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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Artificial Intelligence to the Rescue of Cancer Research

edited by

Asunción Espinosa-Sánchez

and

Amancio Carnero

submission deadline 30 Sep 2025 | 1 articles | Viewed by 874 | Submission Open

Keywords: cancer research; artificial intelligence; personalized medicine; multi-omics data integration; AI-driven drug discovery; precision medicine

(This special issue belongs to the Section Cell Methods)

Cellular Mechanisms and Targeted Therapy of Acute Myeloid Leukemia

edited by

Mookon Song

submission deadline 30 Sep 2025 | 1 articles | Viewed by 867 | Submission Open

Keywords: Acute Myeloid Leukemia (AML); molecular targets; gene therapy; drug resistance; targeted therapy; leukemia stem cells; oncogenic mutations; apoptosis; cell cycle regulation

(This special issue belongs to the Section Cellular Pathology)

Advancements in Research on hiPSC-Derived Cells

edited by Akhilesh Kumar

submission deadline 30 Sep 2025 | 1 articles | Viewed by 767 | Submission Open

Keywords: hiPSCs; hematopoietic progenitors; T cells; NK cells; cardiac cells; B cells; macrophages; neutrophiles; CRISPR/Cas9 technology; genetic engineering

(This special issue belongs to the Section Stem Cells)

Melanoma: From Molecular Mechanisms to Therapeutic Opportunities—3rd Edition

edited by

Cynthia Simbulan-Rosenthal

and

Dean S. Rosenthal

submission deadline 30 Sep 2025 | 1 articles | Viewed by 763 | Submission Open

Keywords: melanomagenesis; treatment response; signal transduction; melanoma-initiating cells; drug resistance; invasiveness; immune evasion; metastasis; MAPK pathway; PI3K/AKT survival pathways; MEKi; BRAFi; trametinib; dabrafenib; immunotherapies

(This special issue belongs to the Section Cellular Pathology)

The Role of Epithelial Cells in Scleroderma—Second Edition

edited by Richard Stratton

submission deadline 30 Sep 2025 | 1 articles | Viewed by 745 | Submission Open

Keywords: fibrosis; epithelial– fibroblast interaction; EMT; cytokeratin 6 and 16

Advances in Reproductive Biology: Cellular and Molecular Mechanisms

edited by

Rosa Roy

and Clara González-Marín

submission deadline 30 Sep 2025 | 1 articles | Viewed by 548 | Submission Open

Keywords: gametogenesis; fertilization; embryo implantation; reproductive genetics; epigenetics in reproduction; hormonal signaling; stem cells and reproduction; assisted reproductive technologies (ARTs); molecular fertility regulation; reproductive health innovations

(This special issue belongs to the Section Reproductive Cells and Development)

Contribution of Omics Sciences to Agricultural Biotechnology

edited by

Sara Rinalducci

Nunzio D'Agostino

and

Giuseppina Fanelli

submission deadline 30 Sep 2025 | Viewed by 377 | Submission Open

Keywords: omics technologies; bioinformatics; systems biology; data mining; knowledge discovery; metabolic engineering; genetic engineering; plant biotechnologies; agrifoods; (a)biotic stress resilience; plant– microbe interactions

(This special issue belongs to the Section Cell Methods)

mRNA Vaccines and Therapeutics in Melanoma: From Mechanisms to Cellular Impact

edited by

Stefano Zoroddu

and

Luigi M. Bagella

submission deadline 30 Sep 2025 | Viewed by 350 | Submission Open

Keywords: mRNA vaccines; melanoma; tumor immunology; mRNA vaccine designs; delivery systems

(This special issue belongs to the Section Cellular Pathology)

Progress of Nanoparticles in the Treatment of Cancers

edited by

Mohammad Asif Sherwani

submission deadline 30 Sep 2025 | Viewed by 308 | Submission Open

Keywords: nanoparticles; cancer treatment; cellular mechanisms; molecular biology; pathophysiology; drug delivery; drug resistance; immunotherapy; tumor microenvironment

(This special issue belongs to the Section Cell Microenvironment)

Yeast Stress Responses and Cell Death Regulation

edited by

Maria João Sousa

Manuela Côrte-Real

and

Susana R. Chaves

submission deadline 30 Sep 2025 | Viewed by 276 | Submission Open

Keywords: yeast stress responses; environmental stresses; signalling pathways; cell death

Spatial Biology: Decoding Cellular Complexity in Tissues

edited by

Alexander E. Kalyuzhny

submission deadline 30 Sep 2025 | Viewed by 167 | Submission Open

Keywords: spatial biology; spatial tissue profiling; proteomics; transcriptomics; cell and tissue

(This special issue belongs to the Section Tissues and Organs)

From Fat to Flame: Targeting Adipose Tissue in Chronic Inflammation and Exploring Therapeutic Strategies

edited by

Francesca Bianchi

Elena Dozio

and

Lucia La Sala

submission deadline 30 Sep 2025 | Viewed by 159 | Submission Open

Keywords: obesity; inflammasomes; immune system; microbiota

(This special issue belongs to the Section Tissues and Organs)

The Interplay Between Tumor Metabolism, Microenvironment and Cell Survival

edited by

Silvia Peppicelli

and Giulio Menegazzi

submission deadline 30 Sep 2025 | Viewed by 153 | Submission Open

Keywords: tumor microenvironment; metabolic cross-talk; metabolic reprogramming; extracellular vesicles; cell survival; therapy resistance

(This special issue belongs to the Section Cell Microenvironment)

Novel Insights into Mechanism and Treatment of Degenerative Disc Disease

edited by Yejia Zhang

submission deadline 30 Sep 2025 | Viewed by 143 | Submission Open

Keywords: intervertebral disc (IVD) degeneration; back pain; age; genetics; injury

(This special issue belongs to the Section Cellular Pathology)

Mechanisms and Dynamics in Cellular Adhesion in Development and Disease

edited by

Daniel Bouvard

submission deadline 30 Sep 2025 | Viewed by 136 | Submission Open

Keywords: actin; integrin; cell adhesion; signalling; mechanotransduction

Biomarkers and Therapeutic Targets in Insulin Resistance

edited by

Mohamed Elrayess

submission deadline 30 Sep 2025 | Viewed by 127 | Submission Open

Keywords: insulin resistance; biomarkers; therapeutic targets; type 2 diabetes; metabolic syndrome; obesity; molecular mechanisms; pharmacologic treatments; precision medicine; cardiovascular diseases

(This special issue belongs to the Section Cellular Pathology)

Mitochondria and Peroxisomes–Individual Roles and Delicate Balance of Redox Organelles

edited by

Andreas Till

submission deadline 30 Sep 2025 | Viewed by 91 | Submission Open

Keywords: mitochondria; peroxisomes; redox organelles; oxidative stress; ROS; organelles; neurodegeneration; autophagy; aging; metabolism

Novel Molecular Insight into Congenital Disorders of N-Linked Glycosylation

edited by

Ashutosh Pandey

submission deadline 30 Sep 2025 | Viewed by 78 | Submission Open

Keywords: N-linked glycosylation; CDG; animal models; genetic variants; glycomics; glycoproteomics; pathophysiology

Psilocybe Mushrooms Constituents—Therapeutic Implications

edited by

Andrea Bugarcic

and Janet Schloss

submission deadline 30 Sep 2025 | Viewed by 71 | Submission Open

Keywords: Psilocybe mushrooms; psilocybin; pre-clinical research; neurodegeneration

(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)

Function of Stress Granules in Normal Cells and in Alzheimer’s Disease

edited by

Paul D. Coleman

and Benjamin Wolozin

submission deadline 30 Sep 2025 | Viewed by 69 | Submission Open

Keywords: stress granules; Alzheimer's disease; neurodegenerative diseases

(This special issue belongs to the Section Cellular Aging)

Novel Insights into Molecular Mechanisms and Therapy of Myeloma

edited by

Yusuke Furukawa

and

Jian Wu

submission deadline 5 Oct 2025 | 3 articles | Viewed by 4068 | Submission Open

Keywords: multiple myeloma; CAR-T therapy; relapse; methylation; drug resistance; treatment strategy; molecular mechanism; novel target; biomarker

(This special issue belongs to the Section Cellular Pathology)

The Interplay of G-Protein-Coupled Receptor Signaling between Humans and Diseases

edited by Victor Garcia

submission deadline 10 Oct 2025 | 1 articles | Viewed by 6199 | Submission Open

Keywords: G-proteins; G-protein-coupled receptors; G-protein-independent signaling; cAMP signals

Study on Immune Activity of Natural Products

edited by Xiu-Min Li

submission deadline 10 Oct 2025 | Viewed by 86 | Submission Open

Keywords: natural products; bioactive compounds; immune activity; immunomodulation; inflammation; autoimmune diseases; immunotherapy; therapeutic potential

Ras Family of Genes and Proteins: Structure, Function and Regulation

edited by

Eugenio Santos

Alberto Fernández-Medarde

and Rosula Garcia-Navas

submission deadline 15 Oct 2025 | 2 articles | Viewed by 2244 | Submission Open

Keywords: HRAS; NRAS; KRAS; RAS-driven tumors; rasopathies; RAS signaling; RAS inhibitors; GAP; GEF; SOS; GRF

Non-Traditional Roles of Protein Ubiquitination in Cellular Processes and Health

edited by

Chuanjin Wu

submission deadline 15 Oct 2025 | 2 articles | Viewed by 2128 | Submission Open

Keywords: Protein Ubiquitination; ; Ubiquitin chain; ; k63-linked ubiquitination; ; linear ubiquitination; ; ubiquitin-binding proteins; ; deubiquitinases; ; NF-kB; ; autophagy; ; inflammation; ; immunodeficiency; ; neurodegenerative diseases.

(This special issue belongs to the Section Cellular Pathology)

Regulation of the Subcellular Compartmentalization of Signaling Pathways by Post-Translational Modifications

edited by Jürgen Fritsch

submission deadline 15 Oct 2025 | 1 articles | Viewed by 688 | Submission Open

Keywords: phosphorylation; ubiquitination; acetylation; acylation; methylation; sumoylation; glycosylation; neddylation; ribosylation; oxidation; proteolysis

Advances in Understanding Inflammation in Atherosclerosis: From Mechanisms to Therapeutic Targets

edited by Yaw Asare and Michael Lacy

submission deadline 15 Oct 2025 | Viewed by 620 | Submission Open

Keywords: atherosclerosis; inflammatory pathways; monocytes/macrophages; endothelial cells; innate immunity; inflammasome; IL-1β ; cytokines and chemokines; neutrophils; epigenetic mechanisms; adaptive immunity; small-molecule inhibitors; T cells; B cells

(This special issue belongs to the Section Cellular Pathology)

LPS-Induced Inflammatory Diseases

edited by

Lin-Hua Jiang

and

Pankaj Kumar

submission deadline 15 Oct 2025 | Viewed by 269 | Submission Open

Keywords: lipopolysaccharide (LPS); endotoxemia; inflammation; LPS signaling; acute lung injury; inflammatory cytokines; therapeutic targets

(This special issue belongs to the Section Cellular Pathology)

The Multifaceted Role of Molecular Chaperones in Cancer: Pro-Tumoral or Therapeutic Function

edited by

Alessandra Maria Vitale

and

Federica Scalia

submission deadline 15 Oct 2025 | Viewed by 222 | Submission Open

Keywords: molecular chaperones; cancer biology; carcinogenesis; tumor progression; diagnostic/prognostic biomarkers; anti-tumor therapeutic strategies; in vitro/in vivo experimental approaches; in silico computational approaches

Molecular and Cellular Mechanisms of Type 1 Diabetes (T1D)

edited by Robert Sharp and

Itamar Raz

submission deadline 15 Oct 2025 | Viewed by 208 | Submission Open

Keywords: T1D; autoimmunity; type 1 diabetes; single-nucleotide polymorphisms (SNPs); viral/bacterial pathogens; T-cell biology; inflammation; pancreatic beta cells; immunoregulatory; molecular biology; cellular biology

(This special issue belongs to the Section Cellular Pathology)

AI, CRISPR, and Molecular Mechanisms in Precision Medicine

edited by Karim Daliri

submission deadline 15 Oct 2025 | Viewed by 96 | Submission Open

Keywords: CRISPR; gene therapy; precision medicine

(This special issue belongs to the Section Cell Methods)

Advances in Adipocyte Biology Research and Their Relevance to Metabolic Health

edited by

Aaron C. Brown

submission deadline 15 Oct 2025 | Viewed by 82 | Submission Open

Keywords: adipose tissue; obesity; inflammation; thermogenesis; adipokines

Membrane Trafficking Components and Mechanisms in Bacterial, Viral or Fungal Infections

edited by

Bor Luen Tang

submission deadline 15 Oct 2025 | Viewed by 76 | Submission Open

Keywords: bacterial intracellular infections; bacterial intracellular sanctuaries; viral infection; viral hijacking of host trafficking machinery; membrane trafficking; Rab; secretory pathway; endocytic pathway; viral replication

Extracellular Vesicles and Exosomes: Novel Insight and Therapeutic Applications in Cancer

edited by Giusi Alberti and

Celeste Caruso Bavisotto

submission deadline 16 Oct 2025 | Viewed by 126 | Submission Open

Keywords: extracellular vesicles (EVs); exosomes (Exos); proteins and miRNA; 2D-EVs and Exos; 3D-EVs and Exos; precision therapy; molecular mechanism; cancer physiology; oncology research

Understanding Spinal Cord Injury and Repair: From Molecules to Neurocircuits and Multimodal Prostheses

edited by

Yang D. Teng

submission deadline 20 Oct 2025 | 9 articles | Viewed by 19388 | Submission Open

(This special issue belongs to the Section Cells of the Nervous System)

Molecular Mechanisms of Autism Spectrum Disorder

edited by Tanya Gandhi and

Charles Lee

submission deadline 20 Oct 2025 | 6 articles | Viewed by 12529 | Submission Open

Keywords: autism spectrum disorder; neurodevelopmental disorders; molecular mechanisms; cellular-molecular mechanisms; neurobiological mechanisms; neural mechanisms; intervention approaches; treatment strategies

(This special issue belongs to the Section Cells of the Nervous System)

Therapeutic Targets in Glioblastoma

edited by Candice Mazewski and

Frank Eckerdt

submission deadline 20 Oct 2025 | 5 articles | Viewed by 8350 | Submission Open

Keywords: glioblastoma; signaling targets; blood-brain-barrier; complementary and alternative medicine; combination therapy; glioma stem cells; progression; resistance; nutrient-sensing

(This special issue belongs to the Section Cells of the Nervous System)

New Trends and Advances in Diagnosis and Prognosis of Head and Neck Cancer from Carcinogenesis to Future Molecular Targeted Therapies: 2nd Edition

edited by

Piotr Cierpikowski

and

Julia Bar

submission deadline 20 Oct 2025 | 4 articles | Viewed by 5232 | Submission Open

Keywords: head and neck cancer; oral cancer; biomarker; prognosis; carcinogenesis; oral premalignant lesions; cancer stem cells; signaling pathways; molecular targeted therapy

(This special issue belongs to the Section Cellular Pathology)

Sperm Biology and Reproductive Health—Second Edition

edited by

Yi-Xun Liu

and

Shou-Long Deng

submission deadline 20 Oct 2025 | 2 articles | Viewed by 2056 | Submission Open

Keywords: spermatogenesis; differentiation of spermatogonial stem cells in vitro; mitosis; meiosis; sperm formation

Experimental Systems to Model Aging Processes

edited by

Natascia Tiso

Giovanni Risato

and Ralf Dahm

submission deadline 20 Oct 2025 | 1 articles | Viewed by 1379 | Submission Open

Keywords: aging; ageing; age-related; longevity; model; animal; signalling pathway; mechanism; in vitro; in vivo; cell culture; marker

(This special issue belongs to the Section Cellular Aging)

Mechanism of Cell Signaling During Eye Development and Diseases—Second Edition

edited by

Mehrnoosh Saghizadeh Ghiam

and

Vivien Coulson-Thomas

submission deadline 20 Oct 2025 | 1 articles | Viewed by 636 | Submission Open

Keywords: cell signaling; ocular; eye disorders; Wnt signaling; TGF-β

(This special issue belongs to the Section Cell Signaling)

New Advances in Anticancer Therapy

edited by

Dooil Jeoung

submission deadline 20 Oct 2025 | 1 articles | Viewed by 296 | Submission Open

Keywords: antibody-based immunotherapy; cell therapy; personalized anticancer therapy; RNA vaccines; nanotechnology

(This special issue belongs to the Section Cellular Pathology)

Cell Therapy for Retinal Diseases

edited by

Girish Kumar Srivastava

and

Yogeswaran Lokanathan

submission deadline 20 Oct 2025 | Viewed by 295 | Submission Open

Keywords: retinal diseases; cell therapy; stem cells; retinal regeneration; cell transplantation; gene editing in retinal therapy; tissue engineering; retinal organoids; vision restoration; clinical translation of cell therapy; future directions in retinal regeneration

(This special issue belongs to the Section Tissues and Organs)

Immune Response in HIV Infection, Pathogenesis and Persistence

edited by Suvadip Mallick

submission deadline 20 Oct 2025 | Viewed by 149 | Submission Open

Keywords: HIV infection; immune response; chronic inflammation; immune activation; antiretroviral therapy (ART); immune reconstitution; immune checkpoints

(This special issue belongs to the Section Cellular Immunology)

New Molecular Insights into Hepatitis and Hepatic Cancer

edited by

Mark A. Feitelson

submission deadline 20 Oct 2025 | Viewed by 119 | Submission Open

Keywords: hepatitis; alcoholic and non-alcoholic steatohepatitis; HBV and HCV; hepatic Cancer; hepatocellular carcinoma; chronic liver disease; cellular and molecular basis; signaling pathways; antiviral therapies; immunotherapy; therapeutic advances

(This special issue belongs to the Section Cellular Pathology)

Autophagy in Neurological Disorders

edited by

Natalia Jimenez-Moreno

and

Ciro Isidoro

submission deadline 20 Oct 2025 | Viewed by 107 | Submission Open

Keywords: autophagy; selective autophagy; neurodegeneration; proteostasis; lysosomes; aging; oxidative stress; aging; biomarkers; pharmacological agents

(This special issue belongs to the Section Cells of the Nervous System)

Cell Death and Its Clearance in Health and Disease

edited by

Turan Tufan

submission deadline 20 Oct 2025 | Viewed by 98 | Submission Open

Keywords: cell death; phagocytosis; immune homeostasis; inflammation

(This special issue belongs to the Section Cellular Pathology)

The Cellular and Molecular Mechanisms of Immunity to Infectious Viruses

edited by

Dimitrios Vlachakis

Tassos Georgakopoulos

and

Marios Agelopoulos

submission deadline 20 Oct 2025 | Viewed by 89 | Submission Open

Keywords: viral infections; immune cell biology; gene expression programs; epigenetics; chromatin architecture; cis-regulatory elements; functional genomics; computational biology applications

(This special issue belongs to the Section Cellular Pathology)

Unraveling Protein–Protein Interactions for Innovative Therapeutics and Nanodelivery

edited by Roberta Montanari and