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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Cellular and Molecular Mechanisms of Liver Diseases

edited by Jieyun Jiang

submission deadline 31 Mar 2026 | 3 articles | Viewed by 6618 | Submission Open

Keywords: liver; alcoholic liver disease (ALD); viral hepatitis; metabolic associated steatotic liver disease (MASLD); autoimmune hepatitis; drug-induced liver injury; liver fibrosis and cirrhosis; liver cancer; cellular and molecular mechanisms

(This special issue belongs to the Section Cellular Pathology)

Computational Biophysics in Cellular Biological Systems

edited by

Lin Li

and Wenhan Guo

submission deadline 31 Mar 2026 | 2 articles | Viewed by 5453 | Submission Open

Keywords: cellular process; protein– protein interactions; single-cell analysis; drug design; molecular dynamics simulations

(This special issue belongs to the Section Cell Methods)

Advances in Reproductive Biology: Cellular and Molecular Mechanisms

edited by

Rosa Roy

and Clara González-Marín

submission deadline 31 Mar 2026 | 4 articles | Viewed by 5334 | Submission Open

Keywords: gametogenesis; fertilization; embryo implantation; reproductive genetics; epigenetics in reproduction; hormonal signaling; stem cells and reproduction; assisted reproductive technologies (ARTs); molecular fertility regulation; reproductive health innovations

(This special issue belongs to the Section Reproductive Cells and Development)

Drosophila as a Model for Understanding Human Disease

edited by Zhe Han

submission deadline 31 Mar 2026 | 4 articles | Viewed by 5055 | Submission Open

Keywords: Drosophila melanogaster; human disease models; genetic and molecular mechanisms; neurodegenerative diseases; cardiovascular diseases; cancer biology; metabolic disorders; high-throughput screening; precision medicine; translational research

(This special issue belongs to the Section Cellular Pathology)

Signaling Pathways Involved in Tumor Microenvironment and Tumor Adaptation to Stresses

edited by Nianli Sang

submission deadline 31 Mar 2026 | 2 articles | Viewed by 4488 | Submission Open

Keywords: microenvironment; metabolic stress; hypoxia; chemoresistance; radiation resistance; apoptosis; metabolic reprogramming; metastasis

(This special issue belongs to the Section Cell Signaling)

Axonal Transport: Mechanisms, Disorders, and Therapeutic Approaches

edited by Yuxiang Xie and Jingqi Yan

submission deadline 31 Mar 2026 | 1 articles | Viewed by 4407 | Submission Open

Keywords: axonal transport; motor proteins; autophagy– lysosome pathway; neurodegenerative diseases; therapeutic strategies

(This special issue belongs to the Section Cellular Neuroscience)

Modulation of Senescence and Differentiation in Human Mesenchymal Stem Cells

edited by

Federica Facchin

and

Silvia Canaider

submission deadline 31 Mar 2026 | 3 articles | Viewed by 3595 | Submission Open

Keywords: tissue-specific mesenchymal stem cells; cell senescence; cell differentiation; natural and synthetic molecules; tissue engineering; regenerative medicine

(This special issue belongs to the Section Stem Cells)

Molecular Insights into Vascular Physiology and Pathology

edited by Suravi Majumder

submission deadline 31 Mar 2026 | 3 articles | Viewed by 3285 | Submission Open

Keywords: vascular physiology; vascular pathology; endothelial cells; vascular smooth muscle cells; vascular inflammation; vascular signaling; vascular aging; vascular remodeling; atherosclerosis; cardiovascular diseases; biomarkers; novel therapeutic approaches

(This special issue belongs to the Section Cellular Pathology)

Cellular Mechanisms in Pregnancy and Foetal Development

edited by

Anya L. Arthurs

and

Giovanni Levi

submission deadline 31 Mar 2026 | 3 articles | Viewed by 2948 | Submission Open

Keywords: pregnancy; fetus; reproduction; placenta; maternal; fertility; preeclampsia; fetal growth restriction; gestational diabetes; stillbirth

Kidney Injury Biomarkers: From Early Detection to Transition to Chronic Kidney Disease

edited by

Alexander E. Berezin

submission deadline 31 Mar 2026 | 1 articles | Viewed by 2738 | Submission Open

Keywords: acute kidney injury; acute kidney disease; chronic kidney disease; circulating biomarkers; urinary biomarkers; multiple biomarker panel; diagnosis; prediction; management

(This special issue belongs to the Section Tissues and Organs)

Lung Cancer: Molecular Mechanisms and Therapeutic Opportunities

edited by

Sherri R. Cervantes

and

Daruka Mahadevan

submission deadline 31 Mar 2026 | 2 articles | Viewed by 1869 | Submission Open

Keywords: precision oncology; immunotherapy; targeted therapy; genomic characterization; biomarker; microenvironment; non-small cell lung cancer; small cell lung cancer

(This special issue belongs to the Section Cell Microenvironment)

Mechanisms of Modulation of Sensory Plasticity in the Cerebral Cortex

edited by

Ángel A. Núñez

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1740 | Submission Open

Keywords: synaptic plasticity; synapses; LTP; LTD; ionotropic and metabotropic receptors

(This special issue belongs to the Section Cellular Neuroscience)

From Energy Metabolism to Disease: The Multifaceted Roles of Mitochondria

edited by Amy H. Attaway and Saurabh Mishra

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1735 | Submission Open

Keywords: mitochondrial oxidation; ROS; aging; disease

The Challenges and Opportunities of Mesenchymal Stromal Cells in Regenerative Medicine

edited by

Lucie Bacakova

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1732 | Submission Open

Keywords: mesenchymal stromal cells; mesenchymal stem cells; medicinal signaling cells; multipotent stem cells; paracrine secretion; angiogenesis; immunomodulation; cell therapy; cell-free cell-based therapy; stem cell differentiation; tissue engineering

The Interplay Between Tumor Metabolism, Microenvironment and Cell Survival

edited by

Silvia Peppicelli

and Giulio Menegazzi

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1063 | Submission Open

Keywords: tumor microenvironment; metabolic cross-talk; metabolic reprogramming; extracellular vesicles; cell survival; therapy resistance

(This special issue belongs to the Section Cell Microenvironment)

Cellular and Molecular Mechanisms of Alcohol-Induced Cellular/Organ Injury and Regeneration

edited by Mukund Srinivasan

submission deadline 31 Mar 2026 | 1 articles | Viewed by 998 | Submission Open

Keywords: alcohol use disorder; ethanol; liver; lung; pancreas; gut; brain; cellular toxicity; alcohol metabolism; alcohol metabolites; oxidative stress; mitochondrial stress; ER stress

Pediatric Liver Tumors: Molecular Mechanisms and Therapeutic Strategies

edited by

Edward V. Prochownik

submission deadline 31 Mar 2026 | 1 articles | Viewed by 707 | Submission Open

Keywords: hepatoblastoma; hepatocellular carcinoma; pediatric liver tumors; fibrolamellar carcinoma; Beck-with-Wiedmann syndrome; hereditary tyrosinemia; molecular mechanisms; therapeutic strategies

Therapeutic Targeting of MicroRNAs in Human Cancer

edited by

Behzad Mansoori

submission deadline 31 Mar 2026 | 1 articles | Viewed by 524 | Submission Open

Keywords: microRNAs; nanoparticle platforms; spatial miRNomics; combination therapeutic strategies

(This special issue belongs to the Section Cell and Gene Therapy)

Cellular and Molecular Insights into Allergies and Allergic Diseases

edited by

Toshiaki Kawakami

submission deadline 31 Mar 2026 | Viewed by 379 | Submission Open

Keywords: allergy; immune regulation; mast cells; Th2 responses; epithelial barrier; IgE; inflammation; cellular signaling; molecular mechanisms

(This special issue belongs to the Section Cellular Immunology)

Mechanisms and Dynamics in Cellular Adhesion in Development and Disease

edited by

Daniel Bouvard

submission deadline 31 Mar 2026 | Viewed by 358 | Submission Open

Keywords: actin; integrin; cell adhesion; signalling; mechanotransduction

Membrane Trafficking Components and Mechanisms in Bacterial, Viral or Fungal Infections

edited by

Bor Luen Tang

submission deadline 31 Mar 2026 | Viewed by 325 | Submission Open

Keywords: bacterial intracellular infections; bacterial intracellular sanctuaries; viral infection; viral hijacking of host trafficking machinery; membrane trafficking; Rab; secretory pathway; endocytic pathway; viral replication

Cellular and Molecular Insights into Gynecologic Tumors

edited by

Mladen Anđić

and

Jianjun Wei

submission deadline 31 Mar 2026 | Viewed by 312 | Submission Open

Keywords: gynecologic cancers; cervical cancer; endometrial cancer; ovarian tumors; tumor microenvironment; molecular biomarkers; genetic mutations; targeted therapies

Organelle Crosstalk: New Insights into Intracellular Communication and Dynamics

edited by

Jonathan Barra

submission deadline 31 Mar 2026 | Viewed by 305 | Submission Open

Keywords: organelle contact sites; membrane contact sites; intracellular communication; early endosomes; recycling endosomes; Golgi; mitochondrial dynamics; ER stress; mitophagy; autophagy; lysosome; calcium signaling; lipid transfer; proteostasis

PI3K/AKT/mTOR Signaling Network in Human Health and Diseases, 3rd Edition

edited by

Jean Christopher Chamcheu

Claudia Bürger

and

Shile Huang

submission deadline 31 Mar 2026 | Viewed by 273 | Submission Open

Keywords: acne; ageing; Akt; Alzheimer’ s disease; autophagy; autoimmunity; PI3K; mTOR; cancer; cardiovascular diseases; diabetes; growth; hamartoma; hypertrophy; inflammation; neurologic; tuberous sclerosis; systemic sclerosis; obesity; Parkinson’ s disease; psoriasis; atopic dermatitis; burns/wound healing; targeted therapy; natural products; biologics

Ubiquitin Ligases: Key Regulators in Cellular Homeostasis and Disease

edited by Praveen Koganti and

Michal Goldberg

submission deadline 31 Mar 2026 | Viewed by 257 | Submission Open

Keywords: ubiquitin ligases; protein ubiquitination; cellular homeostasis; proteasome pathway

Molecular and Cellular Drivers of Parkinson's Disease

edited by

Fatema Currim

and

Jason Cannon

submission deadline 31 Mar 2026 | Viewed by 253 | Submission Open

Keywords: Parkinson’ s disease; neurodegeneration; mitochondrial dysfunction; α -synuclein aggregation; neurotoxicity; neuroinflammation; oxidative stress; environmental factors; gene– environment interactions; cell death

(This special issue belongs to the Section Cellular Neuroscience)

Current Research on Immunotherapy for Glioblastoma

edited by Markella Zannikou

submission deadline 31 Mar 2026 | Viewed by 251 | Submission Open

Keywords: GBM; tumor microenvironment; cancer vaccines; TIL (tumor-infiltrating lymphocytes) therapy; combination therapy; BiTEs; immune checkpoint therapy; CAR T-cell therapy; peptide/dendritic vaccines; tumor-associated antigens; oncolytic virotherapy

(This special issue belongs to the Section Cellular Immunology)

Neurodevelopmental Factors of Autism Spectrum Disorder: Etiology to Therapy

edited by

George Ayoub

submission deadline 31 Mar 2026 | Viewed by 250 | Submission Open

Keywords: autism spectrum disorder; developmental factors; genetic contributions; environmental influences; gene– environment interactions; developing therapies

Neurodegenerative Diseases and Related Proteins

edited by Tian Liu

submission deadline 31 Mar 2026 | Viewed by 242 | Submission Open

Keywords: protein misfolding and aggregation; proteostasis and quality control; neuroinflammation; autophagy and mitophagy; molecular chaperones; Amyloid-β and tau; α -synuclein and TDP-43; multi-omics biomarkers; structural biology; therapeutic targets; mitochondrial– ER crosstalk; genetic and epigenetic regulation

Advances in CAR Cell Therapies and Manufacturing

edited by William J. Kelly and Madhuresh C. Sumit

submission deadline 31 Mar 2026 | Viewed by 231 | Submission Open

Keywords: CAR cells; autologous; allogeneic; crispr; lentivirus; expansion; cryopreservation; isolation; biomarker; cytokines

Multi-Omics Technologies in Immunity Within Tumors

edited by

Muhammad A. Alsherbiny

and

Anas M. Abdel Rahman

submission deadline 31 Mar 2026 | Viewed by 228 | Submission Open

Keywords: multi-omics; proteomics; metabolomics; lipidomics; genomics and epigenomics; synergistic combinations for cancer; AI applications in multi-omics integrations; tumor microenvironment (TME); cancer immunotherapy; immuno-oncology; integrative analysis of multi-omics; biomarkers; precision medicine; tumor heterogeneity

Novel Biomarkers and Dose-Response Modifiers in Radiation Oncology and Nuclear Medicine: Molecular Insights for Personalized Therapy and Precision Medicine

edited by

Wolfgang Sauerwein

and Andrea Wittig

submission deadline 31 Mar 2026 | Viewed by 214 | Submission Open

Keywords: targeted therapies; predictive essays; radiosensitizers; radioprotectors; theranostics; BNCT; alpha-immunotherapy; biological response modifiers; biomarkers

GABA_A Receptor Dynamics: From Cellular Quality Control to Disease Mechanisms

edited by Tingwei Mu and Yajuan Wang

submission deadline 31 Mar 2026 | Viewed by 202 | Submission Open

Keywords: GABAA receptors; trafficking; biogenesis; proteostasis; structure and function; gating; neurotransmission; neurological diseases; disease mechanisms

Stem Cells and Endometrium

edited by Shiying Jin

submission deadline 31 Mar 2026 | Viewed by 184 | Submission Open

Keywords: stem cell; homeostasis; regeneration; endometrium

(This special issue belongs to the Section Stem Cells)

Cell Death and Apoptosis

edited by

Marianna Pap

and

Judit Varga

submission deadline 31 Mar 2026 | Viewed by 180 | Submission Open

Keywords: apoptosis; necroptosis; pyroptosis; ferroptosis; regulated cell death; signaling pathways; tumor biology; resistance mechanisms

(This special issue belongs to the Section Cellular Pathology)

Next-Generation CAR-T Cell Therapy: From Bench to Bedside

edited by

Ping Zhang

and

Yasushi Akahori

submission deadline 31 Mar 2026 | Viewed by 172 | Submission Open

Keywords: chimeric antigen receptor T cells; cytokine release syndrome; immune effector cell-associated neurotoxicity syndrome (ICANS); immunotoxicity; T cell exhaustion; antigen discovery; CAR engineering; mouse models

(This special issue belongs to the Section Cellular Immunology)

Regulation of Ca²⁺ Signals in Human Disease

edited by Yandong Zhou

submission deadline 31 Mar 2026 | Viewed by 154 | Submission Open

Keywords: calcium signaling; cellular homeostasis; disease mechanisms; calcium channels; therapeutic targets

(This special issue belongs to the Section Cell Signaling)

From Liver Transplantation to Gene Therapy: A Therapeutic Revolution in Argininosuccinic Aciduria

edited by Sonam Gurung

submission deadline 31 Mar 2026 | Viewed by 151 | Submission Open

Keywords: urea cycle disorder; argininosuccinic aciduria; gene therapies; mRNA therapies; liver transplantation; arginosuccinate lyase (ASL)

Lung Diseases: From Cellular and Molecular Mechanisms to Targeted Therapies

edited by

Christoph Beisswenger

and Daniela Yildiz

submission deadline 31 Mar 2026 | Viewed by 144 | Submission Open

Keywords: lung diseases; cellular and molecular mechanisms; targeted therapies; OMICS; single-cell sequencing

Cellular and Molecular Mechanisms in Aging

edited by Michel Satya Naslavsky and Mateus Vidigal

submission deadline 1 Apr 2026 | 2 articles | Viewed by 2525 | Submission Open

Keywords: cellular senescence; aging models; DNA repair; neurodegeneration; elderly

(This special issue belongs to the Section Cellular Aging)

Glycolysis in Tumorigenesis: Mechanisms and Therapeutic Implications

edited by

Fabrizio Marcucci

, Shibo Wei and

Marco Cordani

submission deadline 1 Apr 2026 | Viewed by 223 | Submission Open

Keywords: glycolysis; tumorigenesis; moonlighting functions; Warburg effect; metabolic reprogramming; tumor microenvironment; therapeutic targets; cancer metabolism

Evolution, Structure, and Functions of Apolipoproteins L

edited by Etienne Pays

submission deadline 10 Apr 2026 | 4 articles | Viewed by 9484 | Submission Open

Keywords: APOL1 nephropathy; APOL1 risk variants; membrane traffic; membrane fission; membrane fusion; membrane dynamics; autophagy; mitophagy; viral replication; lipid droplets; pathogen resistance; inflammation

Novel and Experimental Strategies for the Treatment of Neurodegenerative Diseases

edited by

Morten Meyer

and Justyna Okarmus

submission deadline 10 Apr 2026 | 3 articles | Viewed by 7800 | Submission Open

Keywords: neurodegenerative diseases; experimental treatments; stem cell transplantation; immunotherapy; gene therapy; focused ultrasound; neuroprotective agents; Parkinson's disease; Alzheimer's disease; Huntington’ s disease; amyotrophic lateral sclerosis

(This special issue belongs to the Section Cellular Neuroscience)

Galectins in Cancer, Fibrosis and Immune Modulation: Mechanisms, Therapeutic Strategies and Translational Advances

edited by Tsung-Chieh Shih

submission deadline 10 Apr 2026 | 3 articles | Viewed by 6094 | Submission Open

Keywords: Galectin; tumor microenvironment; immunosuppression; fibrosis; epithelial– mesenchymal transition (EMT); cancer metastasis; immune evasion; therapy resistance; myeloid-derived suppressor cells (MDSCs); tumor-associated macrophages (TAMs); extracellular matrix remodeling; Galectin-targeted therapy; combination immunotherapy; fibroblast activation; chronic inflammation; tumor– stroma interactions; novel inhibitors of Galectins

(This special issue belongs to the Section Cellular Immunology)

New Tools to Address Old Challenges in Tolerogenic Cellular Therapies

edited by Konstantinos Mengrelis and

Nina Pilat

submission deadline 10 Apr 2026 | Viewed by 198 | Submission Open

Keywords: tolerogenic strategies; immune tolerance; allogeneic cellular therapies; autoimmunity; allergy; systems immunology; artificial intelligence; biomarkers; immune regulation

Cellular Mechanisms of Testosterone in Metabolic Disorders

edited by Daniel M. Kelly

submission deadline 13 Apr 2026 | Viewed by 164 | Submission Open

Keywords: testosterone; metabolism; type 2 diabetes; obesity; metabolic syndrome; MASLD; skeletal muscle; adipose tissue; insulin resistance; endocrine signalling

Modeling Developmental Processes and Disorders in Zebrafish

edited by

Natascia Tiso

and

Francesco Argenton

submission deadline 15 Apr 2026 | 13 articles | Viewed by 59595 | Submission Open

(This special issue belongs to the Section Cellular Biophysics)

Pathogenic Mechanisms of Chronic Inflammation-Associated Cancer

edited by Emiko Mizoguchi

submission deadline 15 Apr 2026 | 5 articles | Viewed by 29150 | Submission Open

Keywords: chronic inflammation; dysplasia; neoplasia; oncogene; cytokine; colitis-associated cancer

(This special issue belongs to the Section Cellular Pathology)

Role of Thyroid Hormone in Neurodegenerative and Neurodevelopmental Disorders

edited by Janaína Sena de Souza

submission deadline 15 Apr 2026 | 5 articles | Viewed by 12565 | Submission Open

Keywords: thyroid hormones; neurodevelopmental and neurodegenerative disorders; central nervous system

(This special issue belongs to the Section Cellular Neuroscience)

Advances in Zebrafish Disease Models

edited by

Natalia Kasica

and

Jaroslaw Widelski

submission deadline 15 Apr 2026 | 4 articles | Viewed by 7825 | Submission Open

Keywords: zebrafish; human disease models; experimental disease models; novel drugs and therapies; organic diseases; functional disorders

Displaying special issue 201-250 on page 5 of 14.

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