Cellular and Molecular Mechanisms of Heart Development

Dear Colleagues,

The heart develops through a highly dynamic and complex process, disruptions to which underlie a broad spectrum of heart diseases. A deeper understanding of the mechanisms governing cardiac development is therefore crucial in elucidating disease etiologies and advancing diagnostic and therapeutic strategies.

This Special Issue will explore regulatory mechanisms in cardiogenesis, with a particular focus on the underlying cellular and molecular events. We aim to highlight research on key signaling pathways and transcriptional networks that coordinate cardiac cell fate specification, differentiation, and tissue morphogenesis. We welcome studies that utilize diverse experimental models—from traditional organisms such as zebrafish and mice to emerging platforms such as human pluripotent stem cell-derived organoids—to reveal evolutionarily conserved and species-specific principles through cross-model comparison.

We invite the submission of original research and review articles. Contributions to this Special Issue should significantly advance our knowledge of developmental biology and provide critical insights into the pathogenesis of heart disease, informing the development of novel therapeutic interventions.

Dr. Jun K. Takeuchi
Guest Editor

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