Immunoregulatory Functions of Mesenchymal Stem Cells (MSCs)
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Stem Cells".
Deadline for manuscript submissions: 30 October 2025 | Viewed by 953
Special Issue Editor
Interests: stem cells; mesenchymal stem cells; 3D culture; bioinformatics; immunology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Mesenchymal stem cells (MSCs) have drawn much interest from scientists for decades. Studies have focused on the basic characteristics and properties of MSCs and have shown that these cells can be obtained from various locations throughout the body, such as bone marrow, adipose tissue, the umbilical cord, and the synovium. Other studies have shown that MSCs can differentiate into many cells, such as osteoblasts, chondrocytes, and adipocytes, providing potential therapeutic approaches. Initially, the MSC-mediated therapeutic effects were thought to be attributed to their ability to differentiate; however, the focus has shifted to their paracrine effects and specifically to their ability to modulate immune responses. Many in vitro and in vivo studies have demonstrated the capability of MSCs to secrete factors and interact with immune cells to either suppress immune reactions or promote specific immune system-related functions.
This Special Issue aims to bring together original research and comprehensive reviews regarding the immunoregulatory functions of MSCs. Invitation extends to both basic and translational research that seeks to further the understanding of the important effects of MSCs on immune cells and systems.
Dr. Joni H. Ylostalo
Guest Editor
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Keywords
- mesenchymal stem cells
- MSCs
- immunoregulation
- immunosuppression
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