Next Article in Journal
Induction of Glucoraphasatin Biosynthesis Genes by MYB29 in Radish (Raphanus sativus L.) Roots
Next Article in Special Issue
Collagen/Chitosan Functionalization of Complex 3D Structures Fabricated by Laser Direct Writing via Two-Photon Polymerization for Enhanced Osteogenesis
Previous Article in Journal
Dietary Phenolics against Breast Cancer. A Critical Evidence-Based Review and Future Perspectives
Previous Article in Special Issue
Benefits of Polydopamine as Particle/Matrix Interface in Polylactide/PD-BaSO4 Scaffolds
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
IJMS
Volume 21
Issue 16
10.3390/ijms21165719
ijms-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Biological Evaluation of Polyvinyl Alcohol Hydrogels Enriched by Hyaluronic Acid and Hydroxyapatite

by
Petra Chocholata
,
Vlastimil Kulda
,
Jana Dvorakova
,
Jana Kolaja Dobra
and
Vaclav Babuska
*
Department of Medical Chemistry and Biochemistry, Faculty of Medicine in Pilsen, Charles University, Karlovarska 48, 301 66 Plzen, Czech Republic
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(16), 5719; https://doi.org/10.3390/ijms21165719
Submission received: 20 July 2020 / Revised: 4 August 2020 / Accepted: 6 August 2020 / Published: 10 August 2020
(This article belongs to the Special Issue Polymeric Scaffolds: Design, Processing, and Biomedical Application)
Browse Figures
Versions Notes

Abstract

This study aimed to develop polyvinyl alcohol (PVA) -based scaffold enriched with hyaluronic acid (HA) and hydroxyapatite (HAp) using physical crosslinking by freezing–thawing method. We accomplished biological evaluation of scaffolds, swelling degree, bioactivity assessment, and hemolytic test. The results showed that all types of scaffolds should be safe for use in the human body. The culturing of human osteoblast-like cells MG-63 and their proliferation showed better adhesion of cells due to the presence of HA and confirmed better proliferation depending on the amount of HAp. This paper gives the optimal composition of the scaffold and the optimal amount of the particular components of the scaffold. Based on our results we concluded that the best PVA/HA/HAp combination is in the ratio 3:1:2.
Keywords: scaffold; polyvinyl alcohol; hyaluronic acid; hydroxyapatite; bone tissue engineering; biological evaluation scaffold; polyvinyl alcohol; hyaluronic acid; hydroxyapatite; bone tissue engineering; biological evaluation

Share and Cite

MDPI and ACS Style

Chocholata, P.; Kulda, V.; Dvorakova, J.; Kolaja Dobra, J.; Babuska, V. Biological Evaluation of Polyvinyl Alcohol Hydrogels Enriched by Hyaluronic Acid and Hydroxyapatite. Int. J. Mol. Sci. 2020, 21, 5719. https://doi.org/10.3390/ijms21165719

AMA Style

Chocholata P, Kulda V, Dvorakova J, Kolaja Dobra J, Babuska V. Biological Evaluation of Polyvinyl Alcohol Hydrogels Enriched by Hyaluronic Acid and Hydroxyapatite. International Journal of Molecular Sciences. 2020; 21(16):5719. https://doi.org/10.3390/ijms21165719

Chicago/Turabian Style

Chocholata, Petra, Vlastimil Kulda, Jana Dvorakova, Jana Kolaja Dobra, and Vaclav Babuska. 2020. "Biological Evaluation of Polyvinyl Alcohol Hydrogels Enriched by Hyaluronic Acid and Hydroxyapatite" International Journal of Molecular Sciences 21, no. 16: 5719. https://doi.org/10.3390/ijms21165719

APA Style

Chocholata, P., Kulda, V., Dvorakova, J., Kolaja Dobra, J., & Babuska, V. (2020). Biological Evaluation of Polyvinyl Alcohol Hydrogels Enriched by Hyaluronic Acid and Hydroxyapatite. International Journal of Molecular Sciences, 21(16), 5719. https://doi.org/10.3390/ijms21165719

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop