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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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From Bench to Bedside: Animal Models and Molecular Mechanisms in Cancer Therapeutics

edited by Sijana H. Dzinic

submission deadline 31 Oct 2025 | Viewed by 106 | Submission Open

Keywords: animal models in cancer research; cancer therapeutics; preclinical research; drug development; efficacy testing of novel anticancer agents; translational research

(This special issue belongs to the Section Cellular Pathology)

Plasticity of Skeletal, Cardiac and Smooth Muscles in COPD: Repair and Remodeling

edited by Joaquim Gea Guiral

submission deadline 31 Oct 2025 | Viewed by 95 | Submission Open

Keywords: injury; repair; adaptation; aerobic metabolism; muscle mass; limb muscles; respiratory muscles; proteolysis

Functional Differences in Periostin Splicing Isoforms in Cancer and Inflammatory Disorders

edited by

Yoshiaki Taniyama

and Nobutaka Koibuchi

submission deadline 31 Oct 2025 | Viewed by 91 | Submission Open

Keywords: periostin; splicing variant; treatment-resistant cancer; diagnostics; periostin suppression therapy

Exploring Mitochondrial Dysfunction and Neuroinflammation in Neurodegeneration for New Therapeutic Advances

edited by Hanhan Liu

submission deadline 31 Oct 2025 | Viewed by 82 | Submission Open

Keywords: mitochondria; neuroinflammation; neurodegeneration; neuroprotective therapy; innate immunity

(This special issue belongs to the Section Cellular Pathology)

Macrophages in Cancer: Immunosuppression, Immunoregulation, and Immunotherapy

edited by

Abdullah Saeed

submission deadline 5 Nov 2025 | 1 articles | Viewed by 4819 | Submission Open

Keywords: macrophage; immunosuppression; immunoregulation; immunotherapy; tumor immune microenvironment

(This special issue belongs to the Section Cellular Immunology)

Stem Cells in Cancer

edited by

Ajit Kumar Sharma

submission deadline 10 Nov 2025 | 2 articles | Viewed by 5161 | Submission Open

Keywords: cancer stem cells; heterogeneity; metastasis; plasticity; self-renewal

(This special issue belongs to the Section Stem Cells)

Molecular Mechanism and Therapeutic Opportunities of Breast Cancer

edited by

Athanasios A. Panagiotopoulos

submission deadline 10 Nov 2025 | 3 articles | Viewed by 2554 | Submission Open

Keywords: breast cancer; molecular mechanisms; targeted therapy; genomic profiling; hormone receptors; tumor microenvironment; immunotherapy; drug resistance; metastasis; precision medicine

(This special issue belongs to the Section Cellular Pathology)

Synaptic Plasticity and the Neurobiology of Learning and Memory

edited by Erica Berretta, Laura Petrosini and Anna Panuccio

submission deadline 10 Nov 2025 | 1 articles | Viewed by 1612 | Submission Open

Keywords: learning and memory; neuronal and glial cells; long-term potentiation and long-term depression; molecular mechanisms

(This special issue belongs to the Section Cells of the Nervous System)

Biomarkers in Breast Cancer

edited by Julie Decock and Sana A. Bentebbal

submission deadline 10 Nov 2025 | 1 articles | Viewed by 950 | Submission Open

Keywords: breast cancer biomarkers; AI in oncology; multi-omics; exosomes; tumor immune microenvironment; liquid biopsy; precision oncology; personalized medicine

(This special issue belongs to the Section Cellular Pathology)

Recent Advances in the Molecular Mechanisms of Neurodegenerative Diseases: Current Progress and Future Directions for Disease-Modifying Therapies

edited by

Rengasamy Balakrishnan

and

Balamuralikrishnan Balasubramanian

submission deadline 10 Nov 2025 | 1 articles | Viewed by 373 | Submission Open

Keywords: neuroprotection; new drug development; natural products; blood– brain barrier; molecular mechanisms; neuronal signaling; neuroinflammation; microglial cells; neurotoxicity; neurodegenerative diseases

(This special issue belongs to the Section Cellular Aging)

Immunoregulation in Cardiovascular Disease

edited by

Hong Wang

submission deadline 10 Nov 2025 | Viewed by 97 | Submission Open

Keywords: cardiovascular disease (CVD); immunoregulation; inflammation; immune cells; immune mediators; immunomodulatory therapies; biomarkers; epigenetics; microbiome; cellular methods/technologies

Modeling Developmental Processes and Disorders in Zebrafish

edited by

Natascia Tiso

and

Francesco Argenton

submission deadline 15 Nov 2025 | 13 articles | Viewed by 46643 | Submission Open

(This special issue belongs to the Section Cellular Biophysics)

Effects and Mechanisms of Environmental Toxicants and Nanoparticles on Germ Cells, Gonads, Embryos and Stem Cells

edited by

Silvia Garagna

Maurizio Zuccotti

Danilo Cimadomo

and Giulia Fiorentino

submission deadline 15 Nov 2025 | 1 articles | Viewed by 2916 | Submission Open

Keywords: environmental toxicants; gonadal steroid hormones; ovary; folliculogenesis; oogenesis and oocyte; testis; spermatogenesis and sperm; embryo development; epigenetics; omics; cells lines and stem cells; embryoid bodies; gastruloids and organoids; 3D cell culture and imaging; nanoparticles; nanomaterials

(This special issue belongs to the Section Stem Cells)

Advances in Intestinal Epithelial Plasticity and Regeneration

edited by

Aiguo Tian

submission deadline 15 Nov 2025 | 1 articles | Viewed by 2756 | Submission Open

Keywords: intestinal epithelium; epithelial plasticity; stem cells; tissue repair; self-renewal; regeneration

Innate-Like T Cells: The Variegated Roles of Semi-Invariant TCRs in Health and Disease

edited by

Ethan Shevach

and Akshat Sharma

submission deadline 15 Nov 2025 | Viewed by 1870 | Submission Open

Keywords: innate-like T cells; cancer; autoimmunity; cytokines; immune mechanisms

(This special issue belongs to the Section Cellular Pathology)

Novel Therapies and Biomarkers for Rare Diseases

edited by Reena Kartha

submission deadline 15 Nov 2025 | Viewed by 160 | Submission Open

Keywords: rare diseases; translational research; novel therapies; biomarker discovery; precision medicine

The Role of Integrins and Small GTPases in Health and Disease

edited by

Tione Buranda

submission deadline 15 Nov 2025 | Viewed by 86 | Submission Open

Keywords: cell signaling; integrins; cell adhesion; integrins diseases; infectious diseases

Lipids and Lipidomics in Neurodegenerative Diseases

edited by

Nathalie Bernoud-Hubac

and Catherine Malaplate

submission deadline 20 Nov 2025 | 1 articles | Viewed by 10065 | Submission Open

Keywords: lipids; lipidomics; neurodegenerative disease diagnosis; prevention; or treatment; cellular and molecular mechanisms

(This special issue belongs to the Section Cells of the Nervous System)

Molecular Advances in Prenatal Exposure to Environmental Toxicants

edited by

Douglas M. Ruden

and

Sudipta Dutta

submission deadline 20 Nov 2025 | 4 articles | Viewed by 8922 | Submission Open

Keywords: prenatal exposures; toxicogenomics; epigenomics; placenta; perinatal outcomes; neurodevelopmental outcomes; respiratory outcomes

Molecular Mechanism of Liver Transplantation

edited by Carmen Peralta and Juan Carlos Cutrin

submission deadline 20 Nov 2025 | 1 articles | Viewed by 3524 | Submission Open

Keywords: liver transplantation; ischemia-reperfusion injury; signaling pathways; graft dysfunction; sterile inflammation; liver regeneration; fatty grafts; normothermic machine perfusion; defatting strategies

(This special issue belongs to the Section Tissues and Organs)

Second Edition of Advances in Adipose Tissue Biology

edited by

Melvin K. S. Leow

submission deadline 20 Nov 2025 | 2 articles | Viewed by 3438 | Submission Open

Keywords: adipocyte differentiation; progenitors; and stem cells; adipokines; myokines; hepatokines; cytokines; cellular signaling; and molecular crosstalk; white adipose tissue (WAT) and brown adipose tissue (BAT); beige fat and browning of WAT; research techniques and methodologies; diagnostics and therapeutics; genomics; metabolomics; other ‘ omics’ technologies; metabolic syndrome; obesity; insulin resistance; cancer

(This special issue belongs to the Section Tissues and Organs)

Decoding the Complexity of Angiogenesis: Insights into Vascular Formation and Disease

edited by

Kay-Dietrich Wagner

submission deadline 20 Nov 2025 | 1 articles | Viewed by 876 | Submission Open

Keywords: angiogenesis; vasculogenesis; development; physiological angiogenesis; pathophysiology; cell– cell communication; cell signaling

(This special issue belongs to the Section Cells of the Cardiovascular System)

Ripening and Degradation Mechanisms of Neutrophil Extracellular Traps

edited by

Martin Herrmann

and Maximilian Dölling

submission deadline 20 Nov 2025 | Viewed by 437 | Submission Open

Keywords: neutrophil extracellular traps; degradation of NETs; ripening of NETs

(This special issue belongs to the Section Cellular Immunology)

Aging and Metabolic Diseases

edited by

Carlos Guillen

submission deadline 20 Nov 2025 | Viewed by 431 | Submission Open

Keywords: aging; insulin resistance; diabetes; obesity; mitochondrial dysfunction; beta-galactosidase; senescent-associated secretory phenotype; pancreatic beta cells

(This special issue belongs to the Section Cellular Aging)

Tumor Stroma Interaction

edited by

Vladimir Jurisic

submission deadline 20 Nov 2025 | 1 articles | Viewed by 408 | Submission Open

Keywords: cells; cancer; inflammation; exocytosis; immune system; tumor stroma

Extracellular Vesicles Based Drug Delivery

edited by

Giovanni Camussi

and

Cristina Grange

submission deadline 20 Nov 2025 | Viewed by 298 | Submission Open

Keywords: EV engineering; targeting; therapy; natural carrier; exosomes

Recent Advances in the Study of Tau Protein

edited by

Santosh Jadhav

submission deadline 20 Nov 2025 | Viewed by 190 | Submission Open

Keywords: tau protein; post-translational modification; tauopathy filaments; neuro-immune interactions

(This special issue belongs to the Section Cells of the Nervous System)

Epigenetic Regulation in Plant–Microbe Interactions and Environmental Adaptation

edited by Zhongshou Wu and Bochen Jiang

submission deadline 20 Nov 2025 | Viewed by 173 | Submission Open

Keywords: epigenetic regulation; plant– microbe interactions; environmental adaptation

(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)

Genetic and Genomic Insights into Complex Human Diseases: Advances, Challenges and Integrative Approaches

edited by Tianxiao Huan and Chan Zhou

submission deadline 20 Nov 2025 | Viewed by 124 | Submission Open

Keywords: genetics; genomics; proteomics; complex diseases; multi-omics; machine learning

Acute Liver Failure: Molecular Actors in Liver–Adipose Tissue Interplay

edited by Marika Crescenzi

submission deadline 20 Nov 2025 | Viewed by 123 | Submission Open

Keywords: inflammasome; adipose tissue; acute liver injury; adipokines; liver macrophages; hepatic stellate cells; liver sinusoidal endothelial cells

(This special issue belongs to the Section Tissues and Organs)

Methane Biosynthesis

edited by

Divya Prakash

, James Ferry and

Shikha Singh Chauhan

submission deadline 20 Nov 2025 | Viewed by 89 | Submission Open

Keywords: methane; methanogenesis; methanogens; carbon cycle; gut microbiota; energy conservation; human diseases

Atherosclerosis and Thrombosis: Molecular and Pathological Research Advance

edited by

Tijana Subotički

Olivera Mitrović Ajtić

and

Vladan P. Čokić

submission deadline 20 Nov 2025 | Viewed by 81 | Submission Open

Keywords: atherosclerosis; thrombosis; molecular mechanisms; translational research; precision medicine

(This special issue belongs to the Section Cellular Pathology)

New Insights into Astrocytes in Health and Disease

edited by

Tao Tao

submission deadline 20 Nov 2025 | Viewed by 75 | Submission Open

Keywords: astrocytes heterogeneity; blood-brain barrier (BBB); synaptic modulation; metabolic support; neuroinflammation; ageing; neurodegenerative disorders; neurodevelopmental disorders; stress response

(This special issue belongs to the Section Cells of the Nervous System)

Transient Receptor Potential (TRP) Channels and Health and Disease

edited by Hiroki Kittaka and Makoto Tominaga

submission deadline 20 Nov 2025 | Viewed by 73 | Submission Open

Keywords: Transient Receptor Potential (TRP) channels; cell signaling; cell physiology

The Metabolic Interactions and Pathways in Cancers

edited by Mohamed Elgendy

submission deadline 20 Nov 2025 | Viewed by 65 | Submission Open

Keywords: cancer metabolism; metastasis; drug resistance; oncometabolites; metabolic plasticity; diet; bioenergetics; metabolic crosstalk; immunotherapy

Targeting Tumor Metabolism and Epigenetics: Mechanisms and Therapeutic Strategies

edited by

Jorge Mata-Garrido

Raquel Francés

and Íñigo Casafont

submission deadline 22 Nov 2025 | Viewed by 196 | Submission Open

Keywords: tumor metabolism; epigenetics; metabolic reprogramming; DNA methylation; histone modification; warburg effect; glycolysis inhibitors; fatty acid synthesis; chromatin remodeling; cancer therapy

(This special issue belongs to the Section Cellular Metabolism)

Cellular and Molecular Basis in Chronic Kidney Disease

edited by

Prabhatchandra Dube

submission deadline 25 Nov 2025 | 8 articles | Viewed by 17779 | Submission Open

Keywords: CKD; renal inflammation; renal fibrosis; RAAS; aldosterone; TGF-B1; uremic toxins; hypertension; GFR; albuminuria

(This special issue belongs to the Section Cellular Pathology)

Glial Cells in Aging Neuroscience

edited by

Renato Socodato

submission deadline 25 Nov 2025 | 1 articles | Viewed by 4976 | Submission Open

Keywords: glial cells; aging; neuroinflammation; neurodegeneration; glial– neuronal interactions; glial– glial crosstalk; astrocytes; oligodendrocytes; microglia; ependymal cells

(This special issue belongs to the Section Cellular Aging)

Biomolecular Condensates in Oncology and Immunology

edited by

Andrzej Mackiewicz

Pravin B. Sehgal

and

Mariusz Kaczmarek

submission deadline 25 Nov 2025 | 1 articles | Viewed by 1095 | Submission Open

Keywords: liquid-liquid phase separation (LLPS); biomolecular condensates; pro-oncogenic signaling; innate and adaptive immunity; transcriptional regulation; epigenetic regulation; condensate targeting; antiviral mechanisms; intercellular adhesion; cell migration and metastasis

(This special issue belongs to the Section Cellular Immunology)

CAR T Cells in Human Cancers

edited by

Tabish H. Khan

and

Naoshad Muhammad

submission deadline 25 Nov 2025 | 1 articles | Viewed by 281 | Submission Open

Keywords: CAR T cells; engineered immune cell therapies; CAR T cell engineering

Cell Signaling in Neurodegeneration Disease

edited by

Rijwan Uddin Ahammad

, Yasuhiro Funahashi,

Akira Sobue

Xinjian Zhang

and Md-nadim Hossain

submission deadline 25 Nov 2025 | Viewed by 178 | Submission Open

Keywords: neurodegeneration; cell signaling; biomarkers; synaptic dysfunction; neuroinflammation; protein aggregation; IPSC and animal models; mitochondrial dysfunction; therapeutic targets; translational neuroscience

(This special issue belongs to the Section Cells of the Nervous System)

Pathology and Treatments of Amyotrophic Lateral Sclerosis (ALS)

edited by Laxman Gangwani

submission deadline 28 Nov 2025 | 1 articles | Viewed by 1197 | Submission Open

Keywords: amyotrophic lateral sclerosis (ALS); pathology; molecular mechanisms; treatments; symptom management; biological mechanisms; risk factors; innovative treatments

(This special issue belongs to the Section Cellular Pathology)

Cellular Senescence and Senotherapies in the Aging Retina

edited by

Bhavana Chhunchha

submission deadline 28 Nov 2025 | Viewed by 294 | Submission Open

Keywords: retina; senescence; aging; inflammasome; oxidative stress; antioxidant; gene therapy; senotherapies; glaucoma; diabetic retinopathy

(This special issue belongs to the Section Cellular Aging)

Cell-to-Cell Crosstalk as a Target of Therapies

edited by

Agnieszka Gizak

and

Dominika Drulis-Fajdasz

submission deadline 30 Nov 2025 | 2 articles | Viewed by 8724 | Submission Open

Keywords: cell-to-cell crosstalk; cellular communication; microenvironment; extracellular vesicles; diagnostic tools; membrane nanotubes; pathogenesis; therapy; cell metabolism; homeostasis

(This special issue belongs to the Section Cell Microenvironment)

Emerging Insights into Natural Killer Cell Immunity in Infection and Cancer

edited by Sumit Sen Santara,

Engin Berber

, Weshely Kujur and Sachin Mulik

submission deadline 30 Nov 2025 | 4 articles | Viewed by 5863 | Submission Open

Keywords: CAR NK cells; cancer immunotherapy; cell therapy; viral infection; memory NK cells; NK cell targeted therapies; NK-immune cell crosstalk; exosomes

(This special issue belongs to the Section Cellular Immunology)

Recent Advances in Metabolism and Oxidative Stress in Human Diseases: 2nd Edition

edited by

Isabella Panfoli

and Vanessa Cossu

submission deadline 30 Nov 2025 | 3 articles | Viewed by 5343 | Submission Open

Keywords: antioxidant responses; redox balance; ROS; hematologic oncology; solid tumors; immune response; ATP; cancer cells; mitochondria-ER interactions; endoplasmic reticulum; glucose metabolism; inflammation; mitochondria; mitochondrial dynamics; autophagy; mitophagy; metabolic plasticity; metabolism

(This special issue belongs to the Section Cellular Metabolism)

Gastrointestinal Cancer: From Cellular and Molecular Mechanisms to Therapeutic Opportunities

edited by

Federica Laudisi

and

Carmine Stolfi

submission deadline 30 Nov 2025 | 4 articles | Viewed by 5170 | Submission Open

Keywords: colorectal cancer; gastric cancer; liver cancer; pancreatic cancer; tumor microenvironment; cytokines; epigenetic; checkpoint inhibitors; biomarkers; immunotherapy

(This special issue belongs to the Section Cellular Pathology)

Advances in Muscle Research in Health and Disease—2nd Edition

edited by

Wan Lee

submission deadline 30 Nov 2025 | 3 articles | Viewed by 4525 | Submission Open

Keywords: skeletal muscle; cardiac muscle; smooth muscle; myocyte; vascular smooth muscle cell; stem cell; development; homeostasis; regeneration; biomarker; therapeutic target

(This special issue belongs to the Section Tissues and Organs)

Harnessing the Tumor Microenvironment and Signaling Pathways for Precision Cancer Therapy

edited by Behzad M. Toosi and

Andrew Freywald

submission deadline 30 Nov 2025 | 2 articles | Viewed by 4360 | Submission Open

Keywords: tumor microenvironment (TME); signaling pathways; precision cancer therapy; immune evasion; metabolic pathways; tumor– stroma interactions; therapeutic targets; personalized medicine; cancer metastasis; molecular oncology

(This special issue belongs to the Section Cell Microenvironment)

Retinal Pigment Epithelium in Degenerative Retinal Diseases

edited by Jian Liu and Shintaro Horie

submission deadline 30 Nov 2025 | 3 articles | Viewed by 3090 | Submission Open

Keywords: RPE; degenerative retinal diseases; macular degeneration; diabetic retinopathy; glaucoma; photoreceptor; vascular endothelium; microglia; macrophage; inflammation; oxidative stress; autophagy; mitochondria; lipid metabolism; senescence; neuropeptide; therapeutics; biomarkers

(This special issue belongs to the Section Cellular Pathology)

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