Next Article in Journal
Clinical Management of Intermittent Fasting in Patients with Diabetes Mellitus
Previous Article in Journal
Putative Effects of Nutritive Polyphenols on Bone Metabolism In Vivo—Evidence from Human Studies
Previous Article in Special Issue
Dietary Polyphenols Targeting Arterial Stiffness: Interplay of Contributing Mechanisms and Gut Microbiome-Related Metabolism
Open AccessEditor’s ChoiceReview

Oxidative Stress and Non-Alcoholic Fatty Liver Disease: Effects of Omega-3 Fatty Acid Supplementation

1
Centre for Nutrition Research, School of Pharmacy and Nutrition, University of Navarra, 31008 Pamplona, Spain
2
Department of Nutrition, Food Science and Physiology, School of Pharmacy and Nutrition, University of Navarra, 31008 Pamplona, Spain
3
IDISNA, Navarra’s Health Research Institute, 31008 Pamplona, Spain
4
CIBERobn Physiopathology of Obesity and Nutrition, Centre of Biomedical Research Network, ISCIII, 28029 Madrid, Spain
*
Author to whom correspondence should be addressed.
Equal authorship.
Nutrients 2019, 11(4), 872; https://doi.org/10.3390/nu11040872
Received: 29 March 2019 / Revised: 12 April 2019 / Accepted: 15 April 2019 / Published: 18 April 2019
(This article belongs to the Special Issue Antioxidant Intake in Older Adults and Elderly People)
Aging is a complex phenomenon characterized by the progressive loss of tissue and organ function. The oxidative-stress theory of aging postulates that age-associated functional losses are due to the accumulation of ROS-induced damage. Liver function impairment and non-alcoholic fatty liver disease (NAFLD) are common among the elderly. NAFLD can progress to non-alcoholic steatohepatitis (NASH) and evolve to hepatic cirrhosis or hepatic carcinoma. Oxidative stress, lipotoxicity, and inflammation play a key role in the progression of NAFLD. A growing body of evidence supports the therapeutic potential of omega-3 polyunsaturated fatty acids (n-3 PUFA), mainly docosahaexenoic (DHA) and eicosapentaenoic acid (EPA), on metabolic diseases based on their antioxidant and anti-inflammatory properties. Here, we performed a systematic review of clinical trials analyzing the efficacy of n-3 PUFA on both systemic oxidative stress and on NAFLD/NASH features in adults. As a matter of fact, it remains controversial whether n-3 PUFA are effective to counteract oxidative stress. On the other hand, data suggest that n-3 PUFA supplementation may be effective in the early stages of NAFLD, but not in patients with more severe NAFLD or NASH. Future perspectives and relevant aspects that should be considered when planning new randomized controlled trials are also discussed. View Full-Text
Keywords: oxidative stress; non-alcoholic fatty liver disease; aging; omega-3 fatty acids oxidative stress; non-alcoholic fatty liver disease; aging; omega-3 fatty acids
Show Figures

Figure 1

  • Externally hosted supplementary file 1
    Link: http://xxxxxxxxx
    Description: Response to reviewers
MDPI and ACS Style

Yang, J.; Fernández-Galilea, M.; Martínez-Fernández, L.; González-Muniesa, P.; Pérez-Chávez, A.; Martínez, J.A.; Moreno-Aliaga, M.J. Oxidative Stress and Non-Alcoholic Fatty Liver Disease: Effects of Omega-3 Fatty Acid Supplementation. Nutrients 2019, 11, 872. https://doi.org/10.3390/nu11040872

AMA Style

Yang J, Fernández-Galilea M, Martínez-Fernández L, González-Muniesa P, Pérez-Chávez A, Martínez JA, Moreno-Aliaga MJ. Oxidative Stress and Non-Alcoholic Fatty Liver Disease: Effects of Omega-3 Fatty Acid Supplementation. Nutrients. 2019; 11(4):872. https://doi.org/10.3390/nu11040872

Chicago/Turabian Style

Yang, Jinchunzi; Fernández-Galilea, Marta; Martínez-Fernández, Leyre; González-Muniesa, Pedro; Pérez-Chávez, Adriana; Martínez, J. A.; Moreno-Aliaga, Maria J. 2019. "Oxidative Stress and Non-Alcoholic Fatty Liver Disease: Effects of Omega-3 Fatty Acid Supplementation" Nutrients 11, no. 4: 872. https://doi.org/10.3390/nu11040872

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop