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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Silent Regulators: Non-Coding RNAs in Cell Function and Disease

edited by

Christiane Branlant

and

Mirolyuba Simeonova Ilieva

submission deadline 31 Aug 2025 | 1 articles | Viewed by 410 | Submission Open

Keywords: non-coding RNAs; microRNAs; long non-coding RNAs (lncRNAs); regulatory RNAs; RNA interference; epigenetic regulation; RNA editing; cellular signaling; disease biomarkers; RNA therapeutics

(This special issue belongs to the Section Cell and Gene Therapy)

The Role of T Cells in Type 1 Diabetes

edited by

Ismail Syed

and

Mayur S. Parmar

submission deadline 31 Aug 2025 | Viewed by 386 | Submission Open

Keywords: T cells; inflammation; T cell receptor; type 1 diabetes

(This special issue belongs to the Section Cellular Immunology)

Hedgehog Signaling: Advances in Development and Cancer—Second Edition

edited by

Xiaoyan Zheng

submission deadline 31 Aug 2025 | Viewed by 370 | Submission Open

Keywords: hedgehog signaling; hh gene; smoothened (SMO)

(This special issue belongs to the Section Cell Signaling)

The Role of Microglia in Neurodegenerative Diseases and Neuroinflammation

edited by

Yun Li

submission deadline 31 Aug 2025 | Viewed by 317 | Submission Open

Keywords: microglia; central nervous system; neurodegenerative diseases; neurodegeneration; Alzheimer’ s disease (AD); Parkinson’ s disease (PD)

(This special issue belongs to the Section Cells of the Nervous System)

Immune Cells from Pluripotent Stem Cells

edited by

Eunju Kang

submission deadline 31 Aug 2025 | Viewed by 309 | Submission Open

Keywords: pluripotent stem cells; T cells; B cells; macrophages; natural killer (NK) cells; dendritic cells; megakaryocytes; platelets

(This special issue belongs to the Section Stem Cells)

Heparanase and Heparanase-2: Function, Regulation, Signaling, and Disease

edited by

Israël Vlodavsky

and

Jin-Ping Li

submission deadline 31 Aug 2025 | Viewed by 250 | Submission Open

Keywords: heparanase (Hpa1); heparanase-2 (Hpa2); tumor microenvironment; extracellular matrix; tumor progression; tumor suppression; metastatic niche; glycocalyx; immune cells; inflammation

(This special issue belongs to the Section Cellular Aging)

Impact of Hyponatremia on Cancer Progression and Organ Function: Insights from Murine Models

edited by Giada Marroncini and Mushfiquddin Khan

submission deadline 31 Aug 2025 | Viewed by 162 | Submission Open

Keywords: hyponatremia; cancer progression; neurological disease; heart failure; osteoporosis; liver cirrhosis; kidney injury; vaptans

(This special issue belongs to the Section Tissues and Organs)

Nuclear Pore Complex in Nanomedicine: Third Edition

edited by

Richard W. Wong

submission deadline 31 Aug 2025 | Viewed by 122 | Submission Open

Keywords: intracellular transport; NPC; mitosis; nano; cancer; brain

Ubiquitin Ligases: Key Regulators in Cellular Homeostasis and Disease

edited by Praveen Koganti and

Michal Goldberg

submission deadline 31 Aug 2025 | Viewed by 105 | Submission Open

Keywords: ubiquitin ligases; protein ubiquitination; cellular homeostasis; proteasome pathway

The Role of Cellular Senescence in Health, Disease, and Aging

edited by

Yasumichi Inoue

submission deadline 5 Sep 2025 | 7 articles | Viewed by 18854 | Submission Open

Keywords: apoptosis; cancer; cell cycle; DNA damage; metabolic diseases; oxidative stress; senolysis; senescence; therapeutic approach

(This special issue belongs to the Section Cellular Aging)

Epigenetic Mechanisms of Tumorigenesis

edited by

Hengbin Wang

submission deadline 10 Sep 2025 | 1 articles | Viewed by 763 | Submission Open

Keywords: epigenetics; tumorigenesis; gene expression; cell identity; precise medicine

New Insights into Vascular Biology in Health and Disease

edited by Bashir M. Rezk

submission deadline 15 Sep 2025 | 5 articles | Viewed by 12329 | Submission Open

Keywords: vascular diseases; cardiovascular; cancer; hyperhomocyteinemia; endothelial dysfunction; vascular smooth muscle cell; autophagy; alcohol; galectins; angiogenesis; neovascularization

(This special issue belongs to the Section Cells of the Cardiovascular System)

Pathogenic Mechanisms of Chronic Inflammation-Associated Cancer

edited by Emiko Mizoguchi

submission deadline 15 Sep 2025 | 5 articles | Viewed by 10236 | Submission Open

Keywords: chronic inflammation; dysplasia; neoplasia; oncogene; cytokine; colitis-associated cancer

(This special issue belongs to the Section Cellular Pathology)

Molecular and Cellular Mechanisms of Marfan Syndrome

edited by

Vivian De Waard

Gustavo Egea

and

María Galán

submission deadline 15 Sep 2025 | 4 articles | Viewed by 3850 | Submission Open

Keywords: Marfan syndrome; aortic aneurysm; aortic dissection; TGFβ ; BMP; matrix metalloproteinase; NO synthase; mitochondrial dysfunction; oxidative stress; endothelium; aortic vascular smooth muscle cells; phenotypic switching; adventitia; hemodynamics; gene therapy; connective tissue disease

(This special issue belongs to the Section Cellular Pathology)

Advancements in Immunotherapy and CAR T Cell Therapy: Unleashing the Power of the Immune System Against Cancer

edited by

Pradeep K. Shukla

submission deadline 15 Sep 2025 | 1 articles | Viewed by 1079 | Submission Open

Keywords: CAR T; immunotherapy; cancer; chimeric antigen receptors

(This special issue belongs to the Section Cellular Immunology)

In Vitro Model for Micro- and Nano-Technologies—Second Edition

edited by Tania Limongi

submission deadline 15 Sep 2025 | Viewed by 140 | Submission Open

Keywords: in vitro cell culture; micro- and nano-technology; extracellular vesicles; nanoparticles; quantum dots; biocompatibility; hemocompatibility; diagnosis; drug delivery; tissue engineering

(This special issue belongs to the Section Cellular Biophysics)

Cancer Cell Signaling, Autophagy and Tumorigenesis

edited by Debanjan Bhattacharya

submission deadline 15 Sep 2025 | Viewed by 77 | Submission Open

Keywords: cancer cell signaling; autophagy; tumorigenesis; PI3K/AKT/mTOR pathway; Ras/Raf/MEK/ERK (MAPK) pathway

Molecular and Cellular Advances in Gut-Brain Axis

edited by

Aditi Bhargava

and Radhakrishna Rao

submission deadline 20 Sep 2025 | 2 articles | Viewed by 25319 | Submission Open

Keywords: gut– brain axis; microbiome; omics; diet; biological sex; gender; early-life stress; immunity; mental health; neurodegenerative diseases; metabolic health

(This special issue belongs to the Section Cells of the Nervous System)

Advances in the Discovery of Retinal Degeneration

edited by

Ram Prasad

and

Yvonne Adu-Rutledge

submission deadline 20 Sep 2025 | 3 articles | Viewed by 2727 | Submission Open

Keywords: retinal cell biology; photoreceptors; oxidative stress; inflammation; blood– retinal barriers; diabetic retinopathy; clinical eye research; inherited retinal diseases; ocular immunology

(This special issue belongs to the Section Cellular Pathology)

Advances in Immunotherapy for Non-Small-Cell Lung Cancer

edited by

Raheleh Roudi

submission deadline 20 Sep 2025 | 1 articles | Viewed by 2538 | Submission Open

Keywords: non-small cell lung cancer; immunotherapy; immune checkpoint inhibitors; PD-1; PD-L1; pembrolizumab; nivolumab; atezolizumab; CTLA4

(This special issue belongs to the Section Cellular Immunology)

Gene and Cellular Signaling Related to Muscle

edited by

Khurshid Ahmad

submission deadline 20 Sep 2025 | 1 articles | Viewed by 1856 | Submission Open

Keywords: skeletal muscle; molecular mechanism; muscle atrophy; therapeutics; metabolic signals; satellite cells

(This special issue belongs to the Section Cell Signaling)

Molecular Insights into Vascular Physiology and Pathology

edited by Suravi Majumder

submission deadline 20 Sep 2025 | Viewed by 293 | Submission Open

Keywords: vascular physiology; vascular pathology; endothelial cells; vascular smooth muscle cells; vascular inflammation; vascular signaling; vascular aging; vascular remodeling; atherosclerosis; cardiovascular diseases; biomarkers; novel therapeutic approaches

(This special issue belongs to the Section Cellular Pathology)

Macrophage-Epithelial Interplay in Pulmonary Fibrosis

edited by

Negah Ahmadvand

and Farhad Khosravi

submission deadline 20 Sep 2025 | Viewed by 242 | Submission Open

Keywords: macrophages; epithelial cells; idiopathic pulmonary fibrosis (IPF); immune response

The Placental Matrix: Trophoblasts, Decidualization, and Embryo Implantation

edited by

Vinay Shukla

submission deadline 20 Sep 2025 | Viewed by 105 | Submission Open

Keywords: trophoblast; decidualization; embryo implantation; uterus; infection; cancer; reproductive immunology; reproductive toxicology; cellular differentiation

(This special issue belongs to the Section Tissues and Organs)

Stem Cells and Endometrium

edited by Shiying Jin

submission deadline 20 Sep 2025 | Viewed by 86 | Submission Open

Keywords: stem cell; homeostasis; regeneration; endometrium

(This special issue belongs to the Section Stem Cells)

Regulation of Vascular Endothelial Growth Factor (VEGF) and Its Receptor (VEGFR) in Angiogenesis

edited by Alessandra Loda and

Paola Bagnoli

submission deadline 25 Sep 2025 | 1 articles | Viewed by 1975 | Submission Open

Keywords: vascular endothelial growth factor (VEGF); VEGF receptors (VEGFRs); angiogenesis; endothelial cells; anti-angiogenic therapies; VEGFR inhibitors

Identifying Functional Genomics and Pathways in Cancer Pathogenesis and Therapy Resistance

edited by

Yang Xu

and Ramkrishna Mitra

submission deadline 25 Sep 2025 | 1 articles | Viewed by 1178 | Submission Open

Keywords: functional genomics; cancer signaling pathways; targeted therapy; drug resistance; tumor microenvironment; oncogenomics; acquired resistance; tumor mutations

(This special issue belongs to the Section Cellular Pathology)

Lipid Homeostasis: Mechanisms, Regulation, and Implications for Health and Disease

edited by

Roger Schneiter

and Museer Ahmad Lone

submission deadline 25 Sep 2025 | Viewed by 420 | Submission Open

Keywords: lipid metabolism; lipid synthesis and degradation; triglyceride storage; fatty acid oxidation; cholesterol homeostasis; adipogenesis; lipid droplets; lipid signaling pathways; lipid transport proteins; phospholipid balance; sphingolipid metabolism; sterol regulatory element-binding proteins (SREBPs); AMP-activated protein kinase (AMPK); peroxisome proliferator-activated receptors (PPARs); insulin signaling and lipid storage; endoplasmic reticulum stress and lipids; lipoprotein metabolism; non-alcoholic fatty liver disease (NAFLD); lipidomics; autophagy and lipid recycling; lysosomal lipid degradation; lipid-binding proteins; oxidized lipids; lipid imbalance and disease; energy homeostasis and lipid storage; lipid transport vesicles; membrane lipid composition; lipid peroxidation; lipid-related genetic disorders; nutrient sensing and lipid regulation

(This special issue belongs to the Section Cellular Biophysics)

Retinal Pigmented Epithelium (RPE) and the Choroid: Players and Partners for Vision

edited by

Luminita Paraoan

and Janet R. Sparrow

submission deadline 25 Sep 2025 | Viewed by 388 | Submission Open

Keywords: retinal pigment epithelium; photoreceptor cell; choroid; Bruch’ s membrane; neural retina; visual cycle; phagocytosis; secretion; organelles; mitochondria; retinoid; melanin; albinism; age-related macular degeneration

(This special issue belongs to the Section Tissues and Organs)

Effective Embryo Maternal Interaction Support Favorable Pregnancy Outcome

edited by Eytan R. Barnea,

Nicoletta Di Simone

and Guarano Alice

submission deadline 25 Sep 2025 | Viewed by 377 | Submission Open

Keywords: pregnancy; fertilization; tubal transport; embryogenesis; maternal quality control

(This special issue belongs to the Section Tissues and Organs)

Insights into the Pathophysiology of NeuroCOVID: Current Topics

edited by

Christian Barbato

Antonio Minni

and

Carla Petrella

submission deadline 25 Sep 2025 | Viewed by 252 | Submission Open

Keywords: neuroCOVID; longCOVID; neurocognitive; cellular and molecular neurobiology; brain fog; anxiety; depression; biomarkers; translational biomedicine; neurodegenerative diseases

(This special issue belongs to the Section Cellular Pathology)

Ovarian Microenvironment and Oocyte Quality: Mechanisms, Aging, and Therapeutic Strategies

edited by Haiyang Wang

submission deadline 25 Sep 2025 | Viewed by 99 | Submission Open

Keywords: ovarian microenvironment; oocyte; mechanisms; aging; therapeutic strategies

(This special issue belongs to the Section Cell Microenvironment)

Amyloid–Metal Interactions in Alzheimer’s Disease: Mechanisms, Biomarkers, and Therapeutic Advances

edited by

Jonathan Pansieri

submission deadline 25 Sep 2025 | Viewed by 74 | Submission Open

Keywords: Alzheimer’ s; amyloids; Aß ; Tau; neurodegeneration; metal homeostasis; oxidative stress; neuropathology; PET

(This special issue belongs to the Section Cellular Aging)

Cell Migration and Invasion

edited by Veronika Miskolci

submission deadline 28 Sep 2025 | Viewed by 147 | Submission Open

Keywords: cell migration; cell invasion; cancer metastasis; molecular mechanisms; therapeutic strategies; signaling pathways

Potential of CAR-Based Cellular Immunotherapy for Non-oncologic Disorders

edited by

Györgyi Műzes

and

Ferenc Sipos

submission deadline 30 Sep 2025 | 5 articles | Viewed by 20062 | Submission Open

Keywords: adoptive cell transfer; CAR-T cells; cell engineering; CAR products; CAR-T cell therapy; non-oncologic disorders; autoimmune diseases; cardiometabolic diseases; inflammatory organ fibrosis; senescent cell pathologies; infections

(This special issue belongs to the Section Cellular Immunology)

Unlocking the Secrets Behind Drug Resistance at the Cellular Level

edited by

Sara Ricardo

and

Cristina Pinto Ribeiro Xavier

submission deadline 30 Sep 2025 | 4 articles | Viewed by 9507 | Submission Open

Keywords: molecular mechanisms; effective treatments; drug tests; bacterial resistance; chemoresistance

(This special issue belongs to the Section Cellular Immunology)

Research on T Cells in Skin Inflammatory Disorders

edited by

Henry K. Wong

and Qing-Sheng Mi

submission deadline 30 Sep 2025 | 1 articles | Viewed by 5208 | Submission Open

Keywords: T cell; vitiligo; atopic dermatitis; T cell lymphoma

(This special issue belongs to the Section Cellular Immunology)

Onco-Hematology and Immunotherapy

edited by

Jean Gabert

and Régis T. Costello

submission deadline 30 Sep 2025 | 2 articles | Viewed by 4860 | Submission Open

Keywords: immunotherapy; onco-hematology; CAR T cells; NK cells; immune system; immune cells; leukemias; lymphomas

(This special issue belongs to the Section Cellular Immunology)

Eosinophils and Their Role in Allergy and Related Diseases

edited by

Paige Lacy

submission deadline 30 Sep 2025 | 4 articles | Viewed by 4715 | Submission Open

Keywords: eosinophils; asthma; allergy; inflammation; anti-eosinophil biologics; interleukin-5; interleukin-5 receptor; degranulation; mediator release

(This special issue belongs to the Section Cellular Immunology)

Antioxidants in Redox Homeostasis of Plant Development

edited by

Dragana Z. Jakovljević

and

Milan Stankovic

submission deadline 30 Sep 2025 | 2 articles | Viewed by 4153 | Submission Open

Keywords: reactive oxygen species; radical scavenging; oxidative stress; plant growth and development; primary and secondary metabolites

(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)

Molecular Therapeutic Advances for Neurodegenerative Diseases

edited by

Vanessa Castelli

submission deadline 30 Sep 2025 | 3 articles | Viewed by 3235 | Submission Open

Keywords: neurodegenerative diseases; neurodegeneration; neurological disorders

(This special issue belongs to the Section Cellular Aging)

Autophagy and Tumor Microenvironment

edited by

Maria Condello

submission deadline 30 Sep 2025 | 2 articles | Viewed by 2993 | Submission Open

Keywords: autophagy; cancer growth; cancer therapy; chemoresistance; microenvironment

(This special issue belongs to the Section Autophagy)

Evolution, Structure, and Functions of Apolipoproteins L

edited by Etienne Pays

submission deadline 30 Sep 2025 | 3 articles | Viewed by 2868 | Submission Open

Keywords: APOL1 nephropathy; APOL1 risk variants; membrane traffic; membrane fission; membrane fusion; membrane dynamics; autophagy; mitophagy; viral replication; lipid droplets; pathogen resistance; inflammation

Sebaceous Gland in Skin Health and Disease

edited by

Stefania Briganti

and Monica Ottaviani

submission deadline 30 Sep 2025 | 2 articles | Viewed by 2632 | Submission Open

Keywords: sebaceous gland; sebocytes; sebaceous lipid; sebum; inflammation; sebaceous gland disease; skin diseases; pathophysiology; biomarkers; therapeutics

(This special issue belongs to the Section Cellular Pathology)

Cell Biology: State of the Art and Perspectives in Italy 2025

edited by

Vincenzo Carafa

submission deadline 30 Sep 2025 | 1 articles | Viewed by 2345 | Submission Open

Keywords: cell biology; physiology; molecular biology

Control of Gene Expression by Co-Transcriptional Processes in Cell Homeostasis and Cell Fate Specification: Second Edition

edited by

Yutaka Hirose

submission deadline 30 Sep 2025 | 1 articles | Viewed by 2195 | Submission Open

Keywords: gene transcription; transcription elongation; RNA processing; RNA modification; RNA transport; lncRNA; histone modification; biomolecular condensates; diseases associated with dysregulation of gene regulation

(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)

Pathogenesis of Diabetic Kidney Disease

edited by Jia Fu

submission deadline 30 Sep 2025 | 1 articles | Viewed by 1686 | Submission Open

Keywords: diabetic kidney disease (DKD); molecular mechanism; oxidative stress; chronic kidney disease; pathogenesis; diagnostic and therapeutic strategies; inflammation; metabolic dysfunction

(This special issue belongs to the Section Cellular Pathology)

Molecular Pathogenesis of Cardiovascular Diseases

edited by

Guo-Chang Fan

Ao Shi

and Chen Gao

submission deadline 30 Sep 2025 | 2 articles | Viewed by 1582 | Submission Open

Keywords: cardiovascular diseases (CVDs); molecular pathogenesis; inflammation; fibrosis; cell death; genetic factors; extracellular vesicle; environmental factors; myocardial infarction; atherosclerosis; arrhythmia; heart failure

(This special issue belongs to the Section Cells of the Cardiovascular System)

CRISPR-Based Genome Editing in Translational Research—Third Edition

edited by

Jie Xu

Dongshan Yang

and Jifeng Zhang

submission deadline 30 Sep 2025 | 2 articles | Viewed by 1533 | Submission Open

Keywords: genome; gene editing; CRISPR/Cas9

Organellar Ca²⁺ Transport in Plant versus Animal Cells: Can We Learn from Each Other?

edited by Shey-Shing Sheu and Marc Freichel

submission deadline 30 Sep 2025 | 1 articles | Viewed by 1526 | Submission Open

Keywords: organellar calcium transport; plant cells; animal cells; intracellular organelle communication; calcium signaling; mitochondria; organelle-targeted florescent Ca2+ indicators; super-resolution imaging

(This special issue belongs to the Section Cell Microenvironment)

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