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Alcohol Interaction with Cocaine, Methamphetamine, Opioids, Nicotine, Cannabis, and γ-Hydroxybutyric Acid

Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA
Biomedicines 2019, 7(1), 16; https://doi.org/10.3390/biomedicines7010016
Received: 9 January 2019 / Revised: 21 February 2019 / Accepted: 27 February 2019 / Published: 7 March 2019
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Abstract

Millions of people around the world drink alcoholic beverages to cope with the stress of modern lifestyle. Although moderate alcohol drinking may have some relaxing and euphoric effects, uncontrolled drinking exacerbates the problems associated with alcohol abuse that are exploding in quantity and intensity in the United States and around the world. Recently, mixing of alcohol with other drugs of abuse (such as opioids, cocaine, methamphetamine, nicotine, cannabis, and γ-hydroxybutyric acid) and medications has become an emerging trend, exacerbating the public health concerns. Mixing of alcohol with other drugs may additively or synergistically augment the seriousness of the adverse effects such as the withdrawal symptoms, cardiovascular disorders, liver damage, reproductive abnormalities, and behavioral abnormalities. Despite the seriousness of the situation, possible mechanisms underlying the interactions is not yet understood. This has been one of the key hindrances in developing effective treatments. Therefore, the aim of this article is to review the consequences of alcohol’s interaction with other drugs and decipher the underlying mechanisms. View Full-Text
Keywords: alcohol; addiction; withdrawal; cocaine; methamphetamine (METH); nicotine; marijuana; opioids; γ-aminobutyric acid (GABA) alcohol; addiction; withdrawal; cocaine; methamphetamine (METH); nicotine; marijuana; opioids; γ-aminobutyric acid (GABA)
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Singh, A.K. Alcohol Interaction with Cocaine, Methamphetamine, Opioids, Nicotine, Cannabis, and γ-Hydroxybutyric Acid. Biomedicines 2019, 7, 16.

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