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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Cellular Pathophysiology of Intensive Care Unit-Acquired Muscle Dysfunction

edited by Lars Larsson

submission deadline 20 Oct 2026 | 1 articles | Viewed by 950 | Submission Open

Keywords: intensive care unit-acquired weakness; ventilator-induced diaphragm dysfunction; skeletal muscle atrophy; protein degradation; mitochondrial dysfunction; JAK-STAT signaling; oxidative stress; critical illness myopathy; autophagy; muscle proteostasis

(This special issue belongs to the Section Cellular Pathology)

Exclusive Review Papers in 'Cellular Biophysics'

edited by

Roger Schneiter

submission deadline 20 Oct 2026 | Viewed by 399 | Submission Open

Keywords: cellular biophysics; membrane biophysics; cytoskeletal dynamics; cellular mechanics; mechanotransduction; phase separation; molecular motors; bioelectricity; single-molecule techniques; computational biophysics; mechanobiology; active matter

(This special issue belongs to the Section Cellular Biophysics)

New Advances and Perspectives in the Molecular Mechanisms of Aging and Skin Cancer: Potential Options for Prevention and Treatment

edited by

Goberdhan P. Dimri

and Ewelina Musielak

submission deadline 20 Oct 2026 | Viewed by 167 | Submission Open

Keywords: skin cancer; malignancy; melanoma; non-melanoma; prevention; skin aging; skin photo-aging; skin inflammation; treatment; inflammaging; immune dysfunction; senescent cell

(This special issue belongs to the Section Cellular Aging)

Polyadenylation-Mediated Regulation of Pulmonary Diseases

edited by

Tingting Weng-Mills

submission deadline 20 Oct 2026 | Viewed by 132 | Submission Open

Keywords: polyadenylation; lung remodeling; pulmonary fibrosis; epitranscriptomics; alveolar epithelial cells

(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)

Regulatory Factors and Signaling Pathways of Anti-Tumor Immune Responses

edited by

Geeta Upadhyay

submission deadline 22 Oct 2026 | 1 articles | Viewed by 1137 | Submission Open

Keywords: anti-tumor immunity; immunotherapy; immune checkpoint blockade; immune receptor and ligand; immune evasion; tumor immune microenvironment; inflammation; T-cell activation and inhibition; myeloid-derived suppressor cell; macrophage; dendritic cell

(This special issue belongs to the Section Cellular Immunology)

The Dual Role of Extracellular Vesicles in Neurodegeneration: Disease Biomarkers and Drug Delivery Platforms Within the Matrix Microenvironment

edited by

Elisa Tonoli

and

Elisabetta Verderio Edwards

submission deadline 25 Oct 2026 | 1 articles | Viewed by 1141 | Submission Open

Keywords: extracellular vesicles; neurodegenerative diseases; extracellular matrix; biomarkers; therapeutic applications; drug delivery

(This special issue belongs to the Section Intracellular and Plasma Membranes)

Caveolae Function in Cell Membrane Dynamics and Signal Transduction

edited by

Alessio D'Alessio

and

Antonio Filippini

submission deadline 25 Oct 2026 | Viewed by 402 | Submission Open

Keywords: caveolae; caveolin and cavin proteins; plasma membrane organization; endocytosis and vesicular trafficking; mechanotransduction; lipid rafts and cholesterol metabolism; signal transduction; vascular biology and angiogenesis; cancer cell biology; membrane remodeling in disease

Vascular Microenvironment and Atherosclerosis

edited by

Abhijnan Chattopadhyay

and

Jacques P. Tremblay

submission deadline 25 Oct 2026 | Viewed by 269 | Submission Open

Keywords: vascular microenvironment; atherosclerosis; vascular inflammation; endothelial cells; smooth muscle cells; vascular–immune cell interactions; extracellular matrix; vascular remodeling; mechanotransduction; vascular biology

(This special issue belongs to the Section Cells of the Cardiovascular System)

Tumor Microenvironment and Immune Regulation

edited by

Xin Liu

submission deadline 25 Oct 2026 | Viewed by 184 | Submission Open

Keywords: cellular immunology; tumor microenvironment; intra- and extracellular signaling; immunometabolism; experimental cytology; tumor-infiltrating lymphocytes; spatial transcriptomics

(This special issue belongs to the Section Cell Microenvironment)

Nuclear Receptors, Drug Discovery, Nutraceuticals, and Neurodegenerative Diseases

edited by Rajesh Haresh Amin,

Kristine Griffett

and Meenakshi Singh

submission deadline 25 Oct 2026 | Viewed by 175 | Submission Open

Keywords: nuclear receptors; neurodegenerative diseases; metabolic dysfunction; inflammation; drug design

(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)

Advances in Annexin Biology

edited by

Raffaella Belvedere

Antonello Petrella

and Nunzia Novizio

submission deadline 28 Oct 2026 | 1 articles | Viewed by 1426 | Submission Open

Keywords: annexin family; calcium-dependent membrane binding; cell signaling; inflammation and immune response; membrane repair; cancer biology; cell motility; cell differentiation; tumor microenvironment; diagnostic/prognostic biomarkers; therapeutic targets

Role of Thyroid Hormone in Neurodegenerative and Neurodevelopmental Disorders

edited by Janaína Sena de Souza

submission deadline 30 Oct 2026 | 6 articles | Viewed by 18975 | Submission Open

Keywords: thyroid hormones; neurodevelopmental and neurodegenerative disorders; central nervous system

(This special issue belongs to the Section Cellular Neuroscience)

Advances in Reproductive Biology: Cellular and Molecular Mechanisms

edited by

Rosa Roy

and Clara González-Marín

submission deadline 30 Oct 2026 | 8 articles | Viewed by 12782 | Submission Open

Keywords: gametogenesis; fertilization; embryo implantation; reproductive genetics; epigenetics in reproduction; hormonal signaling; stem cells and reproduction; assisted reproductive technologies (ARTs); molecular fertility regulation; reproductive health innovations

(This special issue belongs to the Section Reproductive Cells and Development)

Identifying Functional Genomics and Pathways in Cancer Pathogenesis and Therapy Resistance

edited by

Yang Xu

and Ramkrishna Mitra

submission deadline 30 Oct 2026 | 3 articles | Viewed by 8014 | Submission Open

Keywords: functional genomics; cancer signaling pathways; targeted therapy; drug resistance; tumor microenvironment; oncogenomics; acquired resistance; tumor mutations

(This special issue belongs to the Section Cellular Pathology)

Translational Aspects of Cell Signaling

edited by

Marc D. Basson

submission deadline 30 Oct 2026 | 4 articles | Viewed by 6945 | Submission Open

Keywords: cell signaling; drug development; prognostic markers; bioinformatics; translational research

Regulation of Iron Homeostasis

edited by

Huangen Ding

submission deadline 30 Oct 2026 | 2 articles | Viewed by 4314 | Submission Open

Keywords: iron homeostasis; iron transport; iron storage; iron-containing proteins

Mechanisms and Therapies of Cell Death Pathways

edited by

Evripidis Gavathiotis

and Deniz Gulfem Ozturk

submission deadline 30 Oct 2026 | 1 articles | Viewed by 3038 | Submission Open

Keywords: cell death; mitochondrial regulation; BCL-2 family; non-apoptotic cell death; cell death pathways interactions; small molecules; therapeutic strategy; therapy resistance

(This special issue belongs to the Section Cellular Pathology)

New Therapeutic Approaches to Cardiac Repair

edited by Dinakar Iyer

submission deadline 30 Oct 2026 | 1 articles | Viewed by 1412 | Submission Open

Keywords: cardiac regeneration; CRISPR/base editing; mRNA therapeutics; circular RNA (circRNA); lipid nanoparticles (LNPs); engineered exosomes/extracellular vesicles; direct cardiac reprogramming; engineered heart muscle/3D cardiac patches; myocardial infarction repair; translational cardiology

Cellular and Molecular Basis in Chronic Kidney Disease—2nd Edition

edited by

Prabhatchandra Dube

and Dulat Bekbolsynov

submission deadline 30 Oct 2026 | 1 articles | Viewed by 935 | Submission Open

Keywords: CKD; renal inflammation; renal fibrosis; RAAS; aldosterone; TGF-B1; uremic toxins; hypertension; GFR; albuminuria

(This special issue belongs to the Section Cellular Pathology)

Mechanism of Endocrine Therapy Resistance in Breast Cancer

edited by

Debra A. Tonetti

and Clodia Osipo

submission deadline 30 Oct 2026 | Viewed by 574 | Submission Open

Keywords: estrogen receptor, endocrine resistance, mechanism of action; predictive biomarkers; signal transduction; novel therapeutics; drug sequencing; drug targets; pathological findings

(This special issue belongs to the Section Cellular Pathology)

Extracellular Vesicles in Chronic Obstructive Pulmonary Disease: A 2025 Update

edited by

Tommaso Neri

and

Erica Bazzan

submission deadline 30 Oct 2026 | Viewed by 453 | Submission Open

Keywords: extracellular vesicles (EVs); chronic obstructive pulmonary disease (COPD); inflammation; epithelial barrier; cellular senescence; tissue remodeling; biomarkers; exacerbations; microbiota; therapeutic targets

Advancements in Research on Metabolic Syndrome

edited by Gautam Kumar Pandey

submission deadline 30 Oct 2026 | Viewed by 290 | Submission Open

Keywords: metabolic syndrome; multi-omics; insulin resistance; cell signaling in metabolic disease

Gut Microbiota as a Regulator and Target in Cancer Immunology

edited by

Suresh Veeraperumal

and Pazhanichamy Kalailingam

submission deadline 30 Oct 2026 | Viewed by 283 | Submission Open

Keywords: gut microbiota; cancer immunology; tumor microenvironment; immune checkpoint inhibitors; cellular immunotherapy; tumor infiltrating lymphocytes; dysbiosis; microbiota targeted therapy; microbiome biomarkers; immunotherapy resistance

(This special issue belongs to the Section Cellular Immunology)

Decoding Melanoma: Molecular and Cellular Mechanisms and Therapeutic Opportunities

edited by

Cynthia Simbulan-Rosenthal

and

Anirudh Gaur

submission deadline 30 Oct 2026 | Viewed by 216 | Submission Open

Keywords: translational oncology; tumor biology; melanoma-targeted therapy; precision medicine; biomarker discovery

(This special issue belongs to the Section Cellular Pathology)

Cellular and Molecular Mechanisms of Leukemia

edited by Xiangguo Shi

submission deadline 30 Oct 2026 | Viewed by 212 | Submission Open

Keywords: leukemia; genomics; epigenetics; therapeutic resistance; metabolic reprogramming; clonal evolution; immunotherapy

(This special issue belongs to the Section Cellular Pathology)

Cellular and Molecular Mechanisms in Bone and Cartilage Damage and Regeneration

edited by

Philippe Hernigou

submission deadline 31 Oct 2026 | 9 articles | Viewed by 21060 | Submission Open

Keywords: bone morphogenic proteins (BMPs); bone union with cell therapy; advances in stem cell therapies for fracture non-union and cartilage regeneration; novel cell-based therapies for cartilage repair; functional of collagen/PLA scaffolds in cartilage regeneration; regeneration and revascularization of bone osteonecrosis; evaluation of osteonecrosis regeneration with MRI and histology, and arteriography; identification and validation of new cartilage biomarkers; diaphyseal regeneration with callostasis; union with the membrane technique

(This special issue belongs to the Section Cellular Pathology)

Advances in Liquid Biopsy for Early Detection and Monitoring of Cancer

edited by Nicola Normanno,

Paola Ulivi

and

Tania Rossi

submission deadline 31 Oct 2026 | 6 articles | Viewed by 5725 | Submission Open

Keywords: ctDNA; circulating tumor cells; microRNAs; exosomes; methylation; fragmentomics; early detection; minimal residual disease; artificial intelligence

Gene Expression in Adipocytes During Obesity: Understanding Challenges and Future Prospects

edited by

Markus Mandl

submission deadline 31 Oct 2026 | 1 articles | Viewed by 4890 | Submission Open

Keywords: adipocytes; adipose tissue; obesity; hypoxia; transcription factor; metabolism; epigenetics

Immunoregulation in Cardiovascular Disease

edited by

Hong Wang

submission deadline 31 Oct 2026 | 2 articles | Viewed by 4821 | Submission Open

Keywords: cardiovascular disease (CVD); immunoregulation; inflammation; immune cells; immune mediators; immunomodulatory therapies; biomarkers; epigenetics; microbiome; cellular methods/technologies

Novel Immunotherapies for Diffuse Large B-Cell Lymphoma

edited by

Waseem Lone

submission deadline 31 Oct 2026 | 3 articles | Viewed by 4537 | Submission Open

Keywords: diffuse large B-cell lymphoma; immunotherapy; CAR-T cells; bispecific antibodies; immune checkpoint inhibitors; antibody–drug conjugates; tumor microenvironment; biomarkers; translational research

Spatial Biology: Decoding Cellular Complexity in Tissues

edited by

Alexander E. Kalyuzhny

submission deadline 31 Oct 2026 | 2 articles | Viewed by 3877 | Submission Open

Keywords: spatial biology; spatial tissue profiling; proteomics; transcriptomics; cell and tissue

(This special issue belongs to the Section Tissues and Organs)

Cellular and Molecular Mechanisms of Cardiomyopathy

edited by

Zaglia Tania

and

Maurizio Forte

submission deadline 31 Oct 2026 | 2 articles | Viewed by 3330 | Submission Open

Keywords: genetic cardiomyopathies; acquired cardiomyopathies; cardiac arrhythmias; disease mechanisms; disease cause; pathogenesis

(This special issue belongs to the Section Tissues and Organs)

Signalling Mechanisms Regulating Cardiac Fibroblast Function

edited by Haofei Wang and

Yanhan Dong

submission deadline 31 Oct 2026 | 1 articles | Viewed by 3047 | Submission Open

Keywords: cardiac fibroblasts; myofibroblast activation; extracellular matrix remodeling; fibrosis; intercellular communication; mechanotransduction; single-cell and spatial insights; regeneration; therapeutic targeting

Targeting of Cancer Cells with Small Molecule Drugs

edited by

Jannet Kocerha

submission deadline 31 Oct 2026 | 2 articles | Viewed by 2805 | Submission Open

Keywords: small molecule drugs; cancer cell targeting; targeted cancer therapy; drug delivery systems; precision oncology

(This special issue belongs to the Section Cellular Pathology)

Interactions Between Gut Microbiota and Epigenetic Markers in Health and Disease

edited by

Shabnam Nohesara

submission deadline 31 Oct 2026 | 2 articles | Viewed by 2486 | Submission Open

Keywords: gut microbiome; epigenetic marks; cancer; metabolic diseases; neuropsychiatric disorders; inflammatory diseases; infectious diseases; cardiovascular diseases; probiotics; prebiotics

(This special issue belongs to the Section Cell and Gene Therapy)

Molecular Signaling and Mechanism on Vascular Remodeling

edited by

Ki Ho Park

and Yitao Huang

submission deadline 31 Oct 2026 | 2 articles | Viewed by 2437 | Submission Open

Keywords: vascular diseases; atherosclerosis; aneurysm; intimal hyperplasia; vascular remodeling; cellular mechanisms; cellular signaling

Dictyostelium as a Model in Cell Dynamics and Disease

edited by

Ralph Gräf

submission deadline 31 Oct 2026 | 3 articles | Viewed by 1891 | Submission Open

Keywords: dictyostelium; disease; cell migration; chemotaxis; cytoskeleton; cell mechanics; actin; host-bacteria interaction; cell division

(This special issue belongs to the Section Cellular Pathology)

Mechanisms and Dynamics in Cellular Adhesion in Development and Disease

edited by

Daniel Bouvard

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1879 | Submission Open

Keywords: actin; integrin; cell adhesion; signalling; mechanotransduction

Cellular and Molecular Mechanisms of Idiopathic Pulmonary Fibrosis

edited by

Sooyeon Lee

and

Mingyao Liu

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1162 | Submission Open

Keywords: idiopathic pulmonary fibrosis; fibroblast activation; epithelial–mesenchymal interaction; extracellular matrix remodeling; inflammation; signaling pathways; biomarkers; molecular targets; autophagy; senescence

Allergy and Immunity

edited by

Anish R. Maskey

and

Jan Geliebter

submission deadline 31 Oct 2026 | 1 articles | Viewed by 989 | Submission Open

Keywords: allergy; immune regulation; inflammation; epithelial barrier; biomarker; alternate therapy

(This special issue belongs to the Section Cellular Immunology)

Cellular and Molecular Mechanisms Behind Liver Inherited Metabolic Diseases and Novel Therapeutic Strategies

edited by Sonam Gurung

submission deadline 31 Oct 2026 | 1 articles | Viewed by 750 | Submission Open

Keywords: inherited metabolic liver diseases; urea cycle disorders; hepatic metabolic homeostasis; molecular mechanisms of disease; disease-modifying therapies; monogenic disorders; systems biology approaches; rare diseases

(This special issue belongs to the Section Cellular Pathology)

Neurotoxicity: Focusing on Molecular and Cellular Mechanisms

edited by

Pablo Martín-Vasallo

, Manuel José Morales and

Rita Martín-Ramírez

submission deadline 31 Oct 2026 | Viewed by 552 | Submission Open

Keywords: neurotoxicity; neuroinflammation; neurodegeneration; chemotherapy-induced neuropathy; neuroprotection; neuronal injury

Novel Biomarkers and Dose-Response Modifiers in Radiation Oncology and Nuclear Medicine: Molecular Insights for Personalized Therapy and Precision Medicine

edited by

Wolfgang Sauerwein

and Andrea Wittig

submission deadline 31 Oct 2026 | Viewed by 462 | Submission Open

Keywords: targeted therapies; predictive essays; radiosensitizers; radioprotectors; theranostics; BNCT; alpha-immunotherapy; biological response modifiers; biomarkers

Mechanobiological Regulation of Fibroblast-to-Myofibroblast Phenotype Transition

edited by Mirko D’urso and

Nicholas A. Kurniawan

submission deadline 31 Oct 2026 | Viewed by 383 | Submission Open

Keywords: fibroblasts; myofibroblasts; mechanotransduction; extracellular matrix; fibrosis; tissue remodeling; mechanobiology

(This special issue belongs to the Section Cell Microenvironment)

Cellular and Molecular Mechanisms of Oocyte Maturation and the Fertilization Process

edited by

Luigia Santella

, Jong Tai Chun,

Evelyn Telfer

and Bart M. Gadella

submission deadline 31 Oct 2026 | Viewed by 353 | Submission Open

Keywords: oocyte growth; meiotic maturation; sperm capacitation; acrosome reaction; actin; calcium; cortical/zona reaction; polyspermy; cleavage; implantation

(This special issue belongs to the Section Reproductive Cells and Development)

Autophagy, Mitochondria, and Cell Death in Cancer

edited by Yuchen Lei and

Kazuyuki Kitatani

submission deadline 31 Oct 2026 | 1 articles | Viewed by 346 | Submission Open

Keywords: autophagy; cancer; cell death; metabolism; mitochondria

(This special issue belongs to the Section Autophagy)

Crosstalk Between Autophagy, Apoptosis and Inflammation

edited by

Maurizio Sorice

and

Tina Garofalo

submission deadline 31 Oct 2026 | Viewed by 334 | Submission Open

Keywords: autophagy; apoptosis; inflammation; signal transduction; lipid messengers; rheumatic disorders; cancer; neurodegenerative diseases

(This special issue belongs to the Section Autophagy)

Ovarian Tumors—Molecular Mechanisms, Cellular Dynamics, and Therapeutic Advances

edited by David Schweer, Joel Cardenas and

Delia Mezzanzanica

submission deadline 31 Oct 2026 | Viewed by 328 | Submission Open

Keywords: ovarian tumor biology; cellular signaling networks; genetic and epigenetic regulation; tumor microenvironment; cellular heterogeneity; single-cell and spatial omics; functional genomics; mechanisms of therapeutic resistance

(This special issue belongs to the Section Cellular Pathology)

Ion Transporters and Channels in Cellular Homeostasis and Disease

edited by Guanxiao Qi and Raul E. Guzman

submission deadline 31 Oct 2026 | Viewed by 312 | Submission Open

Keywords: patch-clamp recording; ligand-gated channels; ion channel modulators; channel-specific ligands; channelopathies; epilepsy; neurodegenerative disease

Colorectal Cancer: Genetics and Molecular Mechanisms

edited by

Hala Gali-Muhtasib

and

Georgios Antonios Margonis

submission deadline 31 Oct 2026 | Viewed by 311 | Submission Open

Keywords: colorectal cancer; metastasis ; generation alterations; epigenetic regulation; signal transduction pathways; biomarkers; therapeutic resistance; in vitro and in vivo models; translational research

(This special issue belongs to the Section Tissues and Organs)

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