Advances in Ion Channel Biology: From Molecular Mechanisms to Therapeutic Targets

Dear Colleagues,

Ion channels are fundamental in cellular physiology, governing processes from neuronal signaling and muscle contraction to hormone secretion and immune responses. Over the last decade, advances in structural biology, electrophysiology, and computational modeling have dramatically expanded our understanding of ion channel function, regulation, and pharmacology. This Special Issue will bring together cutting-edge studies that highlight the dynamic and multifaceted nature of ion channels in health and disease.

Recent breakthroughs in cryo-electron microscopy have unveiled the high-resolution structures of previously elusive channel complexes, offering unprecedented insights into gating mechanisms and drug-binding sites. Concurrently, novel genetic and optogenetic tools have enabled the precise manipulation of channel activity in vivo, strengthening our grasp of their physiological roles. Moreover, the discovery of new channelopathies has underscored the clinical relevance of ion channels, spurring efforts to develop targeted therapies.

For this Special Issue, we welcome submissions in the form of original research articles and reviews providing insights into spanning molecular mechanisms, biophysical innovations, and translational applications in ion channel research. By integrating diverse perspectives, we aim to inspire a deeper appreciation of ion channels as both intricate molecular machines and promising therapeutic targets.

Dr. Shridhar Sanghvi
Dr. Yang Zheng
Dr. Md Shahidul Islam
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.