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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Harnessing the Tumor Microenvironment and Signaling Pathways for Precision Cancer Therapy

edited by Behzad M. Toosi and

Andrew Freywald

submission deadline 30 Nov 2026 | 3 articles | Viewed by 6911 | Submission Open

Keywords: tumor microenvironment (TME); signaling pathways; precision cancer therapy; immune evasion; metabolic pathways; tumor– stroma interactions; therapeutic targets; personalized medicine; cancer metastasis; molecular oncology

(This special issue belongs to the Section Cell Microenvironment)

Molecular Insights into cAMP/PKA Pathway Regulation in Health and Disease

edited by

Elie Seaayfan

and

Martin Kömhoff

submission deadline 30 Nov 2026 | 1 articles | Viewed by 2711 | Submission Open

Keywords: cAMP/PKA signaling; protein kinase A (PKA); cyclic AMP; EPAC; signal transduction; cellular homeostasis; metabolic regulation; disease mechanisms; molecular signaling; therapeutic targets; cross-talk in signaling pathways; protein– protein interactions; post-translational modifications; pharmacological interventions

Cellular and Molecular Basis of Brain Tumor

edited by

Wojciech Czyżewski

, Tomasz S. Mandat, Grzegorz Turek and Radosław Mlak

submission deadline 30 Nov 2026 | 2 articles | Viewed by 2349 | Submission Open

Keywords: brain tumor; glioma; tumor microenvironment; molecular oncology; epigenetics; tumor stem cells; biomarkers; therapeutic resistance; non-coding RNA; translational research

(This special issue belongs to the Section Cellular Pathology)

Novel Insights into Molecular and Cellular Mechanisms Underlying Chronic Pain

edited by

Mariacristina Mazzitelli

submission deadline 30 Nov 2026 | 1 articles | Viewed by 1882 | Submission Open

Keywords: pain; pain management; sexual dimorphism; neurons; non-neuronal factors

(This special issue belongs to the Section Cellular Pathology)

LPS-Induced Inflammatory Diseases

edited by

Lin-Hua Jiang

and

Pankaj Kumar

submission deadline 30 Nov 2026 | 1 articles | Viewed by 1804 | Submission Open

Keywords: lipopolysaccharide (LPS); endotoxemia; inflammation; LPS signaling; acute lung injury; inflammatory cytokines; therapeutic targets

(This special issue belongs to the Section Cellular Pathology)

Extracellular Vesicles in Disease Pathogenesis, Therapeutics and Biomarker Discovery

edited by

Susmita Sil

submission deadline 30 Nov 2026 | 2 articles | Viewed by 1704 | Submission Open

Keywords: extracellular vesicles; exosomes; exomeres; apoptotic bodies; macrovesicles; EV-cargoes; EVs as biomarkers; EVs in therapy

(This special issue belongs to the Section Intracellular and Plasma Membranes)

Autoimmune Diseases: Immune Cells and Genetic and Epigenetic Regulations

edited by

Moncef M. Zouali

submission deadline 30 Nov 2026 | 2 articles | Viewed by 1443 | Submission Open

Keywords: autoimmune diseases; immune cells; lymphocytes; antigen-presenting cells; natural killer cells; innate lymphoid cells; epigenetic modifications; autoimmunity

(This special issue belongs to the Section Cellular Immunology)

How Does Gene Regulation Affect Cancer Development?

edited by

Ru Chih C. Huang

and

Kotohiko Kimura

submission deadline 30 Nov 2026 | 1 articles | Viewed by 1419 | Submission Open

Keywords: cancer; mutation; transcription factor; non-coding RNA; micro-RNA; gene regulation; histones; gene promoters; anticancer drugs

(This special issue belongs to the Section Cell Microenvironment)

Glycosylation and Glycoproteins in Human Disease

edited by

Mana Mukherjee

and

Bingmei Fu

submission deadline 30 Nov 2026 | 1 articles | Viewed by 1272 | Submission Open

Keywords: glycobiology; glycosylation; glycoproteins; glycolipids; glycan biomarkers; congenital disorders of glycosylation (cdg); immune modulation; glycan profiling; glycoengineering; host– pathogen interactions; therapeutic glycoproteins; bioorthogonal chemistry

Genome Editing in Biomedicine

edited by

Fu-Lei Tang

submission deadline 30 Nov 2026 | 1 articles | Viewed by 1151 | Submission Open

Keywords: genome manipulation; CRISPR/Cas systems; base editing and prime editing; cellular models (organoids/stem cells); stem cell editing; animal models; genetically engineered mouse models (GEMMs); translational research; cell therapy; editing efficiency; virus-like particles (VLPs)

(This special issue belongs to the Section Cell and Gene Therapy)

B Cells in Action: Interaction Dynamics and Functional Decisions

edited by Michael L. Atchison and

Sulagna Sanyal

submission deadline 30 Nov 2026 | 1 articles | Viewed by 1120 | Submission Open

Keywords: B cell development and differentiation; adaptive immunity; germinal center B cell; class-switch recombination; immunosuppression; cytokines; inflammation; epigenetic regulation; metabolic reprogramming; immune response

(This special issue belongs to the Section Cellular Immunology)

Stem Cell Secretome: Therapeutic Potential in Regenerative Medicine

edited by Emanuela Mari

submission deadline 30 Nov 2026 | 1 articles | Viewed by 1105 | Submission Open

Keywords: paracrine factors and tissue regeneration; secretome conditioned by microenvironment or stimuli; extracellularvesicles vs. soluble fraction; formulations and delivery of the therapeutic secretome

(This special issue belongs to the Section Stem Cells)

Organelle Crosstalk: New Insights into Intracellular Communication and Dynamics

edited by

Jonathan Barra

submission deadline 30 Nov 2026 | Viewed by 511 | Submission Open

Keywords: organelle contact sites; membrane contact sites; intracellular communication; early endosomes; recycling endosomes; Golgi; mitochondrial dynamics; ER stress; mitophagy; autophagy; lysosome; calcium signaling; lipid transfer; proteostasis

Molecular Mechanisms of Fibrosis in Chronic Liver Diseases

edited by

Ahmad Salhab

, Regina Golan-Gerstl and Ihab Ansari

submission deadline 30 Nov 2026 | Viewed by 402 | Submission Open

Keywords: liver fibrosis; MASH; immune checkpoints; epigenetic regulation; hepatic stellate cells (HSCs); antifibrotic therapy; molecular mechanisms; inflammation; ROS

State-of-the-Art Insights into the Cell Microenvironment

edited by

Said M. Afify

submission deadline 30 Nov 2026 | Viewed by 339 | Submission Open

Keywords: cell microenvironment; stem cells; organoid and 3D culture models

(This special issue belongs to the Section Cell Microenvironment)

Advances in Cellular Mechanisms and Molecular Targets in Breast Cancer Research

edited by Rahul Sanawar,

Naoshad Muhammad

and Satheesh Kumar Sengodan

submission deadline 30 Nov 2026 | Viewed by 335 | Submission Open

Keywords: breast cancer; cancer stem cells; cell plasticity; immune evasion; drug resistance; tumor microenvironment; non-coding RNAs; circulating tumor cells (CTC); circulating tumor DNA (ctDNA); exosomes; signaling pathways (e.g.; PI3K/AKT; MAPK); targeted therapy; immunotherapy

Mechanisms of Transcriptional Regulation in Disease: From Chromatin Dynamics to Therapeutic Innovation

edited by Valentina Caputo, Joana R. Costa,

Pierangela Sabbattini

and

Chinedu Anene

submission deadline 30 Nov 2026 | Viewed by 307 | Submission Open

Keywords: transcription regulation; epigenomics; multi-omics; non-coding genome; chromatin architecture/dynamics; enhancers

(This special issue belongs to the Section Cell and Gene Therapy)

Cellular and Molecular Mechanisms of Cell Death in Neurodegenerative Diseases

edited by

Nikolaos Patikas

and Emmanouil Metzakopian

submission deadline 30 Nov 2026 | Viewed by 299 | Submission Open

Keywords: cell death; neurodegenerative diseases; molecular biology; genomics; neuroinflammation; protein aggregation; neurobiology; mitochondria dysfunction

Nanoparticle-Mediated Immunotherapy: Reshaping the Tumor Microenvironment for Enhanced Cancer Treatment

edited by

Mohd Ahmar Rauf

submission deadline 30 Nov 2026 | Viewed by 290 | Submission Open

Keywords: tumor microenvironment; drug delivery; nanoparticle

(This special issue belongs to the Section Cell Methods)

Cellular and Molecular Pathways in Immune Tolerance and Autoimmune Regulation

edited by

Md Jahangir Alam

and

Yu-Anne Yap

submission deadline 30 Nov 2026 | Viewed by 276 | Submission Open

Keywords: immune tolerance; autoimmune regulation; immune homeostasis; regulatory T cells; regulatory B cells; cytokine networks; molecular mechanisms; therapeutic strategies

(This special issue belongs to the Section Cellular Immunology)

Molecular Mechanisms of Asthmatic Airway Inflammation

edited by

Pawan Sharma

submission deadline 30 Nov 2026 | Viewed by 255 | Submission Open

Keywords: asthma; airway inflammation; airway smooth muscle; airway remodeling; immune signaling; cytokines and chemokines; cell signaling; inflammatory mechanisms; airway epithelial cells

(This special issue belongs to the Section Cellular Immunology)

Modeling Lung Regeneration and Injury Responses Using Organoids and Engineered Niches

edited by Tristan Frum

submission deadline 30 Nov 2026 | Viewed by 224 | Submission Open

Keywords: lung biology; regeneration; stem cells; intra- and extracellular signaling; cell techniques; organoids; bioengineering

(This special issue belongs to the Section Tissues and Organs)

Cellular Responses to Metal-Based Therapeutics in Cancer Biology

edited by

Tania Gamberi

and

Michele Mannelli

submission deadline 30 Nov 2026 | Viewed by 148 | Submission Open

Keywords: metal-based drugs; metalloptosis (including cuproptosis and ferroptosis); cancer cell metabolism targeting; mitochondrial targeting; tumor microenvironment; drug resistance; drug deliver strategy; therapeutic targeting; metalloimmunotherapy; redox homeostasis disruption

Advances in Molecular Mechanisms and Modeling of Neuroendocrine Tumors

edited by Hermine Mohr, Natalia Simona Pellegata and Margo Dona

submission deadline 30 Nov 2026 | Viewed by 139 | Submission Open

Keywords: tumor microenvironment; molecular heterogeneity; preclinical models; PDX; PDO; treatment resistance

(This special issue belongs to the Section Cellular Neuroscience)

Emerging Roles of Glial Cells in the Nervous System

edited by Manuela Marcoli and

Chiara Cervetto

submission deadline 30 Nov 2026 | 1 articles | Viewed by 129 | Submission Open

Keywords: glial cells; astrocytes; microglia; glia– neuron communication; neurotransmitters; gliotransmitters; transmitter receptors; synapse; physiology; neuron

(This special issue belongs to the Section Cellular Neuroscience)

Exclusive Review Papers in 'Cell Signaling'

edited by

Ralf Weiskirchen

submission deadline 30 Nov 2026 | Viewed by 128 | Submission Open

Keywords: signal transduction; receptor tyrosine kinases; G protein-coupled receptors (GPCRs); intracellular signaling networks; systems biology; pathway crosstalk; targeted therapies

(This special issue belongs to the Section Cell Signaling)

From Development to Degeneration: Advances in Stem Cell and Organoid Models of the Nervous System

edited by

Elena Coccia

submission deadline 30 Nov 2026 | Viewed by 106 | Submission Open

Keywords: neurodevelopment; neurodegeneration; stem cells; brain organoids; disease modeling; therapeutic strategies; personalized medicine

(This special issue belongs to the Section Stem Cells)

Cancer Stem Cells of Glioblastoma: Role of PI3K/Akt/mTOR Signaling Pathways

edited by Meena Jhanwar-Uniyal

submission deadline 30 Nov 2026 | Viewed by 82 | Submission Open

Keywords: glioblastoma; stem cells; mTOR; mTORC1; mTORC2; peritumor area; cancer resistance

(This special issue belongs to the Section Stem Cells)

Mitochondrial Dysfunction in Neurodegeneration and Aging

edited by Abhishek Jauhari

submission deadline 30 Nov 2026 | Viewed by 80 | Submission Open

Keywords: mitochondrial dysfunction; neurodegeneration; aging; mitophagy; oxidative stress

(This special issue belongs to the Section Mitochondria)

Single-Cell Omics Decoding Cellular Heterogeneity in Kidney Diseases

edited by Jia Fu

submission deadline 30 Nov 2026 | Viewed by 65 | Submission Open

Keywords: single-cell omics; spatial omics; multi-omics integration; artificial intelligence; machine learning; kidney disease; cellular heterogeneity; cell– cell communication; organoids; immune microenvironment

(This special issue belongs to the Section Cellular Pathology)

Neuronal Development and Disease: From Molecular Mechanisms to Neurological Disorders—Second Edition

edited by Ramiro Almeida

submission deadline 30 Nov 2026 | Viewed by 8 | Submission Open

Keywords: neuronal development; neurological disorders; neurogenesis; neuroinflammation; synaptic plasticity

(This special issue belongs to the Section Cellular Neuroscience)

Molecular Pathogenesis and Novel Therapeutic Strategies in Chordoma

edited by

Margot Martinez-Moreno

, Patricia L Sullivan and Jeremy J Reynolds

submission deadline 1 Dec 2026 | 1 articles | Viewed by 1337 | Submission Open

Keywords: chordoma; targeted therapy; brachyury; tumor microenvironment; epigenetics; immunotherapy; biomarkers; drug resistance; translational oncology; radiation resistance

Conditional Programming of Cells, Advanced Computational Methods, and Intelligent Systems in Prostate Cancer Research

edited by Ahmed Fadiel

submission deadline 1 Dec 2026 | 1 articles | Viewed by 1055 | Submission Open

Keywords: prostate cancer; conditional programming; cellular reprogramming; computational biology; cell-state transitions; lineage plasticity; tumor microenvironment; ex vivo models; machine learning

Cellular Mechanisms of Testosterone in Metabolic Disorders

edited by Daniel M. Kelly

submission deadline 1 Dec 2026 | Viewed by 277 | Submission Open

Keywords: testosterone; metabolism; type 2 diabetes; obesity; metabolic syndrome; MASLD; skeletal muscle; adipose tissue; insulin resistance; endocrine signalling

Cardiac Cell–Matrix Mechanotransduction: Linking Extracellular Matrix Properties to Signaling and Function

edited by Maja Theresa Dieterlen and Ricardo A. Spampinato

submission deadline 1 Dec 2026 | Viewed by 37 | Submission Open

Keywords: mechanotransduction; extracellular matrix; collagen; integrin; cardiac fibrosis; cell signaling; cardiac function

(This special issue belongs to the Section Cells of the Cardiovascular System)

Cellular Mechanisms and Therapeutic Potentials of Neurodevelopmental Defects

edited by

and

submission deadline 10 Dec 2026 | 1 articles | Viewed by 1144 | Submission Open

Keywords: neurodevelopmental disorders; neuronal connectivity; precocious therapies; synaptic plasticity; neurogenesis; glial function

(This special issue belongs to the Section Cellular Neuroscience)

Resistance of Hematological Malignancies and Solid Tumors to CAR T Cell Therapy

edited by

Ali R. Jazirehi

submission deadline 10 Dec 2026 | Viewed by 229 | Submission Open

Keywords: solid tumors; hematological malignancies; CAR T cell; immunotherapy; resistance; apoptosis

Brain Function and Structure: Mapping Complexity in Neuronal Cells

edited by

José Antonio Del Río Fernández

submission deadline 15 Dec 2026 | 1 articles | Viewed by 1807 | Submission Open

Keywords: optogenetics; lab-on-chip platforms and brain organoids; neuronal and glial networks; neuromechanobiology; system neuroscience

Extracellular Vesicles in Reproductive Communication: From Gametogenesis to Implantation

edited by

Nima Azari-Dolatabad

and Osvaldo Bogado Pascottini

submission deadline 15 Dec 2026 | Viewed by 315 | Submission Open

Keywords: extracellular vesicles; reproductive biology; gametogenesis; oocyte maturation; embryo-maternal communication; implantation; reproductive disorders; epigenetic regulation; EV Cargo; intercellular signaling

Development and Characterization of Innovative In Vitro Models

edited by Fengyan Deng and Chongbei Zhao

submission deadline 18 Dec 2026 | 1 articles | Viewed by 1788 | Submission Open

Keywords: 3D organoid development; iPSC; iPSC reprogramming; primary cell derivation; cell immortalization; disease model development; stem cell therapy; molecular biology; cell signaling

Soluble Niche Factors Regulating Neural Stem Cells in Development and Disease

edited by

Kunimasa Ohta

submission deadline 20 Dec 2026 | Viewed by 123 | Submission Open

Keywords: neural stem cells; niche; soluble factors; development; disease

(This special issue belongs to the Section Stem Cells)

Therapeutic Targets in Glioblastoma—Second Edition

edited by

Frank Eckerdt

and Candice Mazewski

submission deadline 20 Dec 2026 | Viewed by 10 | Submission Open

Keywords: glioblastoma; signaling targets; blood– brain barrier; complementary and alternative medicine; combination therapy; glioma stem cells; progression; resistance; nutrient-sensing

(This special issue belongs to the Section Cellular Neuroscience)

Targeting Hallmarks of Cancer

edited by

Carlos Pérez Plasencia

submission deadline 25 Dec 2026 | 3 articles | Viewed by 8098 | Submission Open

Keywords: epigenetic regulators; organotypic culture models; anticancer drugs; hallmarks of cancer

Cellular Pathology: Emerging Discoveries and Perspectives in the USA

edited by

Mohammed S. Razzaque

submission deadline 31 Dec 2026 | 4 articles | Viewed by 12569 | Submission Open

Keywords: cellular pathology; diseases; mechanisms

(This special issue belongs to the Section Cellular Pathology)

Going with the Flow and Beyond: Understanding Benign Blood Disorders and Their Underlying Mechanisms

edited by Tirthadipa Pradhan-Sundd

submission deadline 31 Dec 2026 | 2 articles | Viewed by 3006 | Submission Open

Keywords: benign blood disorders; sickle cell disease; red blood cells; hemoglobin; heme; iron overload; organ damage; hemophilia; thalassemia; anemia; blood vessels; vascular aging; endothelial cells

Exclusive Reviews on Autophagy: From Molecular Mechanisms to Therapeutic Frontiers

edited by

Chengyu Liang

and Daolin Tang

submission deadline 31 Dec 2026 | 2 articles | Viewed by 2681 | Submission Open

Keywords: autophagy; macro-autophagy; micro-autophagy; lysosomal degradation; adaptation to stresses; physiological functions and pathological situations

(This special issue belongs to the Section Autophagy)

Cellular and Molecular Mechanisms in Endocrine Regulation

edited by Ovidiu Nicolae Pop and

Cosmin Mihai Vesa

submission deadline 31 Dec 2026 | Viewed by 310 | Submission Open

Keywords: endocrine regulation; cellular signaling; hormone secretion; molecular endocrinology; signal transduction; endocrine cells; nuclear receptors; endocrine homeostasis; cellular communication; endocrine disorders

(This special issue belongs to the Section Cellular Pathology)

Molecular Mechanisms Regulating Keratinocyte Biology, Barrier Function, and Skin Inflammation

edited by

Ye Liu

and

Seungphil Hong

submission deadline 31 Dec 2026 | Viewed by 231 | Submission Open

Keywords: keratinocytes; skin barrier; skin inflammation

(This special issue belongs to the Section Cellular Pathology)

Cellular and Molecular Mechanisms of Retinal Diseases

edited by Ravirajsinh N. Jadeja and Menaka C. Thounaojam

submission deadline 31 Dec 2026 | Viewed by 183 | Submission Open

Keywords: retinal diseases; cellular and molecular mechanisms; retinal development; degeneration; oxidative stress; hypoxia; inflammation; cell signaling; metabolic regulation; vascular pathology; translational retinal research

(This special issue belongs to the Section Tissues and Organs)

Immuno-Cardiology: Immune Mechanisms from Ischemia to Heart Failure

edited by Djamel Lebeche

submission deadline 31 Dec 2026 | Viewed by 154 | Submission Open

Keywords: cardiology; immune system; inflammation; ischemic injury; heart failure; immunometabolism; immunotherapy; nanomedicine; fibrotic remodeling; scar immunology; systems immunology

(This special issue belongs to the Section Cellular Immunology)

Displaying special issue 601-650 on page 13 of 14.

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