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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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New Trends and Advances in Diagnosis and Prognosis of Head and Neck Cancer from Carcinogenesis to Future Molecular Targeted Therapies: 2nd Edition

edited by

Piotr Cierpikowski

and

Julia Bar

submission deadline 20 Oct 2025 | 5 articles | Viewed by 6411 | Submission Open

Keywords: head and neck cancer; oral cancer; biomarker; prognosis; carcinogenesis; oral premalignant lesions; cancer stem cells; signaling pathways; molecular targeted therapy

(This special issue belongs to the Section Cellular Pathology)

Experimental Systems to Model Aging Processes

edited by

Natascia Tiso

Giovanni Risato

and Ralf Dahm

submission deadline 20 Oct 2025 | 3 articles | Viewed by 3043 | Submission Open

Keywords: aging; ageing; age-related; longevity; model; animal; signalling pathway; mechanism; in vitro; in vivo; cell culture; marker

(This special issue belongs to the Section Cellular Aging)

Sperm Biology and Reproductive Health—Second Edition

edited by

Yi-Xun Liu

and

Shou-Long Deng

submission deadline 20 Oct 2025 | 2 articles | Viewed by 2758 | Submission Open

Keywords: spermatogenesis; differentiation of spermatogonial stem cells in vitro; mitosis; meiosis; sperm formation

Mechanism of Cell Signaling During Eye Development and Diseases—Second Edition

edited by

Mehrnoosh Saghizadeh Ghiam

and

Vivien Coulson-Thomas

submission deadline 20 Oct 2025 | 3 articles | Viewed by 1783 | Submission Open

Keywords: cell signaling; ocular; eye disorders; Wnt signaling; TGF-β

(This special issue belongs to the Section Cell Signaling)

New Advances in Anticancer Therapy

edited by

Dooil Jeoung

submission deadline 20 Oct 2025 | 1 articles | Viewed by 1061 | Submission Open

Keywords: antibody-based immunotherapy; cell therapy; personalized anticancer therapy; RNA vaccines; nanotechnology

(This special issue belongs to the Section Cellular Pathology)

Immune Response in HIV Infection, Pathogenesis and Persistence

edited by Suvadip Mallick

submission deadline 20 Oct 2025 | 1 articles | Viewed by 781 | Submission Open

Keywords: HIV infection; immune response; chronic inflammation; immune activation; antiretroviral therapy (ART); immune reconstitution; immune checkpoints

(This special issue belongs to the Section Cellular Immunology)

Cell Therapy for Retinal Diseases

edited by

Girish Kumar Srivastava

and

Yogeswaran Lokanathan

submission deadline 20 Oct 2025 | Viewed by 332 | Submission Open

Keywords: retinal diseases; cell therapy; stem cells; retinal regeneration; cell transplantation; gene editing in retinal therapy; tissue engineering; retinal organoids; vision restoration; clinical translation of cell therapy; future directions in retinal regeneration

(This special issue belongs to the Section Tissues and Organs)

Cell Death and Its Clearance in Health and Disease

edited by

Turan Tufan

submission deadline 20 Oct 2025 | Viewed by 180 | Submission Open

Keywords: cell death; phagocytosis; immune homeostasis; inflammation

(This special issue belongs to the Section Cellular Pathology)

Autophagy in Neurological Disorders

edited by

Natalia Jimenez-Moreno

and

Ciro Isidoro

submission deadline 20 Oct 2025 | Viewed by 154 | Submission Open

Keywords: autophagy; selective autophagy; neurodegeneration; proteostasis; lysosomes; aging; oxidative stress; aging; biomarkers; pharmacological agents

(This special issue belongs to the Section Cells of the Nervous System)

New Molecular Insights into Hepatitis and Hepatic Cancer

edited by

Mark A. Feitelson

submission deadline 20 Oct 2025 | Viewed by 147 | Submission Open

Keywords: hepatitis; alcoholic and non-alcoholic steatohepatitis; HBV and HCV; hepatic Cancer; hepatocellular carcinoma; chronic liver disease; cellular and molecular basis; signaling pathways; antiviral therapies; immunotherapy; therapeutic advances

(This special issue belongs to the Section Cellular Pathology)

The Cellular and Molecular Mechanisms of Immunity to Infectious Viruses

edited by

Dimitrios Vlachakis

Tassos Georgakopoulos

and

Marios Agelopoulos

submission deadline 20 Oct 2025 | Viewed by 110 | Submission Open

Keywords: viral infections; immune cell biology; gene expression programs; epigenetics; chromatin architecture; cis-regulatory elements; functional genomics; computational biology applications

(This special issue belongs to the Section Cellular Pathology)

Unraveling Protein–Protein Interactions for Innovative Therapeutics and Nanodelivery

edited by Roberta Montanari and

Alberto Vitali

submission deadline 20 Oct 2025 | Viewed by 83 | Submission Open

Keywords: protein– protein interactions; PPI modulators; nanodelivery; molecular mechanisms

(This special issue belongs to the Section Cellular Biophysics)

Recent Advances in Regenerative Dentistry—Second Edition

edited by

Li Xiao

submission deadline 25 Oct 2025 | 5 articles | Viewed by 13838 | Submission Open

Keywords: oral stem cells; oral tissue regeneration; bioengineering; dental materials; stem cell banking

(This special issue belongs to the Section Tissues and Organs)

3D Cultures and Organ-on-a-Chip in Cell and Tissue Cultures

edited by

Annunziata Mauro

Barbara Barboni

and

Giovanna Della Porta

submission deadline 25 Oct 2025 | 2 articles | Viewed by 4353 | Submission Open

Keywords: three-dimensional cell culture; organ-on-a-chip; tissue engineering; regenerative medicine; drug testing; microfluidics; in vitro models; personalized medicine; cellular interaction; disease modeling

(This special issue belongs to the Section Cell Methods)

Adult Stem Cells in Human Disease

edited by Esther Wolfs, Tim Vangansewinkel and

Annelies Bronckaers

submission deadline 25 Oct 2025 | 2 articles | Viewed by 3635 | Submission Open

Keywords: dental pulp stem cells; disease; regenerative medicine; disease modeling

(This special issue belongs to the Section Stem Cells)

Beyond Bystanders: The Emerging Roles of Glia in Brain Health and Disease

edited by

Ruqayya Afridi

submission deadline 25 Oct 2025 | Viewed by 191 | Submission Open

Keywords: astrocytes; microglia; oligodendrocytes; neuroinflammation; neuroimmunology; synaptic plasticity; blood– brain barrier; neuropsychiatric disorders

(This special issue belongs to the Section Cells of the Nervous System)

Regenerating Poorly Vascularized Tissues

edited by Simone Pacini

submission deadline 25 Oct 2025 | Viewed by 163 | Submission Open

Keywords: regenerative medicine; avascular tissue; angiogenesis; vasculogenesis; cell-based medicinal products; bioengineered materials; cell transplantation

(This special issue belongs to the Section Tissues and Organs)

Molecular Anatomy and Function of Sensory Organs and Sensory Tissues

edited by

Frank Schmitz

submission deadline 25 Oct 2025 | Viewed by 160 | Submission Open

Keywords: sensory organ; sensory tissue; vision; hearing; skin; sensory structures of internal organs

(This special issue belongs to the Section Tissues and Organs)

Immunoregulatory Functions of Mesenchymal Stem Cells (MSCs)

edited by

Joni H. Ylostalo

submission deadline 30 Oct 2025 | 2 articles | Viewed by 1756 | Submission Open

Keywords: mesenchymal stem cells; MSCs; immunoregulation; immunosuppression

(This special issue belongs to the Section Stem Cells)

Emerging Topics in Smooth Muscle Cell Fate and Plasticity in Atherosclerosis

edited by

Mandy Grootaert

and

Julián Albarrán-Juárez

submission deadline 30 Oct 2025 | 1 articles | Viewed by 751 | Submission Open

Keywords: vascular smooth muscle cells; lineage tracing; fate mapping; VSMC plasticity; (single cell) (spatial) omics; vascular heterogeneity; atherosclerosis

(This special issue belongs to the Section Cellular Pathology)

Advances in Cellular and Molecular Treatment of Autoimmune Diseases—Second Edition

edited by

Panagiotis Athanassiou

Dimitrios P. Bogdanos

and

Ifigenia Kostoglou-Athanassiou

submission deadline 30 Oct 2025 | Viewed by 262 | Submission Open

Keywords: autoimmune diseases; disease activity; TNFa inhibitors; tocilizumab; infliximab; golimumab; etanercept; JAK inhibitors; cellular targets; molecular targets

(This special issue belongs to the Section Cellular Immunology)

Thirty plus Years’ Journey—Painting the Molecular Picture of E-C Coupling

edited by Jianjie Ma, Long-Sheng Song,

Jingsong Zhou

and

Hua Zhu

submission deadline 30 Oct 2025 | Viewed by 173 | Submission Open

Keywords: E-C coupling; calcium signaling; muscle physiology; cardiovascular disease

New Advances in Cancer Cell Biology: Biomarkers and Therapeutic Targets

edited by

Verena Damiani

submission deadline 30 Oct 2025 | Viewed by 135 | Submission Open

Keywords: cancer; biomarkers; therapeutic targets

(This special issue belongs to the Section Cellular Immunology)

Molecular Cell Biology of T Cells in Cancer and Infectious Diseases

edited by

Gustavo P. Amarante-Mendes

and João Viola

submission deadline 30 Oct 2025 | Viewed by 116 | Submission Open

Keywords: T cells; cancer; infectious diseases; genomics; proteomics; metabolomics; metabolism

(This special issue belongs to the Section Cellular Immunology)

Perinatal Brain Injury—from Pathophysiology to Therapy

edited by Cora H.A. Nijboer,

Bobbi Fleiss

and

Ivo Bendix

submission deadline 31 Oct 2025 | 6 articles | Viewed by 13599 | Submission Open

Keywords: preterm birth; perinatal brain injury; infection; inflammation; hypoxia; ischemia; hyperoxia; malnutrition; regenerative therapies; pharmacological intervention; stem cells

(This special issue belongs to the Section Cells of the Nervous System)

Gastrointestinal Disease: From Cellular Mechanisms to Targeted Therapy

edited by

Grazia Serino

and

Amilcare Barca

submission deadline 31 Oct 2025 | 5 articles | Viewed by 9643 | Submission Open

Keywords: gastrointestinal cancer; gastric cancer; colorectal cancer; esophageal cancer; liver cancer; pancreatic cancer; inflammatory bowel disease; miRNAs; in vitro and in vivo models; molecular networks; molecular pathways; translational medicine; epithelial barrier functions/processes

(This special issue belongs to the Section Cellular Pathology)

Advances in Cell-Based Studies and Therapeutic Approaches for Tissue Regeneration

edited by

Anişoara Cîmpean

and

Andreea-Mariana Negrescu

submission deadline 31 Oct 2025 | 5 articles | Viewed by 6583 | Submission Open

Keywords: soft/hard tissue regeneration; therapeutical approaches; cell culture studies; inflammation-based diseases; degenerative diseases

(This special issue belongs to the Section Tissues and Organs)

The Role of Cilia in Health and Diseases—2nd Edition

edited by Rim Hjeij

submission deadline 31 Oct 2025 | 4 articles | Viewed by 5140 | Submission Open

Keywords: motile cilia; motile ciliopathy; Primary Ciliary Dyskinesia; genetic screening; bronchiectasis; hydrocephalus; laterality defects; infertility; gene therapy

Non-Coding and Coding RNAs in Targeted Cancer Therapy

edited by

César López-Camarillo

and

Macrina B. Silva-Cázares

submission deadline 31 Oct 2025 | 4 articles | Viewed by 5134 | Submission Open

Keywords: gene expression; non-coding RNAs; lncRNAs; microRNAs; piwi-associated RNA; circular RNAs; therapeutic targets

(This special issue belongs to the Section Cell and Gene Therapy)

Immune Cell Effect on the Endothelium

edited by

Constantinos Mikelis

and Margarita Lamprou

submission deadline 31 Oct 2025 | 1 articles | Viewed by 4521 | Submission Open

Keywords: immune cells; endothelial cells; cytokines; extracellular vesicles; angiogenesis; vascular permeability

(This special issue belongs to the Section Cellular Immunology)

Small Molecular Therapeutics Promoting Neuronal Plasticity, Hippocampal Learning, and Memory

edited by

Avik Roy

submission deadline 31 Oct 2025 | 2 articles | Viewed by 4272 | Submission Open

Keywords: synaptic transmission; dendritic spines; metabotropic calcium influx; dendritic morphogenesis; small molecular therapeutics promoting neuronal plasticity

(This special issue belongs to the Section Cells of the Nervous System)

Cilia-Based New Discoveries: Ciliogenesis, Function, and Human Diseases

edited by

Lisbeth Birk Møller

submission deadline 31 Oct 2025 | 2 articles | Viewed by 4010 | Submission Open

Keywords: primary cilium; human disease; cell signaling; mTOR; Hedgehog; WNT; PDGFRalpha

How Can We Optimise Cancer Therapy? Tumour Microenvironment and Immune Evasion Strategies

edited by

Agnieszka Bojarska-Junak

and

Michal Zarobkiewicz

submission deadline 31 Oct 2025 | 3 articles | Viewed by 3212 | Submission Open

Keywords: immunosurveillance; immune evasion in cancer; tumour microenvironment; immune suppression; immunotherapy; immune checkpoints; cancer immunity; drug intervention

(This special issue belongs to the Section Cell Microenvironment)

The Role of Oxidative Stress in Cardiovascular Diseases—2nd Edition

edited by

Liya Yin

and

Chuanxi Cai

submission deadline 31 Oct 2025 | 1 articles | Viewed by 2826 | Submission Open

Keywords: oxidative stress; antioxidants; apoptosis; atherosclerosis; blood vessel; heart failure; hypertension; inflammation; mitochondria; microcirculation; reactive oxygen species

(This special issue belongs to the Section Cells of the Cardiovascular System)

New Discoveries in Calcium Signaling-Related Neurological Disorders

edited by Matheus De Castro Fonseca

submission deadline 31 Oct 2025 | 1 articles | Viewed by 2325 | Submission Open

Keywords: Ca2+ signaling; neurons; neurological disorders; intracellular signaling; synaptic dysfunction

(This special issue belongs to the Section Cells of the Nervous System)

Natural Killer (NK) Cells in Immunity: Limitations and Potential

edited by Rehan Mujeeb Faridi

submission deadline 31 Oct 2025 | 2 articles | Viewed by 2175 | Submission Open

Keywords: natural killer cells; adaptive NK cells; infection

(This special issue belongs to the Section Cellular Immunology)

Glial Cells: Physiological and Pathological Perspective

edited by

Qing Richard Lu

submission deadline 31 Oct 2025 | 2 articles | Viewed by 2011 | Submission Open

Keywords: neurodegeneration; oligodendrocytes; astrocytes; microglia; neuroinflammation; demyelination neuron– glial interactions; homeostasis; glia-targeted therapies

(This special issue belongs to the Section Cells of the Nervous System)

Galectins in Cancer, Fibrosis and Immune Modulation: Mechanisms, Therapeutic Strategies and Translational Advances

edited by Tsung-Chieh Shih

submission deadline 31 Oct 2025 | 2 articles | Viewed by 1964 | Submission Open

Keywords: Galectin; tumor microenvironment; immunosuppression; fibrosis; epithelial– mesenchymal transition (EMT); cancer metastasis; immune evasion; therapy resistance; myeloid-derived suppressor cells (MDSCs); tumor-associated macrophages (TAMs); extracellular matrix remodeling; Galectin-targeted therapy; combination immunotherapy; fibroblast activation; chronic inflammation; tumor– stroma interactions; novel inhibitors of Galectins

(This special issue belongs to the Section Cellular Immunology)

Cellular Pathways on Brain Control of Energy Metabolism

edited by Liangyou Rui

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1485 | Submission Open

Keywords: energy balance neurocircuit; molecular pathways governing energy balance neurocircuits; gut– brain axis in obesity; neuroinflammation in obesity and metabolic disease; neural sensing of metabolites and hormones

Recent Advances in Astrocyte Neuron Communication

edited by

Stefano Ferroni

and

Francesco Formaggio

submission deadline 31 Oct 2025 | Viewed by 893 | Submission Open

Keywords: astrocytes; calcium signaling; ion channels; gliotransmitters; brain circuits; reactive astrogliosis; astrocyte heterogeneity; astrocyte– neuron networks; synaptic plasticity

(This special issue belongs to the Section Cells of the Nervous System)

Mechanisms Underlying Cell Growth and Development

edited by

Rustem E. Uzbekov

submission deadline 31 Oct 2025 | 1 articles | Viewed by 664 | Submission Open

Keywords: cell growth; cell development; cell differentiation; cell cycle; mitosis; meiosis; molecular rearrangements; chromosomes; gene expression

Molecular Research of Cardiomyopathy

edited by

Luigi Sansone

and

Manuel Belli

submission deadline 31 Oct 2025 | Viewed by 427 | Submission Open

Keywords: cardiomyopathy; heart failure; hypertrophic cardiomyopathy; cellular and molecular rehabilitation

(This special issue belongs to the Section Cells of the Cardiovascular System)

Updates and Perspectives on Prion-Like Tau Pathology Propagation

edited by Kunie Ando, Jean-Pierre Brion and Siranjeevi Nagaraj

submission deadline 31 Oct 2025 | Viewed by 400 | Submission Open

Keywords: tau; amyloid beta; prion-like; propagation; Alzheimer’ s disease; neurodegenerative diseases; protein-protein interactions; synaptic dysfunction; aggregation; protein misfolding; risk factors; post-translational modifications

Advances in Bacterial Cell Biophysics: Metabolic Engineering and Host Interactions

edited by Shahid Khan

submission deadline 31 Oct 2025 | Viewed by 269 | Submission Open

Keywords: bacterial cell biophysics; mechanical properties; biophysical techniques; host interactions; metabolic engineering

Autophagy in Cancer Regulation

edited by Tejinder Pal Khaket

submission deadline 31 Oct 2025 | Viewed by 243 | Submission Open

Keywords: autophagy; drug resistance; immune response: cancer stemness

(This special issue belongs to the Section Autophagy)

Cell and Tissue Engineering for Functional Analysis (2nd Edition)

edited by

Masamichi Kamihira

submission deadline 31 Oct 2025 | Viewed by 229 | Submission Open

Keywords: animal cell engineering; tissue engineering; genome engineering; stem cell technology; synthetic biology

(This special issue belongs to the Section Tissues and Organs)

Potential Therapeutic Biomarkers for Prostate Cancer

edited by Benyi Li

submission deadline 31 Oct 2025 | Viewed by 168 | Submission Open

Keywords: prostate cancer; novel biomarkers; treatment

(This special issue belongs to the Section Cellular Pathology)

Kidney and Lung Disorders: The Role of Tubular and Alveolar Epithelia in Health, Disease, Infection, and Organ Crosstalk

edited by Aparna Renigunta and

Poornima Mahavadi

submission deadline 31 Oct 2025 | Viewed by 167 | Submission Open

Keywords: renal tubular disorders; alveolar lung diseases; transport mechanism; intracellular signaling; viral infection; crosstalk; dialysis; ventilation

Role of Lysosomes in Mediating Cancer Drug Resistance

edited by

Petr Mlejnek

submission deadline 31 Oct 2025 | Viewed by 150 | Submission Open

Keywords: drug resistance; autophagic cell death; lysosomal-mediated cell death; autophagy; apoptosis; lysosomal exocytosis; lysosomal sequestration; tumor microenvironment

(This special issue belongs to the Section Cell Microenvironment)

Cellular and Molecular Mechanisms in Peritoneal Malignancies: Insights into Pathogenesis and Therapeutic Advances

edited by

Tarkan Jäger

, Ibrahim Büdeyri and Jan Philipp Ramspott

submission deadline 31 Oct 2025 | Viewed by 109 | Submission Open

Keywords: peritoneal metastasis; cytoreductive surgery; HIPEC; PIPAC; biomarker; tumor microenvironment; epigenetics; precision oncology; tumor metabolism; immunotherapy

(This special issue belongs to the Section Cellular Pathology)

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