Access
7 Citations
3,956 Views
20 Pages

Influence of Culture Conditions on the Bioreduction of Organic Acids to Alcohols by Thermoanaerobacter pseudoethanolicus

  • Sean Michael Scully,
  • Aaron E. Brown,
  • Yannick Mueller-Hilger,
  • Andrew B. Ross and
  • Jóhann Örlygsson

Thermoanaerobacter species have recently been observed to reduce carboxylic acids to their corresponding alcohols. The present investigation shows that Thermoanaerobacter pseudoethanolicus converts C2–C6 short-chain fatty acids (SCFAs) to their...

  • Review
  • Open Access
76 Citations
7,447 Views
22 Pages

Sugar alcohols and organic acids that derive from the metabolism of certain microorganisms have a panoply of applications in agro-food, chemical and pharmaceutical industries. The main challenge in their production is to reach a productivity threshol...

  • Article
  • Open Access
1 Citations
1,629 Views
13 Pages

24 June 2025

Benzoic acid and benzyl alcohol are the most used raw materials in cosmetics and pharmaceutical industries as preservative ingredients. Cinnamon cassia oil is an important natural starting material to synthesize organic compounds because it contains...

  • Article
  • Open Access
47 Citations
22,420 Views
11 Pages

19 November 2009

Production of fatty acid esters from stearic, oleic, and palmitic acids and short-chain alcohols (methanol, ethanol, propanol, and butanol) for the production of biodiesel was investigated in this work. A series of montmorillonite-based clays catalys...

  • Feature Paper
  • Article
  • Open Access
4 Citations
3,308 Views
11 Pages

31 May 2021

Advanced biofuels possess superior characteristics to serve for gasoline substitutes. In this study, a whole cell biocatalysis system was employed for production of short-chain alcohols from corresponding fatty acids. To do so, Escherichia coli strai...

  • Article
  • Open Access
10 Citations
4,373 Views
18 Pages

Thermoanaerobacter strains have recently gained interest because of their ability to convert short chain fatty acids to alcohols using actively growing cells. Thermoanaerobacter thermohydrosulfuricus strain AK152 was physiologically investigated for...

  • Article
  • Open Access
39 Citations
14,734 Views
9 Pages

10 April 2006

Esterifications of carboxylic acids with equimolar amount of alcohols could beefficiently catalyzed by ZrOCl2·8H2O. Acrylate esters were obtained in good yields undersolvent-free conditions at ambient temperature. The esterification of other carboxyl...

  • Communication
  • Open Access
2 Citations
5,781 Views
20 Pages

7 February 2019

Enzyme-assisted derivatization for sterol analysis (EADSA) is a technology designed to enhance sensitivity and specificity for sterol analysis using electrospray ionization–mass spectrometry. To date it has only been exploited on sterols with a...

  • Article
  • Open Access
18 Citations
8,468 Views
22 Pages

11 March 2013

Catalytic refining of bio-oil by reacting with olefin/alcohol over solid acids can convert bio-oil to oxygen-containing fuels. Reactivities of groups of compounds typically present in bio-oil with 1-octene (or 1-butanol) were studied at 120 °C/3 h ov...

  • Article
  • Open Access
3 Citations
1,900 Views
18 Pages

20 August 2023

The metal-catalyzed dehydrogenation of alcohols without any oxidant or additive has been demonstrated as an atom-economic and environmentally friendly strategy for carboxylic acid synthesis. Among the various catalysts applied to this transformation,...

  • Article
  • Open Access
2 Citations
3,689 Views
16 Pages

5 June 2025

Background: Chronic alcohol intake impairs intestinal function, while L-theanine (LTA) may support intestinal health. However, the protective effects of LTA to chronic alcoholic intestinal injuries remain unclear. Methods: SD rats were administered L...

  • Article
  • Open Access
3,208 Views
17 Pages

In recent years, non-alcoholic beers have been gaining popularity. Among the various components that affect the flavor and sensory characteristics of beers, free fatty acids (FFAs) are minor components. However, due to their involvement in beer quali...

  • Review
  • Open Access
8 Citations
7,358 Views
20 Pages

Obesity is in epidemic proportions in many parts of the world, contributing to increasing rates of non-alcoholic fatty liver disease (NAFLD). NAFLD represents a range of conditions from the initial stage of fatty liver to non-alcoholic steatohepatiti...

  • Review
  • Open Access
66 Citations
21,285 Views
13 Pages

Gamma Hydroxybutyric Acid (GHB) for the Treatment of Alcohol Dependence: A Review

  • Fabio Caputo,
  • Teo Vignoli,
  • Icro Maremmani,
  • Mauro Bernardi and
  • Giorgio Zoli

Gamma-hydroxybutyric acid (GHB) is a short-chain fatty acid structurally similar to the inhibitory neurotransmitter γ-aminobutyric acid. Clinical trials have demonstrated that 50-100 mg/kg of GHB fractioned into three or six daily doses is able to su...

  • Article
  • Open Access
14 Citations
3,661 Views
23 Pages

Hydrocinnamic Acid and Perillyl Alcohol Potentiate the Action of Antibiotics against Escherichia coli

  • Mariana Sousa,
  • Ana Cristina Afonso,
  • Lília Soares Teixeira,
  • Anabela Borges,
  • Maria José Saavedra,
  • Lúcia Chaves Simões and
  • Manuel Simões

The treatment of bacterial infections has been troubled by the increased resistance to antibiotics, instigating the search for new antimicrobial therapies. Phytochemicals have demonstrated broad-spectrum and effective antibacterial effects as well as...

  • Article
  • Open Access
4 Citations
1,464 Views
13 Pages

Hydrophobicity and Pore Structure: Unraveling the Critical Factors of Alcohol and Acid Adsorption in Zeolites

  • Yangyang Xie,
  • Honglei Fan,
  • Mingyang Che,
  • Ya Liu,
  • Chunjing Liu,
  • Xin Hu and
  • Botao Teng

6 November 2024

Adsorbing and recycling alcohols and acids from industrial wastewater is of great significance in wastewater treatment; establishing the possible quantitative relationship of alcohol–acid adsorption capacity with the struct0ures of adsorbents a...

  • Article
  • Open Access
7 Citations
5,677 Views
8 Pages

Rational Engineering of a Flavoprotein Oxidase for Improved Direct Oxidation of Alcohols to Carboxylic Acids

  • Mathias Pickl,
  • Christoph K. Winkler,
  • Silvia M. Glueck,
  • Marco W. Fraaije and
  • Kurt Faber

12 December 2017

The oxidation of alcohols to the corresponding carbonyl or carboxyl compounds represents a convenient strategy for the selective introduction of electrophilic carbon centres into carbohydrate-based starting materials. The O2-dependent oxidation of pr...

  • Article
  • Open Access
34 Citations
4,468 Views
12 Pages

Evaluating the Intoxicating Degree of Liquor Products with Combinations of Fusel Alcohols, Acids, and Esters

  • Jia Xie,
  • Xiao-Fei Tian,
  • Song-Gui He,
  • Yun-Lu Wei,
  • Bin Peng and
  • Zhen-Qiang Wu

To investigate the effects of fusel alcohols on the intoxicating degree of liquor products, formulated liquors (FLs) were prepared by blending 1-propanol, isobutanol, and isoamyl alcohol with ethanol, organic acids, and corresponding ethyl esters to...

  • Article
  • Open Access
13 Citations
5,456 Views
10 Pages

A Recyclable, Metal-Free Mechanochemical Approach for the Oxidation of Alcohols to Carboxylic Acids

  • Kendra Leahy Denlinger,
  • Preston Carr,
  • Daniel C. Waddell and
  • James Mack

16 January 2020

The oxidation of primary alcohols under mechanochemical conditions in a Spex8000M Mixer/Mill was investigated. To facilitate ease of separation and recyclability, a polystyrene-bound version of a TEMPO catalyst was employed. When paired with Oxone&re...

  • Review
  • Open Access
37 Citations
33,437 Views
31 Pages

Millions of people around the world drink alcoholic beverages to cope with the stress of modern lifestyle. Although moderate alcohol drinking may have some relaxing and euphoric effects, uncontrolled drinking exacerbates the problems associated with...

  • Review
  • Open Access
27 Citations
46,748 Views
18 Pages

Key Signaling in Alcohol-Associated Liver Disease: The Role of Bile Acids

  • Grayson W. Way,
  • Kaitlyn G. Jackson,
  • Shreya R. Muscu and
  • Huiping Zhou

18 April 2022

Alcohol-associated liver disease (ALD) is a spectrum of diseases, the onset and progression of which are due to chronic alcohol use. ALD ranges, by increasing severity, from hepatic steatosis to alcoholic hepatitis (AH) and alcohol-associated cirrhos...

  • Article
  • Open Access
3 Citations
2,808 Views
11 Pages

This study focused on applying a patented medium-chain fatty acids (MCFAs) mixture at the end of alcoholic fermentation and monitoring its residues. MCFAs are a promising agent that has the potential to increase the efficiency of sulfur dioxide and u...

  • Article
  • Open Access
11 Citations
8,305 Views
15 Pages

23 February 2021

Solvent extraction is one of the common methods for the recovery of boric acid (or boron) from aqueous solutions. A wide variety of different compounds including monohydric alcohols has been tested, and there is wide recognition that they are rather...

  • Article
  • Open Access
27 Citations
8,080 Views
16 Pages

16 October 2015

Alcohol consumption causes nicotinic acid deficiency. The present study was undertaken to determine whether dietary nicotinic acid supplementation provides beneficial effects on alcohol-induced endotoxin signaling and the possible mechanisms at the g...

  • Opinion
  • Open Access
1,359 Views
7 Pages

Prenatal Alcohol Exposure and Congenital Heart Defects: Retinoic Acid Deficiency as a Potential Mechanism in Dextro-Type Transposition of the Great Arteries

  • Roberto Paparella,
  • Carolina Putotto,
  • Marco Fiore,
  • Fiorenza Colloridi,
  • Paolo Versacci,
  • Mauro Ceccanti,
  • Bruno Marino and
  • Luigi Tarani

Fetal alcohol spectrum disorder (FASD) is a preventable cause of developmental disabilities linked to prenatal alcohol exposure (PAE). Congenital heart defects (CHDs) are frequently observed in FASD, with a notable association between PAE and dextro-...

  • Article
  • Open Access
3 Citations
1,952 Views
18 Pages

Green Radish Polysaccharide Prevents Alcoholic Liver Injury by Interfering with Intestinal Bacteria and Short-Chain Fatty Acids in Mice

  • Xiong Geng,
  • Miaomiao Zhuang,
  • Weina Tian,
  • Huayan Shang,
  • Ziyi Gong,
  • Yanfang Lv and
  • Jianrong Li

22 November 2024

This study aimed to ascertain the potential benefits of green radish polysaccharide (GRP) in treating alcoholic liver disease (ALD) in mice and explore its mechanism of action. Using biochemical analysis, high-throughput sequencing of gut microbiota,...

  • Article
  • Open Access
6 Citations
3,113 Views
12 Pages

Green Catalytic Conversion of Some Benzylic Alcohols to Acids by NiO2 Nanoparticles (NPNPs) in Water

  • Abdel Ghany F. Shoair,
  • Mai M. A. H. Shanab,
  • Nasser A. El-Ghamaz,
  • Mortaga M. Abou-Krisha,
  • Sayed H. Kenawy and
  • Tarek A. Yousef

23 March 2023

The aqueous basic systems NiSO4·6H2O/K2S2O8 (pH = 14) and NiSO4·6H2O/KBrO3 (pH = 11.5) were investigated for the catalytic conversion of benzyl alcohol and some para-substituted benzyl alcohols to their corresponding acids in 75–9...

  • Article
  • Open Access
20 Citations
9,369 Views
20 Pages

2 September 2013

Crude bio-oil from pine chip fast pyrolysis was upgraded with olefins (1-octene, cyclohexene, 1,7-octadiene, and 2,4,4-trimethylpentene) plus 1-butanol (iso-butanol, t-butanol and ethanol) at 120 °C using a silica sulfuric acid (SSA) catalyst that po...

  • Article
  • Open Access
2 Citations
2,004 Views
21 Pages

29 August 2024

Ganoderma lucidum, used in East Asia for its health benefits, contains ganoderic acids (GA) which have various pharmacological activities but are limited by poor water solubility and low oral bioaccessibility. This study synthesized and characterized...

  • Article
  • Open Access
6 Citations
2,389 Views
20 Pages

Dietary Long-Chain Fatty Acids Accelerate Metabolic Dysfunction in Guinea Pigs with Non-Alcoholic Steatohepatitis

  • Kamilla Pedersen,
  • David Højland Ipsen,
  • Josephine Skat-Rørdam,
  • Jens Lykkesfeldt and
  • Pernille Tveden-Nyborg

24 May 2023

The composition of dietary fatty acids may be important for the development and progression of metabolic syndrome and non-alcoholic steatohepatitis (NASH). This study investigated the effect of two high-fat diets based on coconut oil, containing pred...

  • Feature Paper
  • Article
  • Open Access
36 Citations
5,419 Views
13 Pages

Batch Syngas Fermentation by Clostridium carboxidivorans for Production of Acids and Alcohols

  • Fabiana Lanzillo,
  • Giacomo Ruggiero,
  • Francesca Raganati,
  • Maria Elena Russo and
  • Antonio Marzocchella

1 September 2020

Syngas (CO, CO2, and H2) has attracted special attention due to the double benefit of syngas fermentation for carbon sequestration (pollution reduction), while generating energy. Syngas can be either produced by gasification of biomasses or as a by-p...

  • Proceeding Paper
  • Open Access
2,253 Views
6 Pages

30 November 2023

The upgrading of fatty alcohols synthesis from natural fatty acid methyl esters’ reduction using alumina-supported NaBH4 without H2 supply was investigated. It was possible to synthesize fatty alcohols efficiently with high yields. By using pur...

  • Article
  • Open Access
11 Citations
4,205 Views
20 Pages

9 April 2024

Alcohol abuse can lead to alcoholic liver disease, becoming a major global burden. Hovenia dulcis fruit peduncle polysaccharides (HDPs) have the potential to alleviate alcoholic liver injury and play essential roles in treating alcohol-exposed liver...

  • Article
  • Open Access
29 Citations
5,205 Views
16 Pages

Modulation of the Bile Acid Enterohepatic Cycle by Intestinal Microbiota Alleviates Alcohol Liver Disease

  • Dragos Ciocan,
  • Madeleine Spatz,
  • Nicolas Trainel,
  • Kévin Hardonnière,
  • Séverine Domenichini,
  • Françoise Mercier-Nomé,
  • Aurore Desmons,
  • Lydie Humbert,
  • Sylvère Durand and
  • Guido Kroemer
  • + 4 authors

11 March 2022

Reshaping the intestinal microbiota by the ingestion of fiber, such as pectin, improves alcohol-induced liver lesions in mice by modulating bacterial metabolites, including indoles, as well as bile acids (BAs). In this context, we aimed to elucidate...

  • Article
  • Open Access
1 Citations
2,003 Views
11 Pages

Background: Even though many metabolic liver diseases can now be diagnosed using blood tests and diagnostic imaging, early diagnosis remains difficult. Understanding mechanisms contributing to the progression from Metabolic Dysfunction-Associated Ste...

  • Article
  • Open Access
21 Citations
3,774 Views
14 Pages

28 March 2023

Alcoholic fatty liver disease (AFLD) is caused by long-term heavy alcohol consumption; therefore, useful and practical methods for the prevention of AFLD are urgently needed. The edible flower of Dendrobium officinale contains diverse flavonoids, and...

  • Article
  • Open Access
4 Citations
2,325 Views
13 Pages

Co-hydrothermal carbonization (co-HTC) of N-rich and lignocellulosic biomass is a potential way to produce hydrochar with high yield and quality, but the nitrogen will also enrich in a solid product. In this study, a novel co-HTC with acid–alco...

  • Article
  • Open Access
20 Citations
3,928 Views
16 Pages

3 December 2021

This study reports the in-depth investigation of the thermophysical properties and thermal reliability of caprylic acid-stearyl alcohol (CA-SA) eutectic phase change material (PCM) for cooling applications. The phase diagram of CA-SA showed a eutecti...

  • Article
  • Open Access
653 Views
19 Pages

Docosahexaenoic Acid Increases the Pro-Resolving Brain Lipid Mediators of Inflammation in Rat Pups Prenatally Exposed to Alcohol

  • Enrique M. Ostrea,
  • Deepak Yadav,
  • Charlie T. Cheng,
  • Esther D. Kisseih,
  • Krishna R. Maddipati and
  • Ronald L. Thomas

29 September 2025

Fetal alcohol spectrum disorder (FASD/FAS) is a chronic inflammatory process of the fetal brain induced by alcohol and mediated by pro-inflammatory (PILM) and pro-resolving (PRLM) lipid mediators of inflammation. DHA (docosahexaenoic acid) is an esse...

  • Article
  • Open Access
43 Citations
4,298 Views
14 Pages

Bacterial Diversity and Lactic Acid Bacteria with High Alcohol Tolerance in the Fermented Grains of Soy Sauce Aroma Type Baijiu in North China

  • Jiali Wang,
  • Chengshun Lu,
  • Qiang Xu,
  • Zhongyuan Li,
  • Yajian Song,
  • Sa Zhou,
  • Tongcun Zhang and
  • Xuegang Luo

17 June 2022

Soy sauce aroma type baijiu (also known as Maotai-flavor baijiu) is one of the most popular types of baijiu in China. Traditionally, it is mainly produced in Southwest China. However, in recent decades, some other regions in China have also been able...

  • Article
  • Open Access
31 Citations
4,514 Views
19 Pages

13 December 2018

By catalyzing the hydrolysis of sphingomyelin into ceramide, acid sphingomyelinase (ASM) changes the local composition of the plasma membrane with effects on receptor-mediated signaling. Altered enzyme activities have been noted in common human disea...

  • Article
  • Open Access
36 Citations
7,376 Views
18 Pages

Ellagic Acid Prevents Binge Alcohol-Induced Leaky Gut and Liver Injury through Inhibiting Gut Dysbiosis and Oxidative Stress

  • Dong-ha Kim,
  • Yejin Sim,
  • Jin-hyeon Hwang,
  • In-Sook Kwun,
  • Jae-Hwan Lim,
  • Jihoon Kim,
  • Jee-In Kim,
  • Moon-Chang Baek,
  • Mohammed Akbar and
  • Wonhyo Seo
  • + 3 authors

30 August 2021

Alcoholic liver disease (ALD) is a major liver disease worldwide and can range from simple steatosis or inflammation to fibrosis/cirrhosis, possibly through leaky gut and systemic endotoxemia. Many patients with alcoholic steatohepatitis (ASH) die wi...

  • Article
  • Open Access
8 Citations
3,298 Views
15 Pages

Plasma Concentrations of Lysophosphatidic Acid and Autotaxin in Abstinent Patients with Alcohol Use Disorder and Comorbid Liver Disease

  • María Flores-López,
  • Nuria García-Marchena,
  • Francisco Javier Pavon,
  • Estrella Lara,
  • Oscar Porras-Perales,
  • Pedro Araos,
  • Nerea Requena-Ocaña,
  • Sandra Torres-Galván,
  • M. Carmen Mañas-Padilla and
  • Gabriel Rubio
  • + 6 authors

13 September 2021

Lysophosphatidic acid (LPA) is an endogenous lysophospholipid and a bioactive lipid that is synthesized by the enzyme autotaxin (ATX). The ATX–LPA axis has been associated with cognitive dysfunction and inflammatory diseases, mainly in a range of non...

  • Article
  • Open Access
19 Citations
4,236 Views
13 Pages

13 October 2021

Alcohol-related liver disease (ALD) is characterized by accumulation of hepatic free fatty acids (FFAs) and liver injury. The present study aimed to investigate if mechanistic target of rapamycin complex 1 (mTORC1) plays a role in FFA-induced organel...

  • Article
  • Open Access
37 Citations
4,080 Views
11 Pages

Biological Evaluation of Polyvinyl Alcohol Hydrogels Enriched by Hyaluronic Acid and Hydroxyapatite

  • Petra Chocholata,
  • Vlastimil Kulda,
  • Jana Dvorakova,
  • Jana Kolaja Dobra and
  • Vaclav Babuska

10 August 2020

This study aimed to develop polyvinyl alcohol (PVA) -based scaffold enriched with hyaluronic acid (HA) and hydroxyapatite (HAp) using physical crosslinking by freezing–thawing method. We accomplished biological evaluation of scaffolds, swelling...

  • Review
  • Open Access
232 Citations
21,447 Views
37 Pages

Oxidative Stress and Non-Alcoholic Fatty Liver Disease: Effects of Omega-3 Fatty Acid Supplementation

  • Jinchunzi Yang,
  • Marta Fernández-Galilea,
  • Leyre Martínez-Fernández,
  • Pedro González-Muniesa,
  • Adriana Pérez-Chávez,
  • J. Alfredo Martínez and
  • Maria J. Moreno-Aliaga

18 April 2019

Aging is a complex phenomenon characterized by the progressive loss of tissue and organ function. The oxidative-stress theory of aging postulates that age-associated functional losses are due to the accumulation of ROS-induced damage. Liver function...

  • Article
  • Open Access
17 Citations
4,624 Views
13 Pages

Nanocarbon from Rocket Fuel Waste: The Case of Furfuryl Alcohol-Fuming Nitric Acid Hypergolic Pair

  • Nikolaos Chalmpes,
  • Athanasios B. Bourlinos,
  • Smita Talande,
  • Aristides Bakandritsos,
  • Dimitrios Moschovas,
  • Apostolos Avgeropoulos,
  • Michael A. Karakassides and
  • Dimitrios Gournis

22 December 2020

In hypergolics two substances ignite spontaneously upon contact without external aid. Although the concept mostly applies to rocket fuels and propellants, it is only recently that hypergolics has been recognized from our group as a radically new meth...

  • Article
  • Open Access
10 Citations
5,234 Views
10 Pages

Alcoholic beverages stimulate pancreatic enzyme secretions by inducing cholecystokinin (CCK) release. CCK is the major stimulatory hormone of pancreatic exocrine secretions, secreted from enteroendocrine I-cells of the intestine. Fermentation product...

  • Article
  • Open Access
4 Citations
2,166 Views
11 Pages

3 December 2023

An efficient and convenient method for the synthesis of phenols and aliphatic alcohols is described in this paper. The oxidative hydroxylation reaction of various organoboron compounds proceeded smoothly by employing H2O2 as the oxidant and citric ac...

  • Article
  • Open Access
2,096 Views
30 Pages

Alpha-Lipoic Acid in Early-Stage Alcohol-Related Brain Damage in Rats: A Comparative Pilot Study

  • Hristian Staykov,
  • Stela Dragomanova,
  • Yordan Hodzhev,
  • Valya Grigorova,
  • Borislav Minchev,
  • Diamara Uzunova,
  • Ani Georgieva,
  • Inna Sulikovska,
  • Katerina Todorova and
  • Elina Tsvetanova
  • + 6 authors

7 October 2025

Alcohol misuse can lead to alcohol-related brain damage (ARBD), a condition linked to long-term cognitive impairment and considerable disease burden. The pharmacological characteristics of alpha-lipoic acid (ALA) make it a promising candidate for the...

of 102