Endometrial Cancer: From Molecular Mechanisms to Therapeutic Approaches

Dear Colleagues,

The prevalence of endometrial cancer (EC) has been rising steadily for more than two decades, with EC proving fatal to an increasing number of women. Problems in early diagnostics are often a result of false-negative rates, uncomfortable procedures, and low-resolution imaging techniques. Furthermore, the existing treatment options frequently encounter limitations relating to drug resistance, adverse effects, and a lack of specificity. Therefore, there is a necessity to broaden our understanding of this malignancy to enhance patient outcomes.

This Special issue aims to elucidate the molecular and cellular characteristics of EC neoplasms in relation to the development of novel therapeutic approaches or the improvement of existing ones. Submissions may address, but are not limited to, the following areas:

• Molecular (e.g. genetic and epigenetic mechanisms, cell metabolism, cell signalling, and redox homeostasis) and cellular (e.g. CSCs, EMT, and TIME) mechanisms leading to tumorigenesis, tumour growth, and its dissemination;
• Tumour glycobiology;
• Risk factors (e.g. hormonal fluctuations, HPV, and microbiota);
• Molecular biomarkers for disease monitoring;
• Advances and challenges associated with current disease management and treatment;
• Novel therapeutic approaches.

Studies utilising humans, animal models, and in silico approaches in combination with in vitro studies are welcomed.

Dr. Tomaž Büdefeld
Dr. Jure Knez
Guest Editors

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