Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Remyelination: From Molecular Mechanism to Therapy submission deadline 25 Feb 2026 | 1 articles | Viewed by 784 | Submission Open
Keywords: demyelination; oligodendroglia differentiation; regenerative therapies; myelin disease; neurodegeneration
Small Molecule Inhibitors: A New Era in Cancer Treatment
edited by , and Suman Asalla
submission deadline 25 Feb 2026 | 1 articles | Viewed by 695 | Submission Open
Keywords: small-molecule inhibitors; CAR-T cell therapy; immune responsiveness; cancer cell resistance
New Trends and Advances in Induced Neural Cells and iPSC Technologies
edited by
submission deadline 25 Feb 2026 | Viewed by 213 | Submission Open
Keywords: induced neural cells; induced pluripotent stem cell (iPSC); neurological disease modeling
(This special issue belongs to the Section Cellular Neuroscience)
Molecular and Cellular Mechanisms of Ischemic Stroke
edited by Milani Deb-Chatterji
submission deadline 25 Feb 2026 | Viewed by 175 | Submission Open
Keywords: ischemic stroke; neuroinflammation; blood– brain barrier; neurovascular unit; molecular targets for stroke therapy
Antigen Processing in Autoimmunity and Cancer—Mechanisms and Translational Perspectives
edited by Peter Van Endert
submission deadline 25 Feb 2026 | Viewed by 170 | Submission Open
Keywords: major histocompatibility molecule; antigen processing; antigen presentation; protease; endoplasmic reticulum aminopeptidase; antitumor immunity; autoimmunity; immunotherapy
Molecular Mechanisms of Treatment Resistance in Prostate Cancer
edited by
submission deadline 25 Feb 2026 | Viewed by 164 | Submission Open
Keywords: metastatic castration-resistant prostate cancer (mCRPC); molecular mechanisms; novel treatment strategies; systemic precision treatments; epigenetics; cellular plasticity; tumor microenvironment signaling; therapeutic resistance
The Role of the Extracellular Matrix in Tissue Development, Repair, and Disease submission deadline 26 Feb 2026 | Viewed by 157 | Submission Open
Keywords: extracellular matrix; matrisome; cell– ECM interactions; cell signaling
(This special issue belongs to the Section Tissues and Organs)
Advances in Smart and Innovative Nanoparticles for Precision Tumor Therapy: Design, Delivery, Immune Modulation, and Clinical Translation
edited by Hari Krishna Reddy Rachamala and
submission deadline 27 Feb 2026 | 1 articles | Viewed by 3065 | Submission Open
Keywords: smart nanoparticles; tumor-targeted drug delivery; immune modulation; stimuli-responsive nanocarriers; clinical translation in oncology
(This special issue belongs to the Section Cell Methods)
Mitophagy and Mitochondrial Quality Control in Neurodegenerative Disorders
edited by Mohamed Eldeeb
submission deadline 27 Feb 2026 | 1 articles | Viewed by 1932 | Submission Open
Keywords: protein degradation; protein quality control; proteasome; ubiquitin; autophagy; mitophagy; mitochondrial quality control; mitochondrial import; proteolysis; neurodegeneration
(This special issue belongs to the Section Mitochondria)
Novel Insights into Mechanism and Treatment of Degenerative Disc Disease
edited by Yejia Zhang
submission deadline 27 Feb 2026 | 1 articles | Viewed by 1808 | Submission Open
Keywords: intervertebral disc (IVD) degeneration; back pain; age; genetics; injury
(This special issue belongs to the Section Cellular Pathology)
Ion Channels in Cancer: From Molecular Mechanisms to Therapeutic Targets
edited by Saverio Gentile
submission deadline 27 Feb 2026 | Viewed by 147 | Submission Open
Keywords: ion channels; cancer therapeutic targeting; tumor microenvironment
Targeting of Cancer Cells with Small Molecule Drugs
edited by
submission deadline 27 Feb 2026 | Viewed by 146 | Submission Open
Keywords: small molecule drugs; cancer cell targeting; targeted cancer therapy; drug delivery systems; precision oncology
(This special issue belongs to the Section Cellular Pathology)
Pathogenesis of Alcohol-Associated Hepatitis and Its Therapies
edited by Kyle Lauren Poulsen
submission deadline 27 Feb 2026 | Viewed by 134 | Submission Open
Keywords: alcohol-associated hepatitis; drug screening; drug delivery; pathophysiology; therapeutics
Role of Extracellular Matrix in Cancer and Disease submission deadline 28 Feb 2026 | 6 articles | Viewed by 17451 | Submission Open
Keywords: extracellular matrix; cancer; disease; ECM targeting; ECM turn-over and remodeling
(This special issue belongs to the Section Cell Microenvironment)
Signaling in Cancer Stem Cells
edited by Upasana Ray
submission deadline 28 Feb 2026 | 3 articles | Viewed by 16406 | Submission Open
Keywords: cancer stem cells (CSCs); stem cells signaling pathways; cancer progression and metastasis; therapeutic resistance; targeting cancer stem cells signaling; cancer heterogeneity; targeted therapy for CSCs; identifying biomarkers for CSCs
(This special issue belongs to the Section Stem Cells)
The Role of IgE and IgG Antibodies in Allergic Reactions: Cellular Mechanisms and Biological Implications submission deadline 28 Feb 2026 | 3 articles | Viewed by 14725 | Submission Open
Keywords: IgE; IgG; allergy; inflammation; glycosylation; immunotherapy; autoantibodies; Fc receptors; soluble receptors
(This special issue belongs to the Section Cellular Immunology)
The Potential of Induced Pluripotent Stem Cells
edited by Yun Chang
submission deadline 28 Feb 2026 | 2 articles | Viewed by 6911 | Submission Open
Keywords: pluripotent stem cells; reprogramming; engineering; regenerative medicine; differentiation; therapeutic applications; biomaterials
(This special issue belongs to the Section Stem Cells)
Cell Migration and Invasion
edited by Veronika Miskolci
submission deadline 28 Feb 2026 | 3 articles | Viewed by 6384 | Submission Open
Keywords: cell migration; cell invasion; cancer metastasis; molecular mechanisms; therapeutic strategies; signaling pathways
Adipose Tissue Functioning in Health and Diseases
edited by Richard C Chang
submission deadline 28 Feb 2026 | 3 articles | Viewed by 5336 | Submission Open
Keywords: adipose tissue biology; adipogenesis; lipolysis; adipose tissue inflammation; diet-induced obesity; non-coding RNA in metabolism; PPARγ signaling; metabolic health and disease; obesogens; epigenetics and chromatin regulation; transgenerational inheritance
(This special issue belongs to the Section Tissues and Organs)
Biomarkers in Human Diseases and Emerging Diagnostic Technologies for Their Identification and Application
edited by and
submission deadline 28 Feb 2026 | 3 articles | Viewed by 4442 | Submission Open
Keywords: biomarkers; human diseases; disease mechanisms; biomarker validation; early detection; accurate diagnosis; prognosis evaluation; treatment monitoring; diagnostic technologies; biosensors; microfluidics
Membrane Dynamics and the Role of Aquaporins in Plant Cells
edited by
submission deadline 28 Feb 2026 | 2 articles | Viewed by 4026 | Submission Open
Keywords: aquaporins; membrane dynamics; plant cell; water transport; osmoregulation; cell membrane permeability; aquaglyceroporins; stress response; membrane trafficking
(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)
Skeletal Muscle: Structure, Physiology and Diseases submission deadline 28 Feb 2026 | 2 articles | Viewed by 4025 | Submission Open
Keywords: excitation– contraction coupling; store-operated calcium entry; sarcomeric proteins; skeletal muscle metabolism; skeletal muscle diseases; muscle plasticity; development; sarcopenia; aging
(This special issue belongs to the Section Tissues and Organs)
Cell Therapeutics for Corneal Diseases submission deadline 28 Feb 2026 | 2 articles | Viewed by 3532 | Submission Open
Keywords: cell therapies; corneal diseases; drug development; tissue engineering; stem cells; regeneration; tissue repair
(This special issue belongs to the Section Tissues and Organs)
Unconventional T Cells in Health and Disease
edited by Lauren Howson
submission deadline 28 Feb 2026 | 2 articles | Viewed by 3367 | Submission Open
Keywords: MR1-restricted T cells; γ δ T cells; CD1-restricted T cells; unconventional T cells
(This special issue belongs to the Section Cellular Immunology)
Cellular and Molecular Mechanisms in Gynecological Disorders—Second Edition
edited by
submission deadline 28 Feb 2026 | 1 articles | Viewed by 2723 | Submission Open
Keywords: uterus; ovary; fallopian tubes; cervix; vagina; endometriosis; polycystic ovary syndrome; primary ovarian insufficiency; ovarian cysts; adenomyosis; endometriosis; leiomyoma (uterine fibroids); endometrial cancer; leiomyosarcoma; female infertility; breast cancer; cell atlas; biomarkers; stem cells; pathways; transcriptome; proteomics; epigenome
(This special issue belongs to the Section Cellular Pathology)
Cellular Mechanisms in Oral Cavity Homeostasis and Disease
edited by
submission deadline 28 Feb 2026 | 3 articles | Viewed by 2466 | Submission Open
Keywords: oral cavity; cell signaling; periodontal disease; stem cells; regeneration; inflammation; oral epithelium; tissue homeostasis; immunomodulation; cellular microenvironment
Signal Transduction and Targeted Therapy for Tumors submission deadline 28 Feb 2026 | 2 articles | Viewed by 2250 | Submission Open
Keywords: cancer progression; metastasis; invasion; cancer signaling; cell communication; cancer neuroscience; tumor angiogenesis; target therapy; immunotherapy; drug resistance; anti-tumor therapy
(This special issue belongs to the Section Cell Signaling)
Role of RNA as Regulator, Therapeutic Target and Probe for Early Disease Diagnosis
edited by
submission deadline 28 Feb 2026 | 3 articles | Viewed by 1804 | Submission Open
Keywords: coding RNAs; non-coding RNAs (ncRNAs); regulatory RNAs; RNA-based diagnostics; disease biomarkers; RNA monitoring techniques; molecular probes; RNA interference (RNAi)
(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)
Recent Advances in Microfluidics and Organoids for Biomedical Applications
edited by Lionel Fernel Gamarra
submission deadline 28 Feb 2026 | 2 articles | Viewed by 1410 | Submission Open
Keywords: microfluidics; organoids; biomimetic models; organ-on-a-chip; tissue engineering; pharmacology; biosensors; computational modeling; artificial intelligence; nanomedicine; personalized medicine; bioprinting; in silico; induced pluripotent stem cells (iPSCs); mesenchymal and pluripotent stem cells
(This special issue belongs to the Section Tissues and Organs)
The Pivotal Role of Tumor Stem Cells in Glioblastoma: Second Edition
edited by and Silvano J. Santini
submission deadline 28 Feb 2026 | 1 articles | Viewed by 1405 | Submission Open
Keywords: glioblastoma stem cells; resistance; cancer therapy; signaling pathways; tumor microenvironment
Osteoporosis Treatment: Targeting Osteoclast and Osteoblast Function with microRNA Therapeutics submission deadline 28 Feb 2026 | 1 articles | Viewed by 1390 | Submission Open
Keywords: osteoporosis; microRNA; osteoblasts; osteoclasts; osteocytes; fracture; bone remodeling
(This special issue belongs to the Section Tissues and Organs)
Kidney Disease: The Role of Cellular Mechanisms in Renal Pathology
edited by
submission deadline 28 Feb 2026 | 2 articles | Viewed by 1275 | Submission Open
Keywords: kidney fibrosis; acute kidney injury (AKI); chronic kidney disease (CKD); epithelial-to-mesenchymal transition (EMT); renal cell populations; stem cell therapy; renal regeneration; inflammation in kidney disease; cell-based models; renal repair mechanisms
(This special issue belongs to the Section Tissues and Organs)
Parkinson's Disease: Advances in Molecular Understanding and Emerging Therapies
edited by and Sara Elfarrash
submission deadline 28 Feb 2026 | 1 articles | Viewed by 1043 | Submission Open
Keywords: Parkinson’ s disease; atypical Parkinsonism; neurodegeneration; neuroinflammation; alpha-synuclein; disease models; brain organoids; human induced pluripotent stem cells (iPSCs); transcriptomics; proteomics; multi-omics; spatial biology; multiplex imaging; PD genetics
(This special issue belongs to the Section Cellular Aging)
Novel Insights into Neuroinflammation and Related Diseases
edited by Tahmineh Mokhtari
submission deadline 28 Feb 2026 | Viewed by 371 | Submission Open
Keywords: neuroinflammation; neuropsychological disorders; neurodegeneration; neuro-immune interactions; glial-neuronal crosstalk; autophagy and apoptosis; cellular and molecular mechanisms; neuroinflammatory biomarkers; imaging techniques; novel therapeutic strategies
(This special issue belongs to the Section Cellular Neuroscience)
Going with the Flow and Beyond: Understanding Benign Blood Disorders and Their Underlying Mechanisms
edited by Tirthadipa Pradhan-Sundd
submission deadline 28 Feb 2026 | Viewed by 279 | Submission Open
Keywords: benign blood disorders; sickle cell disease; red blood cells; hemoglobin; heme; iron overload; organ damage; hemophilia; thalassemia; anemia; blood vessels; vascular aging; endothelial cells
Ocular Surface and Adnexal Diseases: Molecular Mechanisms and Treatment Progresses
edited by
submission deadline 28 Feb 2026 | Viewed by 245 | Submission Open
Keywords: ocular surface and adnexal diseases; dry eye disease; eyelid diseases; lacrimal gland diseases; molecular mechanisms; therapeutic strategies
The Lipid Metabolism and Signaling in Dry Eye Disease
edited by Ni Made Airanthi Kusuma Widjaja-Adhi and Marcin Golczak
submission deadline 28 Feb 2026 | Viewed by 228 | Submission Open
Keywords: lipid metabolism; meibogenesis; dry eye disease (DED); meibomian gland dysfunction (MGD); ocular surface; neuroinflammation; tear film; lipidomics; spatial transcriptomics; therapeutics development; molecular mechanisms
Microautophagy: The Least Known of the Autophagy Strategies
edited by
submission deadline 28 Feb 2026 | Viewed by 205 | Submission Open
Keywords: core autophagy machinery; ESCRT machinery; lysosomophagy; membrane fission; membrane fusion; microautophagy; SNAREs
(This special issue belongs to the Section Autophagy)
The Role of Pancreatic Beta-Cells in Obesity and Type 2 Diabetes
edited by Mayur Doke, Juan Domínguez-Bendala and Oscar Alcazar
submission deadline 28 Feb 2026 | Viewed by 198 | Submission Open
Keywords: pancreatic beta-cells; GLP-1; obesity; type 2 diabetes; islet biology; beta-cell regeneration; insulin resistance; incretin therapies; single-cell transcriptomics; metabolic stress
Lung Development: Challenges and Opportunities
edited by David Warburton
submission deadline 28 Feb 2026 | Viewed by 162 | Submission Open
Keywords: alveolar gas diffusion surface; alveolar development; injury; repair; and replacement; alveolar stresses and strains; lung microenvironment; tissue engineering in pulmonary regeneration
(This special issue belongs to the Section Tissues and Organs)
Cellular and Molecular Mechanisms in Sepsis: Pathogenesis, Immune Response, and Therapeutic Strategies
edited by and
submission deadline 28 Feb 2026 | Viewed by 139 | Submission Open
Keywords: sepsis; cytokine signaling; immune cell dynamics; epigenetic regulation; metabolic reprogramming; non-coding RNAs; redox signaling; receptor polymorphisms; systems immunology; single-cell omics
(This special issue belongs to the Section Cellular Pathology)
Molecular Insights into Inherited Metabolic Disorders
edited by Paul Gissen
submission deadline 28 Feb 2026 | Viewed by 133 | Submission Open
Keywords: metabolic disorders; enzyme defects; protein misfolding; metabolic pathways; cellular metabolism; molecular pathology; disease mechanisms; therapeutic targets; organelle dysfunction; metabolic networks
(This special issue belongs to the Section Cellular Metabolism)
The Role of Cell Signaling Pathway Starvation Therapy for Cancer
edited by and Min You
submission deadline 28 Feb 2026 | Viewed by 112 | Submission Open
Keywords: signaling pathways; nutrient deprivation; starvation therapy; metabolic reprogramming; metabolic pathways
(This special issue belongs to the Section Cell Signaling)
Advanced Cell-Analyzing Technologies and Their Biosensing Applications
edited by and
submission deadline 28 Feb 2026 | Viewed by 108 | Submission Open
Keywords: cell analysis; biosensors; single-cell technologies; microfluidics; organ-on-a-chip; AI-driven biosensing diagnostics; nanotechnology; cell mechanics; cellular function analysis; cell phenotype assays
Emerging Mechanisms and Therapeutic Strategies in Head and Neck Cancer submission deadline 1 Mar 2026 | 2 articles | Viewed by 1206 | Submission Open
Keywords: tumor microenvironment; epithelial– mesenchymal transition (EMT); tumor– stroma interaction; treatment resistance; radiotherapy sensitization; targeted therapy; precision oncology
Synaptic Senescence in Health and Neurodegeneration: Cellular and Molecular Mechanisms submission deadline 9 Mar 2026 | Viewed by 300 | Submission Open
Keywords: synapses; synaptic transmission; aging; senescent synapse; neurodegeneration; synaptic plasticity; glial cells
Gene Expression in Adipocytes During Obesity: Understanding Challenges and Future Prospects
edited by
submission deadline 10 Mar 2026 | 1 articles | Viewed by 2770 | Submission Open
Keywords: adipocytes; adipose tissue; obesity; hypoxia; transcription factor; metabolism; epigenetics
α-Synuclein in Parkinson’s Disease submission deadline 10 Mar 2026 | 1 articles | Viewed by 974 | Submission Open
Keywords: α -synuclein; protein aggregation; neurodegeneration; Parkinson’ s disease; clinical subtypes; biomarkers; detection techniques; disease heterogeneity; prognostic stratification; translational neuroscience
Targeting Tumor Suppressor Genes for Cancer Therapy
edited by Jogendra Pawar, Smita Kumari and Naseem Akhter
submission deadline 10 Mar 2026 | Viewed by 454 | Submission Open
Keywords: tumor suppressor genes; cancer therapy; gene editing; CRISPR-Cas9; DNA damage repair; oncogenic signaling; immunotherapy; tumor microenvironment; artificial intelligence; personalized medicine
Omics Technologies for Understanding Cell Pathophysiology submission deadline 10 Mar 2026 | Viewed by 446 | Submission Open
Keywords: epigenomics; cytomics; immunomics; exosomics; personalized medicine
(This special issue belongs to the Section Cellular Pathology)
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