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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Symphony of Nature—the Precision of Life’s Regulation

edited by Weiguang Wang and Baocheng Liu

submission deadline 15 Dec 2025 | Viewed by 90 | Submission Open

Keywords: protein structure and function; allosteric regulation; conformational switches; enzyme catalysis and modification; molecular machines; molecular regulation; protein folding and misfolding

(This special issue belongs to the Section Cell Methods)

Cancer and Immune System Interactions

edited by

Hong-Jian Zhu

and

Bradley Creamer

submission deadline 16 Dec 2025 | Viewed by 130 | Submission Open

Keywords: cancer immunology; tumor microenvironment; immune evasion; immunotherapy; tumor– immune interactions; immune checkpoint regulation; translational oncology

(This special issue belongs to the Section Cell Microenvironment)

Molecular Mechanisms of Tumor Pathogenesis

edited by

Saverio Candido

and Alessandro Lavoro

submission deadline 20 Dec 2025 | 9 articles | Viewed by 21117 | Submission Open

Keywords: cancer; therapeutic targets; biomarkers; epigenetics; DNA methylation; microRNAs; somatic mutations; germline mutations; chromatin remodeling; histone modifications

(This special issue belongs to the Section Cellular Pathology)

Physiology of Telocytes

edited by

Catalin G. Manole

and Mihail E. Hinescu

submission deadline 20 Dec 2025 | 1 articles | Viewed by 4573 | Submission Open

Keywords: telocytes; telopodes; physiology; pathology; tissue homeostasis; regenerative medicine

(This special issue belongs to the Section Cellular Pathology)

Molecular Mechanisms of Cognitive Function and Dysfunction

edited by

Parasuraman Padmanabhan

Balázs Gulyás

and

Domokos Máthé

submission deadline 20 Dec 2025 | 1 articles | Viewed by 2855 | Submission Open

Keywords: cognition; neurodevelopment; neurotransmission; molecular mecanisms; signaling; disorders; therapy

(This special issue belongs to the Section Cells of the Nervous System)

Metabolic Hallmarks in Cancer

edited by

Michael Lisanti

, Ubaldo Martinez-Outshoorn and Marta Mauro-Lizcano

submission deadline 20 Dec 2025 | 2 articles | Viewed by 2743 | Submission Open

Keywords: cancer; metabolic reprogramming; metabolic adaptation; cancer energy metabolism; glycolysis; the Warburg effect; the reverse Warburg effect; glutamine addiction; the pentose phosphate pathway; cellular and molecular mechanisms; tumor microenvironment; novel therapeutic interventions

(This special issue belongs to the Section Cellular Metabolism)

Advances in Human Pluripotent Stem Cells

edited by

Peggy Arthur

Sangeetha Kandoi

and

Nagavendra Kommineni

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1688 | Submission Open

Keywords: human pluripotent stem cells; embryonic stem cells; induced pluripotent stem cells

(This special issue belongs to the Section Stem Cells)

Microglial Functions in Neurodegenerative Diseases: In Search of Potential Therapeutic Targets

edited by

Laura Jiménez Sánchez

and María Martín Estebané

submission deadline 20 Dec 2025 | Viewed by 303 | Submission Open

Keywords: microglia; inflammation; neural damage; mitochondria; potential targets

(This special issue belongs to the Section Cellular Aging)

Advanced Research on Genomic Instability and Gene Expression in Developmental Disorders

edited by

Shenzhao Lu

submission deadline 20 Dec 2025 | Viewed by 215 | Submission Open

Keywords: development; neurological disease; cancer; genetic; epigenetic

State-of-the-Art Insights into the Cell Microenvironment

edited by

Said M. Afify

submission deadline 20 Dec 2025 | Viewed by 145 | Submission Open

Keywords: cell microenvironment; stem cells; organoid and 3D culture models

(This special issue belongs to the Section Cell Microenvironment)

Evaluation of the Properties and Effectiveness of Nutritional Factors Using In Vitro Assays, Including Cell Cultures and Organoids

edited by

Joanna Romanek

and Sylwia Orczewska-Dudek

submission deadline 20 Dec 2025 | Viewed by 140 | Submission Open

Keywords: cell cultures; organoids; novel nutritional factors; extract; cells viability; cells proliferation; cells cytotoxicity; cell signaling; cells apoptosis; oxidative stress

Acute Myeloid Leukemia: Molecular Mechanisms and Novel Therapies

edited by Xiangguo Shi

submission deadline 20 Dec 2025 | Viewed by 127 | Submission Open

Keywords: acute myeloid leukemia (AML); genomics and epigenetics; therapeutic resistance; metabolic reprogramming; clonal evolution

(This special issue belongs to the Section Cellular Pathology)

Targeting Thermogenesis in Metabolic Disorders: Novel Pharmacological and Lifestyle Interventions

edited by

Atefeh Rabiee

submission deadline 20 Dec 2025 | Viewed by 120 | Submission Open

Keywords: thermogenesis modulation; metabolic disorders; obesity; adipose tissue biology; thermogenic mechanisms; mitochondrial function

Clockwork Cells: Decoding the Language of Cell Cycle Regulators

edited by

Guanxiong Yan

, Kyung-sang Lee,

Richard W. Wong

and

Gary S. Stein

submission deadline 20 Dec 2025 | Viewed by 109 | Submission Open

Keywords: cyclins; cyclin-dependent kinases (CDKs); checkpoints; cell proliferation; mitosis; meiosis

(This special issue belongs to the Section Cell Proliferation and Division)

Functional Genomics and Morphological Profiling in Saccharomyces cerevisiae

edited by

Yoshikazu Ohya

and Hisao Moriya

submission deadline 24 Dec 2025 | 1 articles | Viewed by 637 | Submission Open

Keywords: functional genomics; morphological profiling; Saccharomyces cerevisiae; overexpression

(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)

Cellular Differentiation in Health and Disease

edited by Christine K. C. Loo and

Grant A. Ramm

submission deadline 25 Dec 2025 | 1 articles | Viewed by 1916 | Submission Open

Keywords: cellular differentiation; tumour microenvironment; human development; regeneration/healing; cell signaling pathways; tumour differentiation

(This special issue belongs to the Section Cell Microenvironment)

Advances in Molecular Genomics and Pathology of Cancers

edited by

Muhammad Kibriya

submission deadline 25 Dec 2025 | Viewed by 212 | Submission Open

Keywords: cancer; somatic mutation; short tandem repeat; gene expression; methylation; cf-DNA; single-cell sequencing; NGS; liquid biopsy; precision medicine

(This special issue belongs to the Section Cellular Pathology)

Dysregulated Synaptic Plasticity in Chronic Pain: Molecular Mechanisms, Circuit Dysfunction, and Translational Approaches

edited by

Neeraj Soni

submission deadline 25 Dec 2025 | Viewed by 135 | Submission Open

Keywords: chronic pain; synaptic plasticity; circuit dysfunction

(This special issue belongs to the Section Cellular Pathology)

Role of T Cells in Immune Disease Treatment

edited by

Ilan Bank

submission deadline 25 Dec 2025 | Viewed by 100 | Submission Open

Keywords: autoimmunity; autoimmune diseases; immunotherapy; immune diseases; T cells; B cells; natural killer T cells

(This special issue belongs to the Section Cellular Immunology)

Host Immunity to Bacterial Infections

edited by Karine Gloux

submission deadline 26 Dec 2025 | Viewed by 327 | Submission Open

Keywords: host immune systemsbacterial pathogens; innate and adaptive immune responses; pathogen evasion; bacterial infections

(This special issue belongs to the Section Cellular Immunology)

Epigenetic Regulation in Neuronal Development, Neurodegeneration and Regeneration

edited by

Guoping Fan

submission deadline 28 Dec 2025 | 1 articles | Viewed by 1371 | Submission Open

Keywords: epigenetic regulation; neuronal development; neuronal regeneration; chromatin remodeling

(This special issue belongs to the Section Cells of the Nervous System)

Neuromodulatory Signaling in Brain Disorders: State-of-the-Art Insights

edited by

Kohji Fukunaga

and

Wenbin Jia

submission deadline 30 Dec 2025 | 2 articles | Viewed by 3978 | Submission Open

Keywords: neuromodulatory signaling; neural circuit; synaptic plasticity; neurotransmitter; signal transduction; neurodegenerative diseases; neuroinflammatory disorder; substance use disorder; neurodevelopmental disorder; targeted therapy

(This special issue belongs to the Section Tissues and Organs)

Fertility Disorders in Testes and Ovaries

edited by

Paweł Kordowitzki

and Joanna Kochan

submission deadline 30 Dec 2025 | 1 articles | Viewed by 780 | Submission Open

Keywords: fertility; ovary; testis; aging; epigenetics; in vitro fertilization; IVF

(This special issue belongs to the Section Tissues and Organs)

Molecular Insights into cAMP/PKA Pathway Regulation in Health and Disease

edited by

Elie Seaayfan

and

Martin Kömhoff

submission deadline 30 Dec 2025 | Viewed by 661 | Submission Open

Keywords: cAMP/PKA signaling; protein kinase A (PKA); cyclic AMP; EPAC; signal transduction; cellular homeostasis; metabolic regulation; disease mechanisms; molecular signaling; therapeutic targets; cross-talk in signaling pathways; protein– protein interactions; post-translational modifications; pharmacological interventions

Emerging Roles of Glial Cells in Human Health and Disease

edited by

Dan Frenkel

and

Menachem Hanani

submission deadline 31 Dec 2025 | 10 articles | Viewed by 38047 | Submission Open

Keywords: neurodegenerative diseases; glia cells; astrocyte; microglia; stroke; pain; epilepsy; trauma; demyelinating diseases’ inflammatory diseases; satellite glia; Schwann cells; enteric glia

(This special issue belongs to the Section Cells of the Nervous System)

Gene Therapy for Rare Diseases

edited by

Cord Brakebusch

submission deadline 31 Dec 2025 | 6 articles | Viewed by 32154 | Submission Open

Keywords: gene therapy; gene editing; rare diseases; CRISPR; viral vectors; base editing; prime editing

(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)

New Insights into Vascular Biology in Health and Disease

edited by Bashir M. Rezk

submission deadline 31 Dec 2025 | 6 articles | Viewed by 17075 | Submission Open

Keywords: vascular diseases; cardiovascular; cancer; hyperhomocyteinemia; endothelial dysfunction; vascular smooth muscle cell; autophagy; alcohol; galectins; angiogenesis; neovascularization

(This special issue belongs to the Section Cells of the Cardiovascular System)

Select Topics in Molecular and Cellular Mechanisms of Mammalian Reproduction

edited by Zhengui Zheng,

Brent M. Bany

and Liang Ma

submission deadline 31 Dec 2025 | 7 articles | Viewed by 13141 | Submission Open

Keywords: reproductive organ development; sexual differentiation; reproductive tract function; fertilization; implantation; placentation; parturition; lactation

(This special issue belongs to the Section Reproductive Cells and Development)

Biological Mechanisms in the Treatment of Neuropsychiatric Diseases

edited by Randall D Marshall and Frank S. Menniti

submission deadline 31 Dec 2025 | 6 articles | Viewed by 12690 | Submission Open

Keywords: neurodevelopmental conditions; rare neurological disease; molecular mechanisms of novel CNS treatments; precision medicine in neuropsychiatry; organoids; molecular mechanisms of effective treatments

(This special issue belongs to the Section Cellular Pathology)

Cellular and Molecular Mechanisms in Bone and Cartilage Damage and Regeneration

edited by

Philippe Hernigou

submission deadline 31 Dec 2025 | 7 articles | Viewed by 10309 | Submission Open

Keywords: bone morphogenic proteins (BMPs); bone union with cell therapy; advances in stem cell therapies for fracture non-union and cartilage regeneration; novel cell-based therapies for cartilage repair; functional of collagen/PLA scaffolds in cartilage regeneration; regeneration and revascularization of bone osteonecrosis; evaluation of osteonecrosis regeneration with MRI and histology; and arteriography; identification and validation of new cartilage biomarkers; diaphyseal regeneration with callostasis; union with the membrane technique

(This special issue belongs to the Section Cellular Pathology)

Cellular Mechanisms of Anti-Cancer Therapies

edited by Ilgen Mender and

Kazuyuki Kitatani

submission deadline 31 Dec 2025 | 5 articles | Viewed by 8586 | Submission Open

Keywords: anti-cancer therapies; innovative treatment strategies; cellular mechanisms; drug resistance; personalized medicine

(This special issue belongs to the Section Cellular Pathology)

Molecular Mechanisms Involved in Musculoskeletal and Other Tissue Injuries and Disruptions—Regenerative Potential of Exercise

edited by

Eugenia Murawska-Ciałowicz

Ana Filipa Silva

and

Gilmara Gomes De Assis

submission deadline 31 Dec 2025 | 2 articles | Viewed by 8118 | Submission Open

Keywords: tissue injury; tissue regeneration; growth factors; inflammation; oxidative stress; metabolic stress; myokines; adipokines; neurokines; hypertrophy; biochemical pathways; skeletal muscles; liver/hepatic regeneration; brain/neuroplasticity; adipose tissue; varia

(This special issue belongs to the Section Tissues and Organs)

Redox and Metabolic Profile of Cancer

edited by

Bato Korac

submission deadline 31 Dec 2025 | 2 articles | Viewed by 7406 | Submission Open

Keywords: cancer; metabolism; redox biology; redox-metabolic reprogramming; reactive species: oxygen; nitrogen; sulfur; etc; cancer microenvironment; cancer-tissue cooperation; mitochondria

(This special issue belongs to the Section Cellular Metabolism)

Signaling Pathways and Mechanisms in Cancer Therapy Resistance

edited by

Natarajan Aravindan

submission deadline 31 Dec 2025 | 3 articles | Viewed by 7091 | Submission Open

Keywords: cancer therapy; therapy resistance; molecular mechanisms; cell signaling pathways; genetic and epigenetic modifications; combination therapies

(This special issue belongs to the Section Cellular Pathology)

Cellular and Molecular Mechanisms in Oxidative Stress-Related Chronic Diseases

edited by Sara Spinelli,

Alessia Remigante

and

Rossana Morabito

submission deadline 31 Dec 2025 | 2 articles | Viewed by 6375 | Submission Open

Keywords: aging; age-related diseases; redox system; cellular and molecular mechanisms; oxidative stress biomarkers; synthetic and natural antioxidant molecules

(This special issue belongs to the Section Cellular Pathology)

Ageing and Neurodegenerative Diseases, Second Edition

edited by Feng Wang and

Antonella Caccamo

submission deadline 31 Dec 2025 | 3 articles | Viewed by 6362 | Submission Open

Keywords: ageing; miRNAs; lncRNA; circRNAs; diabetes; neurodegenerative disease; insulin signaling

(This special issue belongs to the Section Cellular Pathology)

Cell Biology: State of the Art and Perspectives in Italy 2025

edited by

Vincenzo Carafa

submission deadline 31 Dec 2025 | 1 articles | Viewed by 5471 | Submission Open

Keywords: cell biology; physiology; molecular biology

Cell Stress and Intervention in Neurological Disease: In Honor of Dr. Jang-Yen Wu for His Long and Distinguished Career in Neuroscience

edited by Howard Prentice and

Jang-Yen Wu

submission deadline 31 Dec 2025 | 3 articles | Viewed by 5155 | Submission Open

Keywords: neurodegenerative disease; gene therapy; excitotoxicity; calcium dysregulation; Alzheimer’ s disease; stroke; neuroprotection; neurogenesis

(This special issue belongs to the Section Cells of the Nervous System)

Kynurenic Acid: Unveiling Its Impact on the Brain’s Neurotransmission and Neurological Disorders

edited by Korrapati V. Sathyasaikumar, Sarah Beggiato and

Verónica Pérez de la Cruz

submission deadline 31 Dec 2025 | 2 articles | Viewed by 4737 | Submission Open

Keywords: kynurenic acid; cognition; aging; neuromodulation; neurodegeneration; neurodevelopment; neuroinflammation; tryptophan catabolism

(This special issue belongs to the Section Cell Signaling)

Cellular and Molecular Mechanisms of Liver Diseases

edited by Jieyun Jiang

submission deadline 31 Dec 2025 | 2 articles | Viewed by 4551 | Submission Open

Keywords: liver; alcoholic liver disease (ALD); viral hepatitis; metabolic associated steatotic liver disease (MASLD); autoimmune hepatitis; drug-induced liver injury; liver fibrosis and cirrhosis; liver cancer; cellular and molecular mechanisms

(This special issue belongs to the Section Cellular Pathology)

Mechanisms of Immune Responses and Therapy

edited by

Zhuang Wang

and

Bernhard Ryffel

submission deadline 31 Dec 2025 | 2 articles | Viewed by 3718 | Submission Open

Keywords: immunity; immune signaling; immune regulation; cellular immunology; molecular immunology; autoimmunity; immune checkpoint; immunotherapy

(This special issue belongs to the Section Cellular Immunology)

Organelle Contact and Its Physiological Implications

edited by

Patricia Gómez-Suaga

and

Estela Area Gomez

submission deadline 31 Dec 2025 | 1 articles | Viewed by 3672 | Submission Open

Keywords: inter-organelle communication; membrane contact sites; organelle dynamics; mitochondria-associated membranes; cellular homeostasis

Computational Biophysics in Cellular Biological Systems

edited by

Lin Li

and Wenhan Guo

submission deadline 31 Dec 2025 | 1 articles | Viewed by 3473 | Submission Open

Keywords: cellular process; protein– protein interactions; single-cell analysis; drug design; molecular dynamics simulations

(This special issue belongs to the Section Cell Methods)

Cellular and Molecular Mechanisms of Vascular-Related Diseases

edited by

Bingmei Fu

and

Ye Zeng

submission deadline 31 Dec 2025 | 3 articles | Viewed by 2883 | Submission Open

Keywords: cellular and molecular mechanisms; cardiovascular disease; cerebrovascular disease; vascular signaling; vascular dysfunctions in cns disorders; vascular dysfunctions in diabetes; vascular dysfunction in chronic kidney disease; tumor metastasis via vascular system

(This special issue belongs to the Section Cellular Pathology)

Understanding Aging Mechanisms to Prevent Age-Related Diseases: 2nd Edition

edited by

Gérard Lizard

, Pierre Jouanny,

Anne Vejux

and Sonia Hammami

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2700 | Submission Open

Keywords: aging; age-related diseases; pathophysiology; cell mechanisms; therapies; biomarkers

(This special issue belongs to the Section Cellular Aging)

The Role of Mitochondria in Cell Development and Regeneration

edited by

Kenny Rodriguez-Wallberg

and

Xia Hao

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2544 | Submission Open

Keywords: mitochondria; fusion and fission; mtDNA; programmed cell death; cell development; mitochondria-ER contact; organelle

(This special issue belongs to the Section Mitochondria)

Cellular and Molecular Mechanisms in Neuropsychiatric and Neurological Disorders

edited by Irina Balan

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2040 | Submission Open

Keywords: cellular mechanisms; molecular mechanisms; neuropsychiatric disorders; neurological disorders; neuroinflammation; neuronal signaling; gene expression; synaptic function; glial cells; peripheral factors

(This special issue belongs to the Section Cellular Pathology)

The Role of Stem Cells and Circadian Clock in Cancer Immunotherapy

edited by Yool Lee

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1948 | Submission Open

Keywords: circadian clock; circadian disruption; neural stem cells; cancer stem cells; tumor– immune microenvironment; cancer chronotherapy

(This special issue belongs to the Section Stem Cells)

Interplay Between Intestinal Bacteria and Epigenetic Markers in Pathogenesis of Metabolic and Neuropsychiatric Disorders

edited by

Shabnam Nohesara

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1726 | Submission Open

Keywords: gut microbiome; epigenetic marks; metabolic diseases; neuropsychiatric disorders; probiotics; prebiotics; postbiotics; indole derivatives; epigeneic metabolites

(This special issue belongs to the Section Cells of the Nervous System)

Novel Autoantibodies in Systemic Autoimmune Diseases: Challenges and Perspectives

edited by

Clio Mavragani

Nikolaos Marketos

and

Charalampos Skarlis

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1620 | Submission Open

Keywords: autoantibodies; autoimmune diseases; innate and adaptive immunity

(This special issue belongs to the Section Cellular Immunology)

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