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Open AccessArticle

Biological Evaluation of Polyvinyl Alcohol Hydrogels Enriched by Hyaluronic Acid and Hydroxyapatite

Department of Medical Chemistry and Biochemistry, Faculty of Medicine in Pilsen, Charles University, Karlovarska 48, 301 66 Plzen, Czech Republic
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Int. J. Mol. Sci. 2020, 21(16), 5719; https://doi.org/10.3390/ijms21165719
Received: 20 July 2020 / Revised: 4 August 2020 / Accepted: 6 August 2020 / Published: 10 August 2020
(This article belongs to the Special Issue Polymeric Scaffolds: Design, Processing, and Biomedical Application)
This study aimed to develop polyvinyl alcohol (PVA) -based scaffold enriched with hyaluronic acid (HA) and hydroxyapatite (HAp) using physical crosslinking by freezing–thawing method. We accomplished biological evaluation of scaffolds, swelling degree, bioactivity assessment, and hemolytic test. The results showed that all types of scaffolds should be safe for use in the human body. The culturing of human osteoblast-like cells MG-63 and their proliferation showed better adhesion of cells due to the presence of HA and confirmed better proliferation depending on the amount of HAp. This paper gives the optimal composition of the scaffold and the optimal amount of the particular components of the scaffold. Based on our results we concluded that the best PVA/HA/HAp combination is in the ratio 3:1:2. View Full-Text
Keywords: scaffold; polyvinyl alcohol; hyaluronic acid; hydroxyapatite; bone tissue engineering; biological evaluation scaffold; polyvinyl alcohol; hyaluronic acid; hydroxyapatite; bone tissue engineering; biological evaluation
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Chocholata, P.; Kulda, V.; Dvorakova, J.; Kolaja Dobra, J.; Babuska, V. Biological Evaluation of Polyvinyl Alcohol Hydrogels Enriched by Hyaluronic Acid and Hydroxyapatite. Int. J. Mol. Sci. 2020, 21, 5719.

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