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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Mitochondrial Dynamics in Health and Disease Metabolism: Mechanisms and Functional Consequences

edited by

Che-Chia Hsu

submission deadline 30 Jun 2026 | Viewed by 249 | Submission Open

Keywords: mitochondrial fission; mitochondrial fusion; mitophagy; mitochondrial transport; mitochondrial transfer; mitochondrial diseases

(This special issue belongs to the Section Mitochondria)

Bone and Tooth Biology: Development and Regeneration

edited by Xiaofang Wang

submission deadline 30 Jun 2026 | Viewed by 247 | Submission Open

Keywords: bone; tooth; osteogenesis; odontogenesis; enamel; dentin; cementum; amelogenesis; dentinogenesis; regeneration; stem cells

The Immunology of Allergy and Asthma

edited by

Charles Pilette

and

Valerie Hox

submission deadline 30 Jun 2026 | Viewed by 238 | Submission Open

Keywords: type 2 immunity; rhinitis; food allergy; anaphylaxis; drug allergy; dermatitis; eczema; airway inflammation; IgE response; tissue remodelling; disease remission

Novel Insights into Myeloid Leukemias

edited by

Bernhard Zdársky

submission deadline 30 Jun 2026 | Viewed by 235 | Submission Open

Keywords: leukemogenesis; bone marrow microenvironment; leukemia stem cells; immune evasion; hematopoiesis and myeloid differentiation; targeted therapy

(This special issue belongs to the Section Cellular Pathology)

Targeting Retinal Neurogliovascular Injury: Mechanisms and Therapeutic Strategies

edited by

Ruth B. Caldwell

and

Syed A. H. Zaidi

submission deadline 30 Jun 2026 | Viewed by 227 | Submission Open

Keywords: retinal neurogliovascular injury; retinal neurogliovascular disease; mechanisms; therapeutic strategies

(This special issue belongs to the Section Cellular Pathology)

Inflammation in Target Organs—Second Edition

edited by

Itamar Raz

and Sarah Weksler-Zangen

submission deadline 30 Jun 2026 | Viewed by 221 | Submission Open

Keywords: inflammation; fibrosis; cardio-renal; vascular; liver; brain

(This special issue belongs to the Section Cellular Immunology)

Immunometabolic Mechanisms in Aging and Chronic Inflammatory Diseases: From Senescence to Autoimmunity

edited by

Christian Jorgensen

submission deadline 30 Jun 2026 | Viewed by 209 | Submission Open

Keywords: immuno-metabolic; immune response; senescence; inflammation; immune cells; cell differentiation; cell maturation; autoimmunity; cancer

(This special issue belongs to the Section Cellular Immunology)

Role of Macrophages in Tissue Repair

edited by

Guochang Hu

submission deadline 30 Jun 2026 | Viewed by 207 | Submission Open

Keywords: macrophages; inflammation; tissue repair; phagocytosis

(This special issue belongs to the Section Tissues and Organs)

Cellular Reprogramming and Epigenetic Control in Tissue Regeneration

edited by Sanjeeb Kumar Sahu

submission deadline 30 Jun 2026 | Viewed by 202 | Submission Open

Keywords: cellular reprogramming; epigenetic regulation; tissue regeneration; epigenetic rejuvenation; cellular plasticity; stem cell biology; regenerative medicine; DNA methylation

(This special issue belongs to the Section Tissues and Organs)

Cell Metabolism in Endocrine Diseases

edited by Ranjodh Gill

submission deadline 30 Jun 2026 | Viewed by 198 | Submission Open

Keywords: endocrine system; hormones; metabolism; cellular pathways; homeostasis; diabetes mellitus; insulin resistance; thyroid disorders; hypothyroidism; hyperthyroidism; cortisol; Cushing's syndrome

(This special issue belongs to the Section Cellular Metabolism)

Modulation of Mitochondrial Function and Cellular Metabolism Through Physical and Chemical Approaches: Mechanisms and Therapeutic Insights

edited by

Mohammad Golam Sabbir

submission deadline 30 Jun 2026 | Viewed by 194 | Submission Open

Keywords: mitochondrial signaling; bioenergetics; metabolic regulation; oxidative stress; mitochondrial dysfunction; calcium homeostasis; apoptosis; mitochondrial dynamics; metabolic disorders; therapeutic strategies; photobiomodulation; pharmacological modulation

(This special issue belongs to the Section Mitochondria)

Tau Pathobiology and Excitotoxicity in Neurodegeneration and Epilepsy

edited by Janet Van Eersel

submission deadline 30 Jun 2026 | Viewed by 191 | Submission Open

Keywords: tau; excitotoxicity; dementia; epilepsy; seizures; hyperexcitation

The Study of Skeletal Diseases

edited by Weiguang Wang

submission deadline 30 Jun 2026 | Viewed by 189 | Submission Open

Keywords: skeletal diseases; bone; cartilage; synovium; tendon; ligament; spine; craniofacial skeleton; immune– skeletal interaction; vascular and neural networks; stem and progenitor cells; artificial intelligence (AI); single-cell and spatial genomics; imaging and bioengineering; regenerative medicine

(This special issue belongs to the Section Cellular Pathology)

Interaction Between DNA Damage Response and Anti-Cancer Immunity

edited by

Takahiko Murayama

and Jun Nakayama

submission deadline 30 Jun 2026 | Viewed by 182 | Submission Open

Keywords: DNA damage response; tumor microenvironment; DDR inhibitors; immune checkpoint blockade

(This special issue belongs to the Section Cell and Gene Therapy)

Neural Stem Cells and Progenitors: Mechanisms of Neurogenesis and Regenerative Potential

edited by Lidia De Filippis and Maurizio Gelati

submission deadline 30 Jun 2026 | Viewed by 174 | Submission Open

Keywords: neural stem cells; cancer stem cells; neuroregeneration; neurodegenerative diseases; CNS; neurorepair; neurogenesis; neuroinflammation

Gene Regulation in Epithelial Cells

edited by Jennifer Zhang

submission deadline 30 Jun 2026 | Viewed by 162 | Submission Open

Keywords: epithelial cells; gene regulation; epigenetic regulation; epithelium– immune crosstalk; epithelium– microbial interaction

(This special issue belongs to the Section Cell and Gene Therapy)

Innovations in mRNA Delivery Vectors

edited by

Jacques P. Tremblay

submission deadline 30 Jun 2026 | Viewed by 160 | Submission Open

Keywords: mRNA delivery systems; lipid nanoparticles (LNPs); non-viral vectors; targeted RNA delivery; extracellular vesicles

Cancers and Metabolic Diseases—the Molecular Players in the Game

edited by

T.K.S. Kumar

submission deadline 1 Jul 2026 | 1 articles | Viewed by 1081 | Submission Open

Keywords: metabolism; bioenergetics; signaling; cytokines; molecular; mechanisms; receptors; design; therapeutics

Innate-Like T Cells: The Variegated Roles of Semi-Invariant TCRs in Health and Disease

edited by

Ethan Shevach

and Akshat Sharma

submission deadline 5 Jul 2026 | 2 articles | Viewed by 4871 | Submission Open

Keywords: innate-like T cells; cancer; autoimmunity; cytokines; immune mechanisms

(This special issue belongs to the Section Cellular Pathology)

Biochemical Interaction and Supramolecular Complexes of Receptors in Cell Membranes

edited by

Michela Corsini

and

Stefania Mitola

submission deadline 8 Jul 2026 | 1 articles | Viewed by 2569 | Submission Open

Keywords: membrane receptors; molecular complex; membrane microdomains

Experimental Systems to Model Aging Processes

edited by

Natascia Tiso

Giovanni Risato

and Ralf Dahm

submission deadline 10 Jul 2026 | 4 articles | Viewed by 14002 | Submission Open

Keywords: aging; ageing; age-related; longevity; model; animal; signalling pathway; mechanism; in vitro; in vivo; cell culture; marker

(This special issue belongs to the Section Cellular Aging)

Advances in Human Pluripotent Stem Cells

edited by

Peggy Arthur

Sangeetha Kandoi

and

Nagavendra Kommineni

submission deadline 10 Jul 2026 | 4 articles | Viewed by 7977 | Submission Open

Keywords: human pluripotent stem cells; embryonic stem cells; induced pluripotent stem cells

(This special issue belongs to the Section Stem Cells)

Cellular Signaling Networks in Development, Homeostasis, and Disease

edited by

Ying Xia

Mei Xin

and Chia-Yang Liu

submission deadline 10 Jul 2026 | 2 articles | Viewed by 1382 | Submission Open

Keywords: cell fate determination; cell migration and survival; cell proliferation and differentiation; development and homeostasis; developmental disorders; disease mechanisms; regenerative medicine; signal transduction; signaling crosstalk; spatial transcriptomics

(This special issue belongs to the Section Cell Signaling)

Hypoxia and the Immune Landscape in Infection and Cancer

edited by Bernard Burke

submission deadline 10 Jul 2026 | 1 articles | Viewed by 1042 | Submission Open

Keywords: hypoxia; tumor; infection; HIFs; immune checkpoint proteins; immune evasion; metabolic dysregulation; leukocyte recruitment; effector cell function; acidosis

(This special issue belongs to the Section Cellular Immunology)

The Role of Mitochondria in Health, Disease, and Ageing

edited by

Arunkumar Venkatesan

and

Ritva Tikkanen

submission deadline 10 Jul 2026 | 1 articles | Viewed by 941 | Submission Open

Keywords: mitochondrial dysfunction; metabolism; mitochondrial genetics; aging and senescence; bioenergetics; mitophagy; neurodegeneration; cardiomyopathy; metabolic syndrome; ocular diseases

(This special issue belongs to the Section Mitochondria)

Advances in Tissue Engineering Approaches for Bone Repair and Regeneration

edited by

Elaheh Dalir Abdolahinia

submission deadline 10 Jul 2026 | 1 articles | Viewed by 903 | Submission Open

Keywords: bone tissue engineering; bone regeneration; biomaterials and scaffolds; bone cancer; 3D printing; bioprinting

(This special issue belongs to the Section Tissues and Organs)

Ripening and Degradation Mechanisms of Neutrophil Extracellular Traps

edited by

Martin Herrmann

and Maximilian Dölling

submission deadline 10 Jul 2026 | Viewed by 799 | Submission Open

Keywords: neutrophil extracellular traps; degradation of NETs; ripening of NETs

(This special issue belongs to the Section Cellular Immunology)

The Neuro-Immune Axis in Pulmonary Inflammation and Fibrosis

edited by Carlos H. Hiroki

submission deadline 10 Jul 2026 | Viewed by 279 | Submission Open

Keywords: neuroimmune interactions; lung inflammation; lung innervation; neuropeptides; neurotransmitters

(This special issue belongs to the Section Cellular Immunology)

Chronic Coronary Syndromes: Cellular Pathways, Comorbidities, and Prognostic Determinants

edited by Chowdhury H. Ahsan

submission deadline 10 Jul 2026 | Viewed by 122 | Submission Open

Keywords: chronic coronary syndromes; microvascular dysfunction; endothelial injury; vascular biology; inflammation; cardiometabolic comorbidities; ischemic heart disease; risk stratification; precision cardiology

(This special issue belongs to the Section Cells of the Cardiovascular System)

Neuromodulatory Signaling in Brain Disorders: State-of-the-Art Insights

edited by

Kohji Fukunaga

and

Wenbin Jia

submission deadline 15 Jul 2026 | 3 articles | Viewed by 11967 | Submission Open

Keywords: neuromodulatory signaling; neural circuit; synaptic plasticity; neurotransmitter; signal transduction; neurodegenerative diseases; neuroinflammatory disorder; substance use disorder; neurodevelopmental disorder; targeted therapy

(This special issue belongs to the Section Tissues and Organs)

Inflammation in the Brain: From Molecular and Cellular Mechanisms to Therapeutic Strategies

edited by Sujatha Kannan and

Elizabeth Winans Tucker

submission deadline 15 Jul 2026 | 3 articles | Viewed by 7484 | Submission Open

Keywords: neuroinflammation; microglia; astrocytes; immune signaling; neurodegeneration; neuroimmunology; brain injury; therapeutic strategies

Tumor Stroma Interaction

edited by

Vladimir Jurisic

submission deadline 15 Jul 2026 | 2 articles | Viewed by 6092 | Submission Open

Keywords: cells; cancer; inflammation; exocytosis; immune system; tumor stroma

Recent Advances in the Understanding of Neuropsychiatric Illnesses

edited by

Junnan Li

and

Wanli Smith

submission deadline 15 Jul 2026 | 2 articles | Viewed by 2265 | Submission Open

Keywords: neuropsychiatric disorders; neurodegeneration; synaptic plasticity; neuroinflammation; biomarkers; molecular mechanisms; translational neuroscience; intracellular signaling; neuroimaging

(This special issue belongs to the Section Cellular Neuroscience)

The Evolving Landscape of Cell and Gene Therapy—Opportunities, Challenges and the Road Ahead

edited by

Rai Ajit K. Srivastava

submission deadline 15 Jul 2026 | 1 articles | Viewed by 2095 | Submission Open

Keywords: cell therapy; gene therapy/gene editing; micro RNAs; rare diseases; metabolic disease; cancer; diabetes; proatherogenic lipoproteins; drug discovery; ASO

Recent Progress on Fibrosis and Cardiac Dysfunction

edited by

Tabito Kino

and

Tomoaki Ishigami

submission deadline 15 Jul 2026 | 2 articles | Viewed by 1921 | Submission Open

Keywords: regeneration; cardiac fibrosis; cardiac dysfunction; ischemic heart disease; hypertension; atrial fibrillation; inflammation

(This special issue belongs to the Section Cells of the Cardiovascular System)

Role of T Cells in Immune Disease Treatment

edited by

Ilan Bank

submission deadline 15 Jul 2026 | 1 articles | Viewed by 1751 | Submission Open

Keywords: autoimmunity; autoimmune diseases; immunotherapy; immune diseases; T cells; B cells; natural killer T cells

(This special issue belongs to the Section Cellular Immunology)

Phytofactories: From Lab to Applications

edited by

and

submission deadline 15 Jul 2026 | 1 articles | Viewed by 1618 | Submission Open

Keywords: plant cell suspension cultures; phytofactories; bioprocess; specialty molecules; metabolic engineering; germplasm preservation

(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)

Role of Ras-Regulated Signal Pathways

edited by

Takayuki Tsukuba

submission deadline 15 Jul 2026 | Viewed by 533 | Submission Open

Keywords: Ras-regulated signaling pathway; MAPK/ERK pathway; PI3K/AKT pathway; Ral-GDS pathway

(This special issue belongs to the Section Cell Signaling)

Functions of Cilia

edited by

Raj Luxmi

submission deadline 15 Jul 2026 | Viewed by 448 | Submission Open

Keywords: cilia; cilia-derived vesicles; ciliopathies; neuronal cilia; motile cilia; primary cilia; ciliary secretion; peptidergic signaling; ectosomes

MET: Signaling, Regulation, and Biological Roles

edited by Abdulhameed Al-Ghabkari and William W. Lockwood

submission deadline 15 Jul 2026 | Viewed by 268 | Submission Open

Keywords: MET; HGF (hepatocyte growth factor); MET signaling; receptor tyrosine kinase (RTK); cancer; tumor progression; receptor activation; MET-targeted therapy

(This special issue belongs to the Section Cell Signaling)

Role of Hippo Signaling in Cancer

edited by

Dimpi Mukhopadhyay

and

Alessio D'Alessio

submission deadline 15 Jul 2026 | Viewed by 242 | Submission Open

Keywords: angiogenesis; cancer metabolism; cancer stemness; chemoresistance; endothelial cell plasticity; epithelial-to-mesenchymal transition (EMT); hippo signaling pathway; immunotherapy; mechanotransduction; targeted cancer therapy; TEAD transcription factors; therapeutic resistance; tumor microenvironment; tumorigenesis; YAP/TAZ; new therapeutic modalities to target YAP/TAZ-driven tumors including ferroptosis

(This special issue belongs to the Section Cell Signaling)

Skeletal Muscle Plasticity in Health, Aging and Disease

edited by

Junaith S. Mohamed

submission deadline 15 Jul 2026 | Viewed by 178 | Submission Open

Keywords: skeletal muscle; muscle plasticity; muscle regeneration; muscle atrophy; mitochondria; autophagy; non-coding RNAs

(This special issue belongs to the Section Cellular Aging)

Molecular and Cellular Mechanisms of Inherited Retinal Diseases

edited by Holly Yu Chen

submission deadline 15 Jul 2026 | Viewed by 125 | Submission Open

Keywords: inherited retinal diseases; retinal degeneration; retinal organoids; mü ller glia; retinal pigment epithelium

(This special issue belongs to the Section Cellular Pathology)

Select Topics in Molecular and Cellular Mechanisms of Mammalian Reproduction

edited by Zhengui Zheng,

Brent M. Bany

and Liang Ma

submission deadline 20 Jul 2026 | 7 articles | Viewed by 18623 | Submission Open

Keywords: reproductive organ development; sexual differentiation; reproductive tract function; fertilization; implantation; placentation; parturition; lactation

(This special issue belongs to the Section Reproductive Cells and Development)

The Roles of the Extracellular Matrix in Cardiac Structure and Function: A Commemorative Issue in Honor of Dr. Thomas K. Borg

edited by

Wayne Carver

and Edie Goldsmith

submission deadline 20 Jul 2026 | 9 articles | Viewed by 14889 | Submission Open

Keywords: collagen; integrin; extracellular matrix; cardiomyocyte; fibroblast; heart bioengineering

(This special issue belongs to the Section Cell Microenvironment)

Insights into the Pathophysiology of NeuroCOVID: Current Topics

edited by

Christian Barbato

Antonio Minni

and

Carla Petrella

submission deadline 20 Jul 2026 | 4 articles | Viewed by 7840 | Submission Open

Keywords: neuroCOVID; longCOVID; neurocognitive; cellular and molecular neurobiology; brain fog; anxiety; depression; biomarkers; translational biomedicine; neurodegenerative diseases

(This special issue belongs to the Section Cellular Pathology)

Mitochondria at the Crossroad of Health and Disease—Second Edition

edited by

Nickolay Brustovetsky

submission deadline 20 Jul 2026 | 6 articles | Viewed by 7350 | Submission Open

Keywords: mitochondria; oxidative phosphorylation; mitochondrial ion transport; permeability transition pore; mitochondrial ROS generation; mitochondrial quality control; mitochondrial traffic; mitochondrial morphology; mitochondrial dynamics; mitophagy

(This special issue belongs to the Section Cellular Aging)

Second Edition of Advances in Adipose Tissue Biology

edited by

Melvin K. S. Leow

submission deadline 20 Jul 2026 | 2 articles | Viewed by 5841 | Submission Open

Keywords: adipocyte differentiation; progenitors; and stem cells; adipokines; myokines; hepatokines; cytokines; cellular signaling; and molecular crosstalk; white adipose tissue (WAT) and brown adipose tissue (BAT); beige fat and browning of WAT; research techniques and methodologies; diagnostics and therapeutics; genomics; metabolomics; other ‘ omics’ technologies; metabolic syndrome; obesity; insulin resistance; cancer

(This special issue belongs to the Section Tissues and Organs)

Cancer and Immune System Interactions

edited by

Hong-Jian Zhu

and

Bradley Creamer

submission deadline 20 Jul 2026 | 2 articles | Viewed by 1916 | Submission Open

Keywords: cancer immunology; tumor microenvironment; immune evasion; immunotherapy; tumor– immune interactions; immune checkpoint regulation; translational oncology

(This special issue belongs to the Section Cell Microenvironment)

Cellular Signaling and Metabolic Adaptations in the Tumor Microenvironment

edited by Shashi Anand

submission deadline 20 Jul 2026 | 1 articles | Viewed by 457 | Submission Open

Keywords: cancer metabolic plasticity; tumor microenvironment; metabolic vulnerabilities; oncogenic signaling pathways; hypoxia and nutrient stress; therapeutic resistance

(This special issue belongs to the Section Cellular Metabolism)

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