Advanced Research in Neurogenesis and Neuroinflammation
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cells of the Nervous System".
Deadline for manuscript submissions: 15 December 2025 | Viewed by 1655
Special Issue Editor
Special Issue Information
Dear Colleagues,
Neurogenesis refers to the process by which neural stem cells (NSCs) go through multiple stages of proliferation and differentiation, resulting in the generation of new neurons within the brain. These newly formed neurons integrate into the neural networks, playing a crucial role in the management of various brain functions such as learning and memory. The phenomenon of adult neurogenesis introduces a unique type of plasticity to the brain, enabling it to adapt over time. However, the generation of new neurons tends to decrease with age and is influenced by a range of intrinsic and extrinsic factors such as genetics, epigenetics, age, physical activity, dietary habits, sleep quality, sex hormones, and life experiences. An impaired capacity for generating new neurons has been associated with cognitive impairments in several neurodegenerative conditions. Inflammation is another significant key factor affecting altered neurogenesis. While short-term inflammation may be advantageous, chronic or excessive neuroinflammation can hinder neurogenesis. Importantly, neuroinflammation, propelled by various immune components like activated glial cells, cytokines, chemokines, and reactive oxygen species, can influence every aspect of adult neurogenesis, such as cell proliferation, differentiation, migration, survival of newly formed neurons, maturation, synaptogenesis, and neuritogenesis. The relationship between neuroinflammation and neurogenesis suggests that inflammation may affect both the development and functionality of new neurons. To create effective therapeutic strategies and innovative methods aimed at adjusting these two processes to combat neurodegeneration, a deeper understanding of the interactions between changed neurogenesis and neuroinflammation is essential.
This Special Issue will focus on the exploration of different aspects of neurogenesis, ranging from molecular levels to behavioral implications, alongside its connection with neuroinflammation. It encompasses both in vitro and in vivo research examining the interplay between neurogenesis and neuroinflammation. Contributions from diverse research domains, including disease modeling, human neuropathology, biochemical, molecular, and clinical investigations, as well as genomics, proteomics, and therapeutic interventions, are encouraged.
We look forward to receiving your contributions.
Dr. Muskan Gupta
Guest Editor
Manuscript Submission Information
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Keywords
- neurogenesis
- neuroinflammation
- neurodegeneration
- neurodegenerative diseases
- cognitive functions
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