Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Role of Macrophages in Leishmaniasis: Current Perspective
edited by Devki Nandan
submission deadline 31 Jul 2025 | Viewed by 110 | Submission Open
Keywords: Leishmania; leishmaniasis; macrophage biology; host– pathogen interactions
Novel Therapeutic Strategies to Improve Mitochondrial Function in Neurodegenerative Diseases
edited by Patricia Morcillo
submission deadline 31 Jul 2025 | Viewed by 83 | Submission Open
Keywords: mitochondria; cellular signaling; neurodegenerative diseases; mitochondrial dynamics; organelles; neurological diseases; therapies; biomarkers
(This special issue belongs to the Section Cellular Aging)
Lung Development: Challenges and Opportunities
edited by David Warburton
submission deadline 31 Jul 2025 | Viewed by 76 | Submission Open
Keywords: alveolar gas diffusion surface; alveolar development; injury; repair; and replacement; alveolar stresses and strains; lung microenvironment; tissue engineering in pulmonary regeneration
(This special issue belongs to the Section Tissues and Organs)
Retinal Pigment Epithelial Cells in Age-Related Macular Degeneration
edited by Sujoy Bhattacharya
submission deadline 1 Aug 2025 | 2 articles | Viewed by 4193 | Submission Open
Keywords: atrophic age-related macular degeneration; iPSC-derived RPE; animal models
(This special issue belongs to the Section Stem Cells)
Advancements in Cardiac Metabolism
edited by
submission deadline 1 Aug 2025 | 1 articles | Viewed by 378 | Submission Open
Keywords: cardiovascular disease; metabolism; fatty acids; heart failure; mitochondrial dysfunction
(This special issue belongs to the Section Cells of the Cardiovascular System)
Cellular and Molecular Players in Bone Homeostasis
edited by Darja Andreev
submission deadline 1 Aug 2025 | Viewed by 88 | Submission Open
Keywords: bone homeostasis; cellular and molecular mechanisms; bone-related diseases; microenvironmental factors; therapeutic targets
The Dynamic Gut Wall: Innovations and Future Directions in Intestinal Epithelium submission deadline 15 Aug 2025 | 1 articles | Viewed by 703 | Submission Open
Keywords: intestinal epithelium; regenerative medicine; stem cells; gut microbiota; epithelial barrier; bioengineering; morphogenetic signaling
Cachexia: Molecular Mechanisms and Treatment Strategies
edited by Zoltán Lohinai
submission deadline 15 Aug 2025 | Viewed by 134 | Submission Open
Keywords: cachexia; cancer metabolism; dietary interventions; inflammation; malnutrition; cachexia biomarkers
(This special issue belongs to the Section Cellular Pathology)
New Insights into Adipose-Derived Stem Cells (ADSCs)
edited by , and William D’Angelo
submission deadline 20 Aug 2025 | 4 articles | Viewed by 11532 | Submission Open
Keywords: adipose-derived stem cells; immunomodulation; exosomes; cell therapy; clinical translation
(This special issue belongs to the Section Stem Cells)
Role of Thyroid Hormone in Neurodegenerative and Neurodevelopmental Disorders
edited by Janaína Sena de Souza
submission deadline 20 Aug 2025 | 3 articles | Viewed by 5101 | Submission Open
Keywords: thyroid hormones; neurodevelopmental and neurodegenerative disorders; central nervous system
(This special issue belongs to the Section Cells of the Nervous System)
Cell Stress and Intervention in Neurological Disease
edited by Howard Prentice and
submission deadline 20 Aug 2025 | 1 articles | Viewed by 2293 | Submission Open
Keywords: neurodegenerative disease; gene therapy; excitotoxicity; calcium dysregulation; Alzheimer’ s disease; stroke; neuroprotection; neurogenesis
(This special issue belongs to the Section Cells of the Nervous System)
Cell Therapeutics for Corneal Diseases submission deadline 20 Aug 2025 | 1 articles | Viewed by 1861 | Submission Open
Keywords: cell therapies; corneal diseases; drug development; tissue engineering; stem cells; regeneration; tissue repair
(This special issue belongs to the Section Tissues and Organs)
Regulation of Cell Division
edited by Katie Shannon
submission deadline 20 Aug 2025 | 1 articles | Viewed by 1627 | Submission Open
Keywords: mitosis; kinetochore; chromosome segregation; actomyosin ring; cytokinesis; septation; mitotic exit network; spindle assembly checkpoint
(This special issue belongs to the Section Cell Proliferation and Division)
The Roles of the Extracellular Matrix in Cardiac Structure and Function: A Commemorative Issue in Honor of Dr. Thomas K. Borg
edited by and Edie Goldsmith
submission deadline 20 Aug 2025 | 1 articles | Viewed by 850 | Submission Open
Keywords: collagen; integrin; extracellular matrix; cardiomyocyte; fibroblast; heart bioengineering
(This special issue belongs to the Section Cell Microenvironment)
The Cell Biology of Inositol submission deadline 20 Aug 2025 | Viewed by 291 | Submission Open
Keywords: inositol; organic fluids and tissues; cell membranes and organelles; cell metabolism; nutrition; neurodegenerative diseases; cancer; inositol pyrophosphates; inositol phosphates and phosphoinositides
Advances on the Crosstalk Between Cell Senescence and Cellular Metabolism submission deadline 20 Aug 2025 | Viewed by 230 | Submission Open
Keywords: cellular senescence; cellular metabolism; aging
(This special issue belongs to the Section Cellular Aging)
Current Advances in Plant Gene Regulatory Networks submission deadline 20 Aug 2025 | Viewed by 228 | Submission Open
Keywords: plants; light signaling; circadian clock; thermomorphogenesis; hormonal regulation; a/biotic stress-responsive gene expression; flowering time
(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)
Role of the Endophytic Microbiota on Plant Resilience submission deadline 20 Aug 2025 | Viewed by 201 | Submission Open
Keywords: plant growth-promoting microorganisms; climate change; plant defense; drought; salinity; crop improvement; sustainable agriculture; biological control agents
(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)
Increasing Incidence of Retinal Disorders: Addressing Preclinical Studies with Appropriate Animal Models and Advanced Methodologies submission deadline 20 Aug 2025 | Viewed by 176 | Submission Open
Keywords: hypoxia; oxidative stress; angiogenic markers; HIF-1/VEGF axis; retinal diseases; β -adrenoceptors; electroretinographic responses
(This special issue belongs to the Section Tissues and Organs)
Unconventional T Cells in Health and Disease
edited by Lauren Howson
submission deadline 20 Aug 2025 | Viewed by 145 | Submission Open
Keywords: MR1-restricted T cells; γ δ T cells; CD1-restricted T cells; unconventional T cells
(This special issue belongs to the Section Cellular Immunology)
Targeting Tumor Microenvironments for Enhanced Cancer Immunotherapy
edited by
submission deadline 20 Aug 2025 | Viewed by 138 | Submission Open
Keywords: tumor microenvironment; cancer immunotherapy; immune modulation; immunosuppressive mechanisms; combination therapies
(This special issue belongs to the Section Cell Microenvironment)
Immunology in Lung Diseases
edited by
submission deadline 20 Aug 2025 | Viewed by 137 | Submission Open
Keywords: acute lung injury; acute respiratory distress syndrome; respiratory infections; interstitial lung diseases; chronic obstructive pulmonary disease; cystic fibrosis; asthma; lung cancer
(This special issue belongs to the Section Tissues and Organs)
Advances and Breakthroughs in Stem Cell Research submission deadline 25 Aug 2025 | 2 articles | Viewed by 7056 | Submission Open
Keywords: stem cell; induced pluripotent stem cell; iPSC; hematopoietic stem cell
(This special issue belongs to the Section Stem Cells)
Cellular and Molecular Mechanisms of Abiotic Stress Tolerance in Plants
edited by Aziz Khan and
submission deadline 25 Aug 2025 | 1 articles | Viewed by 4055 | Submission Open
Keywords: abiotic stress; molecular mechanism; gene expression; cellular adaptation; signal transduction; plant physiology; molecular pathway; stress resilience; crop productivity; agronomic performance
(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)
Mitochondrial Dysfunction in Neurodegeneration: A Translational Perspective
edited by Hemendra Vekaria
submission deadline 25 Aug 2025 | 2 articles | Viewed by 3687 | Submission Open
Keywords: mitochondrial dysfunction; traumatic brain injury; secondary damage; bioenergetics
(This special issue belongs to the Section Cells of the Nervous System)
Intervertebral Disc Degeneration and Regeneration: New Molecular Mechanisms and Therapeutics—Second Edition
edited by
submission deadline 30 Aug 2025 | 3 articles | Viewed by 6416 | Submission Open
Keywords: spine; intervertebral disc; biomaterial; stem cell; gene therapy
(This special issue belongs to the Section Cellular Pathology)
Molecular Pathways and Potential Therapeutic Targets of Vascular Dysfunction submission deadline 30 Aug 2025 | 4 articles | Viewed by 5310 | Submission Open
Keywords: vascular dysfunction; endothelial dysfunction; vascular remodeling; arterial stiffness; vascular signaling; new vascular targets
(This special issue belongs to the Section Cells of the Cardiovascular System)
Molecular Mechanisms of Exercise on Cardiac and Skeletal Muscle Function
edited by Kisuk Min
submission deadline 30 Aug 2025 | 1 articles | Viewed by 1033 | Submission Open
Keywords: exercise physiology; cardiac muscle function; skeletal muscle function; molecular mechanisms; mitochondrial biogenesis; oxidative stress; muscle hypertrophy; inflammatory responses; cellular signaling pathways; metabolic adaptation
(This special issue belongs to the Section Cellular Pathology)
Cell Biology: The State of the Art and Perspectives in Japan 2025
edited by
submission deadline 30 Aug 2025 | Viewed by 252 | Submission Open
Keywords: cell biology; physiology; molecular biology
Mechanisms of Modulation of Sensory Plasticity in the Cerebral Cortex
edited by
submission deadline 30 Aug 2025 | Viewed by 226 | Submission Open
Keywords: synaptic plasticity; synapses; LTP; LTD; ionotropic and metabotropic receptors
(This special issue belongs to the Section Cells of the Nervous System)
Molecular Mechanisms of Leukemias
edited by and Frode Selheim
submission deadline 30 Aug 2025 | Viewed by 99 | Submission Open
Keywords: acute lymphoblastic leukemia (ALL); chronic lymphocytic leukemia (CLL); acute myelogenous leukemia (AML); chronic myelogenous leukemia (CML)
(This special issue belongs to the Section Cellular Pathology)
Cellular and Molecular Mechanisms in Reproductive System Diseases
edited by Arnab Ghosh, and Sujoy K. Dhara
submission deadline 31 Aug 2025 | 8 articles | Viewed by 24927 | Submission Open
Keywords: male reproductive system; female reproductive system; hormonal regulation; reproductive immunology; adverse pregnancy outcomes; infertility; sexually transmitted infections (STIs)
(This special issue belongs to the Section Reproductive Cells and Development)
Cellular and Molecular Mechanisms Underlying the Pathogenesis of Hepatic Fibrosis III
edited by
submission deadline 31 Aug 2025 | 7 articles | Viewed by 21130 | Submission Open
(This special issue belongs to the Section Tissues and Organs)
Endoplasmic Reticulum Stress Signaling Pathway: From Bench to Bedside
edited by Samuel Stephens and
submission deadline 31 Aug 2025 | 4 articles | Viewed by 8389 | Submission Open
Keywords: ER stress; oxidative protein folding; ER redox; ER calcium homeostasis; UPR; diabetes; cancer; virus
(This special issue belongs to the Section Cell Signaling)
Kinases in Cancer: Advancing Targeted Therapies and Their Implications in Cancer Immunity
edited by Zamal Ahmed and John A. Tainer
submission deadline 31 Aug 2025 | 1 articles | Viewed by 5291 | Submission Open
Keywords: kinase targets; proliferation; cell cycle checkpoints; DNA damage responses; inflammation; cancer immune response; phosphatase targets; adaptor and scaffold targets
(This special issue belongs to the Section Cellular Immunology)
The Role of IgE and IgG Antibodies in Allergic Reactions: Cellular Mechanisms and Biological Implications submission deadline 31 Aug 2025 | 3 articles | Viewed by 4994 | Submission Open
Keywords: IgE; IgG; allergy; inflammation; glycosylation; immunotherapy; autoantibodies; Fc receptors; soluble receptors
(This special issue belongs to the Section Cellular Immunology)
DNA Damage and Repair for Targeted Cancer Therapy
edited by Mohd Saleem Dar, and Sajad Ahmad Bhat
submission deadline 31 Aug 2025 | 2 articles | Viewed by 4377 | Submission Open
Keywords: cancer cells; DNA damage and repair mechanism; genome organization; BER; NER; MMR; HR; and NHEJ; targeted therapy; inhibitors/PROATCS; drug resistance; drug toxicity; biomarkers; personalized medicine
Signaling Pathways Involved in Tumor Microenvironment and Tumor Adaptation to Stresses
edited by Nianli Sang
submission deadline 31 Aug 2025 | 2 articles | Viewed by 2664 | Submission Open
Keywords: microenvironment; metabolic stress; hypoxia; chemoresistance; radiation resistance; apoptosis; metabolic reprogramming; metastasis
(This special issue belongs to the Section Cell Signaling)
The Potential of Induced Pluripotent Stem Cells
edited by Yun Chang
submission deadline 31 Aug 2025 | 2 articles | Viewed by 2609 | Submission Open
Keywords: pluripotent stem cells; reprogramming; engineering; regenerative medicine; differentiation; therapeutic applications; biomaterials
(This special issue belongs to the Section Stem Cells)
Organoids and Models from Stem Cells
edited by Tiziana A. L. Brevini and
submission deadline 31 Aug 2025 | 2 articles | Viewed by 1908 | Submission Open
Keywords: cellular microenvironment; 3D culture; organoid
(This special issue belongs to the Section Stem Cells)
The Epigenetic Landscape of Aging: Mechanisms and Impacts During Cellular and Organismal Longevity
edited by Siyu Shen and
submission deadline 31 Aug 2025 | 2 articles | Viewed by 1546 | Submission Open
Keywords: epigenetic regulation; cellular senescence; aging; DNA methylation; histone modification; non-coding RNA; cancer epigenetics; neurodegenerative diseases; musculoskeletal degenerative disorders; cardiovascular diseases
(This special issue belongs to the Section Cellular Aging)
Drosophila as a Model for Understanding Human Disease
edited by Zhe Han
submission deadline 31 Aug 2025 | 1 articles | Viewed by 1261 | Submission Open
Keywords: Drosophila melanogaster; human disease models; genetic and molecular mechanisms; neurodegenerative diseases; cardiovascular diseases; cancer biology; metabolic disorders; high-throughput screening; precision medicine; translational research
(This special issue belongs to the Section Cellular Pathology)
Pathophysiology of Signal Transduction in Cardiovascular and Pulmonary Disease II
edited by and
submission deadline 31 Aug 2025 | 1 articles | Viewed by 1242 | Submission Open
Keywords: cardiac arrhythmia; atrium; ventricle; pulmonary; vascular; signal transduction
(This special issue belongs to the Section Cellular Pathology)
New Insights into Inflammasome: Mechanisms of Activation, Cell Death, and Diseases
edited by Ana Tapia-Abellán
submission deadline 31 Aug 2025 | 1 articles | Viewed by 822 | Submission Open
Keywords: inflammasomes; inflammation; pyroptosis; chronic diseases; autoinflammatory syndromes
(This special issue belongs to the Section Cellular Pathology)
The Silent Regulators: Non-Coding RNAs in Cell Function and Disease submission deadline 31 Aug 2025 | 1 articles | Viewed by 525 | Submission Open
Keywords: non-coding RNAs; microRNAs; long non-coding RNAs (lncRNAs); regulatory RNAs; RNA interference; epigenetic regulation; RNA editing; cellular signaling; disease biomarkers; RNA therapeutics
(This special issue belongs to the Section Cell and Gene Therapy)
The Role Glial Cells in Neurodegenerative Disorders
edited by
submission deadline 31 Aug 2025 | Viewed by 427 | Submission Open
Keywords: neurodegeneration; neuroinflammation; microglia; astrocytes; neuron; extracellular vesicles; therapeutics
(This special issue belongs to the Section Cells of the Nervous System)
The Role of T Cells in Type 1 Diabetes submission deadline 31 Aug 2025 | Viewed by 386 | Submission Open
Keywords: T cells; inflammation; T cell receptor; type 1 diabetes
(This special issue belongs to the Section Cellular Immunology)
Hedgehog Signaling: Advances in Development and Cancer—Second Edition
edited by
submission deadline 31 Aug 2025 | Viewed by 370 | Submission Open
Keywords: hedgehog signaling; hh gene; smoothened (SMO)
(This special issue belongs to the Section Cell Signaling)
The Role of Microglia in Neurodegenerative Diseases and Neuroinflammation
edited by
submission deadline 31 Aug 2025 | Viewed by 317 | Submission Open
Keywords: microglia; central nervous system; neurodegenerative diseases; neurodegeneration; Alzheimer’ s disease (AD); Parkinson’ s disease (PD)
(This special issue belongs to the Section Cells of the Nervous System)
Immune Cells from Pluripotent Stem Cells
edited by
submission deadline 31 Aug 2025 | Viewed by 309 | Submission Open
Keywords: pluripotent stem cells; T cells; B cells; macrophages; natural killer (NK) cells; dendritic cells; megakaryocytes; platelets
(This special issue belongs to the Section Stem Cells)
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