Glial Cells: Physiological and Pathological Perspective

Dear Colleagues,

Neurodegenerative diseases of the central nervous system (CNS), including Alzheimer's disease, Parkinson's disease, multiple sclerosis, and amyotrophic lateral sclerosis (ALS), are characterized by progressive neuronal loss and dysfunction. Glial cells, comprising astrocytes, microglia, oligodendrocytes, and ependymal cells, play crucial roles in maintaining CNS homeostasis, neuronal support, and response to injury. Emerging evidence implicates glial cells as central players in the pathogenesis of neurodegenerative diseases. Astrocytes contribute to neuroinflammation and neuroprotection, yet their dysfunction can exacerbate neuronal damage. Microglia, the resident immune cells of the CNS, are pivotal in mediating inflammatory responses. Oligodendrocytes, responsible for myelination, are affected in diseases such as multiple sclerosis, where demyelination impairs neural conductivity and leads to neurodegeneration. Additionally, the interactions between glial cells and neurons are critical in modulating the progression of disease. Understanding the molecular mechanisms governing glial cell function and dysfunction would provide insights into the complex interplay between these cells and neurons in neurodegenerative diseases. This knowledge is pivotal for developing glia-targeted therapies that are aimed at modulating glial activity in order to ameliorate disease progression and promote neuroprotection in the fight against neurodegenerative diseases.

Dr. Qing Richard Lu
Guest Editor

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