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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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New Advances in Neuroinflammation

edited by

John W. Chen

and Michael Breckwoldt

submission deadline 15 May 2025 | 14 articles | Viewed by 41459 | Submission Open

Keywords: neuroinflammation; biomarkers; neurodegeneration; microglia; astrocytes; oligodendrocytes; neurological diseases; blood-brain barrier; imaging

(This special issue belongs to the Section Cells of the Nervous System)

Novel Therapeutic Targets and Approaches, Genetic Markers and Signaling Pathways in Neoplasms

edited by

Daria A. Chudakova

and

Kazuyuki Kitatani

submission deadline 15 May 2025 | 10 articles | Viewed by 22161 | Submission Open

Keywords: cancer; neoplasms; personalized medicine; genetic markers; next-generation sequencing (NGS); whole-genome sequencing; signaling pathways in cancer; novel therapeutic targets; drug development

(This special issue belongs to the Section Cell and Gene Therapy)

New Insights into Therapeutic Targets for Cardiovascular Diseases

edited by

Tamer Elbayoumi

and

Molly (Mingyi) Yao

submission deadline 15 May 2025 | 2 articles | Viewed by 5048 | Submission Open

Keywords: cardiovascular disease prevention and treatment; ischemic cardiomyopathies; endothelium injury/damage; cardiac remuscularization and repair; cardiovascular/angiogenic targets and biomarkers; targeted delivery platforms/systems/formulations; precision nanomedicine; targeted nano-theranostic applications; localized and systemic administration; safety and efficacy

(This special issue belongs to the Section Cells of the Cardiovascular System)

The Pathogenetic Triad of Chronic Airway Diseases—Inflammation, Tissue Destruction, and Airway Remodeling

edited by

Christoph Beisswenger

and Michael Wegmann

submission deadline 15 May 2025 | 2 articles | Viewed by 4002 | Submission Open

Keywords: chronic lung disease; inflammation; signaling pathway; disease models; tissue destruction; airway remodeling; epigenetics

(This special issue belongs to the Section Cellular Immunology)

Retinal Disorders: Cellular Mechanisms and Targeted Therapies

edited by

Takeshi Iwata

submission deadline 15 May 2025 | 2 articles | Viewed by 3684 | Submission Open

Keywords: inherited eye diseases; genome; omics; gene editing; iPS cells; animal models; single cell analysis; AI; epigenetics

(This special issue belongs to the Section Cellular Pathology)

Understanding the Extracellular Vesicles (EVs)-Mediated Horizontal Transfer of Non-coding RNAs

edited by

Alice Conigliaro

and

Carla Cicchini

submission deadline 15 May 2025 | 1 articles | Viewed by 3196 | Submission Open

Keywords: extracellular vesicles; non-coding RNA ; horizontal transfer; RNA loading; RNA binding proteins

Caenorhabditis elegans: Model Organism, Endless Possibilities—Volume II

edited by

Paola Fabrizio

submission deadline 15 May 2025 | 2 articles | Viewed by 2468 | Submission Open

Keywords: Caenorhabditis elegans; C. elegans; model organism

Molecular Mechanisms and Therapeutic Targets of Autoimmune Diseases

edited by

Giulio Olivieri

and

Fulvia Ceccarelli

submission deadline 15 May 2025 | 1 articles | Viewed by 1348 | Submission Open

Keywords: systemic autoimmune diseases; inflammation; cytokines; proteomics; transcriptomics; metabolomics; flow cytometry; autoantibodies; molecular mechanisms; novel therapeutic approaches

(This special issue belongs to the Section Cellular Immunology)

Novel Mechanisms of Gene Regulation in Cardiac Development and Congenital Heart Defects

edited by

Marlin Touma

submission deadline 15 May 2025 | Viewed by 487 | Submission Open

Keywords: long noncoding RNA; epigenetic regulation; whole-genome sequencing; cardiomyocyte signaling; cardiovascular development ; congenital heart defects

(This special issue belongs to the Section Cells of the Cardiovascular System)

New Trends and Advances in Diagnosis and Prognosis of Head and Neck Cancer from Carcinogenesis to Future Molecular Targeted Therapies: 2nd Edition

edited by

Piotr Cierpikowski

and

Julia Bar

submission deadline 20 May 2025 | 3 articles | Viewed by 4208 | Submission Open

Keywords: head and neck cancer; oral cancer; biomarker; prognosis; carcinogenesis; oral premalignant lesions; cancer stem cells; signaling pathways; molecular targeted therapy

(This special issue belongs to the Section Cellular Pathology)

Ion Channel Involvement in Neurological and Neuromuscular Disorders

edited by

Elena Conte

and

Concetta Altamura

submission deadline 20 May 2025 | 1 articles | Viewed by 1978 | Submission Open

Keywords: ion channels; neurological diseases; neuromuscular diseases; personalized therapy

(This special issue belongs to the Section Cells of the Nervous System)

Ovarian Cancer and Endometriosis

edited by

Ji-Hye Ahn

and

Jung-Hye Choi

submission deadline 20 May 2025 | 1 articles | Viewed by 1126 | Submission Open

Keywords: ovarian cancer; endometriosis; microenvironment; cell-cell interaction; drug resistance; natural product

(This special issue belongs to the Section Cellular Pathology)

Metabolic Hallmarks in Cancer

edited by

Michael Lisanti

, Ubaldo Martinez-Outshoorn and Marta Mauro-Lizcano

submission deadline 20 May 2025 | 1 articles | Viewed by 354 | Submission Open

Keywords: cancer; metabolic reprogramming; metabolic adaptation; cancer energy metabolism; glycolysis; the Warburg effect; the reverse Warburg effect; glutamine addiction; the pentose phosphate pathway; cellular and molecular mechanisms; tumor microenvironment; novel therapeutic interventions

(This special issue belongs to the Section Cellular Metabolism)

New Advances in Pluripotent Stem Cells

edited by Zack Wang

submission deadline 20 May 2025 | Viewed by 112 | Submission Open

Keywords: pluripotent stem cell; PSCs; disease modeling; 3D organoid models; gene; regenerative medicine; drug discovery

(This special issue belongs to the Section Stem Cells)

Targeting Tumor Metabolism and Epigenetics: Mechanisms and Therapeutic Strategies

edited by

Jorge Mata-Garrido

Raquel Francés

and Íñigo Casafont

submission deadline 22 May 2025 | Viewed by 143 | Submission Open

Keywords: tumor metabolism; epigenetics; metabolic reprogramming; DNA methylation; histone modification; warburg effect; glycolysis inhibitors; fatty acid synthesis; chromatin remodeling; cancer therapy

(This special issue belongs to the Section Cellular Metabolism)

Novel Signaling Mechanisms of G Protein-Coupled Receptors

edited by

András Balla

submission deadline 25 May 2025 | Viewed by 259 | Submission Open

Keywords: G protein-coupled receptor (GPCR); signal transduction; biased agonism; functional selectivity; arrestin; receptor cross-talk; receptor dimerization

Advances in the Cellular and Molecular Mechanisms of Cardiovascular Diseases

edited by

Timothy Martin Palmer

and Katie S. Wraith

submission deadline 25 May 2025 | Viewed by 167 | Submission Open

Keywords: thrombosis; smooth muscle; endothelium; atherosclerosis; inflammation

(This special issue belongs to the Section Cells of the Cardiovascular System)

Neurobiology of Chronicity of Pain

edited by

Charalampos Labrakakis

submission deadline 30 May 2025 | 1 articles | Viewed by 1933 | Submission Open

Keywords: pain; chronicity; synapses; receptors; brain circuits; depression; comorbidities

(This special issue belongs to the Section Cells of the Nervous System)

Current Research on Immunotherapy for Glioblastoma

edited by Markella Zannikou

submission deadline 30 May 2025 | Viewed by 129 | Submission Open

Keywords: GBM; tumor microenvironment; cancer vaccines; TIL (tumor-infiltrating lymphocytes) therapy; combination therapy; BiTEs; immune checkpoint therapy; CAR T-cell therapy; peptide/dendritic vaccines; tumor-associated antigens; oncolytic virotherapy

(This special issue belongs to the Section Cellular Immunology)

Modeling Developmental Processes and Disorders in Zebrafish

edited by

Natascia Tiso

and

Francesco Argenton

submission deadline 31 May 2025 | 12 articles | Viewed by 39113 | Submission Open

(This special issue belongs to the Section Cellular Biophysics)

Advances in Scanning Probe Microscopy in Cell Biology

edited by

Yuri M. Efremov

and

Petr V. Gorelkin

submission deadline 31 May 2025 | 14 articles | Viewed by 32889 | Submission Open

Cellular and Molecular Basis in Chronic Kidney Disease

edited by

Prabhatchandra Dube

submission deadline 31 May 2025 | 6 articles | Viewed by 13078 | Submission Open

Keywords: CKD; renal inflammation; renal fibrosis; RAAS; aldosterone; TGF-B1; uremic toxins; hypertension; GFR; albuminuria

(This special issue belongs to the Section Cellular Pathology)

The Current Applications and Potential of Stem Cell-Derived Organoids

edited by

James Adjaye

and

Nina Graffmann

submission deadline 31 May 2025 | 3 articles | Viewed by 10260 | Submission Open

Keywords: organoids; stem cell-derived organoids; stem cells; pluripotent stem cells; iPSCs; organ-on-a-chip; disease modelling; cellular therapeutics; regenerative medicine

(This special issue belongs to the Section Stem Cells)

Cell-to-Cell Crosstalk as a Target of Therapies

edited by

Agnieszka Gizak

and

Dominika Drulis-Fajdasz

submission deadline 31 May 2025 | 2 articles | Viewed by 4440 | Submission Open

Keywords: cell-to-cell crosstalk; cellular communication; microenvironment; extracellular vesicles; diagnostic tools; membrane nanotubes; pathogenesis; therapy; cell metabolism; homeostasis

Extracellular Vesicles as Biomarkers for Human Disease

edited by

Riccardo Di Santo

submission deadline 31 May 2025 | 3 articles | Viewed by 3839 | Submission Open

Keywords: extracellular vesicles; exosomes; biomarkers; human diseases; diagnostic applications; prognostic indicators; EV subtypes; isolation techniques

(This special issue belongs to the Section Intracellular and Plasma Membranes)

Metabolic Regulation of Hematopoietic Stem Cells

edited by

Wei Du

submission deadline 31 May 2025 | 1 articles | Viewed by 3783 | Submission Open

Keywords: hematopoietic stem cells; metabolic regulation; mitochondrial function; self-renewal and differentiation; quiescence; energy metabolism; HSC exhaustion; aging; bm niche; leukemia stem cells (LSCs)

(This special issue belongs to the Section Stem Cells)

Mechanisms of Respiratory Diseases

edited by

Bernhard Ryffel

and

David Rios-Covián

submission deadline 31 May 2025 | 1 articles | Viewed by 3569 | Submission Open

Keywords: cell death/stress; DNA/RNA sensor; cGAS/STING; inflammasome; microbiome; FMT or transfer of bacteria; metabolite; viral infection; emphysema; progressive fibrosis; innate immune response; defined inhibitors

(This special issue belongs to the Section Cellular Pathology)

Recent Advances in Metabolism and Oxidative Stress in Human Diseases 2.0

edited by

Isabella Panfoli

and Vanessa Cossu

submission deadline 31 May 2025 | 2 articles | Viewed by 3190 | Submission Open

Keywords: antioxidant responses; redox balance; ROS; hematologic oncology; solid tumors; immune response; ATP; cancer cells; mitochondria-ER interactions; endoplasmic reticulum; glucose metabolism; inflammation; mitochondria; mitochondrial dynamics; autophagy; mitophagy; metabolic plasticity; metabolism

(This special issue belongs to the Section Cellular Metabolism)

Extracellular Vesicle-Based Therapeutics: Current Advances and Future Perspectives

edited by Heather Branscome

submission deadline 31 May 2025 | 2 articles | Viewed by 3034 | Submission Open

Keywords: extracellular vesicles (EVs); stem cells; mesenchymal stem cells; in vitro cellular repair models; animal models for repair and or/tissue regeneration; cell-free therapy

Cellular Glycosphingolipids in Human Disease

edited by

Santiago Lima

and

Amanda Dickinson

submission deadline 31 May 2025 | 1 articles | Viewed by 2782 | Submission Open

Keywords: glycosphingolipid; cancer; sphingolipid; signal transduction; epithelial to mesenchymal; ceramide; microdomain; chemoresistance; glucosylceramide; ganglioside; globoside; lactoside; neolactoside; sulfatide; GSL

(This special issue belongs to the Section Cellular Pathology)

Advances in Muscle Research in Health and Disease—2nd Edition

edited by

Wan Lee

submission deadline 31 May 2025 | 2 articles | Viewed by 2655 | Submission Open

Keywords: skeletal muscle; cardiac muscle; smooth muscle; myocyte; vascular smooth muscle cell; stem cell; development; homeostasis; regeneration; biomarker; therapeutic target

(This special issue belongs to the Section Tissues and Organs)

Cellular and Molecular Mechanisms in Oxidative Stress-Related Chronic Diseases

edited by Sara Spinelli,

Alessia Remigante

and

Rossana Morabito

submission deadline 31 May 2025 | 1 articles | Viewed by 2419 | Submission Open

Keywords: aging; age-related diseases; redox system; cellular and molecular mechanisms; oxidative stress biomarkers; synthetic and natural antioxidant molecules

(This special issue belongs to the Section Cellular Pathology)

Non-Coding and Coding RNAs in Targeted Cancer Therapy

edited by

César López-Camarillo

and

Macrina B. Silva-Cázares

submission deadline 31 May 2025 | 4 articles | Viewed by 2089 | Submission Open

Keywords: gene expression; non-coding RNAs; lncRNAs; microRNAs; piwi-associated RNA; circular RNAs; therapeutic targets

(This special issue belongs to the Section Cell and Gene Therapy)

Insight into Lipid Droplets

edited by

Jinhai Yu

submission deadline 31 May 2025 | 1 articles | Viewed by 2070 | Submission Open

Keywords: lipid droplet; lipid droplet protein; lipid droplet biogenesis; lipid droplet growth; lipid droplet degradation; lipid droplet– organelle interaction; lipid metabolism; lipid-metabolism-related diseases

(This special issue belongs to the Section Cellular Biophysics)

Cellular Mechanisms in Mitochondrial Function and Calcium Signaling

edited by Sergio De la Fuente and Jaime Santo-Domingo

submission deadline 31 May 2025 | 1 articles | Viewed by 1667 | Submission Open

Keywords: mitochondria; calcium; MCU; uniporter; NCLX; energy metabolism; disease; MAMs; signaling

(This special issue belongs to the Section Cellular Metabolism)

The Role of Stem Cells and Circadian Clock in Cancer Immunotherapy

edited by Yool Lee

submission deadline 31 May 2025 | 1 articles | Viewed by 950 | Submission Open

Keywords: circadian clock; circadian disruption; neural stem cells; cancer stem cells; tumor– immune microenvironment; cancer chronotherapy

(This special issue belongs to the Section Stem Cells)

Emerging Insights into Natural Killer Cell Immunity in Infection and Cancer

edited by Sumit Sen Santara,

Engin Berber

, Weshely Kujur and Sachin Mulik

submission deadline 31 May 2025 | 1 articles | Viewed by 948 | Submission Open

Keywords: CAR NK cells; cancer immunotherapy; cell therapy; viral infection; memory NK cells; NK cell targeted therapies; NK-immune cell crosstalk; exosomes

(This special issue belongs to the Section Cellular Immunology)

The Role of T-Cells in Lymphomas and Leukemias

edited by

Huda Salman

submission deadline 31 May 2025 | 1 articles | Viewed by 721 | Submission Open

Keywords: T cells; regulatory T cells; leukemia; lymphoma; hematological malignancies; chimeric antigen receptor; CAR T cells; tumor microenvironment; tumor-infiltrating T cells; TCR; adoptive T cell therapy; TCR-engineered T cells

(This special issue belongs to the Section Cellular Immunology)

Genetic and Cellular Basis of Autoimmune Diseases

edited by

Christian Sadik

submission deadline 31 May 2025 | 1 articles | Viewed by 701 | Submission Open

Keywords: autoimmune disease; break of tolerance; effector cells; immunodysregulation; risk genes

(This special issue belongs to the Section Cellular Immunology)

G Protein-Coupled Receptors and Diseases

edited by

Yongqiang Chen

submission deadline 31 May 2025 | Viewed by 398 | Submission Open

Keywords: G protein-coupled receptor; taste receptor; microbiome; cancer; aging; neurodegenerative disease; cardiovascular disease; pulmonary hypertension; cell survival; cell death; apoptosis; autophagy; necroptosis; ferroptosis; proliferation

Development of PET Radiotracers for Imaging Alpha-Synuclein

edited by

Robert H. Mach

and Jamie Eberling

submission deadline 31 May 2025 | Viewed by 377 | Submission Open

Keywords: alpha-synuclein; Parkinson’ s disease; multiple system atrophy; positron emission tomography

(This special issue belongs to the Section Cellular Aging)

New Insight into Tumor–Tumor Microenvironment Crosstalk

edited by

Piotr Dziegiel

and

Karolina Jablonska

submission deadline 31 May 2025 | Viewed by 270 | Submission Open

Keywords: tumor– microenvironment interaction; cancer therapy; signaling; extracellular matrix; immune cells; cell networks; tumorigenesis; cancer metabolism; tumor cell plasticity

(This special issue belongs to the Section Cell Microenvironment)

Immunity to Infections—Respiratory

edited by

Meraj Alam Khan

submission deadline 31 May 2025 | Viewed by 237 | Submission Open

Keywords: immune responses; infections; neutrophils; macrophages; lymphocytes; respiratory pathogens

(This special issue belongs to the Section Cellular Immunology)

Study on Human Mesenchymal Stem Cells—2nd Edition

edited by

Michela Noseda

submission deadline 31 May 2025 | Viewed by 209 | Submission Open

Keywords: mesenchymal stem cells; disease; cardiac; therapy

(This special issue belongs to the Section Stem Cells)

Exploring the Cellular Basis of Steatotic Liver Disease: Insights and Advances

edited by

Henning Gronbaek

submission deadline 31 May 2025 | Viewed by 165 | Submission Open

Keywords: metabolic dysfunction-associated steatotic liver disease (MASLD); hepatocytes; hepatic stellate cells; lipid metabolism; inflammation; fibrosis; mitochondrial dysfunction; Kupffer cells; the microbiome; the gut– liver axis

(This special issue belongs to the Section Cellular Pathology)

Exploring Morphological Changes and Diversity in Cancer

edited by

Mustapha Kandouz

submission deadline 31 May 2025 | Viewed by 136 | Submission Open

Keywords: morphology; heterogeneity; cancer; phenotype; shape

Toll-Like Receptors and Human Disease

edited by Vinothkumar Rajamanickam

submission deadline 31 May 2025 | Viewed by 113 | Submission Open

Keywords: toll-like receptor; Immune response; infectious disease; non-infectious disease; targeted therapy

Role of Lysosomes in Mediating Cancer Drug Resistance

edited by

Petr Mlejnek

submission deadline 31 May 2025 | Viewed by 99 | Submission Open

Keywords: drug resistance; autophagic cell death; lysosomal-mediated cell death; autophagy; apoptosis; lysosomal exocytosis; lysosomal sequestration; tumor microenvironment

Intellectual Disability and Autism Spectrum Disorders

edited by

Xiang-Jiao Yang

submission deadline 31 May 2025 | Viewed by 85 | Submission Open

Keywords: intellectual disability; syndromic intellectual disability; autism; genetic mutation; genetic regulator; epigenetic regulator

Advances in Zebrafish Disease Models

edited by

Natalia Kasica

and

Jaroslaw Widelski

submission deadline 1 Jun 2025 | 2 articles | Viewed by 2672 | Submission Open

Keywords: zebrafish; human disease models; experimental disease models; novel drugs and therapies; organic diseases; functional disorders

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