Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Study on Human Mesenchymal Stem Cells—2nd Edition
edited by
submission deadline 31 May 2025 | Viewed by 206 | Submission Open
Keywords: mesenchymal stem cells; disease; cardiac; therapy
(This special issue belongs to the Section Stem Cells)
Emerging Advances in Neurodegeneration: Innovations in Stem Cell and Organoid Research
edited by
submission deadline 31 May 2025 | Viewed by 185 | Submission Open
Keywords: neurodegeneration; stem cells; induced pluripotent stem cells (iPSCs); brain organoids; disease modeling; therapeutic strategies; personalized medicine
(This special issue belongs to the Section Stem Cells)
Exploring the Cellular Basis of Steatotic Liver Disease: Insights and Advances
edited by
submission deadline 31 May 2025 | Viewed by 160 | Submission Open
Keywords: metabolic dysfunction-associated steatotic liver disease (MASLD); hepatocytes; hepatic stellate cells; lipid metabolism; inflammation; fibrosis; mitochondrial dysfunction; Kupffer cells; the microbiome; the gut– liver axis
(This special issue belongs to the Section Cellular Pathology)
Exploring Morphological Changes and Diversity in Cancer
edited by
submission deadline 31 May 2025 | Viewed by 132 | Submission Open
Keywords: morphology; heterogeneity; cancer; phenotype; shape
Toll-Like Receptors and Human Disease
edited by Vinothkumar Rajamanickam
submission deadline 31 May 2025 | Viewed by 109 | Submission Open
Keywords: toll-like receptor; Immune response; infectious disease; non-infectious disease; targeted therapy
Role of Lysosomes in Mediating Cancer Drug Resistance
edited by
submission deadline 31 May 2025 | Viewed by 98 | Submission Open
Keywords: drug resistance; autophagic cell death; lysosomal-mediated cell death; autophagy; apoptosis; lysosomal exocytosis; lysosomal sequestration; tumor microenvironment
Intellectual Disability and Autism Spectrum Disorders
edited by
submission deadline 31 May 2025 | Viewed by 82 | Submission Open
Keywords: intellectual disability; syndromic intellectual disability; autism; genetic mutation; genetic regulator; epigenetic regulator
Advances in Zebrafish Disease Models submission deadline 1 Jun 2025 | 2 articles | Viewed by 2619 | Submission Open
Keywords: zebrafish; human disease models; experimental disease models; novel drugs and therapies; organic diseases; functional disorders
Mechanisms Underlying Cardiovascular Aging
edited by Soheil Saeedi
submission deadline 1 Jun 2025 | Viewed by 143 | Submission Open
Keywords: cardiovascular aging; cellular senescence; epigenetic clock; endothelial cells; perivascular adipose tissue (PVAT); premature aging; senolytics; rejuvenating strategies
(This special issue belongs to the Section Cells of the Cardiovascular System)
Molecular Mechanism and Therapeutic Opportunities of Breast Cancer submission deadline 5 Jun 2025 | 1 articles | Viewed by 1020 | Submission Open
Keywords: breast cancer; molecular mechanisms; targeted therapy; genomic profiling; hormone receptors; tumor microenvironment; immunotherapy; drug resistance; metastasis; precision medicine
(This special issue belongs to the Section Cellular Pathology)
Autophagy Meets Aging 2025 submission deadline 10 Jun 2025 | 3 articles | Viewed by 9191 | Submission Open
Keywords: aging; autophagy; cellular quality control; mitochondrial dysfunction; redox biology; extracellular vesicles trafficking; inflammation; biomarkers; omics; behavioral and pharmacological interventions
(This special issue belongs to the Section Autophagy)
Modelling Tissue Microenvironments in Development and Disease
edited by , Eva Tomaskovic-Crook, Maryam Alsadat Rad and Panthipa Suwannakot
submission deadline 10 Jun 2025 | 1 articles | Viewed by 2192 | Submission Open
Keywords: tissue microenvironment; developmental biology; disease biology; 3D cell culture; organoids; spheroids; bioprinting; tissue culture; tissue engineering; in silico; extracellular matrix; mechanobiology; signalling molecules; regenerative medicine
(This special issue belongs to the Section Tissues and Organs)
Extracellular Vesicles and Drug Delivery System for Developing Cancer Therapeutics
edited by
submission deadline 10 Jun 2025 | 1 articles | Viewed by 1879 | Submission Open
Keywords: extracellular vesicles; drug delivery; cancer therapeutics  
Advances in Musculoskeletal Tissue Regeneration Using Mesenchymal Stromal/Stem Cells, Biomaterials, and Signaling Molecules: Second Edition submission deadline 10 Jun 2025 | 1 articles | Viewed by 1798 | Submission Open
Keywords: mesenchymal stromal/stem cells; extracellular vesicles; biomaterials; signalling molecules; microphysiological systems; musculoskeletal regeneration; immunomodulation; cell therapy; tissue engineering
(This special issue belongs to the Section Stem Cells)
Mechanistic Insights into Nanomaterial-Induced Immunotoxicity: Exploring Pathways of Immune Dysregulation
edited by
submission deadline 10 Jun 2025 | Viewed by 157 | Submission Open
Keywords: nanomaterials; immune cells; macrophages; inflammasomes; immunotoxicity; immune responses
(This special issue belongs to the Section Cellular Immunology)
Progress in Cancer Immunotherapies
edited by and Phuc Loi Luu
submission deadline 15 Jun 2025 | 1 articles | Viewed by 4095 | Submission Open
Keywords: cancer immunotherapy; immune checkpoint inhibitors; personalized immunotherapy; tumor microenvironment; biomarkers in immunotherapy
(This special issue belongs to the Section Cellular Immunology)
State-of-the-Art Research on Histone Deacetylases (HDACs) and Histone Acetyltransferases (HATs)
edited by
submission deadline 15 Jun 2025 | 2 articles | Viewed by 3660 | Submission Open
Keywords: histone deacetylases; cancer; metabolism; immunotherapy; tumor microenvironment; DNA damage response; cell cycle
(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)
Cellular and Clinical Mechanisms of Obesity and Diabetes and Their Complications submission deadline 15 Jun 2025 | 2 articles | Viewed by 3410 | Submission Open
Keywords: obesity; type 1 diabetes; type 2 diabetes; metabolic disorders; complications; signaling pathways; pathophysiology; insulin; β -cell
(This special issue belongs to the Section Cellular Pathology)
Effects and Mechanisms of Environmental Toxicants and Nanoparticles on Germ Cells, Gonads, Embryos and Stem Cells
edited by , , and Giulia Fiorentino
submission deadline 15 Jun 2025 | 1 articles | Viewed by 2401 | Submission Open
Keywords: environmental toxicants; gonadal steroid hormones; ovary; folliculogenesis; oogenesis and oocyte; testis; spermatogenesis and sperm; embryo development; epigenetics; omics; cells lines and stem cells; embryoid bodies; gastruloids and organoids; 3D cell culture and imaging; nanoparticles; nanomaterials
(This special issue belongs to the Section Stem Cells)
Recent Advances in Cancer Therapy—Second Edition
edited by and
submission deadline 15 Jun 2025 | 1 articles | Viewed by 1863 | Submission Open
Keywords: cancer; immunotherapy; targeted therapy; gene therapy; microRNA (miRNA); chemotherapy; drug resistance; chimeric antigen receptor T-cell (CART) therapy; T-cell receptor (TCR) therapy; tumor-infiltrating lymphocytes (TILs); apoptosis
Targeting Cellular Microenvironment in Aging and Disease
edited by and Egor Dzyubenko
submission deadline 15 Jun 2025 | Viewed by 398 | Submission Open
Keywords: proteoglycans; glycans; glycoproteins; matricellular proteins; integrins; matrix metalloproteinases; extracellular vesicles; EV release; exosomes; extracellular scaffold; ECM remodeling; fibrosis; ECM gene therapy; ECM pharmacology; synthetic ECM
(This special issue belongs to the Section Cellular Aging)
Endoplasmic Reticulum Stress and Human Disease: Lessons from Animal Models
edited by Sébastien Gaumer
submission deadline 15 Jun 2025 | Viewed by 222 | Submission Open
Keywords: endoplasmic reticulum (ER); ER stress; human diseases; neurodegenerative disorders; diabetes; cardiovascular diseases; cancer; animal models; pathomechanisms; therapeutic strategies
(This special issue belongs to the Section Cellular Pathology)
Synaptic Dysregulation in Nervous System Disorders
edited by Pragya Goel
submission deadline 15 Jun 2025 | Viewed by 192 | Submission Open
Keywords: synapses; synaptic transmission; synaptic plasticity; neurodegeneration; neuropsychiatric disorders; neurodevelopmental diseases
Exploring the Structural and Functional Diversity of Proteins: Foundations of Life and Biological Complexity
edited by Jiabei Lin
submission deadline 15 Jun 2025 | Viewed by 126 | Submission Open
Keywords: AAA+ protein; RNA-binding protein; protein kinase; PTMs; protein structure; function; and diseases; protein and RNA homeostasis; neurodegeneration; cancer
Molecular Mechanisms of Tumor Pathogenesis
edited by and Alessandro Lavoro
submission deadline 20 Jun 2025 | 5 articles | Viewed by 9560 | Submission Open
Keywords: cancer; therapeutic targets; biomarkers; epigenetics; DNA methylation; microRNAs; somatic mutations; germline mutations; chromatin remodeling; histone modifications
(This special issue belongs to the Section Cellular Pathology)
Recent Advances in Regenerative Dentistry—Second Edition
edited by
submission deadline 20 Jun 2025 | 5 articles | Viewed by 6896 | Submission Open
Keywords: oral stem cells; oral tissue regeneration; bioengineering; dental materials; stem cell banking
(This special issue belongs to the Section Tissues and Organs)
Advances in Spermatogenesis
edited by and Changmin Niu
submission deadline 20 Jun 2025 | 3 articles | Viewed by 4557 | Submission Open
Keywords: spermatogenesis; mitosis; meiosis; spermiogenesis; omics; organoid culture; infertility; contraception
(This special issue belongs to the Section Reproductive Cells and Development)
Molecular and Cellular Insights into Platelet Function submission deadline 20 Jun 2025 | 5 articles | Viewed by 3287 | Submission Open
Keywords: platelet; wound healing; fibrinolysis; regeneration and tissue remodeling; angiogenesis; lymphatic development; inflammation and immunity
(This special issue belongs to the Section Cells of the Cardiovascular System)
Molecular Mechanism of Liver Transplantation
edited by Carmen Peralta and Juan Carlos Cutrin
submission deadline 20 Jun 2025 | 1 articles | Viewed by 2896 | Submission Open
Keywords: liver transplantation; ischemia-reperfusion injury; signaling pathways; graft dysfunction; sterile inflammation; liver regeneration; fatty grafts; normothermic machine perfusion; defatting strategies
(This special issue belongs to the Section Tissues and Organs)
Drosophila: Contribution to Cell Research
edited by
submission deadline 20 Jun 2025 | 1 articles | Viewed by 2450 | Submission Open
Keywords: Drosophila; cell research; cell biology; gene function; disease processes; fruit fly
Mechanisms of Antimicrobial Treatment in Human Diseases
edited by
submission deadline 20 Jun 2025 | 1 articles | Viewed by 2029 | Submission Open
Keywords: multidrug resistance; epidemiology; novel antimicrobial resistance traits
Molecular and Cellular Mechanisms of Central Nervous System Autoimmunity submission deadline 20 Jun 2025 | 1 articles | Viewed by 1180 | Submission Open
Keywords: neuroimmunity; central nervous system; autoimmunity; immune tolerance; multiple sclerosis; antibody-mediated autoimmunity; cellular immunology; neuroinflammation
(This special issue belongs to the Section Cells of the Nervous System)
Molecular Insight into the Pathogenesis of Spontaneous Preterm Birth
edited by Khondoker M. Akram
submission deadline 20 Jun 2025 | 1 articles | Viewed by 1120 | Submission Open
Keywords: pathogenesis of preterm birth; placental dysfunctions in preterm birth; environmental impacts on placental function in preterm birth; vaginal dysbiosis in preterm birth
(This special issue belongs to the Section Cellular Pathology)
T Cells in Inflammation and Cancer
edited by
submission deadline 20 Jun 2025 | 1 articles | Viewed by 914 | Submission Open
Keywords: T cell; immunity; disease; infection; cancer; inflammation; pathology; immunotherapy
(This special issue belongs to the Section Cellular Immunology)
Immunoregulatory Functions of Mesenchymal Stem Cells (MSCs)
edited by
submission deadline 20 Jun 2025 | Viewed by 252 | Submission Open
Keywords: mesenchymal stem cells; MSCs; immunoregulation; immunosuppression
(This special issue belongs to the Section Stem Cells)
Advances in Cell Therapy for Leukemias
edited by Salman Otoukesh and Idoroenyi U. Amanam
submission deadline 20 Jun 2025 | Viewed by 105 | Submission Open
Keywords: acute leukemia; cell therapy; target cell therapy; immunotherapy; bi-specific therapy; relapse leukemia; refractory leukemia
(This special issue belongs to the Section Cell and Gene Therapy)
Current Status and Future Challenges of Liquid Biopsy
edited by and
submission deadline 25 Jun 2025 | 4 articles | Viewed by 11545 | Submission Open
Keywords: liquid biopsy; biomarker; minimal residual disease (MRD); circulating tumor DNA (ctDNA); tumor-educated platelet (TEP)
(This special issue belongs to the Section Cellular Pathology)
Natural Products and Their Derivatives Against Human Disease
edited by
submission deadline 25 Jun 2025 | 3 articles | Viewed by 4718 | Submission Open
Keywords: natural products; immunomodulatory; diseases; molecular mechanism of immunity
(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)
Emerging Therapies for Hereditary Ataxia—Second Edition submission deadline 25 Jun 2025 | Viewed by 181 | Submission Open
Keywords: hereditary ataxia; movement disorder; emerging neurotherapeutics; complementary and alternative medicines; secondary metabolites; neuroprotection; mitigation of oxidative stress; mitochondria-targeted antioxidants
Gene Editing Therapies for Hereditary Diseases submission deadline 25 Jun 2025 | Viewed by 149 | Submission Open
Keywords: gene therapy; base editing; prime editing; genome editing; hereditary diseases
Understanding Spinal Cord Injury and Repair: From Molecules to Neurocircuits and Multimodal Prostheses
edited by
submission deadline 30 Jun 2025 | 9 articles | Viewed by 17306 | Submission Open
(This special issue belongs to the Section Cells of the Nervous System)
Cellular and Molecular Mechanisms in Gynecological Disorders
edited by
submission deadline 30 Jun 2025 | 10 articles | Viewed by 17174 | Submission Open
Keywords: uterus; ovary; breast; cervix; cancer; endometriosis; leiomyoma; adenomyosis; polycystic ovary syndrome; female infertility; pathways; cell atlas; transcriptome; epigenome
(This special issue belongs to the Section Reproductive Cells and Development)
Insight into Cardiomyopathy
edited by Sobuj Mia
submission deadline 30 Jun 2025 | 1 articles | Viewed by 14969 | Submission Open
Keywords: heart failure; ventricular dysfunction; hypertrophic cardiomyopathy; dilated cardiomyopathy; cardiac fibrosis; cardiac hypertrophy; biomarkers
(This special issue belongs to the Section Cells of the Cardiovascular System)
Highlights in Red Blood Cell Research submission deadline 30 Jun 2025 | 3 articles | Viewed by 12815 | Submission Open
Keywords: red blood cells; anemia; transfusion; erythropoiesis; signaling
Cellular and Molecular Mechanisms in Immune Regulation
edited by Fábio Rinaldo Santori and Natalia B. Ivanova
submission deadline 30 Jun 2025 | 7 articles | Viewed by 10063 | Submission Open
Keywords: innate immunity; dendritic cells; macrophages; T cells; B cells; cytokines; immunotherapy
(This special issue belongs to the Section Cellular Immunology)
Exclusive Review Papers in Autophagy—Second Edition
edited by
submission deadline 30 Jun 2025 | 4 articles | Viewed by 9105 | Submission Open
Keywords: biquitination; autophagy; peroxisomes; macroautophagy; pexophagy; mitophagy; lysosome; vacuole; organellar homeostasis; posttranslational modifications; lipids; signaling cascades
(This special issue belongs to the Section Autophagy)
Radiation-Induced Brain Injury: Molecular Mechanisms and Therapeutic Strategies
edited by
submission deadline 30 Jun 2025 | 3 articles | Viewed by 9087 | Submission Open
Keywords: radiation injury; brain; neurological and neuropsychiatric disorders; molecular mechanisms; novel therapeutic approaches
(This special issue belongs to the Section Cells of the Nervous System)
Natural Products in Neurodegenerative Diseases: Current Trends and Future Perspectives
edited by and Nikolaos Kokras
submission deadline 30 Jun 2025 | 2 articles | Viewed by 7931 | Submission Open
Keywords: bioactive compounds; protein aggregation processes in AD; cognitive; anxiolytic and antidepressant effects
(This special issue belongs to the Section Cells of the Nervous System)
Charming Micro-Insights into Health and Diseases submission deadline 30 Jun 2025 | 4 articles | Viewed by 7330 | Submission Open
Keywords: cellular pathology of cancers neural cell biology cellular antivirus immune responses cell therapies cellular signaling cell research in animal models cellular metabolism protein quality control proteasomal degradation and autophagy
Male Infertility Update: Current Knowledge on Etiology, Comorbidities, Diagnosis and Treatment: Preclinical Topics submission deadline 30 Jun 2025 | 3 articles | Viewed by 7076 | Submission Open
Keywords: male infertility; diagnosis; treatment; etiology; pre-testicular/testicular/post-testicular causes; genetic causes; seminal parameters; hormonal parameters; ultrasound; general health; azoospermia
(This special issue belongs to the Section Reproductive Cells and Development)
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