Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Intestinal Epithelial Plasticity and Regeneration
edited by
submission deadline 20 Jul 2025 | 1 articles | Viewed by 2118 | Submission Open
Keywords: intestinal epithelium; epithelial plasticity; stem cells; tissue repair; self-renewal; regeneration
Role of Autophagy in Plant Cells
edited by
submission deadline 20 Jul 2025 | 1 articles | Viewed by 1997 | Submission Open
Keywords: autophagy; endoplasmic reticulum; TOR; vacuoles; lysosomes; mitochondria; plastids
(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)
The Role of Cilia in Health and Diseases—2nd Edition
edited by Rim Hjeij
submission deadline 20 Jul 2025 | 3 articles | Viewed by 1665 | Submission Open
Keywords: motile cilia; motile ciliopathy; Primary Ciliary Dyskinesia; genetic screening; bronchiectasis; hydrocephalus; laterality defects; infertility; gene therapy
Protein Misfolding and Aggregation: From Molecular Mechanisms to Human Diseases
edited by Xinrui Gui and Jinjun Wu
submission deadline 20 Jul 2025 | 1 articles | Viewed by 630 | Submission Open
Keywords: protein aggregation; amyloid fibrils; protein quality control; neurodegenerative diseases
(This special issue belongs to the Section Cellular Biophysics)
Host–Microbial Interactions: Second Edition submission deadline 20 Jul 2025 | Viewed by 522 | Submission Open
Keywords: virus– host interactions; signaling pathway; virus entry; life cycle
(This special issue belongs to the Section Cellular Immunology)
Neurotoxicity and Neurodegenerative Diseases: The Potential of Regenerative Medicine
edited by Elisabetta Mormone, Paola Crociani and
submission deadline 20 Jul 2025 | Viewed by 119 | Submission Open
Keywords: inflammation; iPSCs; MSCs; neural stem cells niche; neurodegeneration; regenerative medicine; ROS; PRP
(This special issue belongs to the Section Cellular Aging)
Glioblastoma: What Do We Know?
edited by
submission deadline 25 Jul 2025 | 5 articles | Viewed by 12417 | Submission Open
Keywords: carcinoma cell; diagnoses; molecular mechanism; cellular mechanism; signaling pathways; biomarkers; therapeutics
(This special issue belongs to the Section Cells of the Nervous System)
Fibrosis in Chronic Inflammatory Diseases submission deadline 25 Jul 2025 | 6 articles | Viewed by 10249 | Submission Open
Keywords: fibrosis; fibroblasts; myofibroblasts; inflammation; molecular pathways; pathogenetic mechanisms; therapeutic targets
(This special issue belongs to the Section Cellular Pathology)
Regulation of Receptor Tyrosine Kinase Signaling and Its Implication in Cancer
edited by
submission deadline 25 Jul 2025 | 2 articles | Viewed by 3017 | Submission Open
Keywords: RTKs; EGFR family; PDGFR family; FGF receptor family; VEGFR family; growth factors; phosphorylation; cell signaling; cell cycle; cancer; targeted cancer therapy; the antibody-based cancer therapies; small molecule-based tyrosine kinase inhibitor (TKI)
(This special issue belongs to the Section Cell Signaling)
Neuroinflammation in Brain Health and Diseases
edited by Debashis Dutta and Nemil Bhatt
submission deadline 25 Jul 2025 | 2 articles | Viewed by 2940 | Submission Open
Keywords: neuroinflammation; gliosis; inflammasome; neurodegeneration; neurotherapeutics
(This special issue belongs to the Section Cells of the Nervous System)
New Molecular and Computational Approaches to Study Immune and Metabolic Interactions in Cancer Biology
edited by Federica Mornata, Luca De Feo, Rebecca Polidori and
submission deadline 25 Jul 2025 | Viewed by 329 | Submission Open
Keywords: solid and liquid cancer; cancer metabolism; tumor microenvironment; digital pathology; immunoncology
(This special issue belongs to the Section Cell Methods)
Novel Molecular Targets for the Treatment of Sleep Disorders
edited by
submission deadline 25 Jul 2025 | Viewed by 114 | Submission Open
Keywords: sleep disorders; molecular targets; glymphatic system; neuroinflammation; circadian rhythms; microbiome; biomarkers; pharmacological therapy; gene therapy; neurodegeneration
Soluble Interleukin-6 Receptor (sIL-6R): Role in Health and Disease submission deadline 25 Jul 2025 | Viewed by 78 | Submission Open
Keywords: sIL-6R; IL-6 signalling; IL-6ST; genetic polymorphism; health; disease; exercise physiology; therapeutics; mental health
(This special issue belongs to the Section Cell Signaling)
Recent Developments in Cellular and Molecular Mechanisms and Therapeutic Approaches to Cardiovascular and Metabolic Diseases submission deadline 30 Jul 2025 | 1 articles | Viewed by 925 | Submission Open
Keywords: cardiometabolic diseases; developmental programming; sexual dimorphism
Going with the Flow and Beyond: Understanding Benign Blood Disorders and Their Underlying Mechanisms
edited by Tirthadipa Pradhan-Sundd
submission deadline 30 Jul 2025 | Viewed by 111 | Submission Open
Keywords: benign blood disorders; sickle cell disease; red blood cells; hemoglobin; heme; iron overload; organ damage; hemophilia; thalassemia; anemia; blood vessels; vascular aging; endothelial cells
State-of-the-Art of Cell Cultures in Drug Validation and Toxicity Assessment submission deadline 31 Jul 2025 | 7 articles | Viewed by 18107 | Submission Open
Keywords: human in vitro models; toxicity testing; drug development; mandatory requirements; regulatory approval; standardization; validation
(This special issue belongs to the Section Cell Methods)
Proteomic Applications in Ageing and Neurodegenerative Conditions submission deadline 31 Jul 2025 | 4 articles | Viewed by 16012 | Submission Open
(This special issue belongs to the Section Cell Methods)
Cancer-Associated Fibroblasts: Challenges and Directions submission deadline 31 Jul 2025 | 4 articles | Viewed by 9628 | Submission Open
Keywords: cancer-associated fibroblast (CAFs); tumor microenvironment (TME); fibroblast activation protein alpha (FAPα ); immunotherapy; cytokines; angiogenesis; metastasis; FAP inhibitors; radioligands; imaging agents
(This special issue belongs to the Section Cell Microenvironment)
Cancer Immunotherapy Harnessing Innate and Adaptive Immune Effector Cells and PD-1 Immune Checkpoint Inhibitors
edited by
submission deadline 31 Jul 2025 | 3 articles | Viewed by 8790 | Submission Open
Keywords: PD-1 immune checkpoint; CAR-T cells; γ δ T cells; NK cells
(This special issue belongs to the Section Cellular Immunology)
Imaging Methods in Cell Biology submission deadline 31 Jul 2025 | 3 articles | Viewed by 5716 | Submission Open
Keywords: cellular organelles; molecular function; molecular interaction; disease- and drug-related subcellular phenomena; single-molecule imaging; light microscopy; electron microscopy; fluorescence microscopy; fluorescence correlation methods; fluorescence lifetime imaging microscopy (FLIM); Raman microscopy; spatial biology
(This special issue belongs to the Section Cell Methods)
Signaling in Cancer Stem Cells
edited by Upasana Ray
submission deadline 31 Jul 2025 | 3 articles | Viewed by 3860 | Submission Open
Keywords: cancer stem cells (CSCs); stem cells signaling pathways; cancer progression and metastasis; therapeutic resistance; targeting cancer stem cells signaling; cancer heterogeneity; targeted therapy for CSCs; identifying biomarkers for CSCs
(This special issue belongs to the Section Stem Cells)
Cell–Cell Interactome-Based Therapies for Osteosarcoma
edited by and Javier Munoz
submission deadline 31 Jul 2025 | 2 articles | Viewed by 3660 | Submission Open
Keywords: osteosarcoma; cell– cell interactions; microenvironment; metastases; resistance; chemotherapy; immune checkpoints
(This special issue belongs to the Section Cell Microenvironment)
Biological Mechanisms in the Treatment of Neuropsychiatric Diseases
edited by Randall D Marshall and Frank S. Menniti
submission deadline 31 Jul 2025 | 2 articles | Viewed by 3290 | Submission Open
Keywords: neurodevelopmental conditions; rare neurological disease; molecular mechanisms of novel CNS treatments; precision medicine in neuropsychiatry; organoids; molecular mechanisms of effective treatments
(This special issue belongs to the Section Cellular Pathology)
Ion Channels in Cancer: An Update
edited by and
submission deadline 31 Jul 2025 | 1 articles | Viewed by 2183 | Submission Open
Keywords: ion channels; cancer therapy; cancer cell biology; mitogenic signaling; cancer signaling
(This special issue belongs to the Section Cell Proliferation and Division)
The Cell Biology of Heart Disease
edited by Rajeshwary Ghosh and
submission deadline 31 Jul 2025 | 1 articles | Viewed by 757 | Submission Open
Keywords: cardiomyopathy; endothelial dysfunction; cellular senescence; fibrosis; myocardial infarction; inflammation; mitochondrial dysfunction; CAD; arrhythmia; heart failure
(This special issue belongs to the Section Cells of the Cardiovascular System)
Neuronal Development and Disease: From Molecular Bases to Neurological Disorders
edited by Ramiro Almeida
submission deadline 31 Jul 2025 | 1 articles | Viewed by 713 | Submission Open
Keywords: neuronal development; neurological disorders; neurogenesis; neuroinflammation; synaptic plasticity
(This special issue belongs to the Section Cells of the Nervous System)
Adipose Tissue Functioning in Health and Diseases
edited by Richard C Chang
submission deadline 31 Jul 2025 | 1 articles | Viewed by 624 | Submission Open
Keywords: adipose tissue biology; adipogenesis; lipolysis; adipose tissue inflammation; diet-induced obesity; non-coding RNA in metabolism; PPARγ signaling; metabolic health and disease; obesogens; epigenetics and chromatin regulation; transgenerational inheritance
(This special issue belongs to the Section Tissues and Organs)
Retinal Pigment Epithelium in Degenerative Retinal Diseases
edited by Jian Liu and Shintaro Horie
submission deadline 31 Jul 2025 | Viewed by 374 | Submission Open
Keywords: RPE; degenerative retinal diseases; macular degeneration; diabetic retinopathy; glaucoma; photoreceptor; vascular endothelium; microglia; macrophage; inflammation; oxidative stress; autophagy; mitochondria; lipid metabolism; senescence; neuropeptide; therapeutics; biomarkers
(This special issue belongs to the Section Cellular Pathology)
Therapeutic Applications of Magnetotactic Bacteria and Magnetosomes: State of the Art and Perspectives
edited by
submission deadline 31 Jul 2025 | Viewed by 297 | Submission Open
Keywords: biomedical applications; biotechnology; magnetite nanocrystals; magnetosomes; magnetotactic bacteria; nanotechnology; nanotargeting
(This special issue belongs to the Section Cellular Biophysics)
Role of RNA as Regulator, Therapeutic Target and Probe for Early Disease Diagnosis
edited by
submission deadline 31 Jul 2025 | Viewed by 267 | Submission Open
Keywords: coding RNAs; non-coding RNAs (ncRNAs); regulatory RNAs; RNA-based diagnostics; disease biomarkers; RNA monitoring techniques; molecular probes; RNA interference (RNAi)
Advances in Understanding Skeletal Muscle Metabolism and Regeneration: From Mechanisms to Therapeutics
edited by
submission deadline 31 Jul 2025 | Viewed by 170 | Submission Open
Keywords: skeletal muscle; satellite cells; myoblast; myogenesis; regeneration; mitochondria; metabolism; sarcopenia; cachexia
(This special issue belongs to the Section Tissues and Organs)
Mechanisms That Link Olfactory Perception with Aging in Drosophila
edited by , Anindya Ganguly and Jordan A. Munroe
submission deadline 31 Jul 2025 | Viewed by 168 | Submission Open
Keywords: olfaction; aging; neuroscience
(This special issue belongs to the Section Cellular Aging)
Membrane Dynamics and the Role of Aquaporins in Plant Cells
edited by
submission deadline 31 Jul 2025 | Viewed by 155 | Submission Open
Keywords: aquaporins; membrane dynamics; plant cell; water transport; osmoregulation; cell membrane permeability; aquaglyceroporins; stress response; membrane trafficking
(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)
New Research on Immunity and Inflammation in Cardiovascular Disease
edited by Pavel Poredoš
submission deadline 31 Jul 2025 | Viewed by 148 | Submission Open
Keywords: inflammation; atherosclerosis; coronary artery disease; peripheral arterial disease; cerebrovascular disease; venous thromboembolic disease; circulating biomarkers; anti-innflammatory treatment of cardiovascular disease
(This special issue belongs to the Section Cells of the Cardiovascular System)
Biomarkers in Human Diseases and Emerging Diagnostic Technologies for Their Identification and Application
edited by and
submission deadline 31 Jul 2025 | 1 articles | Viewed by 148 | Submission Open
Keywords: biomarkers; human diseases; disease mechanisms; biomarker validation; early detection; accurate diagnosis; prognosis evaluation; treatment monitoring; diagnostic technologies; biosensors; microfluidics
Role of Extracellular Matrix in Cancer and Disease submission deadline 31 Jul 2025 | Viewed by 146 | Submission Open
Keywords: extracellular matrix; cancer; disease; ECM targeting; ECM turn-over and remodeling
(This special issue belongs to the Section Cell Microenvironment)
Neuro-Oncological Advances in Stem Cell Research: A New Era in Brain Tumor Therapy submission deadline 31 Jul 2025 | Viewed by 142 | Submission Open
Keywords: brain tumor genetics and epigenetics; brain tumor stem cells; stem cell therapy against brain tumors; mesenchymal stem cells; iPSC; resistance to therapy
(This special issue belongs to the Section Stem Cells)
Molecular Pathobiology and Drug Targeting Cardiovascular and Kidney Injury in Obesity and Diabetes
edited by Annayya R. Aroor
submission deadline 31 Jul 2025 | Viewed by 142 | Submission Open
Keywords: obesity; hypertension; diabetes; atherosclerosis; cardiorenal metabolic syndrome
(This special issue belongs to the Section Cellular Pathology)
Establishment and Characterization of Novel Patient-Derived Cancer Model submission deadline 31 Jul 2025 | Viewed by 141 | Submission Open
Keywords: patient-derived cancer model; primary tissue culture; cell line; spheroid; organoid; xenograft; PDX; organ-on-a-chip; comparative oncology; precision medicine
Advances in the Regulation of Proteins and Genes for Stem Cells
edited by
submission deadline 31 Jul 2025 | Viewed by 124 | Submission Open
Keywords: stem cells; pluripotency; differentiation; diagnosis; therapeutics
(This special issue belongs to the Section Stem Cells)
Skeletal Muscle: Structure, Physiology and Diseases submission deadline 31 Jul 2025 | Viewed by 121 | Submission Open
Keywords: excitation– contraction coupling; store-operated calcium entry; sarcomeric proteins; skeletal muscle metabolism; skeletal muscle diseases; muscle plasticity; development; sarcopenia; aging
(This special issue belongs to the Section Tissues and Organs)
Role of Gene Regulation in Neurological Disorders
edited by and Yulin Jin
submission deadline 31 Jul 2025 | Viewed by 116 | Submission Open
Keywords: gene regulation; neurological disorders; central nervous system (CNS); peripheral nervous system (PNS); Alzheimer's disease (AD); Parkinson's disease (PD); Huntington's disease (HD); autism spectrum disorder (ASD); fragile X syndrome (FXS); fragile X-associated tremor/ataxia syndrome (FXTAS); amyotrophic lateral sclerosis (ALS); multiple sclerosis (MS)
(This special issue belongs to the Section Cell and Gene Therapy)
Recent Advances in Extracellular-Intracellular Communication and Cancer Therapies
edited by Ana Rita Carlos
submission deadline 31 Jul 2025 | Viewed by 110 | Submission Open
Keywords: extracellular matrix; ECM– cell communication; integrins; cytoskeleton; cancer therapies
MicroRNAs: Regulators of Cellular Fate
edited by
submission deadline 31 Jul 2025 | Viewed by 110 | Submission Open
Keywords: microRNA targets; microRNA conservation; microRNA pathway; microRNA mimics; microRNA antagonist; disease biomarker
Role of Mitochondrial Metabolism in Kidney Disease
edited by
submission deadline 31 Jul 2025 | Viewed by 106 | Submission Open
Keywords: kidney disease; mitochondria; metabolism
(This special issue belongs to the Section Tissues and Organs)
Emerging Topics in Cachexia
edited by Gabriela Salim Ferreira De Castro
submission deadline 31 Jul 2025 | Viewed by 94 | Submission Open
Keywords: cachexia; skeletal muscle loss; adipose tissue loss; inflammation; sarcopenia; cancer; body composition; biomarkers
The Role of Macrophages in Leishmaniasis: Current Perspective
edited by Devki Nandan
submission deadline 31 Jul 2025 | Viewed by 79 | Submission Open
Keywords: Leishmania; leishmaniasis; macrophage biology; host– pathogen interactions
Novel Therapeutic Strategies to Improve Mitochondrial Function in Neurodegenerative Diseases
edited by Patricia Morcillo
submission deadline 31 Jul 2025 | Viewed by 62 | Submission Open
Keywords: mitochondria; cellular signaling; neurodegenerative diseases; mitochondrial dynamics; organelles; neurological diseases; therapies; biomarkers
(This special issue belongs to the Section Cellular Aging)
Lung Development: Challenges and Opportunities
edited by David Warburton
submission deadline 31 Jul 2025 | Viewed by 54 | Submission Open
Keywords: alveolar gas diffusion surface; alveolar development; injury; repair; and replacement; alveolar stresses and strains; lung microenvironment; tissue engineering in pulmonary regeneration
(This special issue belongs to the Section Tissues and Organs)
Retinal Pigment Epithelial Cells in Age-Related Macular Degeneration
edited by Sujoy Bhattacharya
submission deadline 1 Aug 2025 | 2 articles | Viewed by 3688 | Submission Open
Keywords: atrophic age-related macular degeneration; iPSC-derived RPE; animal models
(This special issue belongs to the Section Cellular Aging)
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