Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Non-Coding RNAs as Regulators of Cellular Function and Disease
edited by
submission deadline 31 May 2026 | 2 articles | Viewed by 2807 | Submission Open
Keywords: non-coding RNAs; gene regulation; disease mechanisms; therapeutic targets; molecular mechanisms
The Multifaceted Role of Molecular Chaperones in Cancer: Pro-Tumoral or Therapeutic Function
edited by and Federica Scalia
submission deadline 31 May 2026 | 1 articles | Viewed by 2762 | Submission Open
Keywords: molecular chaperones; cancer biology; carcinogenesis; tumor progression; diagnostic/prognostic biomarkers; anti-tumor therapeutic strategies; in vitro/in vivo experimental approaches; in silico computational approaches
Molecular Insights into cAMP/PKA Pathway Regulation in Health and Disease submission deadline 31 May 2026 | 1 articles | Viewed by 2608 | Submission Open
Keywords: cAMP/PKA signaling; protein kinase A (PKA); cyclic AMP; EPAC; signal transduction; cellular homeostasis; metabolic regulation; disease mechanisms; molecular signaling; therapeutic targets; cross-talk in signaling pathways; protein– protein interactions; post-translational modifications; pharmacological interventions
Exploring the Structural and Functional Diversity of Proteins: Foundations of Life and Biological Complexity
edited by Jiabei Lin
submission deadline 31 May 2026 | 1 articles | Viewed by 2463 | Submission Open
Keywords: AAA+ protein; RNA-binding protein; protein kinase; PTMs; protein structure; function; and diseases; protein and RNA homeostasis; neurodegeneration; cancer
Sex Differences in Cardiovascular Structure and Function—from Mechanisms to Therapeutics submission deadline 31 May 2026 | 1 articles | Viewed by 1857 | Submission Open
Keywords: cardiovascular diseases; sex hormones; sex differences; vascular and cell signaling; therapeutic targets
Circadian Rhythms in Action: Cellular and Molecular Mechanisms Revealed by Model Organisms submission deadline 31 May 2026 | 1 articles | Viewed by 1744 | Submission Open
Keywords: circadian rhythm; molecular regulation; cellular mechanisms; model organisms; time-restricted feeding; metabolism; aging; neurodegeneration
Molecular and Cellular Mechanisms of Type 1 Diabetes (T1D)
edited by Robert Sharp and
submission deadline 31 May 2026 | 1 articles | Viewed by 1703 | Submission Open
Keywords: T1D; autoimmunity; type 1 diabetes; single-nucleotide polymorphisms (SNPs); viral/bacterial pathogens; T-cell biology; inflammation; pancreatic beta cells; immunoregulatory; molecular biology; cellular biology
(This special issue belongs to the Section Cellular Pathology)
B Cells in Action: Interaction Dynamics and Functional Decisions
edited by Michael L. Atchison and
submission deadline 31 May 2026 | 1 articles | Viewed by 1072 | Submission Open
Keywords: B cell development and differentiation; adaptive immunity; germinal center B cell; class-switch recombination; immunosuppression; cytokines; inflammation; epigenetic regulation; metabolic reprogramming; immune response
(This special issue belongs to the Section Cellular Immunology)
Exploring Morphological Changes and Diversity in Cancer
edited by
submission deadline 31 May 2026 | Viewed by 538 | Submission Open
Keywords: morphology; heterogeneity; cancer; phenotype; shape
Molecular Bases Underlying Early Embryonic Development in Mammals
edited by , Julio Ávila Marrero and Angela Palumbo
submission deadline 31 May 2026 | 1 articles | Viewed by 527 | Submission Open
Keywords: embryonic development; early embryogenesis; gene expression; miRNA profile; reproductive physiology; cell signalling; embryo quality; developmental competence; in vitro embryo culture
(This special issue belongs to the Section Reproductive Cells and Development)
Cellular Responses to Heavy Metals: From Intestinal Uptake to Disease submission deadline 31 May 2026 | Viewed by 369 | Submission Open
Keywords: cadmium (Cd) bioavailability; heavy metal intestinal uptake; heavy metal-induced cardiotoxicity; heavy metal-induced neurotoxicity; heavy metal-induced osteotoxicity; heavy metals and malignancies
Role of Lysosomes in Mediating Cancer Drug Resistance
edited by
submission deadline 31 May 2026 | Viewed by 355 | Submission Open
Keywords: drug resistance; autophagic cell death; lysosomal-mediated cell death; autophagy; apoptosis; lysosomal exocytosis; lysosomal sequestration; tumor microenvironment
(This special issue belongs to the Section Cell Microenvironment)
Mitochondria Beyond Energy: Signaling, Immunity, and Cell Fate
edited by and Mohd Parvez Khan
submission deadline 31 May 2026 | Viewed by 355 | Submission Open
Keywords: mitochondria; stem cells; cell fate; organogenesis; immunometabolism
Brain Insulin Resistance in Neurodegenerative Disorders and Its Treatments
edited by Konrad Talbot
submission deadline 31 May 2026 | Viewed by 330 | Submission Open
Keywords: Alzheimer’ s disease; brain insulin resistance; Down syndrome; incretin receptor agonist; insulin; insulin resistance; multiple system atrophy; neurodegenerative disease; Parkinson’ s disease
(This special issue belongs to the Section Cellular Neuroscience)
Extracellular Vesicles in Reproductive Communication: From Gametogenesis to Implantation
edited by and Osvaldo Bogado Pascottini
submission deadline 31 May 2026 | Viewed by 299 | Submission Open
Keywords: extracellular vesicles; reproductive biology; gametogenesis; oocyte maturation; embryo-maternal communication; implantation; reproductive disorders; epigenetic regulation; EV Cargo; intercellular signaling
Molecular Mechanisms of Drug Delivery in Ophthalmology
edited by Alekha K. Dash and Surabhi Shukla
submission deadline 31 May 2026 | Viewed by 291 | Submission Open
Keywords: drug delivery; ophthalmology; nanocarriers; ocular barriers; molecular transport; targeted therapy; ocular gene delivery
(This special issue belongs to the Section Tissues and Organs)
Cellular and Molecular Mechanisms of Heart Development
edited by Jun K. Takeuchi
submission deadline 31 May 2026 | Viewed by 284 | Submission Open
Keywords: heart development; cardiovascular; epigenetics; cell fate; differentiation; cardiac growth; cardiac morphogenesis; heart regeneration; cardiac organoid
Inflammatory Signaling and Vascular Dysfunction in Atherosclerosis
edited by and Jianzhong Shen
submission deadline 31 May 2026 | Viewed by 276 | Submission Open
Keywords: inflammation in atherosclerosis; atherothrombosis; cell signaling
Immunotherapy-Induced Cardiotoxicity: Unraveling the Immune Landscape of Myocarditis
edited by
submission deadline 31 May 2026 | Viewed by 270 | Submission Open
Keywords: immunotherapy; immune checkpoints; adoptive cell therapy; cardiac adverse events; cardiac inflammation; immune checkpoint inhibitor associated myocarditis; cardiac immune landscape; innate immune response; adaptive immune response; myeloid cells; macrophages; antigen presentation & phagocytosis; T cells; T cell clonality; cytokines; chemokines; chemotaxis; immune crosstalk; immune– stromal crosstalk; multi-omics
Skeletal Muscle Aging and Regeneration: Mitochondrial Health, Molecular Signaling, and Therapeutic Interventions
edited by
submission deadline 31 May 2026 | Viewed by 256 | Submission Open
Keywords: aging; skeletal muscle; regeneration; satellite cells; muscle stem cells; muscle wasting; mitochondria; fibro-adipogenic progenitor cells; repair
Epigenetic and Cellular Regulation in Hematologic Disorders
edited by
submission deadline 31 May 2026 | Viewed by 256 | Submission Open
Keywords: epigenetics; hematologic disorders; leukemia; myelodysplastic syndrome; thrombosis; thrombocytopenia; bleeding
Molecular Mechanisms and Therapeutic Strategies for Skeletal Muscle Disorders submission deadline 31 May 2026 | Viewed by 248 | Submission Open
Keywords: skeletal muscle; muscular disorders; myokines; muscle regeneration; muscle atrophy; inflammation; stress response; myoblast
Regulatory Mechanisms of Vascular Smooth Muscle Cells and Immune Cells in Vascular Disease Progression
edited by and
submission deadline 31 May 2026 | Viewed by 244 | Submission Open
Keywords: vascular smooth muscle cells; immune cells; inflammation; vascular disease; atherosclerosis; aneurysm; cellular crosstalk; phenotypic transition
(This special issue belongs to the Section Cells of the Cardiovascular System)
Advances in Ion Channel Biology: From Molecular Mechanisms to Therapeutic Targets
edited by Shridhar Sanghvi, and
submission deadline 31 May 2026 | Viewed by 229 | Submission Open
Keywords: ion channels; electrophysiology; cryo-electron microscopy; channelopathy; membrane protein; gating mechanism; structural biology
DNA Damage and Repair in Targeted Cancer Therapy
edited by , Sajad Ahmad Bhat and
submission deadline 31 May 2026 | Viewed by 229 | Submission Open
Keywords: cancer cells; DNA damage and repair mechanism; genome organization; BER; NER; MMR; HR; and NHEJ; targeted therapy; inhibitors/PROATCS; drug resistance; drug toxicity; biomarkers; personalized medicine
Endometrial Cancer: From Molecular Mechanisms to Therapeutic Approaches
edited by Tomaž Büdefeld and
submission deadline 31 May 2026 | Viewed by 225 | Submission Open
Keywords: endometrial cancer; genetic mutation; epigenetics; cell signaling; TIME; metastasis; biomarker; therapy; drug delivery; risk factor
New Advances in Cardiac and Vascular Physiology
edited by Robert M. Lust
submission deadline 31 May 2026 | Viewed by 221 | Submission Open
Keywords: environmental exposure; immune responses; remodeling; receptors; ischemia; pre-conditioning; post-conditioning; heart failure
(This special issue belongs to the Section Tissues and Organs)
Decoding Heart Failure: From Mechanisms to Treatment
edited by and Dirk L. Brutsaert
submission deadline 31 May 2026 | Viewed by 201 | Submission Open
Keywords: heart failure; pathological process; molecular mechanisms; cellular mechanisms; genetic mechanisms; therapeutic target
Advancements in Research on Metabolic Syndrome
edited by Gautam Kumar Pandey
submission deadline 31 May 2026 | Viewed by 169 | Submission Open
Keywords: metabolic syndrome; multi-omics; insulin resistance; cell signaling in metabolic disease
Stem Cell-Based Strategies for Cardiac Tissue Engineering and Regeneration
edited by Munira Xaymardan and
submission deadline 31 May 2026 | Viewed by 157 | Submission Open
Keywords: cardiac tissue engineering; stem cells; cardiomyocytes; cardiac organoids; engineered heart tissues; biomaterials; scaffolds; gene therapy; RNA reprogramming; cardiac fibrosis; cardiac regeneration; myocardial repair; translational studies
(This special issue belongs to the Section Stem Cells)
Human Pluripotent Stem Cells and Organoids: Current Trends and Future Perspectives submission deadline 1 Jun 2026 | 2 articles | Viewed by 3024 | Submission Open
Keywords: human pluripotent stem cells; organoids; disease modeling; regenerative medicine; genome editing; single-cell omics; tissue engineering; drug discovery; precision medicine
(This special issue belongs to the Section Stem Cells)
Mechanisms, Biomarkers, and Therapeutics of Neurodegeneration
edited by
submission deadline 1 Jun 2026 | 1 articles | Viewed by 1191 | Submission Open
Keywords: neurodegeneration; biomarkers; mechanistic studies; protein aggregation; protein degradation; neuroinflammation; targeted therapies; genetics; precision medicine
(This special issue belongs to the Section Cellular Neuroscience)
Macrophages in Cancer: Immunosuppression, Immunoregulation, and Immunotherapy
edited by
submission deadline 5 Jun 2026 | 4 articles | Viewed by 18002 | Submission Open
Keywords: macrophage; immunosuppression; immunoregulation; immunotherapy; tumor immune microenvironment
(This special issue belongs to the Section Cellular Immunology)
Novel Insights into Molecular Mechanisms and Therapy of Myeloma
edited by and
submission deadline 10 Jun 2026 | 8 articles | Viewed by 26762 | Submission Open
Keywords: multiple myeloma; CAR-T therapy; relapse; methylation; drug resistance; treatment strategy; molecular mechanism; novel target; biomarker
(This special issue belongs to the Section Cellular Pathology)
Advances in Pulmonary Fibrosis
edited by Sergio Piñeiro Hermida
submission deadline 10 Jun 2026 | 3 articles | Viewed by 3888 | Submission Open
Keywords: pulmonary fibrosis; animal models; biomarkers; experimental therapeutics
(This special issue belongs to the Section Cellular Pathology)
Molecular Mechanisms of Cardiac Repair and Regeneration
edited by Mahesh Thirunavukkarasu
submission deadline 10 Jun 2026 | 1 articles | Viewed by 1333 | Submission Open
Keywords: cardiac repair and regeneration; cardiomyocyte; cardiac fibrosis; signaling pathways; immune regulation; extracellular vesicles; stem cell therapies; epigenetics; biomarkers
(This special issue belongs to the Section Cells of the Cardiovascular System)
The Metabolic Edge: How Cancer Cells Adapt, Survive, and Resist Therapy
edited by
submission deadline 10 Jun 2026 | Viewed by 287 | Submission Open
Keywords: cancer metabolism; metabolic rewiring; therapy resistance; metabolic plasticity; nutrient uptake; mitochondrial remodeling; tumor microenvironment; metabolic vulnerabilities
(This special issue belongs to the Section Cellular Metabolism)
Lipid Mediators in Cardiometabolic Regulation and Disease
edited by Adeniyi Michael Adebesin
submission deadline 10 Jun 2026 | Viewed by 181 | Submission Open
Keywords: lipid mediators; lipoprotein; fatty acid metabolites; cellular membranes; cardiometabolic regulation; cellular metabolism; adipogenesis; signaling pathways; receptors; lipid transport proteins
(This special issue belongs to the Section Cellular Metabolism)
The Role of Oxidative Stress in Cardiovascular Diseases—2nd Edition
edited by and
submission deadline 15 Jun 2026 | 4 articles | Viewed by 6527 | Submission Open
Keywords: oxidative stress; antioxidants; apoptosis; atherosclerosis; blood vessel; heart failure; hypertension; inflammation; mitochondria; microcirculation; reactive oxygen species
(This special issue belongs to the Section Cells of the Cardiovascular System)
Genomics and Cellular Mechanisms in Ovarian Cancer
edited by Hao Huang
submission deadline 15 Jun 2026 | 3 articles | Viewed by 3413 | Submission Open
Keywords: ovarian cancer; tumor heterogeneity; genomics and epigenomics; therapy resistance; tumor microenvironment
(This special issue belongs to the Section Tissues and Organs)
Cellular Origin of Glioma: From Triggers to Treatments submission deadline 15 Jun 2026 | 2 articles | Viewed by 2003 | Submission Open
Keywords: glioblastoma; brain tumour; tumour heterogeneity; targeted therapy; glioma stem cells
Novel Insights into Developing Therapeutic Strategies for Neurological Disorders
edited by , Joanna A. Korecka and
submission deadline 15 Jun 2026 | 1 articles | Viewed by 1850 | Submission Open
Keywords: neurological disorders; RNA therapeutics; gene therapy; antisense oligonucleotides; gene editing; cell therapy; precision medicine; neurodegenerative diseases; neurodevelopmental disorders; neurogenetic disorders
Decoding Cellular Organization Through Spatial Omics
edited by Elizabeth Neumann
submission deadline 15 Jun 2026 | 1 articles | Viewed by 1689 | Submission Open
Keywords: spatial proteomics; lipomics; cellular architecture; biomolecular interactions; bioinformatics; integrative biology
Cellular Metabolism and Immune Regulation in Cancer Progression and Metastasis
edited by Xu Jing
submission deadline 15 Jun 2026 | 1 articles | Viewed by 1328 | Submission Open
Keywords: cellular metabolism; tumor immunology; cancer progression; metastasis; immunometabolism; metabolic reprogramming; tumor microenvironment; immune evasion; cancer therapy; metabolic biomarkers
(This special issue belongs to the Section Cellular Metabolism)
Bone and Soft Tissue Tumors: Molecular Mechanisms and Emerging Therapeutics
edited by
submission deadline 15 Jun 2026 | 1 articles | Viewed by 533 | Submission Open
Keywords: sarcoma; bone and soft tissue tumors; molecular pathology; dysregulated signaling pathways; genetic and epigenetic alterations; therapeutic resistance; novel molecular biomarkers; therapeutic strategies; in vitro and in vivo models
Regulation of Hormone Secretion from Islets in Health and Disease
edited by
submission deadline 15 Jun 2026 | Viewed by 342 | Submission Open
Keywords: islet hormone secretion; paracrine signaling; autocrine regulation; intra-islet communication; islet cell plasticity; transdifferentiation; multi-hormonal dysregulation; circadian regulation; single-cell omics; islet inflammation and immune crosstalk
Overcoming Resistance to Immune Checkpoint Inhibitors in Cancer: Mechanisms, Models, and Therapeutic Strategies
edited by Nai-Yun Sun, and
submission deadline 15 Jun 2026 | Viewed by 223 | Submission Open
Keywords: immune checkpoint inhibitors; primary resistance; acquired resistance; tumor microenvironment; immune exhaustion; preclinical cancer models; genetic and epigenetic alterations; excluded/desert tumors; inflamed tumors; cancer immunotherapy
Decoding the Complexity of Angiogenesis: Insights into Vascular Formation and Disease submission deadline 20 Jun 2026 | 4 articles | Viewed by 6493 | Submission Open
Keywords: angiogenesis; vasculogenesis; development; physiological angiogenesis; pathophysiology; cell– cell communication; cell signaling
(This special issue belongs to the Section Cells of the Cardiovascular System)
Molecular Mechanism of Liver Transplantation
edited by Carmen Peralta and Juan Carlos Cutrin
submission deadline 20 Jun 2026 | 1 articles | Viewed by 5025 | Submission Open
Keywords: liver transplantation; ischemia-reperfusion injury; signaling pathways; graft dysfunction; sterile inflammation; liver regeneration; fatty grafts; normothermic machine perfusion; defatting strategies
(This special issue belongs to the Section Tissues and Organs)
Mechanisms of Antimicrobial Treatment in Human Diseases
edited by
submission deadline 20 Jun 2026 | 1 articles | Viewed by 3593 | Submission Open
Keywords: multidrug resistance; epidemiology; novel antimicrobial resistance traits
(This special issue belongs to the Section Cellular Pathology)
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