Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Research on T Cells in Skin Inflammatory Disorders
edited by and Qing-Sheng Mi
submission deadline 30 Sep 2025 | 1 articles | Viewed by 6050 | Submission Open
Keywords: T cell; vitiligo; atopic dermatitis; T cell lymphoma
(This special issue belongs to the Section Cellular Immunology)
Onco-Hematology and Immunotherapy
edited by and Régis T. Costello
submission deadline 30 Sep 2025 | 2 articles | Viewed by 5263 | Submission Open
Keywords: immunotherapy; onco-hematology; CAR T cells; NK cells; immune system; immune cells; leukemias; lymphomas
(This special issue belongs to the Section Cellular Immunology)
Sebaceous Gland in Skin Health and Disease
edited by and Monica Ottaviani
submission deadline 30 Sep 2025 | 2 articles | Viewed by 4901 | Submission Open
Keywords: sebaceous gland; sebocytes; sebaceous lipid; sebum; inflammation; sebaceous gland disease; skin diseases; pathophysiology; biomarkers; therapeutics
(This special issue belongs to the Section Cellular Pathology)
Antioxidants in Redox Homeostasis of Plant Development submission deadline 30 Sep 2025 | 2 articles | Viewed by 4706 | Submission Open
Keywords: reactive oxygen species; radical scavenging; oxidative stress; plant growth and development; primary and secondary metabolites
(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)
Evolution, Structure, and Functions of Apolipoproteins L
edited by Etienne Pays
submission deadline 30 Sep 2025 | 3 articles | Viewed by 4143 | Submission Open
Keywords: APOL1 nephropathy; APOL1 risk variants; membrane traffic; membrane fission; membrane fusion; membrane dynamics; autophagy; mitophagy; viral replication; lipid droplets; pathogen resistance; inflammation
Cell Biology: State of the Art and Perspectives in Italy 2025
edited by
submission deadline 30 Sep 2025 | 1 articles | Viewed by 3702 | Submission Open
Keywords: cell biology; physiology; molecular biology
Autophagy and Tumor Microenvironment
edited by
submission deadline 30 Sep 2025 | 2 articles | Viewed by 3525 | Submission Open
Keywords: autophagy; cancer growth; cancer therapy; chemoresistance; microenvironment
(This special issue belongs to the Section Autophagy)
Molecular Pathogenesis of Cardiovascular Diseases
edited by , and Chen Gao
submission deadline 30 Sep 2025 | 3 articles | Viewed by 3062 | Submission Open
Keywords: cardiovascular diseases (CVDs); molecular pathogenesis; inflammation; fibrosis; cell death; genetic factors; extracellular vesicle; environmental factors; myocardial infarction; atherosclerosis; arrhythmia; heart failure
(This special issue belongs to the Section Cells of the Cardiovascular System)
Control of Gene Expression by Co-Transcriptional Processes in Cell Homeostasis and Cell Fate Specification: Second Edition
edited by
submission deadline 30 Sep 2025 | 1 articles | Viewed by 2437 | Submission Open
Keywords: gene transcription; transcription elongation; RNA processing; RNA modification; RNA transport; lncRNA; histone modification; biomolecular condensates; diseases associated with dysregulation of gene regulation
(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)
Organellar Ca2+ Transport in Plant versus Animal Cells: Can We Learn from Each Other?
edited by Shey-Shing Sheu and Marc Freichel
submission deadline 30 Sep 2025 | 2 articles | Viewed by 2399 | Submission Open
Keywords: organellar calcium transport; plant cells; animal cells; intracellular organelle communication; calcium signaling; mitochondria; organelle-targeted florescent Ca2+ indicators; super-resolution imaging
(This special issue belongs to the Section Cell Microenvironment)
CRISPR-Based Genome Editing in Translational Research—Third Edition
edited by , and Jifeng Zhang
submission deadline 30 Sep 2025 | 2 articles | Viewed by 2053 | Submission Open
Keywords: genome; gene editing; CRISPR/Cas9
Pathogenesis of Diabetic Kidney Disease
edited by Jia Fu
submission deadline 30 Sep 2025 | 1 articles | Viewed by 1999 | Submission Open
Keywords: diabetic kidney disease (DKD); molecular mechanism; oxidative stress; chronic kidney disease; pathogenesis; diagnostic and therapeutic strategies; inflammation; metabolic dysfunction
(This special issue belongs to the Section Cellular Pathology)
Modulation of P2X Receptors: Emerging Implications for Cellular Signaling and Disease Management
edited by Luca Antonioli and
submission deadline 30 Sep 2025 | 2 articles | Viewed by 1713 | Submission Open
Keywords: purinergic receptors; purinergic signaling; adenosine; ATP; ADP
Advances in Cardiomyocyte and Stem Cell Biology in Heart Disease
edited by Ki Ho Park
submission deadline 30 Sep 2025 | 1 articles | Viewed by 1164 | Submission Open
Keywords: cardiomyocytes; stem cells; heart disease; regenerative medicine; ion channels; protein therapeutics; bioengineering; molecular biology
(This special issue belongs to the Section Cells of the Cardiovascular System)
Advancements in Research on hiPSC-Derived Cells
edited by Akhilesh Kumar
submission deadline 30 Sep 2025 | 1 articles | Viewed by 1146 | Submission Open
Keywords: hiPSCs; hematopoietic progenitors; T cells; NK cells; cardiac cells; B cells; macrophages; neutrophiles; CRISPR/Cas9 technology; genetic engineering
(This special issue belongs to the Section Stem Cells)
The Role of Epithelial Cells in Scleroderma—Second Edition
edited by Richard Stratton
submission deadline 30 Sep 2025 | 1 articles | Viewed by 1118 | Submission Open
Keywords: fibrosis; epithelial– fibroblast interaction; EMT; cytokeratin 6 and 16
Melanoma: From Molecular Mechanisms to Therapeutic Opportunities—3rd Edition submission deadline 30 Sep 2025 | 1 articles | Viewed by 1108 | Submission Open
Keywords: melanomagenesis; treatment response; signal transduction; melanoma-initiating cells; drug resistance; invasiveness; immune evasion; metastasis; MAPK pathway; PI3K/AKT survival pathways; MEKi; BRAFi; trametinib; dabrafenib; immunotherapies
(This special issue belongs to the Section Cellular Pathology)
The Artificial Intelligence to the Rescue of Cancer Research submission deadline 30 Sep 2025 | 1 articles | Viewed by 1101 | Submission Open
Keywords: cancer research; artificial intelligence; personalized medicine; multi-omics data integration; AI-driven drug discovery; precision medicine
(This special issue belongs to the Section Cell Methods)
Cellular Mechanisms and Targeted Therapy of Acute Myeloid Leukemia
edited by
submission deadline 30 Sep 2025 | 1 articles | Viewed by 1068 | Submission Open
Keywords: Acute Myeloid Leukemia (AML); molecular targets; gene therapy; drug resistance; targeted therapy; leukemia stem cells; oncogenic mutations; apoptosis; cell cycle regulation
(This special issue belongs to the Section Cellular Pathology)
Biomarkers and Therapeutic Targets in Insulin Resistance
edited by
submission deadline 30 Sep 2025 | 1 articles | Viewed by 871 | Submission Open
Keywords: insulin resistance; biomarkers; therapeutic targets; type 2 diabetes; metabolic syndrome; obesity; molecular mechanisms; pharmacologic treatments; precision medicine; cardiovascular diseases
(This special issue belongs to the Section Cellular Pathology)
Advances in Reproductive Biology: Cellular and Molecular Mechanisms
edited by and Clara González-Marín
submission deadline 30 Sep 2025 | 1 articles | Viewed by 744 | Submission Open
Keywords: gametogenesis; fertilization; embryo implantation; reproductive genetics; epigenetics in reproduction; hormonal signaling; stem cells and reproduction; assisted reproductive technologies (ARTs); molecular fertility regulation; reproductive health innovations
(This special issue belongs to the Section Reproductive Cells and Development)
Progress of Nanoparticles in the Treatment of Cancers submission deadline 30 Sep 2025 | 1 articles | Viewed by 527 | Submission Open
Keywords: nanoparticles; cancer treatment; cellular mechanisms; molecular biology; pathophysiology; drug delivery; drug resistance; immunotherapy; tumor microenvironment
(This special issue belongs to the Section Cell Microenvironment)
Contribution of Omics Sciences to Agricultural Biotechnology submission deadline 30 Sep 2025 | Viewed by 407 | Submission Open
Keywords: omics technologies; bioinformatics; systems biology; data mining; knowledge discovery; metabolic engineering; genetic engineering; plant biotechnologies; agrifoods; (a)biotic stress resilience; plant– microbe interactions
(This special issue belongs to the Section Cell Methods)
Yeast Stress Responses and Cell Death Regulation submission deadline 30 Sep 2025 | Viewed by 310 | Submission Open
Keywords: yeast stress responses; environmental stresses; signalling pathways; cell death
Spatial Biology: Decoding Cellular Complexity in Tissues submission deadline 30 Sep 2025 | Viewed by 234 | Submission Open
Keywords: spatial biology; spatial tissue profiling; proteomics; transcriptomics; cell and tissue
(This special issue belongs to the Section Tissues and Organs)
The Interplay Between Tumor Metabolism, Microenvironment and Cell Survival
edited by and Giulio Menegazzi
submission deadline 30 Sep 2025 | Viewed by 176 | Submission Open
Keywords: tumor microenvironment; metabolic cross-talk; metabolic reprogramming; extracellular vesicles; cell survival; therapy resistance
(This special issue belongs to the Section Cell Microenvironment)
From Fat to Flame: Targeting Adipose Tissue in Chronic Inflammation and Exploring Therapeutic Strategies submission deadline 30 Sep 2025 | Viewed by 174 | Submission Open
Keywords: obesity; inflammasomes; immune system; microbiota
(This special issue belongs to the Section Tissues and Organs)
Mechanisms and Dynamics in Cellular Adhesion in Development and Disease
edited by
submission deadline 30 Sep 2025 | Viewed by 165 | Submission Open
Keywords: actin; integrin; cell adhesion; signalling; mechanotransduction
Mitochondria and Peroxisomes–Individual Roles and Delicate Balance of Redox Organelles
edited by
submission deadline 30 Sep 2025 | Viewed by 114 | Submission Open
Keywords: mitochondria; peroxisomes; redox organelles; oxidative stress; ROS; organelles; neurodegeneration; autophagy; aging; metabolism
Psilocybe Mushrooms Constituents—Therapeutic Implications
edited by and Janet Schloss
submission deadline 30 Sep 2025 | Viewed by 105 | Submission Open
Keywords: Psilocybe mushrooms; psilocybin; pre-clinical research; neurodegeneration
(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)
Novel Molecular Insight into Congenital Disorders of N-Linked Glycosylation
edited by
submission deadline 30 Sep 2025 | Viewed by 98 | Submission Open
Keywords: N-linked glycosylation; CDG; animal models; genetic variants; glycomics; glycoproteomics; pathophysiology
Cell Stress and Intervention in Neurological Disease
edited by Howard Prentice and
submission deadline 1 Oct 2025 | 1 articles | Viewed by 2884 | Submission Open
Keywords: neurodegenerative disease; gene therapy; excitotoxicity; calcium dysregulation; Alzheimer’ s disease; stroke; neuroprotection; neurogenesis
(This special issue belongs to the Section Cells of the Nervous System)
Novel Insights into Molecular Mechanisms and Therapy of Myeloma
edited by and
submission deadline 5 Oct 2025 | 5 articles | Viewed by 7847 | Submission Open
Keywords: multiple myeloma; CAR-T therapy; relapse; methylation; drug resistance; treatment strategy; molecular mechanism; novel target; biomarker
(This special issue belongs to the Section Cellular Pathology)
The Interplay of G-Protein-Coupled Receptor Signaling between Humans and Diseases
edited by Victor Garcia
submission deadline 10 Oct 2025 | 1 articles | Viewed by 7601 | Submission Open
Keywords: G-proteins; G-protein-coupled receptors; G-protein-independent signaling; cAMP signals
Study on Immune Activity of Natural Products
edited by Xiu-Min Li
submission deadline 10 Oct 2025 | 1 articles | Viewed by 720 | Submission Open
Keywords: natural products; bioactive compounds; immune activity; immunomodulation; inflammation; autoimmune diseases; immunotherapy; therapeutic potential
Non-Traditional Roles of Protein Ubiquitination in Cellular Processes and Health
edited by
submission deadline 15 Oct 2025 | 2 articles | Viewed by 3125 | Submission Open
Keywords: Protein Ubiquitination; ; Ubiquitin chain; ; k63-linked ubiquitination;   ; linear ubiquitination; ; ubiquitin-binding proteins; ; deubiquitinases; ; NF-kB; ; autophagy; ; inflammation; ; immunodeficiency; ; neurodegenerative diseases.
(This special issue belongs to the Section Cellular Pathology)
Ras Family of Genes and Proteins: Structure, Function and Regulation
edited by , and Rosula Garcia-Navas
submission deadline 15 Oct 2025 | 2 articles | Viewed by 2631 | Submission Open
Keywords: HRAS; NRAS; KRAS; RAS-driven tumors; rasopathies; RAS signaling; RAS inhibitors; GAP; GEF; SOS; GRF
Regulation of the Subcellular Compartmentalization of Signaling Pathways by Post-Translational Modifications
edited by Jürgen Fritsch
submission deadline 15 Oct 2025 | 1 articles | Viewed by 978 | Submission Open
Keywords: phosphorylation; ubiquitination; acetylation; acylation; methylation; sumoylation; glycosylation; neddylation; ribosylation; oxidation; proteolysis
Advances in Understanding Inflammation in Atherosclerosis: From Mechanisms to Therapeutic Targets
edited by Yaw Asare and Michael Lacy
submission deadline 15 Oct 2025 | Viewed by 656 | Submission Open
Keywords: atherosclerosis; inflammatory pathways; monocytes/macrophages; endothelial cells; innate immunity; inflammasome; IL-1β ; cytokines and chemokines; neutrophils; epigenetic mechanisms; adaptive immunity; small-molecule inhibitors; T cells; B cells
(This special issue belongs to the Section Cellular Pathology)
LPS-Induced Inflammatory Diseases
edited by and
submission deadline 15 Oct 2025 | Viewed by 320 | Submission Open
Keywords: lipopolysaccharide (LPS); endotoxemia; inflammation; LPS signaling; acute lung injury; inflammatory cytokines; therapeutic targets
(This special issue belongs to the Section Cellular Pathology)
The Multifaceted Role of Molecular Chaperones in Cancer: Pro-Tumoral or Therapeutic Function submission deadline 15 Oct 2025 | Viewed by 284 | Submission Open
Keywords: molecular chaperones; cancer biology; carcinogenesis; tumor progression; diagnostic/prognostic biomarkers; anti-tumor therapeutic strategies; in vitro/in vivo experimental approaches; in silico computational approaches
Molecular and Cellular Mechanisms of Type 1 Diabetes (T1D)
edited by Robert Sharp and
submission deadline 15 Oct 2025 | Viewed by 284 | Submission Open
Keywords: T1D; autoimmunity; type 1 diabetes; single-nucleotide polymorphisms (SNPs); viral/bacterial pathogens; T-cell biology; inflammation; pancreatic beta cells; immunoregulatory; molecular biology; cellular biology
(This special issue belongs to the Section Cellular Pathology)
Membrane Trafficking Components and Mechanisms in Bacterial, Viral or Fungal Infections
edited by
submission deadline 15 Oct 2025 | Viewed by 140 | Submission Open
Keywords: bacterial intracellular infections; bacterial intracellular sanctuaries; viral infection; viral hijacking of host trafficking machinery; membrane trafficking; Rab; secretory pathway; endocytic pathway; viral replication
AI, CRISPR, and Molecular Mechanisms in Precision Medicine
edited by Karim Daliri
submission deadline 15 Oct 2025 | Viewed by 128 | Submission Open
Keywords: CRISPR; gene therapy; precision medicine
(This special issue belongs to the Section Cell Methods)
Advances in Adipocyte Biology Research and Their Relevance to Metabolic Health
edited by
submission deadline 15 Oct 2025 | Viewed by 121 | Submission Open
Keywords: adipose tissue; obesity; inflammation; thermogenesis; adipokines
Extracellular Vesicles and Exosomes: Novel Insight and Therapeutic Applications in Cancer
edited by Giusi Alberti and
submission deadline 16 Oct 2025 | Viewed by 185 | Submission Open
Keywords: extracellular vesicles (EVs); exosomes (Exos); proteins and miRNA; 2D-EVs and Exos; 3D-EVs and Exos; precision therapy; molecular mechanism; cancer physiology; oncology research
Understanding Spinal Cord Injury and Repair: From Molecules to Neurocircuits and Multimodal Prostheses
edited by
submission deadline 20 Oct 2025 | 9 articles | Viewed by 21178 | Submission Open
(This special issue belongs to the Section Cells of the Nervous System)
Molecular Mechanisms of Autism Spectrum Disorder
edited by Tanya Gandhi and
submission deadline 20 Oct 2025 | 7 articles | Viewed by 17964 | Submission Open
Keywords: autism spectrum disorder; neurodevelopmental disorders; molecular mechanisms; cellular-molecular mechanisms; neurobiological mechanisms; neural mechanisms; intervention approaches; treatment strategies
(This special issue belongs to the Section Cells of the Nervous System)
Therapeutic Targets in Glioblastoma
edited by Candice Mazewski and
submission deadline 20 Oct 2025 | 5 articles | Viewed by 11098 | Submission Open
Keywords: glioblastoma; signaling targets; blood-brain-barrier; complementary and alternative medicine; combination therapy; glioma stem cells; progression; resistance; nutrient-sensing
(This special issue belongs to the Section Cells of the Nervous System)
New Trends and Advances in Diagnosis and Prognosis of Head and Neck Cancer from Carcinogenesis to Future Molecular Targeted Therapies: 2nd Edition submission deadline 20 Oct 2025 | 5 articles | Viewed by 6412 | Submission Open
Keywords: head and neck cancer; oral cancer; biomarker; prognosis; carcinogenesis; oral premalignant lesions; cancer stem cells; signaling pathways; molecular targeted therapy
(This special issue belongs to the Section Cellular Pathology)
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