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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Metabolic Reprogramming in Organ Fibrosis and Regeneration

edited by

Melanie Tran

and Dong Yang

submission deadline 20 Jun 2026 | Viewed by 313 | Submission Open

Keywords: metabolic reprogramming; fibrosis; tissue regeneration; cellular metabolism; mitochondrial dysfunction; tissue repair and remodeling

(This special issue belongs to the Section Cellular Metabolism)

Cutaneous Regeneration and Tissue Engineering: From Hair Follicle Regeneration to Skin Restoration

edited by Soung-Hoon Lee

submission deadline 25 Jun 2026 | 4 articles | Viewed by 3031 | Submission Open

Keywords: skin regeneration; hair follicle regeneration; tissue engineering; regenerative biology; biomaterial scaffolds; organoids and 3D skin models; wound healing; acellular matrices; exosome-based therapy; translational dermatology

The Orchestration of Glial Cells in Health and Disease

edited by Keying Zhu

submission deadline 25 Jun 2026 | 1 articles | Viewed by 2176 | Submission Open

Keywords: microglia; oligodendrocytes; astrocytes; myelin; neuroinflammation

The Function of Stem Cells in the Biomedical Applications

edited by Rakesh Kumar Srivastava

submission deadline 25 Jun 2026 | 1 articles | Viewed by 1184 | Submission Open

Keywords: stem cells; regenerative medicine; cell therapy; differentiation; disease modeling; tissue engineering; drug discovery

Extracellular Vesicles Based Drug Delivery

edited by

Giovanni Camussi

and

Cristina Grange

submission deadline 25 Jun 2026 | Viewed by 583 | Submission Open

Keywords: EV engineering; targeting; therapy; natural carrier; exosomes

Regenerating Poorly Vascularized Tissues

edited by Simone Pacini

submission deadline 25 Jun 2026 | Viewed by 372 | Submission Open

Keywords: regenerative medicine; avascular tissue; angiogenesis; vasculogenesis; cell-based medicinal products; bioengineered materials; cell transplantation

(This special issue belongs to the Section Tissues and Organs)

Novel Insights in Chronic Epilepsy—from Molecular Mechanisms to Future Therapies

edited by Kjell Heuser and

Cecilie Nome

submission deadline 25 Jun 2026 | Viewed by 224 | Submission Open

Keywords: epilepsy; epileptogenesis; seizure mechanisms; neuroinflammation; glial cells; reactive gliosis; astrocytes; microglia; antiseizure medication

Systemic Sclerosis: Cellular Mechanisms, Innovative Diagnostics and Advanced Therapeutics

edited by Muhammad Soyfoo

submission deadline 25 Jun 2026 | Viewed by 193 | Submission Open

Keywords: systemic sclerosis; fibrosis; myofibroblasts; immune dysregulation; endothelial dysfunction; extracellular matrix (ECM); autoimmune disease

Inflammation and Atherosclerosis: Emerging Mechanisms, Biomarkers and Therapeutic Opportunities

edited by Victoria McGilligan

submission deadline 25 Jun 2026 | Viewed by 179 | Submission Open

Keywords: atherosclerosis; inflammation; inflammatory biomarkers; anti-inflammatory therapies; plaque vulnerability; diagnostics and prognostics

Diabetes-Induced Organ Damage: Cellular Mechanisms and Therapeutic Opportunities

edited by

Mohammed S. Razzaque

submission deadline 30 Jun 2026 | 9 articles | Viewed by 54105 | Submission Open

Keywords: diabetes mellitus; vascular lesions; nephropathy; cardiomyopathy; neuropathy; retinopathy; therapeutic opportunities

(This special issue belongs to the Section Tissues and Organs)

Exclusive Review Papers in Parkinson's Research

edited by

Wolfgang Jost

and Ronald F. Pfeiffer

submission deadline 30 Jun 2026 | 3 articles | Viewed by 19025 | Submission Open

Keywords: Parkinson’ s disease; alpha-synuclein; substantia nigra; mitochondria; non-motor symptoms; dopamine; levodopa

(This special issue belongs to the Section Cellular Aging)

New Research on Immunity and Inflammation in Cardiovascular Disease

edited by Pavel Poredoš

submission deadline 30 Jun 2026 | 7 articles | Viewed by 18815 | Submission Open

Keywords: inflammation; atherosclerosis; coronary artery disease; peripheral arterial disease; cerebrovascular disease; venous thromboembolic disease; circulating biomarkers; anti-innflammatory treatment of cardiovascular disease

(This special issue belongs to the Section Cells of the Cardiovascular System)

Role of Calpains in Health and Diseases

edited by

Michel Baudry

and Peter A. Greer

submission deadline 30 Jun 2026 | 7 articles | Viewed by 13663 | Submission Open

Keywords: calpain; physiology; biochemistry; disease; mutation; target; inhibitor

(This special issue belongs to the Section Cellular Pathology)

Emerging Topics in Smooth Muscle Cell Fate and Plasticity in Atherosclerosis

edited by

Mandy Grootaert

and

Julián Albarrán-Juárez

submission deadline 30 Jun 2026 | 6 articles | Viewed by 12598 | Submission Open

Keywords: vascular smooth muscle cells; lineage tracing; fate mapping; VSMC plasticity; (single cell) (spatial) omics; vascular heterogeneity; atherosclerosis

(This special issue belongs to the Section Cellular Pathology)

Cell Migration and Invasion

edited by Veronika Miskolci

submission deadline 30 Jun 2026 | 7 articles | Viewed by 11636 | Submission Open

Keywords: cell migration; cell invasion; cancer metastasis; molecular mechanisms; therapeutic strategies; signaling pathways

Myocardial Ischemia/Reperfusion Injury: Mechanisms and New Directions in Cardioprotection

edited by Sauri Hernandez-Resendiz

submission deadline 30 Jun 2026 | 3 articles | Viewed by 9881 | Submission Open

Keywords: myocardial infarction; heart failure; ischemia/reperfusion injury; no-reflow phenomenon; oxidative stress; cell death; cardiac metabolism; mitochondrial quality control; inflammation; cardioprotection

(This special issue belongs to the Section Tissues and Organs)

Pathology and Treatments of Amyotrophic Lateral Sclerosis (ALS)

edited by Laxman Gangwani

submission deadline 30 Jun 2026 | 2 articles | Viewed by 8687 | Submission Open

Keywords: amyotrophic lateral sclerosis (ALS); pathology; molecular mechanisms; treatments; symptom management; biological mechanisms; risk factors; innovative treatments

(This special issue belongs to the Section Cellular Pathology)

Novel Insights into Mechanism and Treatment of Degenerative Disc Disease

edited by Yejia Zhang

submission deadline 30 Jun 2026 | 4 articles | Viewed by 6898 | Submission Open

Keywords: intervertebral disc (IVD) degeneration; back pain; age; genetics; injury

(This special issue belongs to the Section Cellular Pathology)

AMPK: From Mechanisms to New Therapies

edited by

Roland Abi Nahed

and

Farah Diab

submission deadline 30 Jun 2026 | 3 articles | Viewed by 5004 | Submission Open

Keywords: metabolism; AMPK; cancer; biosensors; reproduction; metabolic disorders; therapies

Study on Immune Activity of Natural Products

edited by Xiu-Min Li

submission deadline 30 Jun 2026 | 3 articles | Viewed by 4979 | Submission Open

Keywords: natural products; bioactive compounds; immune activity; immunomodulation; inflammation; autoimmune diseases; immunotherapy; therapeutic potential

Multifaceted Nature of Immune Responses to Viral Infection

edited by Homayon Ghiasi and Susmit Suvas

submission deadline 30 Jun 2026 | 4 articles | Viewed by 4032 | Submission Open

Keywords: viral infection; innate and adaptive immunity; protection; RNA and DNA viruses; autoimmunity; immune escape

MicroRNAs: Regulators of Cellular Fate

edited by

Hsiuying Wang

submission deadline 30 Jun 2026 | 3 articles | Viewed by 3641 | Submission Open

Keywords: microRNA targets; microRNA conservation; microRNA pathway; microRNA mimics; microRNA antagonist; disease biomarker

Protein and RNA Regulation in Cells

edited by

Delai Huang

and

Denis Mottet

submission deadline 30 Jun 2026 | 2 articles | Viewed by 3271 | Submission Open

Keywords: gene expression; post-transcriptional regulation; post-translational modifications; non-coding RNAs; regulatory networks; protein degradation; RNA decay

Emerging Topics in Cachexia

edited by Gabriela Salim Ferreira De Castro

submission deadline 30 Jun 2026 | 2 articles | Viewed by 2693 | Submission Open

Keywords: cachexia; skeletal muscle loss; adipose tissue loss; inflammation; sarcopenia; cancer; body composition; biomarkers

Understanding Nasal Inflammation: The Interplay of Diagnosis, Endotypes, and Environmental Shifts

edited by Simonetta Masieri and

Carlo Cavaliere

submission deadline 30 Jun 2026 | 1 articles | Viewed by 2362 | Submission Open

Keywords: rhinology; allergy; immunology; environment; pollution; microbiome; inflammation; united airway disease; lymphocyte cells; interleukins

(This special issue belongs to the Section Tissues and Organs)

The Role of T Cells and Cellular Signalling in Immune Diseases

edited by Daniela Gallo

submission deadline 30 Jun 2026 | 1 articles | Viewed by 2064 | Submission Open

Keywords: T cells; autoimmune disorders; autoimmune endocrine disorders; targeted therapies

(This special issue belongs to the Section Cellular Immunology)

Hematopoietic Cell Lines as Models for Leukemia and Lymphoma

edited by Stefan Nagel

submission deadline 30 Jun 2026 | 2 articles | Viewed by 1800 | Submission Open

Keywords: hematopoiesis; leukemia; lymphoma; transcription factor; homeobox genes

The Role of PPARs in Disease - Volume IV

edited by

Kay-Dietrich Wagner

and

Nicole Wagner

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1606 | Submission Open

Keywords: PPAR; immune function; liver; adipose tissue; cardiovascular system; muscle; brain; neurological disease; psychiatric diseases; cancer; transcriptional regulation; ligands; agonists/antagonists

(This special issue belongs to the Section Cells of the Cardiovascular System)

Mitochondrial Dynamics and Remodelling

edited by Edmund Carvalho

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1308 | Submission Open

Keywords: mitochondrial dynamics; fission; fusion; mitophagy; cristae remodeling; bioenergetics; ER– mitochondria contacts; immune reprogramming; signaling pathways; therapeutic targeting

Recent Advances in Extracellular-Intracellular Communication and Cancer Therapies

edited by Ana Rita Carlos

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1285 | Submission Open

Keywords: extracellular matrix; ECM– cell communication; integrins; cytoskeleton; cancer therapies

Extracellular Vesicles and Cell Therapies in Regenerative Nephrology and Urology

edited by

Amankeldi Salybekov

and Ciro Tetta

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1214 | Submission Open

Keywords: extracellular vesicles (EVs); microRNA (miRNA); acute kidney injury (AKI); chronic kidney disease (CKD); glomerulonephritis; kidney transplantation; fibrosis; mesenchymal stromal cells (MSCs); engineered EVs; single-cell and spatial omics; machine learning and artificial intelligence; ; precision nephrology; GMP manufacturing; regenerative medicine; biomarkers; artificial intelligence (AI)

(This special issue belongs to the Section Cell Microenvironment)

Cell Cycle Dysregulation in Cancer: From Basic Mechanisms to Therapeutic Targeting

edited by Toshiyuki Sakamaki

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1168 | Submission Open

Keywords: cell cycle; cancer; cyclin-dependent kinases; checkpoint control; targeted therapy; therapeutic resistance; precision oncology; biomarker

(This special issue belongs to the Section Cell Proliferation and Division)

Kidney and Lung Disorders: The Role of Tubular and Alveolar Epithelia in Health, Disease, Infection, and Organ Crosstalk

edited by Aparna Renigunta and

Poornima Mahavadi

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1161 | Submission Open

Keywords: renal tubular disorders; alveolar lung diseases; transport mechanism; intracellular signaling; viral infection; crosstalk; dialysis; ventilation

Pulmonary Hypertension: From the Molecular Mechanisms to Novel Therapies

edited by Mohamed Ahmed

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1158 | Submission Open

Keywords: molecular pathways; multi-omics in PH; new therapeutic targets; innovative therapy

(This special issue belongs to the Section Cellular Pathology)

Translating Extracellular Vesicle Science

edited by

Masato Mitsuhashi

and

Theresa L. Whiteside

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1058 | Submission Open

Keywords: extracellular vesicles (EVs); EV isolation; EV purification; EV characterization; EV images; EV tracking; EV-based diagnostics; EV-based monitoring; EV therapeutics; blood biomarkers; translational medicine; exosomes; cell signaling

Thoracic Tumors: Decoding Cellular Heterogeneity, Tumor Microenvironment Crosstalk, and Therapeutic Vulnerabilities

edited by

Vesna Ceriman Krstic

and Dragana Jovanovic

submission deadline 30 Jun 2026 | 1 articles | Viewed by 937 | Submission Open

Keywords: NSCLC; SCLC; mesothelioma; thymoma; thymic carcinoma; immunotherapy; molecular therapy; chemotherapy

(This special issue belongs to the Section Cell Microenvironment)

Epithelial–Immune Cell Interactions in Gut Homeostasis and Inflammation

edited by Neeraj Kapur

submission deadline 30 Jun 2026 | 1 articles | Viewed by 835 | Submission Open

Keywords: gut homeostasis; epithelial barrier; immune cell crosstalk; barrier dysfunction; intestinal inflammation; microbiota; dysbiosis

(This special issue belongs to the Section Cellular Immunology)

Extracellular Vesicles in Neurodegenerative Diseases: From Biomarker Discovery to Precision Therapeutics

edited by Mangesh Dattu Hade

submission deadline 30 Jun 2026 | 1 articles | Viewed by 802 | Submission Open

Keywords: neurodegenerative diseases; extracellular vesicles; Alzheimer's disease; Parkinson's disease; multiple sclerosis; blood– brain barrier; neuroinflammation; biomarker discovery; EV-based therapeutics; precision medicine

(This special issue belongs to the Section Cellular Aging)

The Cross-Talk Between Obesity and Metabolism

edited by

Hong Shi

submission deadline 30 Jun 2026 | 1 articles | Viewed by 793 | Submission Open

Keywords: obesity; metabolic disorders; insulin resistance; adipose tissue; inflammation; glucose metabolism; lipid metabolism; cardiovascular disease; type 2 diabetes; therapeutic targets

Plant Stress Biology Under Biotic and Abiotic Environment

edited by

Violetta Katarzyna Macioszek

and

Andrzej K. Kononowicz

submission deadline 30 Jun 2026 | 1 articles | Viewed by 732 | Submission Open

Keywords: abiotic stress; microscopy; molecular biology; photosynthesis; phytohormnes; plant-pathogen interaction; plant physiology; plant biology; transcriptomics

(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)

Cellular and Molecular Mechanisms in Gastrointestinal Diseases

edited by

Shakti Ranjan Satapathy

and

Vikas Yadav

submission deadline 30 Jun 2026 | Viewed by 698 | Submission Open

Keywords: gastrointestinal pathophysiology ; epithelial– mesenchymal transition (EMT) ; inflammation and immune regulation ; tumor microenvironment ; cell signaling pathways ; stem cell biology in GI tract ; molecular biomarkers ; organoids and disease modeling ; microbiome– host interactions ; drug discovery

(This special issue belongs to the Section Tissues and Organs)

Retinoic Acid and Retinoid X Receptors - Series II

edited by

Michael Schubert

and

Pierre Germain

submission deadline 30 Jun 2026 | Viewed by 628 | Submission Open

Keywords: nuclear receptor signaling; retinoic acid receptor; retinoid X receptor; pharmacology; structure/function relationships; genomic and non-genomic signaling; post-translational modification; homeostasis and disease; development; origin and evolution

(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)

Cellular and Molecular Mechanisms in Reproductive Biology and Fertility

edited by

Giorgio Maria Baldini

and Antonio Malvasi

submission deadline 30 Jun 2026 | Viewed by 469 | Submission Open

Keywords: gametogenesis; fertilization; fertility; endocrinology; implantation; gametogenesis regulation; embryo– maternal interaction; reproductive signaling; IVF; in vitro fertilization; ovarian stimulation

(This special issue belongs to the Section Reproductive Cells and Development)

Crossroad Between Oxidative Stress and DNA Damage and Repair in Stroke

edited by

William James Antonisamy

Zahoor Shah

and Moorthi Ponnusamy

submission deadline 30 Jun 2026 | Viewed by 446 | Submission Open

Keywords: oxidative stress; DNA damage; DNA repair; stroke; ischemic stroke; neuroinflamamtion; intracranial hemorrhagic stroke; neuronal death

(This special issue belongs to the Section Cellular Neuroscience)

Nuclear Pore Complex in Nanomedicine: Third Edition

edited by

Richard W. Wong

submission deadline 30 Jun 2026 | Viewed by 376 | Submission Open

Keywords: intracellular transport; NPC; mitosis; nano; cancer; brain

Advances in the Biology and Treatment of T-Cell Lymphoma

edited by

Pier Paolo Piccaluga

submission deadline 30 Jun 2026 | Viewed by 357 | Submission Open

Keywords: T-cell lymphoma; cancer biology; oncogenic signaling; cellular mechanisms; cell– cell interactions; targeted therapy

(This special issue belongs to the Section Cellular Immunology)

Synaptic Condensates: Liquid–Liquid Phase Separation of Pre- and Postsynaptic Scaffold Proteins in Synapse Development and Memory Formation

edited by Norbert Bencsik and

Michel Baudry

submission deadline 30 Jun 2026 | Viewed by 338 | Submission Open

Keywords: liquid– liquid phase separation (LLPS); synaptic plasticity; synapse development; postsynaptic density (PSD); scaffold proteins; synaptic dysfunction; neural circuits

(This special issue belongs to the Section Cellular Neuroscience)

Cellular and Molecular Mechanisms of Hepatobiliary Diseases

edited by

Stefan Hoehme

and

Jan G. Hengstler

submission deadline 30 Jun 2026 | Viewed by 325 | Submission Open

Keywords: hepatobiliary diseases; bile metabolism; hepatobiliary models; artificial intelligence; cholestatic diseases; systems medicine; spatio-temporal liver models

(This special issue belongs to the Section Tissues and Organs)

Neuromuscular Disorders: Advances in Cellular and Molecular Understanding, Emerging Therapies, and Outcome Measures

edited by

Ivo Bozovic

and

Bogdan Bjelica

submission deadline 30 Jun 2026 | Viewed by 314 | Submission Open

Keywords: neuromuscular disorders; pathophysiology; biomarkers; treatment; impairment and disability measures; outcome measures

(This special issue belongs to the Section Tissues and Organs)

Melatonin in Neuroprotection: Mechanisms, Mitochondria, and Therapeutic Potential

edited by

Walter Balduini

Silvia Carloni

and

Walter Manucha

submission deadline 30 Jun 2026 | Viewed by 309 | Submission Open

Keywords: neurodegenerative disorders; melatonin; neuroprotection; mitochondria; oxidative stress; neuroinflammation; mitochondrial dynamics; therapeutic potential

(This special issue belongs to the Section Mitochondria)

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