736 Results Found

Proteasome inhibitors, like bortezomib, play a key role in the treatment of multiple myeloma (MM); however, most patients eventually relapse and eventually show multiple drug resistance, and the molecular mechanisms of this resistance remain unclear....

Diamond Blackfan anemia typically presents in infants and is often associated with many kinds of malformations. Severity of anemia often needs transfusional support in the first months of life. We describe here a patient with Diamond Blackfan anemia...

Colorectal cancer remains a significant global health concern. In this study, we investigated the anticancer potential of Circaea mollis Siebold & Zucc. (CS&Z), a traditional medicinal plant known for its anti-inflammatory, anti-arthritic, an...

The IPv6 Routing Protocol for Low-power and Lossy Networks (RPL) has been recently developed by the Internet Engineering Task Force (IETF). Given its crucial role in enabling the Internet of Things, a significant amount of research effort has already...

The Internet of Things (IoT) will bring together billions of devices, denoted as Smart Objects (SOs), in an Internet-like architecture. Typically, SOs are embedded devices with severe constraints in terms of processing capabilities, available memory...

Previously, Segev and Gerst found that mutants in any of the four ribosomal protein genes rpl1b, rpl2b, rps11a, or rps26b had a petite phenotype—i.e., the mutants were deficient in respiration. Strikingly, mutants of their paralogs rpl1a, rpl2a...

RPL is the IPv6 routing protocol for low-power and lossy networks in the Internet of Things which supports point-to-point (P2P) communication. However, the partition of two modes of operations (MOPs) in downward routing complicates achieving high per...

Diamond–Blackfan anemia (DBA) is a congenital bone marrow failure syndrome associated with malformations. DBA is related to defective ribosome biogenesis, which impairs erythropoiesis, causing hyporegenerative macrocytic anemia. The disease has...

Wireless multi-hop ad hoc routing is one of the critical design factors that determine the network performance of various wireless IoT applications. IETF has standardized the point-to-point RPL (P2P-RPL) routing protocol to overcome the inefficient r...

In recent years, mobility support has become an important requirement in various wireless sensor network (WSN) applications. However, due to the strict resource constraints of power, memory, and processing resources in WSNs, routing protocols are mai...

RPL (IPv6 routing protocol for low power and lossy networks) proposed by the IETF (Internet Engineering Task Force) ROLL (routing over low-power and lossy networks) working group is a de facto standard routing protocol for IoT environments. Since the...

The proliferation of the internet of things (IoT) technology has led to numerous challenges in various life domains, such as healthcare, smart systems, and mission-critical applications. The most critical issue is the security of IoT nodes, networks,...

RPL (routing protocol for low-power and lossy networks) is an important candidate routing algorithm for low-power and lossy network (LLN) scenarios. To solve the problems of using a single routing metric or no clearly weighting distribution theory of...

Recently, the Internet of Things (IoT) has emerged as an important way to connect diverse physical devices to the internet. The IoT paves the way for a slew of new cutting-edge applications. Despite the prospective benefits and many security solution...

The rpl1001 gene encodes 60S ribosomal protein L10, which is involved in intracellular protein synthesis and cell growth. However, it is not yet known whether it is involved in the regulation of cell mitosis dynamics. This study focuses on the growth...

IETF has standardized the point-to-point RPL (P2P-RPL) to ensure reliable and optimal P2P route discovery for low-power and lossy networks (LLNs). P2P-RPL propagates route discovery packets to all nodes in the network, which results in high routing c...

The rapid growth of the Internet of Things (IoT) and the massive propagation of wireless technologies has revealed recent opportunities for development in various domains of real life, such as smart cities and E-Health applications. A slight defense...

In IoT networks, the de facto Routing Protocol for Low Power and Lossy Networks (RPL) is vulnerable to various attacks. Routing attacks in RPL-based IoT are becoming critical with the increase in the number of IoT applications and devices globally. T...

Recurrent Pregnancy Loss (RPL) affects 1–2% of women, and its triggering factors are unclear. Several studies have shown that the vaginal, endometrial, and gut microbiota may play a role in RPL. A decrease in the quantity of Lactobacillus crisp...

Neonatal dilated cardiomyopathy (DCM) is rare with high etiologic heterogeneity. Recently, biallelic, autosomal recessive, pathogenic variants in RPL3L (ribosomal protein L3-like) have been reported in the literature with severe early-onset DCM. In t...

Spondyloepimetaphyseal dysplasia type Isidor-Toutain (RPL13-SEMD) is an autosomal dominant skeletal dysplasia caused by heterozygous pathogenic variants in the RPL13 gene, encoding the ribosomal protein eL13. To date, 13 pathogenic variants in RPL13...

Efficient and reliable data routing is critical in Advanced Metering Infrastructure (AMI) within Smart Grids, dictating the overall network performance and resilience. This paper introduces Q-RPL, a novel Q-learning-based Routing Protocol designed to...

RPL—Routing Protocol for Low-Power and Lossy Networks (usually pronounced “ripple”)—is the de facto standard for IoT networks. However, it neglects to exploit IoT devices’ full capacity to optimize their transmission pow...

Wireless sensor networks (WSNs) play a key role in the ecosystem of the Industrial Internet of Things (IIoT) and the definition of today’s Industry 4.0. These WSNs have the ability to sensor large amounts of data, thanks to their easy scalability. WS...

Routing Protocol for Low power and Lossy network (RPL) topology attacks can downgrade the network performance significantly by disrupting the optimal protocol structure. To detect such threats, we propose a RPL-specification, obtained by a semi-auto...

The IPv6 Routing Protocol for Low Power and Lossy Networks (RPL) was proposed for various applications of IPv6 low power wireless networks. While RPL supports various routing metrics and is designed to be suitable for wireless sensor network environm...

Previously we characterized radiophotoluminescent (RPL) detectors for measuring both fast and thermal neutrons for personal monitoring. The linear response and angular dependence, which satisfies the ISO 21909 standard makes their application possibl...

The Routing Protocol for Low-power and Lossy Networks (RPL) is a popular routing layer protocol for multi-hop Wireless Sensor Networks (WSNs). However, typical RPL configurations are based on decade-old assumptions, leading to a mismatch with: (1) ad...

Internet of Things (IoT) is evolving to multi-application scenarios in smart cities, which demand specific traffic patterns and requirements. Multi-applications share resources from a single multi-hop wireless networks, where smart devices collaborat...

MicroRNAs (miRNAs) are a class of small non-coding RNA molecules that regulate a countless number of genes in the cell, and the aberrant expression of miRNA can lead to cancer. Here, we demonstrate that miR-101-3p regulates the RPL11–MDM2&ndash...

RPL23A gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L23P family of ribosomal proteins, which is located in the cytoplasm. The purpose of this paper was to explore the structure and anti-cancer fu...

The increasing use of wireless communication and IoT devices has raised concerns about security, particularly with regard to attacks on the Routing Protocol for Low-Power and Lossy Networks (RPL), such as the wormhole attack. In this study, the autho...

Recurrent pregnancy loss (RPL) occurs in approximately 5% of women. Despite an abundance of evidence, the molecular mechanism of RPL’s pathology remains unclear. Here, we report the protective role of polo-like kinase 1 (PLK1) during RPL. We ai...

The Internet of things (IoT) is a concept that has gained traction over the last decade. IoT networks have evolved around the wireless sensor network (WSN), and the following research looks at relevant IoT concepts and the different security issues t...

The genus Nymphaea L. (water lily) is the most diverse genus in the family Nymphaeaceae, with more than 50 species worldwide, including 11 species distributed in Africa. The complex and variable morphology of Nymphaea makes it extremely difficult to...

Chromatin is a highly dynamic biological entity that allows for both the control of gene expression and the stabilization of chromosomal domains. Given the high degree of plasticity observed in model and non-model organisms, it is not surprising that...

The Advanced Metering Infrastructure (AMI) is one of the Smart Grid (SG) applications that used to upgrade the current power system by proposing a two-way communication system to connect the smart meter devices at homes with the electric control comp...

Mycoplasma genitalium is a newly recognized pathogen associated with sexually transmitted diseases (STDs). MgPa, the adhesion protein of Mycoplasma genitalium, is the main adhesin and the key factor for M. genitalium interacting with host cells. Curr...

The Smart Grid (SG) aims to transform the current electric grid into a “smarter” network where the integration of renewable energy resources, energy efficiency and fault tolerance are the main benefits. This is done by interconnecting every energy so...

Recurrent Pregnancy Loss (RPL), also named Recurrent Spontaneous Abortion (RSA), is a common fertility problem that refers to at least two consecutive pregnancy losses and affects 1–2% of couples all over the world. Despite common causes such a...

The Internet of Things (IoT) has become very popular during the last decade by providing new solutions to modern industry and to entire societies. At the same time, the rise of the industrial Internet of Things (IIoT) has provided various benefits by...

Radioresistance is one of the major factors that contributes to radiotherapy failure in oral cavity squamous cell carcinoma (OSCC). By comparing the prognostic values of 20,502 genes expressed in patients in The Cancer Genome Atlas (TCGA)-OSCC cohort...

Whole exome sequencing has identified an infant girl with fulminant dilated cardiomyopathy (DCM), leading to severe acute heart failure associated with ribosomal protein large 3-like (RPL3L) gene pathologic variants. Other genetic tests for mitochond...

Routing attacks are a major security issue for Internet of Things (IoT) networks utilising routing protocols, as malicious actors can overwhelm resource-constrained devices with denial-of-service (DoS) attacks, notably rank and blackhole attacks. In...

The IETF Routing Over Low power and Lossy network (ROLL) working group defined IPv6 Routing Protocol for Low Power and Lossy Network (RPL) to facilitate efficient routing in IPv6 over Low-Power Wireless Personal Area Networks (6LoWPAN). Limited resou...

The Internet of Things (IoT) continues to expand rapidly, with the Routing Protocol for Low-Power and Lossy Networks (RPL) serving as its core communication backbone. However, RPL remains vulnerable to a range of insider routing attacks such as the V...

The RPL protocol is essential for efficient communication within the Internet of Things (IoT) ecosystem, yet it remains vulnerable to various attacks, particularly in dense and mobile environments where it shows certain limitations and susceptibiliti...

Mobility of eukaryotic transposable elements (TEs) are finely regulated to avoid an excessive mutational load caused by their movement. The transposition of retrotransposons is usually regulated through the interaction of host- and TE-encoded protein...

This paper presents the adaptation of a specific metric for the RPL protocol in the objective function MRHOF. Among the functions standardized by IETF, we find OF0, which is based on the minimum hop count, as well as MRHOF, which is based on the Expe...

The use of resource-constrained Low-Power and Lossy Networks (LLNs), where the IPv6 Routing Protocol for LLNs (RPL) is the de facto routing standard, has increased due to the Internet of Things’ (IoT) explosive growth. Because of the dynamic na...