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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Biomarkers and Therapeutic Targets in Insulin Resistance

edited by

Mohamed Elrayess

submission deadline 30 Mar 2026 | 1 articles | Viewed by 3080 | Submission Open

Keywords: insulin resistance; biomarkers; therapeutic targets; type 2 diabetes; metabolic syndrome; obesity; molecular mechanisms; pharmacologic treatments; precision medicine; cardiovascular diseases

(This special issue belongs to the Section Cellular Pathology)

Novel Insights into Molecular and Cellular Mechanisms Underlying Chronic Pain

edited by

Mariacristina Mazzitelli

submission deadline 30 Mar 2026 | 1 articles | Viewed by 843 | Submission Open

Keywords: pain; pain management; sexual dimorphism; neurons; non-neuronal factors

(This special issue belongs to the Section Cellular Pathology)

Novel Insights into Cancer Immune Responsiveness

edited by

Luigi Racioppi

and

Tanmoy Mondal

submission deadline 30 Mar 2026 | 1 articles | Viewed by 724 | Submission Open

Keywords: cancers; tumors; immune cells; tumor immunology; cancer immunology; onco-immunology; immunotherapies; resistance; immunotherapy resistance; immune checkpoint; CAR; antibody; cancer vaccines

Neuroimaging of Cerebrovascular Diseases

edited by Dragan Stojanov

submission deadline 30 Mar 2026 | Viewed by 231 | Submission Open

Keywords: neuroimaging; cerebrovascular diseases; stroke; intracerebral hemorrhage; SAHA neurysms; AVM; small vessels diseases; CT; MRI; advance MRI techniques; DSA; AI

Mechanisms of miRNA Metabolism and Extracellular Transport

edited by

Suvendra N Bhattacharyya

submission deadline 30 Mar 2026 | Viewed by 209 | Submission Open

Keywords: miRNA metabolism; miRNA transport; miRNA exchange; miRNA storage; mRNA biogenesis; extracellular vesicles and miRNA; non-EV miRNA export; miRNA binding proteins; miRNA sponge and inhibitors; miRNA biomarkers

Impact of Chronic Substance Exposure on Hematopoiesis and Immunity

edited by

Mary Mohrin

and

Hami Hemati

submission deadline 30 Mar 2026 | Viewed by 151 | Submission Open

Keywords: Substance Use Alcohol Immunity Inflammation Hematopoietic stem and progenitor cells Monocytes Neutrophils Macrophages T cells

Nanoparticle-Mediated Immunotherapy: Reshaping the Tumor Microenvironment for Enhanced Cancer Treatment

edited by

Mohd Ahmar Rauf

submission deadline 30 Mar 2026 | Viewed by 141 | Submission Open

Keywords: tumor microenvironment; drug delivery; nanoparticle

(This special issue belongs to the Section Cell Methods)

Cellular and Molecular Mechanisms of Cardiomyopathy

edited by

Zaglia Tania

and

Maurizio Forte

submission deadline 30 Mar 2026 | Viewed by 138 | Submission Open

Keywords: genetic cardiomyopathies; acquired cardiomyopathies; cardiac arrhythmias; disease mechanisms; disease cause; pathogenesis

(This special issue belongs to the Section Tissues and Organs)

Molecular Mechanisms and Biomarker Development in Prostate Cancer

edited by Vikas Mehta and Behtash Ghazi Nezami

submission deadline 30 Mar 2026 | Viewed by 110 | Submission Open

Keywords: androgen receptor; prostate molecular alterations; biomarkers

Potential of CAR-Based Cellular Immunotherapy for Non-oncologic Disorders

edited by

Györgyi Műzes

and

Ferenc Sipos

submission deadline 31 Mar 2026 | 5 articles | Viewed by 26443 | Submission Open

Keywords: adoptive cell transfer; CAR-T cells; cell engineering; CAR products; CAR-T cell therapy; non-oncologic disorders; autoimmune diseases; cardiometabolic diseases; inflammatory organ fibrosis; senescent cell pathologies; infections

(This special issue belongs to the Section Cellular Immunology)

Flow Cytometry in Immunology Research

edited by

Ziv Porat

and Ekaterina Kopitman

submission deadline 31 Mar 2026 | 3 articles | Viewed by 15017 | Submission Open

Keywords: multi-parametric analysis; full-spectrum flow cytometry; imaging flow cytometry; immuno-phenotyping; immune synapse; cytokines; activation markers; cancer immunology; host-pathogen interactions; functional immune assays

(This special issue belongs to the Section Cell Methods)

Organoids and Models from Stem Cells

edited by Tiziana A. L. Brevini and

Georgia Pennarossa

submission deadline 31 Mar 2026 | 3 articles | Viewed by 9954 | Submission Open

Keywords: cellular microenvironment; 3D culture; organoid

(This special issue belongs to the Section Stem Cells)

mRNA Vaccines and Therapeutics in Melanoma: From Mechanisms to Cellular Impact

edited by

Stefano Zoroddu

and

Luigi M. Bagella

submission deadline 31 Mar 2026 | 3 articles | Viewed by 9776 | Submission Open

Keywords: mRNA vaccines; melanoma; tumor immunology; mRNA vaccine designs; delivery systems

(This special issue belongs to the Section Cellular Pathology)

Cellular and Molecular Mechanisms of Liver Diseases

edited by Jieyun Jiang

submission deadline 31 Mar 2026 | 2 articles | Viewed by 6247 | Submission Open

Keywords: liver; alcoholic liver disease (ALD); viral hepatitis; metabolic associated steatotic liver disease (MASLD); autoimmune hepatitis; drug-induced liver injury; liver fibrosis and cirrhosis; liver cancer; cellular and molecular mechanisms

(This special issue belongs to the Section Cellular Pathology)

Computational Biophysics in Cellular Biological Systems

edited by

Lin Li

and Wenhan Guo

submission deadline 31 Mar 2026 | 2 articles | Viewed by 5304 | Submission Open

Keywords: cellular process; protein– protein interactions; single-cell analysis; drug design; molecular dynamics simulations

(This special issue belongs to the Section Cell Methods)

Advances in Reproductive Biology: Cellular and Molecular Mechanisms

edited by

Rosa Roy

and Clara González-Marín

submission deadline 31 Mar 2026 | 4 articles | Viewed by 4830 | Submission Open

Keywords: gametogenesis; fertilization; embryo implantation; reproductive genetics; epigenetics in reproduction; hormonal signaling; stem cells and reproduction; assisted reproductive technologies (ARTs); molecular fertility regulation; reproductive health innovations

(This special issue belongs to the Section Reproductive Cells and Development)

Drosophila as a Model for Understanding Human Disease

edited by Zhe Han

submission deadline 31 Mar 2026 | 4 articles | Viewed by 4672 | Submission Open

Keywords: Drosophila melanogaster; human disease models; genetic and molecular mechanisms; neurodegenerative diseases; cardiovascular diseases; cancer biology; metabolic disorders; high-throughput screening; precision medicine; translational research

(This special issue belongs to the Section Cellular Pathology)

Signaling Pathways Involved in Tumor Microenvironment and Tumor Adaptation to Stresses

edited by Nianli Sang

submission deadline 31 Mar 2026 | 2 articles | Viewed by 4389 | Submission Open

Keywords: microenvironment; metabolic stress; hypoxia; chemoresistance; radiation resistance; apoptosis; metabolic reprogramming; metastasis

(This special issue belongs to the Section Cell Signaling)

Axonal Transport: Mechanisms, Disorders, and Therapeutic Approaches

edited by Yuxiang Xie and Jingqi Yan

submission deadline 31 Mar 2026 | 1 articles | Viewed by 4328 | Submission Open

Keywords: axonal transport; motor proteins; autophagy– lysosome pathway; neurodegenerative diseases; therapeutic strategies

(This special issue belongs to the Section Cellular Neuroscience)

Modulation of Senescence and Differentiation in Human Mesenchymal Stem Cells

edited by

Federica Facchin

and

Silvia Canaider

submission deadline 31 Mar 2026 | 3 articles | Viewed by 3397 | Submission Open

Keywords: tissue-specific mesenchymal stem cells; cell senescence; cell differentiation; natural and synthetic molecules; tissue engineering; regenerative medicine

(This special issue belongs to the Section Stem Cells)

Molecular Insights into Vascular Physiology and Pathology

edited by Suravi Majumder

submission deadline 31 Mar 2026 | 3 articles | Viewed by 3123 | Submission Open

Keywords: vascular physiology; vascular pathology; endothelial cells; vascular smooth muscle cells; vascular inflammation; vascular signaling; vascular aging; vascular remodeling; atherosclerosis; cardiovascular diseases; biomarkers; novel therapeutic approaches

(This special issue belongs to the Section Cellular Pathology)

Cellular Mechanisms in Pregnancy and Foetal Development

edited by

Anya L. Arthurs

and

Giovanni Levi

submission deadline 31 Mar 2026 | 3 articles | Viewed by 2748 | Submission Open

Keywords: pregnancy; fetus; reproduction; placenta; maternal; fertility; preeclampsia; fetal growth restriction; gestational diabetes; stillbirth

Kidney Injury Biomarkers: From Early Detection to Transition to Chronic Kidney Disease

edited by

Alexander E. Berezin

submission deadline 31 Mar 2026 | 1 articles | Viewed by 2689 | Submission Open

Keywords: acute kidney injury; acute kidney disease; chronic kidney disease; circulating biomarkers; urinary biomarkers; multiple biomarker panel; diagnosis; prediction; management

(This special issue belongs to the Section Tissues and Organs)

Mechanisms of Modulation of Sensory Plasticity in the Cerebral Cortex

edited by

Ángel A. Núñez

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1687 | Submission Open

Keywords: synaptic plasticity; synapses; LTP; LTD; ionotropic and metabotropic receptors

(This special issue belongs to the Section Cellular Neuroscience)

The Challenges and Opportunities of Mesenchymal Stromal Cells in Regenerative Medicine

edited by

Lucie Bacakova

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1654 | Submission Open

Keywords: mesenchymal stromal cells; mesenchymal stem cells; medicinal signaling cells; multipotent stem cells; paracrine secretion; angiogenesis; immunomodulation; cell therapy; cell-free cell-based therapy; stem cell differentiation; tissue engineering

Lung Cancer: Molecular Mechanisms and Therapeutic Opportunities

edited by

Sherri R. Cervantes

and

Daruka Mahadevan

submission deadline 31 Mar 2026 | 2 articles | Viewed by 1642 | Submission Open

Keywords: precision oncology; immunotherapy; targeted therapy; genomic characterization; biomarker; microenvironment; non-small cell lung cancer; small cell lung cancer

(This special issue belongs to the Section Cell Microenvironment)

From Energy Metabolism to Disease: The Multifaceted Roles of Mitochondria

edited by Amy H. Attaway and Saurabh Mishra

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1641 | Submission Open

Keywords: mitochondrial oxidation; ROS; aging; disease

The Interplay Between Tumor Metabolism, Microenvironment and Cell Survival

edited by

Silvia Peppicelli

and Giulio Menegazzi

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1011 | Submission Open

Keywords: tumor microenvironment; metabolic cross-talk; metabolic reprogramming; extracellular vesicles; cell survival; therapy resistance

(This special issue belongs to the Section Cell Microenvironment)

Cellular and Molecular Mechanisms of Alcohol-Induced Cellular/Organ Injury and Regeneration

edited by Mukund Srinivasan

submission deadline 31 Mar 2026 | 1 articles | Viewed by 914 | Submission Open

Keywords: alcohol use disorder; ethanol; liver; lung; pancreas; gut; brain; cellular toxicity; alcohol metabolism; alcohol metabolites; oxidative stress; mitochondrial stress; ER stress

Pediatric Liver Tumors: Molecular Mechanisms and Therapeutic Strategies

edited by

Edward V. Prochownik

submission deadline 31 Mar 2026 | 1 articles | Viewed by 633 | Submission Open

Keywords: hepatoblastoma; hepatocellular carcinoma; pediatric liver tumors; fibrolamellar carcinoma; Beck-with-Wiedmann syndrome; hereditary tyrosinemia; molecular mechanisms; therapeutic strategies

Cellular and Molecular Insights into Allergies and Allergic Diseases

edited by

Toshiaki Kawakami

submission deadline 31 Mar 2026 | Viewed by 373 | Submission Open

Keywords: allergy; immune regulation; mast cells; Th2 responses; epithelial barrier; IgE; inflammation; cellular signaling; molecular mechanisms

(This special issue belongs to the Section Cellular Immunology)

Mechanisms and Dynamics in Cellular Adhesion in Development and Disease

edited by

Daniel Bouvard

submission deadline 31 Mar 2026 | Viewed by 341 | Submission Open

Keywords: actin; integrin; cell adhesion; signalling; mechanotransduction

Membrane Trafficking Components and Mechanisms in Bacterial, Viral or Fungal Infections

edited by

Bor Luen Tang

submission deadline 31 Mar 2026 | Viewed by 301 | Submission Open

Keywords: bacterial intracellular infections; bacterial intracellular sanctuaries; viral infection; viral hijacking of host trafficking machinery; membrane trafficking; Rab; secretory pathway; endocytic pathway; viral replication

Cellular and Molecular Insights into Gynecologic Tumors

edited by

Mladen Anđić

and

Jianjun Wei

submission deadline 31 Mar 2026 | Viewed by 296 | Submission Open

Keywords: gynecologic cancers; cervical cancer; endometrial cancer; ovarian tumors; tumor microenvironment; molecular biomarkers; genetic mutations; targeted therapies

Organelle Crosstalk: New Insights into Intracellular Communication and Dynamics

edited by

Jonathan Barra

submission deadline 31 Mar 2026 | Viewed by 287 | Submission Open

Keywords: organelle contact sites; membrane contact sites; intracellular communication; early endosomes; recycling endosomes; Golgi; mitochondrial dynamics; ER stress; mitophagy; autophagy; lysosome; calcium signaling; lipid transfer; proteostasis

Therapeutic Targeting of MicroRNAs in Human Cancer

edited by

Behzad Mansoori

submission deadline 31 Mar 2026 | 1 articles | Viewed by 250 | Submission Open

Keywords: microRNAs; nanoparticle platforms; spatial miRNomics; combination therapeutic strategies

(This special issue belongs to the Section Cell and Gene Therapy)

PI3K/AKT/mTOR Signaling Network in Human Health and Diseases, 3rd Edition

edited by

Jean Christopher Chamcheu

Claudia Bürger

and

Shile Huang

submission deadline 31 Mar 2026 | Viewed by 249 | Submission Open

Keywords: acne; ageing; Akt; Alzheimer’ s disease; autophagy; autoimmunity; PI3K; mTOR; cancer; cardiovascular diseases; diabetes; growth; hamartoma; hypertrophy; inflammation; neurologic; tuberous sclerosis; systemic sclerosis; obesity; Parkinson’ s disease; psoriasis; atopic dermatitis; burns/wound healing; targeted therapy; natural products; biologics

Current Research on Immunotherapy for Glioblastoma

edited by Markella Zannikou

submission deadline 31 Mar 2026 | Viewed by 245 | Submission Open

Keywords: GBM; tumor microenvironment; cancer vaccines; TIL (tumor-infiltrating lymphocytes) therapy; combination therapy; BiTEs; immune checkpoint therapy; CAR T-cell therapy; peptide/dendritic vaccines; tumor-associated antigens; oncolytic virotherapy

(This special issue belongs to the Section Cellular Immunology)

Ubiquitin Ligases: Key Regulators in Cellular Homeostasis and Disease

edited by Praveen Koganti and

Michal Goldberg

submission deadline 31 Mar 2026 | Viewed by 245 | Submission Open

Keywords: ubiquitin ligases; protein ubiquitination; cellular homeostasis; proteasome pathway

Neurodevelopmental Factors of Autism Spectrum Disorder: Etiology to Therapy

edited by

George Ayoub

submission deadline 31 Mar 2026 | Viewed by 232 | Submission Open

Keywords: autism spectrum disorder; developmental factors; genetic contributions; environmental influences; gene– environment interactions; developing therapies

Molecular and Cellular Drivers of Parkinson's Disease

edited by

Fatema Currim

and

Jason Cannon

submission deadline 31 Mar 2026 | Viewed by 231 | Submission Open

Keywords: Parkinson’ s disease; neurodegeneration; mitochondrial dysfunction; α -synuclein aggregation; neurotoxicity; neuroinflammation; oxidative stress; environmental factors; gene– environment interactions; cell death

(This special issue belongs to the Section Cellular Neuroscience)

Neurodegenerative Diseases and Related Proteins

edited by Tian Liu

submission deadline 31 Mar 2026 | Viewed by 228 | Submission Open

Keywords: protein misfolding and aggregation; proteostasis and quality control; neuroinflammation; autophagy and mitophagy; molecular chaperones; Amyloid-β and tau; α -synuclein and TDP-43; multi-omics biomarkers; structural biology; therapeutic targets; mitochondrial– ER crosstalk; genetic and epigenetic regulation

Multi-Omics Technologies in Immunity Within Tumors

edited by

Muhammad A. Alsherbiny

and

Anas M. Abdel Rahman

submission deadline 31 Mar 2026 | Viewed by 212 | Submission Open

Keywords: multi-omics; proteomics; metabolomics; lipidomics; genomics and epigenomics; synergistic combinations for cancer; AI applications in multi-omics integrations; tumor microenvironment (TME); cancer immunotherapy; immuno-oncology; integrative analysis of multi-omics; biomarkers; precision medicine; tumor heterogeneity

Advances in CAR Cell Therapies and Manufacturing

edited by William J. Kelly and Madhuresh C. Sumit

submission deadline 31 Mar 2026 | Viewed by 201 | Submission Open

Keywords: CAR cells; autologous; allogeneic; crispr; lentivirus; expansion; cryopreservation; isolation; biomarker; cytokines

Novel Biomarkers and Dose-Response Modifiers in Radiation Oncology and Nuclear Medicine: Molecular Insights for Personalized Therapy and Precision Medicine

edited by

Wolfgang Sauerwein

and Andrea Wittig

submission deadline 31 Mar 2026 | Viewed by 196 | Submission Open

Keywords: targeted therapies; predictive essays; radiosensitizers; radioprotectors; theranostics; BNCT; alpha-immunotherapy; biological response modifiers; biomarkers

GABA_A Receptor Dynamics: From Cellular Quality Control to Disease Mechanisms

edited by Tingwei Mu and Yajuan Wang

submission deadline 31 Mar 2026 | Viewed by 188 | Submission Open

Keywords: GABAA receptors; trafficking; biogenesis; proteostasis; structure and function; gating; neurotransmission; neurological diseases; disease mechanisms

Stem Cells and Endometrium

edited by Shiying Jin

submission deadline 31 Mar 2026 | Viewed by 175 | Submission Open

Keywords: stem cell; homeostasis; regeneration; endometrium

(This special issue belongs to the Section Stem Cells)

Cell Death and Apoptosis

edited by

Marianna Pap

and

Judit Varga

submission deadline 31 Mar 2026 | Viewed by 166 | Submission Open

Keywords: apoptosis; necroptosis; pyroptosis; ferroptosis; regulated cell death; signaling pathways; tumor biology; resistance mechanisms

(This special issue belongs to the Section Cellular Pathology)

Next-Generation CAR-T Cell Therapy: From Bench to Bedside

edited by

Ping Zhang

and

Yasushi Akahori

submission deadline 31 Mar 2026 | Viewed by 164 | Submission Open

Keywords: chimeric antigen receptor T cells; cytokine release syndrome; immune effector cell-associated neurotoxicity syndrome (ICANS); immunotoxicity; T cell exhaustion; antigen discovery; CAR engineering; mouse models

(This special issue belongs to the Section Cellular Immunology)

From Liver Transplantation to Gene Therapy: A Therapeutic Revolution in Argininosuccinic Aciduria

edited by Sonam Gurung

submission deadline 31 Mar 2026 | Viewed by 138 | Submission Open

Keywords: urea cycle disorder; argininosuccinic aciduria; gene therapies; mRNA therapies; liver transplantation; arginosuccinate lyase (ASL)

Displaying special issue 201-250 on page 5 of 13.

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