Emerging Advances in Neurodegeneration: Innovations in Stem Cell and Organoid Research

Dear Colleagues,

The rising prevalence of neurodegenerative diseases poses a significant public health challenge, requiring innovative research strategies. These disorders involve the progressive degeneration of specific neural circuits, leading to debilitating symptoms and a decline in quality of life. The exact causes remain largely unknown, with genetic, environmental, and lifestyle factors all contributing to their development. Despite advances in understanding the underlying molecular mechanisms, effective treatments are limited, partly due to the lack of cellular models that accurately replicate the physiological and pathological aspects of these diseases. Furthermore, differences between the human central nervous system and laboratory animal models complicate therapeutic development.

In this scenario, the use of stem cells and brain organoids offers a promising approach to research and therapy. Induced pluripotent stem cells (iPSCs) can be derived from patients, providing a unique platform for in vitro modeling and drug testing. Brain organoids created from iPSCs simulate the human brain's architecture and functions, enabling deeper insights into neural development and disease mechanisms. This Special Issue aims to highlight recent advancements in stem cell and organoid research, emphasizing their potential to revolutionize our understanding of neurodegeneration and enhance the development of targeted, personalized treatments.

Dr. Elena Coccia
Guest Editor

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