Cells

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Role of Glial Cells in the Nervous System

edited by

Shenzhao Lu

and Lindsey Goodman

submission deadline 31 Dec 2026 | Viewed by 118 | Submission Open

Keywords: glia; astrocytes; microglia; oligodendrocytes; Schwann cells; lipids; inflammation; immunity; neurodegeneration; neurodevelopment

(This special issue belongs to the Section Cellular Neuroscience)

Emerging Topics in Vascular Endothelial Cell Biology—Second Edition

edited by

Julia Schumann

submission deadline 31 Dec 2026 | Viewed by 65 | Submission Open

Keywords: endothelial cells; endothelial dysfunction; cancer; coronary artery disease; inflammation; angiogenesis

(This special issue belongs to the Section Cells of the Cardiovascular System)

Cellular and Molecular Mechanisms in Male Fertility

edited by

Joana Santiago

and

Magda Carvalho Henriques

submission deadline 31 Dec 2026 | Viewed by 61 | Submission Open

Keywords: male fertility; spermatogenesis; testicular function; germ cell development; spermatozoa; molecular signaling; infertility mechanisms; reproductive health; epigenetic regulation

(This special issue belongs to the Section Reproductive Cells and Development)

Inflammation in the Brain: Cellular Interactions, Molecular Pathways and Translation Toward Novel Therapies

edited by

Maria Marino

Marco Fiocchetti

and

Evelyne Gozal

submission deadline 15 Jan 2027 | Viewed by 272 | Submission Open

Keywords: neuroinflammatory pathways; inflammasome; neurodegeneration

(This special issue belongs to the Section Cellular Neuroscience)

The Dynamic Tumor Microenvironment: Mechanisms of Therapy Resistance and Opportunities for Intervention

edited by Ahmed Lasfar and

Pranela Rameshwar

submission deadline 20 Jan 2027 | Viewed by 111 | Submission Open

Keywords: tumor microenvironment/TME; therapeutic resistance; mechanisms

(This special issue belongs to the Section Cell Microenvironment)

New Advances in Tissue Engineering and Regeneration

edited by

Giorgia Borciani

and

Giorgia Montalbano

submission deadline 25 Jan 2027 | 4 articles | Viewed by 6425 | Submission Open

Keywords: tissue regeneration; tissue engineering; regenerative medicine; musculoskeletal tissues; biomaterials; stem cells; 3D bioprinting; scaffold design; cell therapy; organoids; translational research

(This special issue belongs to the Section Tissues and Organs)

Retinal Diseases: Cellular and Molecular Mechanisms

edited by

Yang Pan

and

Takeshi Iwata

submission deadline 31 Jan 2027 | Viewed by 178 | Submission Open

Keywords: retinal disease; age-related macular degeneration; glaucoma; genetic risk factors; WES; WGS; GWAS; functional analysis of mutations; retinal cell signaling; pathogenic mechanisms

(This special issue belongs to the Section Cellular Pathology)

Therapeutic Advances in Leukemia: Unraveling Molecular and Immune Mechanisms

edited by

Agata Szymańska

, Justyna Woś and

Agnieszka Bojarska-Junak

submission deadline 31 Jan 2027 | Viewed by 163 | Submission Open

Keywords: molecular diagnostics; targeted therapy; immunotherapy; genetic mutations; leukemia pathogenesis; leukemia treatment; epigenetic regulation; cancer biomarkers; hematologic malignancies

(This special issue belongs to the Section Cellular Immunology)

Molecular Signal Transduction in Cancer

edited by

Goberdhan P. Dimri

and

Bernhard Zdársky

submission deadline 28 Feb 2027 | Viewed by 112 | Submission Open

Keywords: molecular signal transduction; tumor microenvironment; tumor suppressor; kinase signaling; transcriptional and epigenetic regulation; immune signaling; cancer cell communication

(This special issue belongs to the Section Cell Signaling)

Novel Insights into Amyotrophic Lateral Sclerosis (ALS)

edited by Zane Zeier

submission deadline 1 Mar 2027 | Viewed by 169 | Submission Open

Keywords: TDP-43 proteinopathy; protein aggregation; RNA metabolism; DNA damage; cryptic splicing; nucleocytoplasmic transport; liquid– liquid phase separation; mitochondrial dysfunction; mitophagy; neuroinflammation; microglial activation; astrogliosis; glutamate excitotoxicity; multi-omics; integrative omics

Current Status and Future Challenges of Liquid Biopsy—2nd Edition

edited by

Kenichi Suda

and

Shuta Ohara

submission deadline 1 Oct 2027 | 1 articles | Viewed by 1239 | Submission Open

Keywords: minimal residual disease (MRD); ctDNA; cfDNA; heterogeneity; comprehensive genomic profiling; biomarker; diagnosis; personalization; prognostic marker

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