Molecular and Cellular Mechanisms of Type 1 Diabetes (T1D)
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".
Deadline for manuscript submissions: 31 May 2026 | Viewed by 1603
Special Issue Editors
Interests: autoimmunity; inflammation; genetic mutations; single nucleotide polymorphisms (SNPs); T cell biology; innate immunity; cell signaling; viral/bacterial triggers
Interests: insulin resistance; diabetes; lipid metabolism; glucose metabolism; disease prevention; obesity metabolic endocrinology; high fructose corn syrup; cardiovascular disease; obesity; telemedicine; telehealth; eHealth; mHealth; digital health; review; connected diabetes care; diabetes mellitus; glucose monitoring
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Type 1 diabetes (T1D) is an extremely complex disease, where pathogenesis is highly debated. Many different genetic meta-analyses and full-genome sequencing have divulged a wide range of genetic risk factors, where single-nucleotide polymorphisms (SNPs) and other anomalies have been associated with the disease. However, many of these mutations have not been properly connected towards how precisely they contribute to pancreatic beta cell destruction on a molecular or cellular level. It is also unclear how exactly environmental pressures and pathogens contribute as triggers of an autoimmune response towards beta cells. The connection between both genetic and environmental triggers towards T1D development needs to be better identified and how on a mechanistic level do these two factors lead towards pancreatic cellular destruction.
Some questions that will be answered in this Special Issue include the following: How do SNPs involved with immunoregulatory genes and even non-immunoregulatory genes affect the way immune cells process antigens and allow autoantigens to elicit an immune response towards oneself? Do pathogens and other environmental factors trigger these SNPs to cause an autoimmune response? Why are pancreatic beta cells targeted specifically in T1D development? What other risk factors are involved in an autoimmune response on the molecular and cellular level?
These and many more questions will be the focus of this Special Issue, where it will highlight recent findings on how both the genetic and environmental factors contribute towards T1D and how do they contribute towards targeting pancreatic beta cells on a cellular level. The overall goal of this Issue is to provide researchers with research papers, reviews, and meta-analyses concentrated on identifying key genes and other triggers that lead to the development of T1D, focusing on molecular and cellular techniques.
Dr. Robert Sharp
Prof. Dr. Itamar Raz
Guest Editors
Manuscript Submission Information
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Keywords
- T1D
- autoimmunity
- type 1 diabetes
- single-nucleotide polymorphisms (SNPs)
- viral/bacterial pathogens
- T-cell biology
- inflammation
- pancreatic beta cells
- immunoregulatory
- molecular biology
- cellular biology
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