Human DNA Replication/Repair Factors
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 25 May 2026 | Viewed by 12
Special Issue Editors
Interests: biophysics; single-molecule; DNA replication; transcription; nucleosome; chromatin; structural biology
Interests: DNA damage response; DNA double-strand break repair; ubiquitination; UFMylation; DNA damage checkpoint
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
High-fidelity DNA replication and efficient DNA repair are essential for maintaining genome integrity. In human cells, DNA replication relies on the highly coordinated actions of key factors such as DNA polymerases, helicases, primases, sliding clamps, and clamp loaders. Despite the remarkable accuracy of this complex machinery, replication errors remain inevitable and must be corrected promptly to prevent genomic instability. Failure in these surveillance and repair processes can induce replication stress, stalling or reversal of replication forks, and ultimately contribute to a broad spectrum of human diseases, including neurological disorders, aging-associated pathologies, and cancer.
This Special Issue aims to gather the most recent research focusing on the roles, mechanisms, and regulation of key human DNA replication and repair factors. Submissions addressing molecular insights into replication initiation, replisome progression, fork stabilization, DNA damage response, homologous recombination, mismatch repair, base excision repair, and other genome maintenance pathways are welcome. Studies exploring genetic disorders, therapeutic implications, and innovative techniques, such as cryo-EM and single-molecule approaches, for interrogating DNA replication and repair factors are also highly encouraged. We hope that this collection can provide new perspectives, advance our understanding, and highlight emerging trends in human genome stability research.
Dr. Shuming Zhang
Dr. Michal Goldberg
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- DNA replication
- replisome
- DNA polymerase
- helicase
- replication fork
- DNA repair
- replication stress
- DNA damage response
- homologous recombination
- replication-coupled DNA repair
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