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94 Results Found

  • Article
  • Open Access
8 Citations
4,425 Views
15 Pages

Analysis of Chemical Constituents of Traditional Chinese Medicine Jianqu before and after Fermentation Based on LC-MS/MS

  • Yishuo Wang,
  • Ruisheng Wang,
  • Zhenling Zhang,
  • Yitian Chen,
  • Mengmei Sun,
  • Jia Qiao and
  • Ziwei Du

21 December 2022

Objective: To detect the chemical constituents in Jianqu samples under different fermentated states by using UPLC-QTOF-MS/MS technology, to conduct preliminary analyses, and to establish an HPLC method for the simultaneous determination of hesperidin...

  • Article
  • Open Access
1,753 Views
31 Pages

Amoxicillin and sulbactam are widely used in animal food compounding. Amoxicillin–sulbactam hybrid molecules are bicester compounds made by linking amoxicillin and sulbactam with methylene groups and have good application prospects. However, the resi...

  • Article
  • Open Access
2 Citations
1,758 Views
13 Pages

Serum Metabolomic Analysis of Synchronous Estrus in Yaks Based on UPLC-Q-TOF MS Technology

  • Fen Feng,
  • Chun Huang,
  • Dunzhu Luosang,
  • Xiaoming Ma,
  • Yongfu La,
  • Xiaoyun Wu,
  • Xian Guo,
  • Zhandui Pingcuo and
  • Chunnian Liang

7 May 2024

The yak is a unique species of livestock found in the Qinghai-Tibet Plateau and its surrounding areas. Due to factors such as late sexual maturity and a low rate of estrus, its reproductive efficiency is relatively low. The process of estrus synchron...

  • Article
  • Open Access
25 Citations
5,585 Views
19 Pages

22 February 2020

A method for the simultaneous determination of robenidine, halofuginone, lasalocid, monensin, nigericin, salinomycin, narasin, and maduramicin residues in eggs by liquid chromatography–tandem mass spectrometry (LC–MS/MS) was developed. Th...

  • Article
  • Open Access
38 Citations
5,970 Views
18 Pages

Cornus mas L. Stones: A Valuable by-Product as an Ellagitannin Source with High Antioxidant Potential

  • Dominika Przybylska,
  • Alicja Z. Kucharska,
  • Iwona Cybulska,
  • Tomasz Sozański,
  • Narcyz Piórecki and
  • Izabela Fecka

12 October 2020

The stone of Cornus mas L. remains the least known morphological part of this plant, whereas the fruit is appreciated for both consumption purposes and biological activity. The stone is considered to be a byproduct of fruit processing and very little...

  • Article
  • Open Access
21 Citations
4,548 Views
20 Pages

Quantification of 15 Antibiotics Widely Used in the Critical Care Unit with a LC-MS/MS System: An Easy Method to Perform a Daily Therapeutic Drug Monitoring

  • Catherine Feliu,
  • Celine Konecki,
  • Tristan Candau,
  • Damien Vautier,
  • Cyril Haudecoeur,
  • Claire Gozalo,
  • Yoann Cazaubon and
  • Zoubir Djerada

24 November 2021

Potential under- or overdose of antibiotics may occur in intensive care units due to high variability in plasma concentrations. The risk is either treatment failure or toxicity. Thus, therapeutic drug monitoring of antibiotics may guide dosing adjust...

  • Article
  • Open Access
36 Citations
4,695 Views
15 Pages

The discovery of medicinal plants is crucial for drug development. Eucalyptus globulus leaves are used as a traditional medicine in many areas of world due to herbicidal and insecticidal activity. While natural products are difficult to be separated...

  • Article
  • Open Access
9 Citations
3,256 Views
24 Pages

Quality Markers’ Discovery and Quality Evaluation of Jigucao Capsule Using UPLC-MS/MS Method

  • Yanmei He,
  • Fangfang Wu,
  • Zhien Tan,
  • Mengli Zhang,
  • Taiping Li,
  • Aihua Zhang,
  • Jianhua Miao,
  • Min Ou,
  • Lihuo Long and
  • Hui Sun
  • + 1 author

Jigucao capsules (JGCC) have the effects of soothing the liver and gallbladder and clearing heat and detoxification. It is a good medicine for treating acute and chronic hepatitis cholecystitis with damp heat of the liver and gallbladder. However, th...

  • Article
  • Open Access
1 Citations
1,821 Views
20 Pages

Widely Targeted Metabolomics Reveal the Distribution of Metabolites in Shatian Pomelo Fruit

  • Jing Wen,
  • Haocheng Liu,
  • Huining Lai,
  • Yujuan Xu,
  • Jijun Wu,
  • Yuanshan Yu,
  • Wenqian Huang,
  • Manqin Fu and
  • Haiyang Liu

20 November 2024

Using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) technology in multiple reaction monitoring mode, a widely targeted metabolomics approach was employed to identify metabolites in five tissues (exocarp, endocarp, segm...

  • Review
  • Open Access
68 Citations
13,830 Views
17 Pages

Monitoring of patients with inherited metabolic disorders (IMDs) using dried blood spot (DBS) specimens has been routinely used since the inception of newborn screening (NBS) for phenylketonuria in the 1960s. The introduction of flow injection analys...

  • Article
  • Open Access
1,672 Views
15 Pages

27 July 2024

Pak choi exhibits a wide range of phenotypic and morphological variations, significantly impacting its carbohydrate composition. This study aimed to analyze these variations by employing UPLC-MS/MS technology on eight biological replicates of seven P...

  • Article
  • Open Access
83 Citations
6,904 Views
11 Pages

29 September 2018

A microwave-assisted extraction (MAE) technology optimized by response surface methodology (RSM) was established to extract phenolic compounds from the fruit of Melastoma sanguineum. The effects of solvent composition, ratio of solvent to material, t...

  • Article
  • Open Access
6 Citations
4,912 Views
12 Pages

Superior Stability of Hydroxysafflor Yellow A in Xuebijing Injection and the Associated Mechanism

  • Weiling Pu,
  • Huijie Zhang,
  • Meng Wang,
  • Yanan Liu,
  • Lili Sun and
  • Xiaoliang Ren

2 December 2017

Hydroxysafflor yellow A (HSYA) is the main bioactive ingredient of XBJ injection. At first, the stability of HSYA in solution and in a Xuebijing injection was investigated, then the mechanisms of the increased stability of HSYA in the XBJ injection w...

  • Article
  • Open Access
11 Citations
4,331 Views
13 Pages

Nanobody-Based Indirect Competitive ELISA for Sensitive Detection of 19-Nortestosterone in Animal Urine

  • Yuan-yuan Yang,
  • Yu Wang,
  • Yi-feng Zhang,
  • Feng Wang,
  • Yi-fan Liang,
  • Jin-yi Yang,
  • Zhen-lin Xu,
  • Yu-dong Shen and
  • Hong Wang

27 January 2021

Nanobody (Nb), a new type of biorecognition element generally from Camelidae, has the characteristics of small molecular weight, high stability, great solubility and high expression level in E. coli. In this study, with 19-nortestosterone (19-NT), an...

  • Article
  • Open Access
21 Citations
4,067 Views
17 Pages

The Inactivation by Curcumin-Mediated Photosensitization of Botrytis cinerea Spores Isolated from Strawberry Fruits

  • Li Huang,
  • Ken W. L. Yong,
  • W. Chrishanthi Fernando,
  • Matheus Carpinelli de Jesus,
  • James J. De Voss,
  • Yasmina Sultanbawa and
  • Mary T. Fletcher

9 March 2021

Photosensitization is a novel environmentally friendly technology with promising applications in the food industry to extend food shelf life. In this study, the natural food dye curcumin, when combined with visible light (430 nm), was shown to be an...

  • Article
  • Open Access
23 Citations
4,771 Views
18 Pages

13 May 2020

Many detection methods for phycotoxins, bioactive compounds produced by harmful algae, focus on one compound or a class of related compounds. Multiple harmful algal species often co-occur in the environment, however, emphasizing the need to analyze f...

  • Article
  • Open Access
4 Citations
1,560 Views
19 Pages

Inonotus hispidus (Bull.) P. Karst., is a medicinal fungus, which parasitizes broad-leaved tree such as Morus alba L., Fraxinus mandshurica Rupr., and Ulmus macrocarpa Hance. To elucidate the internal relationship between I. hispidus and its hosts, t...

  • Article
  • Open Access
1 Citations
2,540 Views
16 Pages

Electrodegradation of Acid Mixture Dye through the Employment Electrooxidation and Lemnoideae in Na2SO4 Synthetic Wastewater

  • Agnieszka Bęś,
  • Łukasz Sikorski,
  • Tomasz Mikołajczyk,
  • Mateusz Kuczyński,
  • Mateusz Łuba,
  • Bogusław Pierożyński and
  • Agnieszka Jasiecka-Mikołajczyk

29 August 2022

In this study, we report on the effectiveness of electrochemical and biological wastewater treatment for artificially prepared industrial wastewater, comprising small amounts of technologically important dyes, namely Acid Mixture composed of Acid Vio...

  • Article
  • Open Access
75 Citations
7,569 Views
29 Pages

Phenolic and Antioxidant Analysis of Olive Leaves Extracts (Olea europaea L.) Obtained by High Voltage Electrical Discharges (HVED)

  • Irena Žuntar,
  • Predrag Putnik,
  • Danijela Bursać Kovačević,
  • Marinela Nutrizio,
  • Filip Šupljika,
  • Andreja Poljanec,
  • Igor Dubrović,
  • Francisco J. Barba and
  • Anet Režek Jambrak

8 July 2019

Background: The aim of this study was to evaluate high voltage electrical discharges (HVED) as a green technology, in order to establish the effectiveness of phenolic extraction from olive leaves against conventional extraction (CE). HVED parameters...

  • Article
  • Open Access
3 Citations
2,359 Views
16 Pages

UPLC–MS/MS and Gene Expression Research to Distinguish the Colour Differences of Rhododendron liliiflorum H. Lév

  • Jin Dai,
  • Xinglin Wang,
  • Xingpan Meng,
  • Xu Zhang,
  • Qihang Zhou,
  • Zhengdong Zhang,
  • Ximin Zhang,
  • Yin Yi,
  • Lunxian Liu and
  • Tie Shen

Among ornamental plants, the colour of the petals is an important feature. However, the reason for the colour differences of Rhododendron liliiflorum remains unclear. To reveal the differences in the colour of R. liliiflorum, high-efficiency liquid c...

  • Article
  • Open Access
1 Citations
2,100 Views
17 Pages

31 August 2024

Despite a higher safety profile compared to vitamin K antagonists, rivaroxaban therapy is still connected with multiple adverse effects, such as a high risk of bleeding. Thus, therapeutic drug monitoring (TDM) of rivaroxaban concentrations is suggest...

  • Article
  • Open Access
4,883 Views
12 Pages

The Pharmacokinetic and Absolute Bioavailability of Cyclosporine (Atopica for Cats®) in Cats

  • Jingyuan Kong,
  • Yuxin Yang,
  • Yu Liu,
  • Yuying Cao,
  • Jicheng Qiu,
  • Pan Sun and
  • Xingyuan Cao

18 June 2023

This study aimed to evaluate the absolute bioavailability of cyclosporine in cats by investigating the pharmacokinetic profile after intravenous and oral administration, respectively. Twenty-four clinically healthy cats were enrolled in this study an...

  • Article
  • Open Access
8 Citations
3,140 Views
15 Pages

30 December 2022

Phelipanche aegyptiaca Pers. is a holoparasitic plant that causes tremendous losses of agricultural crops worldwide. The initiation and development of the haustoria (special intrusive organs) is a key step in the growth of parasitic plants. The initi...

  • Article
  • Open Access
1 Citations
3,282 Views
17 Pages

Dodder Parasitism Leads to the Enrichment of Pathogen Alternaria and Flavonoid Metabolites in Soybean Root

  • Wen Luo,
  • Yuanli Li,
  • Ruiping Luo,
  • Gehong Wei,
  • Yongxin Liu and
  • Weimin Chen

9 June 2023

Dodders (Cuscuta chinensis) are rootless and holoparasitic herbs that can infect a variety of host plants, including the vitally important economic and bioenergy crop soybean (Glycine max). Although dodder parasitism severely affects the physiology o...

  • Article
  • Open Access
3 Citations
1,701 Views
22 Pages

Formononetin (FM), an isoflavone with a range of anti-cancer activities, has not been fully elucidated regarding its anti-hepatocellular carcinoma (HCC) mechanisms. Therefore, this study aims to explore the underlying mechanisms of FM using a compreh...

  • Article
  • Open Access
13 Citations
3,254 Views
14 Pages

18 August 2022

Lipid components in green coffee were clarified to provide essential data support for green coffee processing. The types, components, and relative contents of lipids in green coffee were first analyzed by ultra-performance liquid chromatography&ndash...

  • Article
  • Open Access
21 Citations
9,349 Views
16 Pages

Phytochemical, Technological, and Pharmacological Study on the Galenic Dry Extracts Prepared from German Chamomile (Matricaria chamomilla L.) Flowers

  • Janne Sepp,
  • Oleh Koshovyi,
  • Valdas Jakstas,
  • Vaidotas Žvikas,
  • Iryna Botsula,
  • Igor Kireyev,
  • Karina Tsemenko,
  • Oleksandr Kukhtenko,
  • Karin Kogermann and
  • Jyrki Heinämäki
  • + 1 author

24 January 2024

Galenic preparations of German chamomile are used to treat mild skin diseases, inflammation, and spasms, and they have also been reported to have anxiolytic and sedative effects. The medicinal use of chamomile is well known in ethnomedicine. After ob...

  • Article
  • Open Access
3 Citations
2,574 Views
21 Pages

Interventional Effect of Donkey Bone Collagen Peptide Iron Chelate on Cyclophosphamide Induced Immunosuppressive Mice

  • Xiang-Rong Cheng,
  • Zi-Wei Zhao,
  • Yu-Yao Chen,
  • Jie Song,
  • Jia-Hui Ma,
  • Chen-Xi Zhang,
  • Issoufou Amadou,
  • Nai-Yan Lu,
  • Xue Tang and
  • Bin Guan

25 July 2024

Immunodeficiency can disrupt normal physiological activity and function. In this study, donkey bone collagen peptide (DP) and its iron chelate (DPI) were evaluated their potential as immunomodulators in cyclophosphamide (Cytoxan®, CTX)-induced Ba...

  • Article
  • Open Access
1,115 Views
18 Pages

5 February 2025

Background: Semiliquidambar cathayensis Chang is an extremely valuable and endangered medicinal plant. To investigate the exploitation and rational utilization of S. cathayensis, this study conducted metabolomics analysis of the leaves and bark...

  • Article
  • Open Access
2 Citations
2,036 Views
25 Pages

Elucidating the Differentiation Synthesis Mechanisms of Differently Colored Resistance Quinoa Seedings Using Metabolite Profiling and Transcriptome Analysis

  • Junna Liu,
  • Jian Liu,
  • Ping Zhang,
  • Qianchao Wang,
  • Li Li,
  • Heng Xie,
  • Hanxue Li,
  • Hongxin Wang,
  • Shunhe Cheng and
  • Peng Qin

10 October 2023

Quinoa (Chenopodium quinoa wild.), a dicotyledonous plant native to the Andes, is an increasingly popular pseudograin owing to its high nutritional value, stress resistance capabilities, and gluten-free properties. In this study, we aimed to explore...

  • Article
  • Open Access
4 Citations
3,104 Views
16 Pages

Matrix-assisted laser-desorption/ionization time-of-flight (MALDI–TOF) mass spectrometry is a widely used and reliable technology to identify microbial species and subspecies. The current methodology is based on spectral fingerprinting, analyzing pro...

  • Article
  • Open Access
1 Citations
673 Views
15 Pages

22 September 2025

Amitriptyline (AMT), a widely prescribed antidepressant, and its metabolites have emerged as significant environmental contaminants, posing substantial risks to aquatic organisms and human health. Systematic and in-depth investigations into advanced...

  • Article
  • Open Access
40 Citations
4,686 Views
12 Pages

pH Effect and Chemical Mechanisms of Antioxidant Higenamine

  • Yulu Xie,
  • Xican Li,
  • Jingyu Chen,
  • Yuman Deng,
  • Wenbiao Lu and
  • Dongfeng Chen

29 August 2018

In this article, we determine the pH effect and chemical mechanism of antioxidant higenamine by using four spectrophotometric assays: (1) 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide radical (PTIO•)-scavenging assay (at pH 4.5, 6.0, an...

  • Article
  • Open Access
25 Citations
3,800 Views
12 Pages

26 November 2018

To clarify the role of the B-ring in antioxidant flavonols, we performed a comparative study between galangin with a null B-ring and 3,5,7-trihydroxychromone without a B-ring using five spectrophotometric assays, namely, •O2−-scavenging, 1...

  • Article
  • Open Access
19 Citations
3,581 Views
22 Pages

Metabolomic Profiling Reveals Protective Effects and Mechanisms of Sea Buckthorn Sterol against Carbon Tetrachloride-Induced Acute Liver Injury in Rats

  • Changting Sheng,
  • Yang Guo,
  • Jing Ma,
  • Eun-Kyung Hong,
  • Benyin Zhang,
  • Yongjing Yang,
  • Xiaofeng Zhang and
  • Dejun Zhang

29 March 2022

The present study was designed to examine the efficacy and protection mechanisms of sea buckthorn sterol (SBS) against acute liver injury induced by carbon tetrachloride (CCl4) in rats. Five-week-old male Sprague-Dawley (SD) rats were divided into si...

  • Article
  • Open Access
43 Citations
6,039 Views
16 Pages

Red pigment (RP) was extracted from the peels of Zanthoxylum bungeanum Maxim (PZB) by ultrasonic-assisted extraction (UAE) in this work. Box–Behnken design–response surface methodology (BBD-RSM) was employed to research the efficiency of...

  • Article
  • Open Access
35 Citations
5,062 Views
14 Pages

Evaluation of Antioxidant Capacity, Protective Effect on Human Erythrocytes and Phenolic Compound Identification in Two Varieties of Plum Fruit (Spondias spp.) by UPLC-MS

  • Karen L. Hernández-Ruiz,
  • Saul Ruiz-Cruz,
  • Luis A. Cira-Chávez,
  • Laura E. Gassos-Ortega,
  • José de Jesús Ornelas-Paz,
  • Carmen L. Del-Toro-Sánchez,
  • Enrique Márquez-Ríos,
  • Marco A. López-Mata and
  • Francisco Rodríguez-Félix

4 December 2018

Plum edible part was used to obtained extracts by during a 4 h maceration process using three different solvents (ethanol, methanol and water) for the determination of total phenols and flavonoids, antioxidant capacity by (2,2′-azino-bis(3-ethy...

  • Article
  • Open Access
8 Citations
2,398 Views
17 Pages

23 March 2024

Soil salinization is a major factor that reduces crop yields. There are some plant growth-promoting rhizobacteria (PGPR) that can stimulate and enhance the salt tolerance of plants near their roots in saline–alkali environments. Currently, ther...

  • Article
  • Open Access
3 Citations
2,182 Views
18 Pages

Effects of Postharvest SO2 Treatment on Longan Aril Flavor and Glucosinolate Metabolites

  • Rob Md Mahfuzur,
  • Dongmei Han,
  • Jianhang Xu,
  • Yuqiong Lin,
  • Xiaomeng Guo,
  • Tao Luo,
  • Zhenxian Wu,
  • Shilian Huang,
  • Xinmin Lv and
  • Junbin Wei

31 October 2024

SO2 fumigation treatment (commonly known as sulfur treatment, ST) is a key method in the postharvest preservation of imported and exported fresh longan fruits, effectively reducing pericarp browning and enhancing color. Nonetheless, distinctive aroma...

  • Article
  • Open Access
54 Citations
8,245 Views
15 Pages

31 August 2017

Natural borneol (NB, called “Bingpian”) is an important traditional Chinese medicine to restore consciousness, remove heat and relieve pain, all of which are inflammation-related diseases. Recently, due to the limited source of NB, synthetic borneol...

  • Article
  • Open Access
13 Citations
3,755 Views
12 Pages

11 March 2023

The avocado peel is a waste material from consumption avocado (Persea americana Mill.) with big biotechnology potential. The purpose of the present work was to study the influence of six extraction methods, maceration (M), maceration plus β-cycl...

  • Review
  • Open Access
11 Citations
8,243 Views
29 Pages

Over the years, there has been notable progress in understanding the pathogenesis and treatment modalities of diabetes and its complications, including the application of metabolomics in the study of diabetes, capturing attention from researchers wor...

  • Article
  • Open Access
1 Citations
1,961 Views
15 Pages

21 August 2025

Background: Liuwei Dihuang Pills, a classic traditional Chinese medicine formula, has been widely used in clinical practice for its multiple pharmacological effects. However, the systematic characterization and identification of its chemical constitu...

  • Article
  • Open Access
2 Citations
2,063 Views
14 Pages

Comparison of Aroma and Taste Profiles Between Two Fermented Pea Pastes Using Intelligent Sensory Analysis and Gas Chromatography–Mass Spectrometry

  • Tianyang Wang,
  • Lian Yang,
  • Wanting Tang,
  • Haibin Yuan,
  • Chuantao Zeng,
  • Ping Dong,
  • Yuwen Yi,
  • Jing Deng,
  • Huachang Wu and
  • Ju Guan

The traditionally produced pea paste (PP) suffers from suboptimal flavor and inferior quality. Based on the study of single-strain fermentation, we further selected S. cerevisiae, Z. rouxii, and L. paracasei for PP production by dual-strain fermentat...

  • Article
  • Open Access
1,709 Views
24 Pages

Mid-Level Data Fusion Techniques of LC-MS and HS-GC-MS for Distinguishing Green and Ripe Forsythiae Fructus

  • Qingling Xie,
  • Hanwen Yuan,
  • Shiqi Liu,
  • Ling Liang,
  • Jiangyi Luo,
  • Mengyun Wang,
  • Bin Li and
  • Wei Wang

21 March 2025

Forsythia suspensa is a crucial plant resource due to its considerable edible and medicinal value. Its fruit, named Forsythiae Fructus (FF), has been widely used in Traditional Chinese Medicine (TCM). According to the fruit maturity stage, FF is cate...

  • Article
  • Open Access
2 Citations
1,545 Views
13 Pages

Exploration of Freshness Identification Method for Refrigerated Vegetables Based on Metabolomics

  • Zixuan Meng,
  • Haichao Zhang,
  • Jing Wang,
  • Lianfeng Ai and
  • Weijun Kang

1 December 2024

Background: The rapid development of refrigerated transportation technology for fresh vegetables has extended their shelf life. Some vegetables may appear undamaged on the surface, but their freshness may have decreased, often resulting in the phenom...

  • Article
  • Open Access
7 Citations
3,450 Views
12 Pages

Mass Spectrometry-Based System for Identifying and Typing Norovirus Major Capsid Protein VP1

  • Pei-Yu Chu,
  • Hui-Wen Huang,
  • Michittra Boonchan,
  • Yu-Chang Tyan,
  • Kevin Leroy Louis,
  • Kun-Mu Lee,
  • Kazushi Motomura and
  • Liang-Yin Ke

22 November 2021

Norovirus-associated diseases are the most common foodborne illnesses worldwide. Polymerase chain reaction-based methods are the primary diagnostics for clinical samples; however, the high mutation rate of norovirus makes viral amplification and geno...

  • Article
  • Open Access
43 Citations
6,210 Views
22 Pages

Dynamic Changes in Metabolite Accumulation and the Transcriptome during Leaf Growth and Development in Eucommia ulmoides

  • Long Li,
  • Minhao Liu,
  • Kan Shi,
  • Zhijing Yu,
  • Ying Zhou,
  • Ruishen Fan and
  • Qianqian Shi

18 August 2019

Eucommia ulmoides Oliver is widely distributed in China. This species has been used mainly in medicine due to the high concentration of chlorogenic acid (CGA), flavonoids, lignans, and other compounds in the leaves and barks. However, the categories...

  • Article
  • Open Access
5 Citations
2,159 Views
22 Pages

15 April 2024

Marigold oleoresin is an oil-soluble natural colorant mainly extracted from marigold flowers. Xinjiang of China, India, and Zambia of Africa are the three main production areas of marigold flowers. Therefore, this study utilized ultra-performance liq...

  • Article
  • Open Access
22 Citations
4,399 Views
10 Pages

21 January 2021

The triticale grain has high nutritive value and good technological suitability. Triticale flour can be a valuable raw material for bread-making. The aim of this work was to determine the profile of phenolic acids in triticale grain of selected Polis...

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