From Fat to Flame: Targeting Adipose Tissue in Chronic Inflammation and Exploring Therapeutic Strategies
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Tissues and Organs".
Deadline for manuscript submissions: 29 May 2026 | Viewed by 1163
Special Issue Editors
Interests: breast cancer; inflammation; physical exercise; cardiotoxicity; circulating biomarkers
Special Issues, Collections and Topics in MDPI journals
Interests: obesity; metabolic disorders; biomarkers of cardiovascular diseases; advanced glycation end products
Special Issues, Collections and Topics in MDPI journals
Interests: glycemic variability; redox systems; diabetes; insulin resistance; prediabetes; microRNA; extracellular vesicles; obesity; innate immune response; cutaneous and visceral adipose tissues; inflammation; signaling pathways
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue focuses on the complex interplay between obesity-induced inflammation and its role in the development of various metabolic disorders. Obesity, particularly visceral obesity, is characterized by low-grade chronic inflammation that contributes significantly to the onset of conditions such as atherosclerosis, metabolic syndrome, insulin resistance, type 2 diabetes mellitus (T2DM), and non-alcoholic fatty liver disease. The expansion of visceral adipose tissue (VAT) through adipocyte hypertrophy triggers inflammatory responses that have systemic effects. This Special Issue aims to delve into the molecular pathways and therapeutic opportunities within this context by providing a thorough update of recent biological observations including, but not limited to, the following areas:
- Inflammatory Mechanisms in Obesity: An exploration of how VAT expansion leads to chronic inflammation and the systemic effects of cytokine and chemokine release.
- The Role of Inflammasomes: An investigation into the activation of inflammasomes, particularly NLR family proteins, and their contribution to obesity-related inflammation and metabolic dysfunction.
- The Role of the Immune System: An investigation into the alteration in the activation and dysfunction of infiltrating immune cells.
- Clinical Implications and Outcomes: An examination of clinical studies highlighting the impact of DPP-4 inhibitors, GLP-1 analogs, and SGLT2 inhibitors on inflammation markers, endothelial function, and arterial stiffness in patients.
- Biomarkers: Identification of markers characterizing and/or predicting obesity-induced inflammation and cardiometabolic diseases, including epigenetic changes and miRNA.
- The Impact of Lifestyle Changes on VAT features, obesity-induced inflammation, and associated co-morbidities.
- Microbiota and Obesity: An investigation into how gut microbiota affects VAT function and adipose tissue inflammation.
Dr. Francesca Bianchi
Prof. Dr. Elena Dozio
Dr. Lucia La Sala
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- obesity
- inflammasomes
- immune system
- microbiota
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
