Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Updates and Perspectives on Prion-Like Tau Pathology Propagation
edited by Kunie Ando, Jean-Pierre Brion and Siranjeevi Nagaraj
submission deadline 31 Oct 2025 | Viewed by 450 | Submission Open
Keywords: tau; amyloid beta; prion-like; propagation; Alzheimer’ s disease; neurodegenerative diseases; protein-protein interactions; synaptic dysfunction; aggregation; protein misfolding; risk factors; post-translational modifications
Molecular Research of Cardiomyopathy
edited by and
submission deadline 31 Oct 2025 | Viewed by 447 | Submission Open
Keywords: cardiomyopathy; heart failure; hypertrophic cardiomyopathy; cellular and molecular rehabilitation
(This special issue belongs to the Section Cells of the Cardiovascular System)
Advances in Bacterial Cell Biophysics: Metabolic Engineering and Host Interactions
edited by Shahid Khan
submission deadline 31 Oct 2025 | Viewed by 298 | Submission Open
Keywords: bacterial cell biophysics; mechanical properties; biophysical techniques; host interactions; metabolic engineering
Autophagy in Cancer Regulation
edited by Tejinder Pal Khaket
submission deadline 31 Oct 2025 | Viewed by 261 | Submission Open
Keywords: autophagy; drug resistance; immune response: cancer stemness
(This special issue belongs to the Section Autophagy)
Cell and Tissue Engineering for Functional Analysis (2nd Edition)
edited by
submission deadline 31 Oct 2025 | Viewed by 236 | Submission Open
Keywords: animal cell engineering; tissue engineering; genome engineering; stem cell technology; synthetic biology
(This special issue belongs to the Section Tissues and Organs)
Kidney and Lung Disorders: The Role of Tubular and Alveolar Epithelia in Health, Disease, Infection, and Organ Crosstalk
edited by Aparna Renigunta and
submission deadline 31 Oct 2025 | Viewed by 201 | Submission Open
Keywords: renal tubular disorders; alveolar lung diseases; transport mechanism; intracellular signaling; viral infection; crosstalk; dialysis; ventilation
Potential Therapeutic Biomarkers for Prostate Cancer
edited by Benyi Li
submission deadline 31 Oct 2025 | Viewed by 186 | Submission Open
Keywords: prostate cancer; novel biomarkers; treatment
(This special issue belongs to the Section Cellular Pathology)
Role of Lysosomes in Mediating Cancer Drug Resistance
edited by
submission deadline 31 Oct 2025 | Viewed by 170 | Submission Open
Keywords: drug resistance; autophagic cell death; lysosomal-mediated cell death; autophagy; apoptosis; lysosomal exocytosis; lysosomal sequestration; tumor microenvironment
(This special issue belongs to the Section Cell Microenvironment)
From Bench to Bedside: Animal Models and Molecular Mechanisms in Cancer Therapeutics
edited by Sijana H. Dzinic
submission deadline 31 Oct 2025 | Viewed by 130 | Submission Open
Keywords: animal models in cancer research; cancer therapeutics; preclinical research; drug development; efficacy testing of novel anticancer agents; translational research
(This special issue belongs to the Section Cellular Pathology)
Cellular and Molecular Mechanisms in Peritoneal Malignancies: Insights into Pathogenesis and Therapeutic Advances
edited by , Ibrahim Büdeyri and Jan Philipp Ramspott
submission deadline 31 Oct 2025 | Viewed by 125 | Submission Open
Keywords: peritoneal metastasis; cytoreductive surgery; HIPEC; PIPAC; biomarker; tumor microenvironment; epigenetics; precision oncology; tumor metabolism; immunotherapy
(This special issue belongs to the Section Cellular Pathology)
Plasticity of Skeletal, Cardiac and Smooth Muscles in COPD: Repair and Remodeling
edited by Joaquim Gea Guiral
submission deadline 31 Oct 2025 | Viewed by 123 | Submission Open
Keywords: injury; repair; adaptation; aerobic metabolism; muscle mass; limb muscles; respiratory muscles; proteolysis
Functional Differences in Periostin Splicing Isoforms in Cancer and Inflammatory Disorders
edited by and Nobutaka Koibuchi
submission deadline 31 Oct 2025 | Viewed by 119 | Submission Open
Keywords: periostin; splicing variant; treatment-resistant cancer; diagnostics; periostin suppression therapy
Exploring Mitochondrial Dysfunction and Neuroinflammation in Neurodegeneration for New Therapeutic Advances
edited by Hanhan Liu
submission deadline 31 Oct 2025 | Viewed by 100 | Submission Open
Keywords: mitochondria; neuroinflammation; neurodegeneration; neuroprotective therapy; innate immunity
(This special issue belongs to the Section Cellular Pathology)
Macrophages in Cancer: Immunosuppression, Immunoregulation, and Immunotherapy
edited by
submission deadline 5 Nov 2025 | 2 articles | Viewed by 5828 | Submission Open
Keywords: macrophage; immunosuppression; immunoregulation; immunotherapy; tumor immune microenvironment
(This special issue belongs to the Section Cellular Immunology)
Stem Cells in Cancer
edited by
submission deadline 10 Nov 2025 | 2 articles | Viewed by 5992 | Submission Open
Keywords: cancer stem cells; heterogeneity; metastasis; plasticity; self-renewal
(This special issue belongs to the Section Stem Cells)
Molecular Mechanism and Therapeutic Opportunities of Breast Cancer submission deadline 10 Nov 2025 | 3 articles | Viewed by 3327 | Submission Open
Keywords: breast cancer; molecular mechanisms; targeted therapy; genomic profiling; hormone receptors; tumor microenvironment; immunotherapy; drug resistance; metastasis; precision medicine
(This special issue belongs to the Section Cellular Pathology)
Synaptic Plasticity and the Neurobiology of Learning and Memory
edited by Erica Berretta, Laura Petrosini and Anna Panuccio
submission deadline 10 Nov 2025 | 1 articles | Viewed by 1813 | Submission Open
Keywords: learning and memory; neuronal and glial cells; long-term potentiation and long-term depression; molecular mechanisms
(This special issue belongs to the Section Cells of the Nervous System)
Recent Advances in the Molecular Mechanisms of Neurodegenerative Diseases: Current Progress and Future Directions for Disease-Modifying Therapies submission deadline 10 Nov 2025 | 1 articles | Viewed by 1077 | Submission Open
Keywords: neuroprotection; new drug development; natural products; blood– brain barrier; molecular mechanisms; neuronal signaling; neuroinflammation; microglial cells; neurotoxicity; neurodegenerative diseases
(This special issue belongs to the Section Cellular Aging)
Biomarkers in Breast Cancer
edited by Julie Decock and Sana A. Bentebbal
submission deadline 10 Nov 2025 | 1 articles | Viewed by 1073 | Submission Open
Keywords: breast cancer biomarkers; AI in oncology; multi-omics; exosomes; tumor immune microenvironment; liquid biopsy; precision oncology; personalized medicine
(This special issue belongs to the Section Cellular Pathology)
Immunoregulation in Cardiovascular Disease
edited by
submission deadline 10 Nov 2025 | Viewed by 134 | Submission Open
Keywords: cardiovascular disease (CVD); immunoregulation; inflammation; immune cells; immune mediators; immunomodulatory therapies; biomarkers; epigenetics; microbiome; cellular methods/technologies
Modeling Developmental Processes and Disorders in Zebrafish submission deadline 15 Nov 2025 | 13 articles | Viewed by 48756 | Submission Open
(This special issue belongs to the Section Cellular Biophysics)
Effects and Mechanisms of Environmental Toxicants and Nanoparticles on Germ Cells, Gonads, Embryos and Stem Cells
edited by , , and Giulia Fiorentino
submission deadline 15 Nov 2025 | 1 articles | Viewed by 3058 | Submission Open
Keywords: environmental toxicants; gonadal steroid hormones; ovary; folliculogenesis; oogenesis and oocyte; testis; spermatogenesis and sperm; embryo development; epigenetics; omics; cells lines and stem cells; embryoid bodies; gastruloids and organoids; 3D cell culture and imaging; nanoparticles; nanomaterials
(This special issue belongs to the Section Stem Cells)
Advances in Intestinal Epithelial Plasticity and Regeneration
edited by
submission deadline 15 Nov 2025 | 1 articles | Viewed by 2942 | Submission Open
Keywords: intestinal epithelium; epithelial plasticity; stem cells; tissue repair; self-renewal; regeneration
Innate-Like T Cells: The Variegated Roles of Semi-Invariant TCRs in Health and Disease
edited by and Akshat Sharma
submission deadline 15 Nov 2025 | Viewed by 2016 | Submission Open
Keywords: innate-like T cells; cancer; autoimmunity; cytokines; immune mechanisms
(This special issue belongs to the Section Cellular Pathology)
Novel Therapies and Biomarkers for Rare Diseases
edited by Reena Kartha
submission deadline 15 Nov 2025 | Viewed by 190 | Submission Open
Keywords: rare diseases; translational research; novel therapies; biomarker discovery; precision medicine
The Role of Integrins and Small GTPases in Health and Disease
edited by
submission deadline 15 Nov 2025 | Viewed by 110 | Submission Open
Keywords: cell signaling; integrins; cell adhesion; integrins diseases; infectious diseases
Lipids and Lipidomics in Neurodegenerative Diseases
edited by and Catherine Malaplate
submission deadline 20 Nov 2025 | 1 articles | Viewed by 10951 | Submission Open
Keywords: lipids; lipidomics; neurodegenerative disease diagnosis; prevention; or treatment; cellular and molecular mechanisms
(This special issue belongs to the Section Cells of the Nervous System)
Molecular Advances in Prenatal Exposure to Environmental Toxicants submission deadline 20 Nov 2025 | 4 articles | Viewed by 9851 | Submission Open
Keywords: prenatal exposures; toxicogenomics; epigenomics; placenta; perinatal outcomes; neurodevelopmental outcomes; respiratory outcomes
Molecular Mechanism of Liver Transplantation
edited by Carmen Peralta and Juan Carlos Cutrin
submission deadline 20 Nov 2025 | 1 articles | Viewed by 3714 | Submission Open
Keywords: liver transplantation; ischemia-reperfusion injury; signaling pathways; graft dysfunction; sterile inflammation; liver regeneration; fatty grafts; normothermic machine perfusion; defatting strategies
(This special issue belongs to the Section Tissues and Organs)
Second Edition of Advances in Adipose Tissue Biology
edited by
submission deadline 20 Nov 2025 | 2 articles | Viewed by 3642 | Submission Open
Keywords: adipocyte differentiation; progenitors; and stem cells; adipokines; myokines; hepatokines; cytokines; cellular signaling; and molecular crosstalk; white adipose tissue (WAT) and brown adipose tissue (BAT); beige fat and browning of WAT; research techniques and methodologies; diagnostics and therapeutics; genomics; metabolomics; other ‘ omics’ technologies; metabolic syndrome; obesity; insulin resistance; cancer
(This special issue belongs to the Section Tissues and Organs)
Tumor Stroma Interaction
edited by
submission deadline 20 Nov 2025 | 1 articles | Viewed by 1313 | Submission Open
Keywords: cells; cancer; inflammation; exocytosis; immune system; tumor stroma
Decoding the Complexity of Angiogenesis: Insights into Vascular Formation and Disease submission deadline 20 Nov 2025 | 1 articles | Viewed by 1055 | Submission Open
Keywords: angiogenesis; vasculogenesis; development; physiological angiogenesis; pathophysiology; cell– cell communication; cell signaling
(This special issue belongs to the Section Cells of the Cardiovascular System)
Ripening and Degradation Mechanisms of Neutrophil Extracellular Traps
edited by and Maximilian Dölling
submission deadline 20 Nov 2025 | Viewed by 453 | Submission Open
Keywords: neutrophil extracellular traps; degradation of NETs; ripening of NETs
(This special issue belongs to the Section Cellular Immunology)
Aging and Metabolic Diseases
edited by
submission deadline 20 Nov 2025 | Viewed by 445 | Submission Open
Keywords: aging; insulin resistance; diabetes; obesity; mitochondrial dysfunction; beta-galactosidase; senescent-associated secretory phenotype; pancreatic beta cells
(This special issue belongs to the Section Cellular Aging)
Extracellular Vesicles Based Drug Delivery submission deadline 20 Nov 2025 | Viewed by 323 | Submission Open
Keywords: EV engineering; targeting; therapy; natural carrier; exosomes
Recent Advances in the Study of Tau Protein
edited by
submission deadline 20 Nov 2025 | Viewed by 214 | Submission Open
Keywords: tau protein; post-translational modification; tauopathy filaments; neuro-immune interactions
(This special issue belongs to the Section Cells of the Nervous System)
Epigenetic Regulation in Plant–Microbe Interactions and Environmental Adaptation
edited by Zhongshou Wu and Bochen Jiang
submission deadline 20 Nov 2025 | Viewed by 182 | Submission Open
Keywords: epigenetic regulation; plant– microbe interactions; environmental adaptation
(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)
Genetic and Genomic Insights into Complex Human Diseases: Advances, Challenges and Integrative Approaches
edited by Tianxiao Huan and Chan Zhou
submission deadline 20 Nov 2025 | Viewed by 156 | Submission Open
Keywords: genetics; genomics; proteomics; complex diseases; multi-omics; machine learning
Acute Liver Failure: Molecular Actors in Liver–Adipose Tissue Interplay
edited by Marika Crescenzi
submission deadline 20 Nov 2025 | Viewed by 139 | Submission Open
Keywords: inflammasome; adipose tissue; acute liver injury; adipokines; liver macrophages; hepatic stellate cells; liver sinusoidal endothelial cells
(This special issue belongs to the Section Tissues and Organs)
Transient Receptor Potential (TRP) Channels and Health and Disease
edited by Hiroki Kittaka and Makoto Tominaga
submission deadline 20 Nov 2025 | Viewed by 120 | Submission Open
Keywords: Transient Receptor Potential (TRP) channels; cell signaling; cell physiology
Methane Biosynthesis
edited by , James Ferry and
submission deadline 20 Nov 2025 | Viewed by 117 | Submission Open
Keywords: methane; methanogenesis; methanogens; carbon cycle; gut microbiota; energy conservation; human diseases
Atherosclerosis and Thrombosis: Molecular and Pathological Research Advance submission deadline 20 Nov 2025 | Viewed by 101 | Submission Open
Keywords: atherosclerosis; thrombosis; molecular mechanisms; translational research; precision medicine
(This special issue belongs to the Section Cellular Pathology)
The Metabolic Interactions and Pathways in Cancers
edited by Mohamed Elgendy
submission deadline 20 Nov 2025 | Viewed by 90 | Submission Open
Keywords: cancer metabolism; metastasis; drug resistance; oncometabolites; metabolic plasticity; diet; bioenergetics; metabolic crosstalk; immunotherapy
New Insights into Astrocytes in Health and Disease
edited by
submission deadline 20 Nov 2025 | Viewed by 88 | Submission Open
Keywords: astrocytes heterogeneity; blood-brain barrier (BBB); synaptic modulation; metabolic support; neuroinflammation; ageing; neurodegenerative disorders; neurodevelopmental disorders; stress response
(This special issue belongs to the Section Cells of the Nervous System)
Targeting Tumor Metabolism and Epigenetics: Mechanisms and Therapeutic Strategies
edited by , and Íñigo Casafont
submission deadline 22 Nov 2025 | Viewed by 217 | Submission Open
Keywords: tumor metabolism; epigenetics; metabolic reprogramming; DNA methylation; histone modification; warburg effect; glycolysis inhibitors; fatty acid synthesis; chromatin remodeling; cancer therapy
(This special issue belongs to the Section Cellular Metabolism)
Cellular and Molecular Basis in Chronic Kidney Disease submission deadline 25 Nov 2025 | 8 articles | Viewed by 18903 | Submission Open
Keywords: CKD; renal inflammation; renal fibrosis; RAAS; aldosterone; TGF-B1; uremic toxins; hypertension; GFR; albuminuria
(This special issue belongs to the Section Cellular Pathology)
Glial Cells in Aging Neuroscience
edited by
submission deadline 25 Nov 2025 | 1 articles | Viewed by 5703 | Submission Open
Keywords: glial cells; aging; neuroinflammation; neurodegeneration; glial– neuronal interactions; glial– glial crosstalk; astrocytes; oligodendrocytes; microglia; ependymal cells
(This special issue belongs to the Section Cellular Aging)
Biomolecular Condensates in Oncology and Immunology submission deadline 25 Nov 2025 | 1 articles | Viewed by 1212 | Submission Open
Keywords: liquid-liquid phase separation (LLPS); biomolecular condensates; pro-oncogenic signaling; innate and adaptive immunity; transcriptional regulation; epigenetic regulation; condensate targeting; antiviral mechanisms; intercellular adhesion; cell migration and metastasis
(This special issue belongs to the Section Cellular Immunology)
CAR T Cells in Human Cancers submission deadline 25 Nov 2025 | 1 articles | Viewed by 820 | Submission Open
Keywords: CAR T cells; engineered immune cell therapies; CAR T cell engineering
Cell Signaling in Neurodegeneration Disease
edited by , Yasuhiro Funahashi, , and Md-nadim Hossain
submission deadline 25 Nov 2025 | Viewed by 208 | Submission Open
Keywords: neurodegeneration; cell signaling; biomarkers; synaptic dysfunction; neuroinflammation; protein aggregation; IPSC and animal models; mitochondrial dysfunction; therapeutic targets; translational neuroscience
(This special issue belongs to the Section Cells of the Nervous System)
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