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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Extracellular Vesicles in Neurodegenerative Diseases: From Biomarker Discovery to Precision Therapeutics

edited by Mangesh Dattu Hade

submission deadline 30 Nov 2025 | Viewed by 81 | Submission Open

Keywords: neurodegenerative diseases; extracellular vesicles; Alzheimer's disease; Parkinson's disease; multiple sclerosis; blood– brain barrier; neuroinflammation; biomarker discovery; EV-based therapeutics; precision medicine

(This special issue belongs to the Section Cellular Aging)

Cellular and Molecular Mechanisms of Hepatobiliary Diseases

edited by

Stefan Hoehme

and

Jan G. Hengstler

submission deadline 30 Nov 2025 | Viewed by 81 | Submission Open

Keywords: hepatobiliary diseases; bile metabolism; hepatobiliary models; artificial intelligence; cholestatic diseases; systems medicine; spatio-temporal liver models

(This special issue belongs to the Section Tissues and Organs)

Brain Insulin Resistance in Neurodegenerative Disorders and Its Treatments

edited by Konrad Talbot

submission deadline 30 Nov 2025 | Viewed by 79 | Submission Open

Keywords: Alzheimer’ s disease; brain insulin resistance; Down syndrome; incretin receptor agonist; insulin; insulin resistance; multiple system atrophy; neurodegenerative disease; Parkinson’ s disease

(This special issue belongs to the Section Cells of the Nervous System)

New Advances in Cardiac and Vascular Physiology

edited by Robert M. Lust

submission deadline 30 Nov 2025 | Viewed by 63 | Submission Open

Keywords: environmental exposure; immune responses; remodeling; receptors; ischemia; pre-conditioning; post-conditioning; heart failure

(This special issue belongs to the Section Tissues and Organs)

The Spatial and Temporal Dynamics of the Tumor Microenvironment

edited by

Shilpa Bisht

, Abhishek Gupta, Anjali Trivedi and

Alessandra Ferraresi

submission deadline 1 Dec 2025 | Viewed by 439 | Submission Open

Keywords: tumor microenvironment; spatial heterogeneity; spatial transcriptomics; tumor evolution; immune landscape; extracellular matrix; tumor– immune crosstalk; cancer heterogeneity; intra-tumoral heterogeneity; tumor niches

(This special issue belongs to the Section Cell Microenvironment)

Advances in Pulmonary Fibrosis

edited by Sergio Piñeiro Hermida

submission deadline 1 Dec 2025 | Viewed by 189 | Submission Open

Keywords: pulmonary fibrosis; animal models; biomarkers; experimental therapeutics

(This special issue belongs to the Section Cellular Pathology)

The Role of Macrophages and Neutrophils in Chronic Inflammation-Related Disorders

edited by

Pei-Hui Lin

and

Kumaraswami Konda

submission deadline 5 Dec 2025 | 6 articles | Viewed by 15068 | Submission Open

Keywords: chronic inflammation; neutrophils; macrophages; Alzheimer’ s disease; aging; cardiovascular diseases; obesity; cancer; fibrosis; tissue injury and repair

(This special issue belongs to the Section Cellular Immunology)

New Targets and Therapeutic Approaches Based on Molecular Mechanisms in Tumorigenesis and Cancer Metastasis

edited by

Francesc Mitjans

submission deadline 10 Dec 2025 | 2 articles | Viewed by 3919 | Submission Open

Keywords: metastasis; cancer; therapy; precision medicine; cancer stem cells; immuno-oncology; tumor microenvironment; antibody

(This special issue belongs to the Section Cell Microenvironment)

Therapeutic Mechanism of Nervous System Inflammation—Second Edition

edited by

Maria Anttonietta Panaro

and

Antonia Cianciulli

submission deadline 10 Dec 2025 | 1 articles | Viewed by 1798 | Submission Open

Keywords: neuroinflammation; neurodegeneration; therapy; drug target; cell signaling; cells of nervous system

(This special issue belongs to the Section Cells of the Nervous System)

The Role of Stem Cells in Retinal Conditions

edited by

Georgios Panos

, Theo Empeslidis and Lorenzo Motta

submission deadline 10 Dec 2025 | Viewed by 445 | Submission Open

Keywords: stem cells; retinal conditions; regenerative medicine; age-related macular degeneration (AMD); retinitis pigmentosa; diabetic retinopathy; induced pluripotent stem cells (iPSCs); cell differentiation; vision restoration; clinical trials

(This special issue belongs to the Section Stem Cells)

Cell Death Mechanisms and Therapeutic Opportunities in Glioblastoma

edited by

Swapan K. Ray

submission deadline 15 Dec 2025 | 21 articles | Viewed by 68203 | Submission Open

Keywords: apoptosis; autophagy; cell death mechanisms; cell signaling; glioblastoma; therapeutic opportunities

(This special issue belongs to the Section Cells of the Nervous System)

New Advances in Neuroinflammation

edited by

John W. Chen

and Michael Breckwoldt

submission deadline 15 Dec 2025 | 14 articles | Viewed by 51348 | Submission Open

Keywords: neuroinflammation; biomarkers; neurodegeneration; microglia; astrocytes; oligodendrocytes; neurological diseases; blood-brain barrier; imaging

(This special issue belongs to the Section Cells of the Nervous System)

Focus on Machinery of Cell Death

edited by

Subhadip Mukhopadhyay

, Prashanta Kumar Panda and

Suprabhat Mukherjee

submission deadline 15 Dec 2025 | 6 articles | Viewed by 15973 | Submission Open

Keywords: cell death; autophagy; apoptosis; necrosis; ferroptosis; metabolism; stem cell biology; infection; aging; development; Alzheimer’ s; neurodegeneration; therapy

(This special issue belongs to the Section Cellular Pathology)

Epigenetics and DNA Repair: Regulatory Mechanisms and Therapeutic Opportunities

edited by

Vasily M. Studitsky

submission deadline 15 Dec 2025 | 5 articles | Viewed by 8368 | Submission Open

Keywords: DNA damage; DNA repair; epigenetics; chromatin; remodeling

(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)

Exclusive Review Papers in Parkinson's Research

edited by

Wolfgang Jost

and Ronald F. Pfeiffer

submission deadline 15 Dec 2025 | 1 articles | Viewed by 3583 | Submission Open

Keywords: Parkinson’ s disease; alpha-synuclein; substantia nigra; mitochondria; non-motor symptoms; dopamine; levodopa

(This special issue belongs to the Section Cellular Aging)

Mitochondria and Metabolism in Cancer Stem Cells (CSCs)

edited by

Michael Lisanti

and Christopher Albanese

submission deadline 15 Dec 2025 | 2 articles | Viewed by 3474 | Submission Open

Keywords: cancer stem cells; circulating tumor cells; drug resistance; metabolism; mitochondria; OXPHSOS; mitochondrial DNA (mtDNA); glycolysis; cell cycle; DNA damage; other metabolic processes; oxidative stress; senescence; therapeutic approaches

(This special issue belongs to the Section Stem Cells)

Cell Therapies in Cancer Treatment

edited by

Giovanni Amabile

submission deadline 15 Dec 2025 | 1 articles | Viewed by 1775 | Submission Open

Keywords: cellular therapies; cancer; immune

DNA Methylation in Human Health and Disease: From Molecular Mechanisms to Clinical Applications

edited by

Michele Longo

and

Jyotirmoy Das

submission deadline 15 Dec 2025 | 1 articles | Viewed by 1714 | Submission Open

Keywords: DNA methylation; epigenetics; diseases; biomarkers; functional analysis

(This special issue belongs to the Section Cellular Pathology)

Mechanisms and Therapies in Chronic Pain

edited by Nikesh Kunder and June Bryan I. de la Peña

submission deadline 15 Dec 2025 | 1 articles | Viewed by 968 | Submission Open

Keywords: chronic pain; pain mechanisms; pain targets; opioid alternatives; neurobiology; pre-clinical; translational research; pathophysiology; pain management

(This special issue belongs to the Section Cellular Pathology)

Advanced Research in Neurogenesis and Neuroinflammation

edited by

Muskan Gupta

submission deadline 15 Dec 2025 | 1 articles | Viewed by 928 | Submission Open

Keywords: neurogenesis; neuroinflammation; neurodegeneration; neurodegenerative diseases; cognitive functions

(This special issue belongs to the Section Cells of the Nervous System)

Physics of Cancer: How Mechanobiology Drives Cancer Progression

edited by

Claudia Tanja Mierke

submission deadline 15 Dec 2025 | Viewed by 138 | Submission Open

Keywords: migration and invasion of cancer cells; cytomechanics and adhesive properties; cellular mechanotransduction; mechanical signals; viscoelasticity and stiffness; physics of cancer

Functions of Cilia

edited by

Raj Luxmi

submission deadline 15 Dec 2025 | Viewed by 133 | Submission Open

Keywords: cilia; cilia-derived vesicles; ciliopathies; neuronal cilia; motile cilia; primary cilia; ciliary secretion; peptidergic signaling; ectosomes

AMPK: From Mechanisms to New Therapies

edited by

Roland Abi Nahed

and

Farah Diab

submission deadline 15 Dec 2025 | Viewed by 127 | Submission Open

Keywords: metabolism; AMPK; cancer; biosensors; reproduction; metabolic disorders; therapies

Recent Advances in the Understanding of Neuropsychiatric Illnesses

edited by

Junnan Li

and

Wanli Smith

submission deadline 15 Dec 2025 | Viewed by 121 | Submission Open

Keywords: neuropsychiatric disorders; neurodegeneration; synaptic plasticity; neuroinflammation; biomarkers; molecular mechanisms; translational neuroscience; intracellular signaling; neuroimaging

(This special issue belongs to the Section Cells of the Nervous System)

The Cross-Talk Between Obesity and Metabolism

edited by

Hong Shi

submission deadline 15 Dec 2025 | Viewed by 93 | Submission Open

Keywords: obesity; metabolic disorders; insulin resistance; adipose tissue; inflammation; glucose metabolism; lipid metabolism; cardiovascular disease; type 2 diabetes; therapeutic targets

Hormone Receptors in Cancers: From Molecular Insights to Clinical Applications

edited by

Edris Choupani

and Kambiz Hassanzadeh

submission deadline 15 Dec 2025 | Viewed by 92 | Submission Open

Keywords: cancer progression; endocrine therapy resistance; estrogen and androgen receptors; hormone receptors; nuclear receptors; receptor signaling pathways

Organ and Tissue Fibrosis: Molecular Signals and Cellular Mechanisms—Second Edition

edited by

Zhuo Wang

submission deadline 15 Dec 2025 | Viewed by 82 | Submission Open

Keywords: fibrosis; scarring; cytokine; myofibroblasts; extracellular matrix; growth factors; mesenchymal transition

(This special issue belongs to the Section Tissues and Organs)

From Energy Metabolism to Disease: The Multifaceted Roles of Mitochondria

edited by Amy H. Attaway and Saurabh Mishra

submission deadline 15 Dec 2025 | Viewed by 75 | Submission Open

Keywords: mitochondrial oxidation; ROS; aging; disease

The Symphony of Nature—the Precision of Life’s Regulation

edited by Weiguang Wang and Baocheng Liu

submission deadline 15 Dec 2025 | Viewed by 75 | Submission Open

Keywords: protein structure and function; allosteric regulation; conformational switches; enzyme catalysis and modification; molecular machines; molecular regulation; protein folding and misfolding

(This special issue belongs to the Section Cell Methods)

Extracellular Vesicles and Cell Therapies in Regenerative Nephrology and Urology

edited by

Amankeldi Salybekov

and Ciro Tetta

submission deadline 15 Dec 2025 | Viewed by 67 | Submission Open

Keywords: extracellular vesicles (EVs); microRNA (miRNA); acute kidney injury (AKI); chronic kidney disease (CKD); glomerulonephritis; kidney transplantation; fibrosis; mesenchymal stromal cells (MSCs); engineered EVs; single-cell and spatial omics; machine learning and artificial intelligence; ; precision nephrology; GMP manufacturing; regenerative medicine; biomarkers; artificial intelligence (AI)

(This special issue belongs to the Section Cell Microenvironment)

Understanding Nasal Inflammation: The Interplay of Diagnosis, Endotypes, and Environmental Shifts

edited by Simonetta Masieri and

Carlo Cavaliere

submission deadline 15 Dec 2025 | Viewed by 64 | Submission Open

Keywords: rhinology; allergy; immunology; environment; pollution; microbiome; inflammation; united airway disease; lymphocyte cells; interleukins

(This special issue belongs to the Section Tissues and Organs)

Cancer and Immune System Interactions

edited by

Hong-Jian Zhu

and

Bradley Creamer

submission deadline 16 Dec 2025 | Viewed by 99 | Submission Open

Keywords: cancer immunology; tumor microenvironment; immune evasion; immunotherapy; tumor– immune interactions; immune checkpoint regulation; translational oncology

(This special issue belongs to the Section Cell Microenvironment)

Molecular Mechanisms of Tumor Pathogenesis

edited by

Saverio Candido

and Alessandro Lavoro

submission deadline 20 Dec 2025 | 8 articles | Viewed by 17557 | Submission Open

Keywords: cancer; therapeutic targets; biomarkers; epigenetics; DNA methylation; microRNAs; somatic mutations; germline mutations; chromatin remodeling; histone modifications

(This special issue belongs to the Section Cellular Pathology)

Physiology of Telocytes

edited by

Catalin G. Manole

and Mihail E. Hinescu

submission deadline 20 Dec 2025 | 1 articles | Viewed by 4177 | Submission Open

Keywords: telocytes; telopodes; physiology; pathology; tissue homeostasis; regenerative medicine

(This special issue belongs to the Section Cellular Pathology)

Molecular Mechanisms of Cognitive Function and Dysfunction

edited by

Parasuraman Padmanabhan

Balázs Gulyás

and

Domokos Máthé

submission deadline 20 Dec 2025 | 1 articles | Viewed by 2614 | Submission Open

Keywords: cognition; neurodevelopment; neurotransmission; molecular mecanisms; signaling; disorders; therapy

(This special issue belongs to the Section Cells of the Nervous System)

Metabolic Hallmarks in Cancer

edited by

Michael Lisanti

, Ubaldo Martinez-Outshoorn and Marta Mauro-Lizcano

submission deadline 20 Dec 2025 | 2 articles | Viewed by 2202 | Submission Open

Keywords: cancer; metabolic reprogramming; metabolic adaptation; cancer energy metabolism; glycolysis; the Warburg effect; the reverse Warburg effect; glutamine addiction; the pentose phosphate pathway; cellular and molecular mechanisms; tumor microenvironment; novel therapeutic interventions

(This special issue belongs to the Section Cellular Metabolism)

Advances in Human Pluripotent Stem Cells

edited by

Peggy Arthur

Sangeetha Kandoi

and

Nagavendra Kommineni

submission deadline 20 Dec 2025 | 1 articles | Viewed by 947 | Submission Open

Keywords: human pluripotent stem cells; embryonic stem cells; induced pluripotent stem cells

(This special issue belongs to the Section Stem Cells)

Microglial Functions in Neurodegenerative Diseases: In Search of Potential Therapeutic Targets

edited by

Laura Jiménez Sánchez

and María Martín Estebané

submission deadline 20 Dec 2025 | Viewed by 270 | Submission Open

Keywords: microglia; inflammation; neural damage; mitochondria; potential targets

(This special issue belongs to the Section Cellular Aging)

Advanced Research on Genomic Instability and Gene Expression in Developmental Disorders

edited by

Shenzhao Lu

submission deadline 20 Dec 2025 | Viewed by 157 | Submission Open

Keywords: development; neurological disease; cancer; genetic; epigenetic

State-of-the-Art Insights into the Cell Microenvironment

edited by

Said M. Afify

submission deadline 20 Dec 2025 | Viewed by 119 | Submission Open

Keywords: cell microenvironment; stem cells; organoid and 3D culture models

(This special issue belongs to the Section Cell Microenvironment)

Acute Myeloid Leukemia: Molecular Mechanisms and Novel Therapies

edited by Xiangguo Shi

submission deadline 20 Dec 2025 | Viewed by 101 | Submission Open

Keywords: acute myeloid leukemia (AML); genomics and epigenetics; therapeutic resistance; metabolic reprogramming; clonal evolution

(This special issue belongs to the Section Cellular Pathology)

Evaluation of the Properties and Effectiveness of Nutritional Factors Using In Vitro Assays, Including Cell Cultures and Organoids

edited by

Joanna Romanek

and Sylwia Orczewska-Dudek

submission deadline 20 Dec 2025 | Viewed by 93 | Submission Open

Keywords: cell cultures; organoids; novel nutritional factors; extract; cells viability; cells proliferation; cells cytotoxicity; cell signaling; cells apoptosis; oxidative stress

Clockwork Cells: Decoding the Language of Cell Cycle Regulators

edited by

Guanxiong Yan

, Kyung-sang Lee,

Richard W. Wong

and

Gary S. Stein

submission deadline 20 Dec 2025 | Viewed by 80 | Submission Open

Keywords: cyclins; cyclin-dependent kinases (CDKs); checkpoints; cell proliferation; mitosis; meiosis

(This special issue belongs to the Section Cell Proliferation and Division)

Targeting Thermogenesis in Metabolic Disorders: Novel Pharmacological and Lifestyle Interventions

edited by

Atefeh Rabiee

submission deadline 20 Dec 2025 | Viewed by 69 | Submission Open

Keywords: thermogenesis modulation; metabolic disorders; obesity; adipose tissue biology; thermogenic mechanisms; mitochondrial function

Functional Genomics and Morphological Profiling in Saccharomyces cerevisiae

edited by

Yoshikazu Ohya

and Hisao Moriya

submission deadline 24 Dec 2025 | 1 articles | Viewed by 127 | Submission Open

Keywords: functional genomics; morphological profiling; Saccharomyces cerevisiae; overexpression

(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)

Cellular Differentiation in Health and Disease

edited by Christine K. C. Loo and

Grant A. Ramm

submission deadline 25 Dec 2025 | 1 articles | Viewed by 1312 | Submission Open

Keywords: cellular differentiation; tumour microenvironment; human development; regeneration/healing; cell signaling pathways; tumour differentiation

(This special issue belongs to the Section Cell Microenvironment)

Advances in Molecular Genomics and Pathology of Cancers

edited by

Muhammad Kibriya

submission deadline 25 Dec 2025 | Viewed by 170 | Submission Open

Keywords: cancer; somatic mutation; short tandem repeat; gene expression; methylation; cf-DNA; single-cell sequencing; NGS; liquid biopsy; precision medicine

(This special issue belongs to the Section Cellular Pathology)

Dysregulated Synaptic Plasticity in Chronic Pain: Molecular Mechanisms, Circuit Dysfunction, and Translational Approaches

edited by