Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Intestinal Stem Cells submission deadline 20 Jan 2026 | Viewed by 190 | Submission Open
Keywords: stem cells; self-renewal; enterocytes; intestinal organoid; villus; crypt
(This special issue belongs to the Section Stem Cells)
Gliomas: Molecular Insights, Next-Generation Therapies, and Precision Targeting
edited by
submission deadline 20 Jan 2026 | Viewed by 149 | Submission Open
Keywords: gliomas; molecular targets; precision oncology; immunotherapy; gene editing; tumor microenvironment
Molecular Basis of Gynecological Disorders and Associated Infertility submission deadline 20 Jan 2026 | Viewed by 99 | Submission Open
Keywords: gynecological disorders; endometriosis; polycystic ovary syndrome (PCOS); cervical cancer; ovarian cancer; uterine and vaginal pathologies
(This special issue belongs to the Section Cellular Pathology)
Fibrosis in Chronic Inflammatory Diseases submission deadline 25 Jan 2026 | 8 articles | Viewed by 18306 | Submission Open
Keywords: fibrosis; fibroblasts; myofibroblasts; inflammation; molecular pathways; pathogenetic mechanisms; therapeutic targets
(This special issue belongs to the Section Cellular Pathology)
Targeting Hallmarks of Cancer submission deadline 25 Jan 2026 | 3 articles | Viewed by 6481 | Submission Open
Keywords: epigenetic regulators; organotypic culture models; anticancer drugs; hallmarks of cancer
Soluble Interleukin-6 Receptor (sIL-6R): Role in Health and Disease submission deadline 25 Jan 2026 | 1 articles | Viewed by 1760 | Submission Open
Keywords: sIL-6R; IL-6 signalling; IL-6ST; genetic polymorphism; health; disease; exercise physiology; therapeutics; mental health
(This special issue belongs to the Section Cell Signaling)
Decoding the Tumor-Immune Intersection: Opportunities for Breakthroughs in Cancer Therapies
edited by
submission deadline 25 Jan 2026 | 1 articles | Viewed by 1301 | Submission Open
Keywords: immuno-oncology; tumor-immune interface; tumor microenvironment; cancer immunotherapy; targeted therapy; immunometabolism; oncometabolism; epigenetics; combination strategies
(This special issue belongs to the Section Cellular Immunology)
The Role of T Cells in Type 1 Diabetes submission deadline 25 Jan 2026 | Viewed by 550 | Submission Open
Keywords: T cells; inflammation; T cell receptor; type 1 diabetes
(This special issue belongs to the Section Cellular Immunology)
Metabolic Flexibility in Cancer: How Tumor Cells Adapt Their Metabolism to Growth and Spread
edited by Erica Pranzini
submission deadline 25 Jan 2026 | Viewed by 204 | Submission Open
Keywords: cancer metabolism; metabolic plasticity; tumor microenvironment; oncometabolites; targeting cancer metabolism
Targeting Immune Dysfunction in Aging and Age-Related Diseases
edited by and
submission deadline 25 Jan 2026 | Viewed by 192 | Submission Open
Keywords: immunosenescence; inflammaging; immune dysfunction; aging; age-related diseases (ARDs); immune– metabolic interactions; immunomodulators; immunoceuticals; senotherapeutics; lifestyle interventions
Induced Pluripotent Stem Cells (iPSCs): Molecular and Cellular Mechanisms
edited by Masmoudi-Kouki Olfa and
submission deadline 25 Jan 2026 | Viewed by 151 | Submission Open
Keywords: iPSCs; gene regulation; epigenetic reprogramming; cellular signaling; disease modeling
(This special issue belongs to the Section Stem Cells)
Plant Stress and Acclimation Responses During Global Warming submission deadline 25 Jan 2026 | Viewed by 132 | Submission Open
Keywords: acclimatory responses in plants; chloroplast retrograde and nuclear anterograde signaling; excess light and heat shock responses; global warming and regulation of gene expression; energy dissipation as heat and cell death regulation; photosynthesis; stomatal conductance and transpiration regulation during heat waves
(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)
Immune Cell Signaling Networks in Tumor and Regenerative Stem Cell Niches
edited by
submission deadline 25 Jan 2026 | Viewed by 86 | Submission Open
Keywords: tumor microenvironment; stem cell niche; macrophage polarization; T-cell activation; immune checkpoints; targetable signaling pathways; engineered biomaterials; immune signaling in 3D culture; organ-on-chip models; single-cell omics
(This special issue belongs to the Section Stem Cells)
The Developments and Applications of Vibrational Spectroscopy in Cellular Research
edited by
submission deadline 25 Jan 2026 | Viewed by 78 | Submission Open
Keywords: vibrational spectroscopy; FT-IR spectroscopy; Raman spectroscopy; biomedical diagnostics; cancer research; Alzheimer’ s disease; neurodegeneration; tissue engineering; spectroscopic biomarkers; label-free imaging
(This special issue belongs to the Section Cell Methods)
Insights into the Pathophysiology of NeuroCOVID: Current Topics submission deadline 26 Jan 2026 | 1 articles | Viewed by 1453 | Submission Open
Keywords: neuroCOVID; longCOVID; neurocognitive; cellular and molecular neurobiology; brain fog; anxiety; depression; biomarkers; translational biomedicine; neurodegenerative diseases
(This special issue belongs to the Section Cellular Pathology)
The Roles of the Extracellular Matrix in Cardiac Structure and Function: A Commemorative Issue in Honor of Dr. Thomas K. Borg
edited by and Edie Goldsmith
submission deadline 30 Jan 2026 | 7 articles | Viewed by 6271 | Submission Open
Keywords: collagen; integrin; extracellular matrix; cardiomyocyte; fibroblast; heart bioengineering
(This special issue belongs to the Section Cell Microenvironment)
Neuronal Development and Disease: From Molecular Bases to Neurological Disorders
edited by Ramiro Almeida
submission deadline 30 Jan 2026 | 4 articles | Viewed by 5847 | Submission Open
Keywords: neuronal development; neurological disorders; neurogenesis; neuroinflammation; synaptic plasticity
(This special issue belongs to the Section Cellular Neuroscience)
Mechanisms Underlying Cardiovascular Aging
edited by Soheil Saeedi
submission deadline 30 Jan 2026 | 2 articles | Viewed by 3438 | Submission Open
Keywords: cardiovascular aging; cellular senescence; epigenetic clock; endothelial cells; perivascular adipose tissue (PVAT); premature aging; senolytics; rejuvenating strategies
(This special issue belongs to the Section Cells of the Cardiovascular System)
Stem Cells, Disease Mechanisms, and Therapeutic Innovations in Breast and Endometrial Disorders
edited by , Benedikt Schaefgen and
submission deadline 30 Jan 2026 | Viewed by 221 | Submission Open
Keywords: endometrial stem cells; breast cancer; endometrial diseases; tumor microenvironment; matrix remodeling; regenerative medicine; bioengineering; stem cell therapy; molecular pathogenesis; disease modeling
(This special issue belongs to the Section Stem Cells)
Tumor Immune Responsiveness in the Era of T Cell Immunotherapy
edited by and
submission deadline 30 Jan 2026 | Viewed by 205 | Submission Open
Keywords: T cell-mediated immunity; cancer immune responsiveness; cytokine modulation
Ubiquitin Ligases in Health and Diseases
edited by Haitao Luan
submission deadline 30 Jan 2026 | Viewed by 117 | Submission Open
Keywords: ubiquitination; E3 ubiquitin ligase; Proteasome; protein degradation; cell cycle regulation; immune response; neurodegeneration; cancer; autoimmune disorders; therapeutic targeting
(This special issue belongs to the Section Cell Signaling)
Advanced Technology for Cellular Imaging
edited by Alessandro Grinzato, and
submission deadline 31 Jan 2026 | 9 articles | Viewed by 22131 | Submission Open
Keywords: electron tomography; fluorescence microscopy; live cell imaging; multimodal imaging; super resolution microscopy; cell– cell interaction
(This special issue belongs to the Section Cell Methods)
Molecular and Cellular Mechanisms of Cardiovascular and Metabolic Diseases
edited by
submission deadline 31 Jan 2026 | 7 articles | Viewed by 20843 | Submission Open
Keywords: mitochondrial dysfunction; endoplasmic reticulum (ER) stress; oxidative/nitrosative stress; diabetes; obesity; diet; atherosclerosis; hypertension; metabolomics; cell death; nutraceuticals/functional foods
(This special issue belongs to the Section Cells of the Cardiovascular System)
Neuroinflammation in Brain Health and Diseases
edited by Debashis Dutta and Nemil Bhatt
submission deadline 31 Jan 2026 | 9 articles | Viewed by 17129 | Submission Open
Keywords: neuroinflammation; gliosis; inflammasome; neurodegeneration; neurotherapeutics
(This special issue belongs to the Section Cellular Neuroscience)
Imaging Methods in Cell Biology submission deadline 31 Jan 2026 | 6 articles | Viewed by 16181 | Submission Open
Keywords: cellular organelles; molecular function; molecular interaction; disease- and drug-related subcellular phenomena; single-molecule imaging; light microscopy; electron microscopy; fluorescence microscopy; fluorescence correlation methods; fluorescence lifetime imaging microscopy (FLIM); Raman microscopy; spatial biology
(This special issue belongs to the Section Cell Methods)
Cancer-Associated Fibroblasts: Challenges and Directions submission deadline 31 Jan 2026 | 5 articles | Viewed by 16059 | Submission Open
Keywords: cancer-associated fibroblast (CAFs); tumor microenvironment (TME); fibroblast activation protein alpha (FAPα ); immunotherapy; cytokines; angiogenesis; metastasis; FAP inhibitors; radioligands; imaging agents
(This special issue belongs to the Section Cell Microenvironment)
Emerging Targets and Therapeutic Potential Drugs in Tumor Progression and Therapeutic Resistance
edited by , and Yuancheng Li
submission deadline 31 Jan 2026 | 3 articles | Viewed by 6966 | Submission Open
Keywords: cancer; tumor progression; therapeutic resistance; molecular targets; tumor microenvironment; innovative therapies; targeted drug delivery; natural product
(This special issue belongs to the Section Cell Microenvironment)
Renewing Reasons to Believe in Gene Therapies for Epilepsy
edited by Casper Gøtzsche
submission deadline 31 Jan 2026 | 2 articles | Viewed by 6481 | Submission Open
Keywords: epilepsy; seizure; gene therapy; gene editing; disease modification; transformative; unmet need
(This special issue belongs to the Section Cellular Neuroscience)
CRISPR-Based Genome Editing in Translational Research—Third Edition
edited by , and Jifeng Zhang
submission deadline 31 Jan 2026 | 3 articles | Viewed by 6055 | Submission Open
Keywords: genome; gene editing; CRISPR/Cas9
Neuro-Oncological Advances in Stem Cell Research: A New Era in Brain Tumor Therapy submission deadline 31 Jan 2026 | 2 articles | Viewed by 3921 | Submission Open
Keywords: brain tumor genetics and epigenetics; brain tumor stem cells; stem cell therapy against brain tumors; mesenchymal stem cells; iPSC; resistance to therapy
(This special issue belongs to the Section Stem Cells)
New Advances in Tissue Engineering and Regeneration submission deadline 31 Jan 2026 | 1 articles | Viewed by 2546 | Submission Open
Keywords: tissue regeneration; tissue engineering; regenerative medicine; musculoskeletal tissues; biomaterials; stem cells; 3D bioprinting; scaffold design; cell therapy; organoids; translational research
(This special issue belongs to the Section Tissues and Organs)
Novel Therapeutic Strategies to Improve Mitochondrial Function in Neurodegenerative Diseases
edited by Patricia Morcillo
submission deadline 31 Jan 2026 | 1 articles | Viewed by 2266 | Submission Open
Keywords: mitochondria; cellular signaling; neurodegenerative diseases; mitochondrial dynamics; organelles; neurological diseases; therapies; biomarkers
(This special issue belongs to the Section Cellular Aging)
Cell Behavior Under Blood Flow
edited by Alexander Gural, Ivana Pajic-Lijakovic and
submission deadline 31 Jan 2026 | 1 articles | Viewed by 1672 | Submission Open
Keywords: blood flow; shear stress; red blood cells; white blood cells; platelets; endothelial cells; cell stimulation; mechanical stress
Cellular and Molecular Mechanisms in Immune Regulation—Second Edition
edited by Fábio Rinaldo Santori and Natalia B. Ivanova
submission deadline 31 Jan 2026 | 2 articles | Viewed by 979 | Submission Open
Keywords: innate immunity; dendritic cells; macrophages; T cells; B cells; cytokines; immunotherapy
(This special issue belongs to the Section Cellular Pathology)
The Role of Macrophages in Leishmaniasis: Current Perspective
edited by Devki Nandan
submission deadline 31 Jan 2026 | 1 articles | Viewed by 960 | Submission Open
Keywords: Leishmania; leishmaniasis; macrophage biology; host– pathogen interactions
Autophagy and Neurodegeneration: Unveiling Cellular Pathways in ALS and Beyond
edited by Valeria Gerbino
submission deadline 31 Jan 2026 | 1 articles | Viewed by 710 | Submission Open
Keywords: autophagy; neurodegeneration; amyotrophic lateral sclerosis (ALS); protein aggregation; cellular homeostasis; lysosomal dysfunction; neuronal health; therapeutic targets; molecular pathways; neuroprotective strategies
(This special issue belongs to the Section Cellular Neuroscience)
Acute Myeloid Leukemia: Unraveling Molecular Drivers, Cellular Plasticity, and Therapeutic Vulnerabilities
edited by Fabio Guolo
submission deadline 31 Jan 2026 | 1 articles | Viewed by 602 | Submission Open
Keywords: acute myeloid leukemia (AML); hematologic malignancy; AML classification; myeloid precursors; hematopoiesis; high-risk AML; biomarkers
(This special issue belongs to the Section Cellular Immunology)
Single-Molecule Tracking for Live Cells
edited by
submission deadline 31 Jan 2026 | Viewed by 372 | Submission Open
Keywords: single-molecule level; many-molecule level; biological cell; diluted liquids; single-molecule localization microscopy; nanoscopy; modeling; diffusion; theory
Diagnostic and Therapeutic Application of Extracellular Vesicles (EV) submission deadline 31 Jan 2026 | Viewed by 317 | Submission Open
Keywords: extracellular vesicles (EVs); diseases biomarkers; therapeutic targets; drugs delivery; engineered extracellular vesicles; EVs therapeutic applications
Mechanisms That Link Olfactory Perception with Aging
edited by , Anindya Ganguly and Jordan A. Munroe
submission deadline 31 Jan 2026 | Viewed by 300 | Submission Open
Keywords: olfaction; aging; neuroscience
(This special issue belongs to the Section Cellular Aging)
Human Organoids: A New Frontier in Disease Modeling
edited by and Umesh Kumar
submission deadline 31 Jan 2026 | Viewed by 223 | Submission Open
Keywords: 3D organ culture; embryonic stem cells; induced pluripotent stem cells; 3D bioprinting; personalized medicine; regenerative medicine
(This special issue belongs to the Section Tissues and Organs)
Gastrointestinal Disorders: Immunity and Inflammation
edited by Faizan Ahmed and
submission deadline 31 Jan 2026 | Viewed by 210 | Submission Open
Keywords: gastrointestinal disorders; immunity; inflammation; immune system; microbiota; gastroenterology; biomarkers; pathways
Genetics and Gene Regulation
edited by and
submission deadline 31 Jan 2026 | Viewed by 203 | Submission Open
Keywords: genetics; gene regulation; human diseases
New Trends and Advances in Molecular Targeted Therapy for Cancers
edited by Dhivya Sridaran and
submission deadline 31 Jan 2026 | Viewed by 182 | Submission Open
Keywords: cancer targeted therapy; antibodies; small-molecule inhibitors; antibody– drug conjugates; combination therapies
(This special issue belongs to the Section Cell and Gene Therapy)
Function of Stress Granules in Normal Cells and in Alzheimer’s Disease
edited by and Benjamin Wolozin
submission deadline 31 Jan 2026 | Viewed by 167 | Submission Open
Keywords: stress granules; Alzheimer's disease; neurodegenerative diseases
(This special issue belongs to the Section Cellular Aging)
New Perspectives of Respiratory Diseases: From Microbiome, Metabolism, and Immune Response
edited by
submission deadline 31 Jan 2026 | Viewed by 156 | Submission Open
Keywords: cell death/stress; DNA/RNA sensor; cGAS/STING; inflammasome; microbiome; FMT or transfer of bacteria; metabolite; viral infection; emphysema; progressive fibrosis; innate immune response; defined inhibitors
Aquaporins at the Crossroads of Human Health and Disease
edited by
submission deadline 31 Jan 2026 | Viewed by 155 | Submission Open
Keywords: aquaporins; membrane molecular transport; channels proteins in health and disease; novel drug targets; cellular biophysics
Examining the Cellular Biology of Adenovirus
edited by Susan J. Morris, Adam C. T. Gillman and Erwan Sallard
submission deadline 31 Jan 2026 | Viewed by 150 | Submission Open
Keywords: adenovirus; replication; maturation; transduction; tropism; intracellular trafficking; targeting; virus– host interactions; transcriptome
Biochemical Mechanisms and Physiological Implication of Stem Cell Differentiation submission deadline 31 Jan 2026 | Viewed by 128 | Submission Open
Keywords: stem cells; differentiation; 3D cultures; co-cultures; biochemistry; physiology; epigenetics
(This special issue belongs to the Section Stem Cells)
The Language of Neural Cells: Decoding Molecular Signaling in Neurodevelopmental and Neuro-Oncological Disorders
edited by , and Adriana C. E. Graziano
submission deadline 31 Jan 2026 | Viewed by 125 | Submission Open
Keywords: neural cells; molecular signaling; neurodevelopmental disorders; neuro-oncological disorders; transcriptional dysregulation
(This special issue belongs to the Section Cellular Neuroscience)
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