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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Signaling Pathways in Endometrial Cancer Cells

edited by

Tomohiko Fukuda

submission deadline 20 Jan 2026 | 4 articles | Viewed by 9602 | Submission Open

Keywords: endometrial cancer; cellular signaling; cell metabolism; DNA damage repair pathway; the PI3K/AKT/mTOR pathway; the RAS/MAPK pathway; molecular classification

(This special issue belongs to the Section Cell Signaling)

New Trends and Advances in Diagnosis and Prognosis of Head and Neck Cancer from Carcinogenesis to Future Molecular Targeted Therapies: 2nd Edition

edited by

Piotr Cierpikowski

and

Julia Bar

submission deadline 20 Jan 2026 | 5 articles | Viewed by 8693 | Submission Open

Keywords: head and neck cancer; oral cancer; biomarker; prognosis; carcinogenesis; oral premalignant lesions; cancer stem cells; signaling pathways; molecular targeted therapy

(This special issue belongs to the Section Cellular Pathology)

Adipose-Derived Stem Cells: Current Applications and Future Directions

edited by

Yasuhito Ishigaki

submission deadline 20 Jan 2026 | 4 articles | Viewed by 6536 | Submission Open

Keywords: cell therapy; regenerative medicine; adipose-derived stem cells (ADSCs); exosome; cytokine

(This special issue belongs to the Section Stem Cells)

Pathophysiology of Signal Transduction in Cardiovascular and Pulmonary Disease: 2nd Edition

edited by

Yung-Hsin Yeh

and

Ying-Ju Lai

submission deadline 20 Jan 2026 | 1 articles | Viewed by 2237 | Submission Open

Keywords: cardiac arrhythmia; atrium; ventricle; pulmonary; vascular; signal transduction

(This special issue belongs to the Section Cellular Pathology)

Mitochondria at the Crossroad of Health and Disease—Second Edition

edited by

Nickolay Brustovetsky

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1670 | Submission Open

Keywords: mitochondria; oxidative phosphorylation; mitochondrial ion transport; permeability transition pore; mitochondrial ROS generation; mitochondrial quality control; mitochondrial traffic; mitochondrial morphology; mitochondrial dynamics; mitophagy

(This special issue belongs to the Section Cellular Aging)

Neurotoxicity and Neurodegenerative Diseases: The Potential of Regenerative Medicine

edited by Elisabetta Mormone, Paola Crociani and

Gianluigi Ubaldo Mazzoccoli

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1505 | Submission Open

Keywords: inflammation; iPSCs; MSCs; neural stem cells niche; neurodegeneration; regenerative medicine; ROS; PRP

(This special issue belongs to the Section Cellular Aging)

Applications of Proteomics in Human Diseases and Treatments

edited by

Giovanni Cuda

and

Marco Gaspari

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1148 | Submission Open

Keywords: biomarkers; clinical proteomics; single-cell proteomics; next-generation proteomics; biofluids; high-throughput proteomics

(This special issue belongs to the Section Cell Methods)

Role of Cell Organelles in Normal Aging, Senescence, and Cancer

edited by

Michael Lisanti

and Christopher Albanese

submission deadline 20 Jan 2026 | Viewed by 510 | Submission Open

Keywords: aging; accumulated damage; ROS-induced damage; protein aggregation; senescence; cancer; senescence escape; cell organelles; mitochondria; lysosomes; SASP; inflammation; IL1-beta/IL-6/IL-8

(This special issue belongs to the Section Cellular Aging)

Cellular Origin of Glioma: From Triggers to Treatments

edited by Katherine Karakoula

submission deadline 20 Jan 2026 | Viewed by 325 | Submission Open

Keywords: glioblastoma; brain tumour; tumour heterogeneity; targeted therapy; glioma stem cells

Study on Human Mesenchymal Stem Cells—2nd Edition

edited by

Michela Noseda

submission deadline 20 Jan 2026 | Viewed by 320 | Submission Open

Keywords: mesenchymal stem cells; disease; cardiac; therapy

(This special issue belongs to the Section Stem Cells)

The Evolving Landscape of Cell and Gene Therapy—Opportunities, Challenges and the Road Ahead

edited by

Rai Ajit K. Srivastava

submission deadline 20 Jan 2026 | Viewed by 165 | Submission Open

Keywords: cell therapy; gene therapy/gene editing; micro RNAs; rare diseases; metabolic disease; cancer; diabetes; proatherogenic lipoproteins; drug discovery; ASO

Intestinal Stem Cells

edited by

Natalia Soshnikova

and

Arunkumar Jagadeesan

submission deadline 20 Jan 2026 | Viewed by 163 | Submission Open

Keywords: stem cells; self-renewal; enterocytes; intestinal organoid; villus; crypt

(This special issue belongs to the Section Stem Cells)

Gliomas: Molecular Insights, Next-Generation Therapies, and Precision Targeting

edited by

Mehdi Sanati

submission deadline 20 Jan 2026 | Viewed by 124 | Submission Open

Keywords: gliomas; molecular targets; precision oncology; immunotherapy; gene editing; tumor microenvironment

Molecular Basis of Gynecological Disorders and Associated Infertility

edited by

Ahmad Albaghdadi

and

Nihar R. Nayak

submission deadline 20 Jan 2026 | Viewed by 85 | Submission Open

Keywords: gynecological disorders; endometriosis; polycystic ovary syndrome (PCOS); cervical cancer; ovarian cancer; uterine and vaginal pathologies

(This special issue belongs to the Section Cellular Pathology)

Fibrosis in Chronic Inflammatory Diseases

edited by

Mirko Manetti

Irene Rosa

and

Eloisa Romano

submission deadline 25 Jan 2026 | 8 articles | Viewed by 16560 | Submission Open

Keywords: fibrosis; fibroblasts; myofibroblasts; inflammation; molecular pathways; pathogenetic mechanisms; therapeutic targets

(This special issue belongs to the Section Cellular Pathology)

Targeting Hallmarks of Cancer

edited by

Carlos Pérez Plasencia

submission deadline 25 Jan 2026 | 3 articles | Viewed by 5973 | Submission Open

Keywords: epigenetic regulators; organotypic culture models; anticancer drugs; hallmarks of cancer

Soluble Interleukin-6 Receptor (sIL-6R): Role in Health and Disease

edited by

Rebecca Aicheler

and

Richard Webb

submission deadline 25 Jan 2026 | 1 articles | Viewed by 1129 | Submission Open

Keywords: sIL-6R; IL-6 signalling; IL-6ST; genetic polymorphism; health; disease; exercise physiology; therapeutics; mental health

(This special issue belongs to the Section Cell Signaling)

The Role of T Cells in Type 1 Diabetes

edited by

Ismail Syed

and

Mayur S. Parmar

submission deadline 25 Jan 2026 | Viewed by 512 | Submission Open

Keywords: T cells; inflammation; T cell receptor; type 1 diabetes

(This special issue belongs to the Section Cellular Immunology)

Decoding the Tumor-Immune Intersection: Opportunities for Breakthroughs in Cancer Therapies

edited by

Qiwei Wang

submission deadline 25 Jan 2026 | 1 articles | Viewed by 482 | Submission Open

Keywords: immuno-oncology; tumor-immune interface; tumor microenvironment; cancer immunotherapy; targeted therapy; immunometabolism; oncometabolism; epigenetics; combination strategies

(This special issue belongs to the Section Cellular Immunology)

Targeting Immune Dysfunction in Aging and Age-Related Diseases

edited by

Anna Aiello

and

Anna Calabrò

submission deadline 25 Jan 2026 | Viewed by 173 | Submission Open

Keywords: immunosenescence; inflammaging; immune dysfunction; aging; age-related diseases (ARDs); immune– metabolic interactions; immunomodulators; immunoceuticals; senotherapeutics; lifestyle interventions

Metabolic Flexibility in Cancer: How Tumor Cells Adapt Their Metabolism to Growth and Spread

edited by Erica Pranzini

submission deadline 25 Jan 2026 | Viewed by 171 | Submission Open

Keywords: cancer metabolism; metabolic plasticity; tumor microenvironment; oncometabolites; targeting cancer metabolism

Induced Pluripotent Stem Cells (iPSCs): Molecular and Cellular Mechanisms

edited by Masmoudi-Kouki Olfa and

Gérard Lizard

submission deadline 25 Jan 2026 | Viewed by 130 | Submission Open

Keywords: iPSCs; gene regulation; epigenetic reprogramming; cellular signaling; disease modeling

(This special issue belongs to the Section Stem Cells)

Plant Stress and Acclimation Responses During Global Warming

edited by

Stanisław Karpiński

submission deadline 25 Jan 2026 | Viewed by 122 | Submission Open

Keywords: acclimatory responses in plants; chloroplast retrograde and nuclear anterograde signaling; excess light and heat shock responses; global warming and regulation of gene expression; energy dissipation as heat and cell death regulation; photosynthesis; stomatal conductance and transpiration regulation during heat waves

(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)

Immune Cell Signaling Networks in Tumor and Regenerative Stem Cell Niches

edited by

Luigi Racioppi

submission deadline 25 Jan 2026 | Viewed by 77 | Submission Open

Keywords: tumor microenvironment; stem cell niche; macrophage polarization; T-cell activation; immune checkpoints; targetable signaling pathways; engineered biomaterials; immune signaling in 3D culture; organ-on-chip models; single-cell omics

(This special issue belongs to the Section Stem Cells)

The Developments and Applications of Vibrational Spectroscopy in Cellular Research

edited by

Maria Lasalvia

submission deadline 25 Jan 2026 | Viewed by 68 | Submission Open

Keywords: vibrational spectroscopy; FT-IR spectroscopy; Raman spectroscopy; biomedical diagnostics; cancer research; Alzheimer’ s disease; neurodegeneration; tissue engineering; spectroscopic biomarkers; label-free imaging

(This special issue belongs to the Section Cell Methods)

Insights into the Pathophysiology of NeuroCOVID: Current Topics

edited by

Christian Barbato

Antonio Minni

and

Carla Petrella

submission deadline 26 Jan 2026 | 1 articles | Viewed by 1265 | Submission Open

Keywords: neuroCOVID; longCOVID; neurocognitive; cellular and molecular neurobiology; brain fog; anxiety; depression; biomarkers; translational biomedicine; neurodegenerative diseases

(This special issue belongs to the Section Cellular Pathology)

Neuronal Development and Disease: From Molecular Bases to Neurological Disorders

edited by Ramiro Almeida

submission deadline 30 Jan 2026 | 4 articles | Viewed by 4898 | Submission Open

Keywords: neuronal development; neurological disorders; neurogenesis; neuroinflammation; synaptic plasticity

(This special issue belongs to the Section Cells of the Nervous System)

The Roles of the Extracellular Matrix in Cardiac Structure and Function: A Commemorative Issue in Honor of Dr. Thomas K. Borg

edited by

Wayne Carver

and Edie Goldsmith

submission deadline 30 Jan 2026 | 5 articles | Viewed by 4164 | Submission Open

Keywords: collagen; integrin; extracellular matrix; cardiomyocyte; fibroblast; heart bioengineering

(This special issue belongs to the Section Cell Microenvironment)

Mechanisms Underlying Cardiovascular Aging

edited by Soheil Saeedi

submission deadline 30 Jan 2026 | 2 articles | Viewed by 2894 | Submission Open

Keywords: cardiovascular aging; cellular senescence; epigenetic clock; endothelial cells; perivascular adipose tissue (PVAT); premature aging; senolytics; rejuvenating strategies

(This special issue belongs to the Section Cells of the Cardiovascular System)

Tumor Immune Responsiveness in the Era of T Cell Immunotherapy

edited by

Xin Li

and

Wenjian Wang

submission deadline 30 Jan 2026 | Viewed by 193 | Submission Open

Keywords: T cell-mediated immunity; cancer immune responsiveness; cytokine modulation

Stem Cells, Disease Mechanisms, and Therapeutic Innovations in Breast and Endometrial Disorders

edited by

Walid Shaalan

, Benedikt Schaefgen and

Nourhan Hassan

submission deadline 30 Jan 2026 | Viewed by 185 | Submission Open

Keywords: endometrial stem cells; breast cancer; endometrial diseases; tumor microenvironment; matrix remodeling; regenerative medicine; bioengineering; stem cell therapy; molecular pathogenesis; disease modeling

(This special issue belongs to the Section Stem Cells)

Ubiquitin Ligases in Health and Diseases

edited by Haitao Luan

submission deadline 30 Jan 2026 | Viewed by 101 | Submission Open

Keywords: ubiquitination; E3 ubiquitin ligase; Proteasome; protein degradation; cell cycle regulation; immune response; neurodegeneration; cancer; autoimmune disorders; therapeutic targeting

(This special issue belongs to the Section Cell Signaling)

Advanced Technology for Cellular Imaging

edited by Alessandro Grinzato,

Vittoria Raimondi

and

J. Bernard Heymann

submission deadline 31 Jan 2026 | 8 articles | Viewed by 20668 | Submission Open

Keywords: electron tomography; fluorescence microscopy; live cell imaging; multimodal imaging; super resolution microscopy; cell– cell interaction

(This special issue belongs to the Section Cell Methods)

Molecular and Cellular Mechanisms of Cardiovascular and Metabolic Diseases

edited by

Prathapan Ayyappan

submission deadline 31 Jan 2026 | 7 articles | Viewed by 18506 | Submission Open

Keywords: mitochondrial dysfunction; endoplasmic reticulum (ER) stress; oxidative/nitrosative stress; diabetes; obesity; diet; atherosclerosis; hypertension; metabolomics; cell death; nutraceuticals/functional foods

(This special issue belongs to the Section Cells of the Cardiovascular System)

Cancer-Associated Fibroblasts: Challenges and Directions

edited by

Paul J. Higgins

and

Ramesh Mukkamala

submission deadline 31 Jan 2026 | 5 articles | Viewed by 14579 | Submission Open

Keywords: cancer-associated fibroblast (CAFs); tumor microenvironment (TME); fibroblast activation protein alpha (FAPα ); immunotherapy; cytokines; angiogenesis; metastasis; FAP inhibitors; radioligands; imaging agents

(This special issue belongs to the Section Cell Microenvironment)

Imaging Methods in Cell Biology

edited by

Claudia Moscheni

and

Nicoletta Gagliano

submission deadline 31 Jan 2026 | 6 articles | Viewed by 14373 | Submission Open

Keywords: cellular organelles; molecular function; molecular interaction; disease- and drug-related subcellular phenomena; single-molecule imaging; light microscopy; electron microscopy; fluorescence microscopy; fluorescence correlation methods; fluorescence lifetime imaging microscopy (FLIM); Raman microscopy; spatial biology

(This special issue belongs to the Section Cell Methods)

Neuroinflammation in Brain Health and Diseases

edited by Debashis Dutta and Nemil Bhatt

submission deadline 31 Jan 2026 | 8 articles | Viewed by 12897 | Submission Open

Keywords: neuroinflammation; gliosis; inflammasome; neurodegeneration; neurotherapeutics

(This special issue belongs to the Section Cells of the Nervous System)

Emerging Targets and Therapeutic Potential Drugs in Tumor Progression and Therapeutic Resistance

edited by

Xinyu Wang

Lei Zhu

and Yuancheng Li

submission deadline 31 Jan 2026 | 3 articles | Viewed by 6255 | Submission Open

Keywords: cancer; tumor progression; therapeutic resistance; molecular targets; tumor microenvironment; innovative therapies; targeted drug delivery; natural product

(This special issue belongs to the Section Cell Microenvironment)

Renewing Reasons to Believe in Gene Therapies for Epilepsy

edited by Casper Gøtzsche

submission deadline 31 Jan 2026 | 2 articles | Viewed by 5500 | Submission Open

Keywords: epilepsy; seizure; gene therapy; gene editing; disease modification; transformative; unmet need

(This special issue belongs to the Section Cells of the Nervous System)

Neuro-Oncological Advances in Stem Cell Research: A New Era in Brain Tumor Therapy

edited by

Javier S. Castresana

submission deadline 31 Jan 2026 | 2 articles | Viewed by 2589 | Submission Open

Keywords: brain tumor genetics and epigenetics; brain tumor stem cells; stem cell therapy against brain tumors; mesenchymal stem cells; iPSC; resistance to therapy

(This special issue belongs to the Section Stem Cells)

Novel Therapeutic Strategies to Improve Mitochondrial Function in Neurodegenerative Diseases

edited by Patricia Morcillo

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1943 | Submission Open

Keywords: mitochondria; cellular signaling; neurodegenerative diseases; mitochondrial dynamics; organelles; neurological diseases; therapies; biomarkers

(This special issue belongs to the Section Cellular Aging)

New Advances in Tissue Engineering and Regeneration

edited by

Giorgia Borciani

and

Giorgia Montalbano

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1786 | Submission Open

Keywords: tissue regeneration; tissue engineering; regenerative medicine; musculoskeletal tissues; biomaterials; stem cells; 3D bioprinting; scaffold design; cell therapy; organoids; translational research

(This special issue belongs to the Section Tissues and Organs)

Cell Behavior Under Blood Flow

edited by Alexander Gural, Ivana Pajic-Lijakovic and

Gregory Barshtein

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1192 | Submission Open

Keywords: blood flow; shear stress; red blood cells; white blood cells; platelets; endothelial cells; cell stimulation; mechanical stress

The Role of Macrophages in Leishmaniasis: Current Perspective

edited by Devki Nandan

submission deadline 31 Jan 2026 | 1 articles | Viewed by 842 | Submission Open

Keywords: Leishmania; leishmaniasis; macrophage biology; host– pathogen interactions

Single-Molecule Tracking for Live Cells

edited by

Zeno Földes-Papp

submission deadline 31 Jan 2026 | Viewed by 343 | Submission Open

Keywords: single-molecule level; many-molecule level; biological cell; diluted liquids; single-molecule localization microscopy; nanoscopy; modeling; diffusion; theory

Diagnostic and Therapeutic Application of Extracellular Vesicles (EV)

edited by

Maria Magdalena Barreca

and

Chiara Corrado

submission deadline 31 Jan 2026 | Viewed by 293 | Submission Open

Keywords: extracellular vesicles (EVs); diseases biomarkers; therapeutic targets; drugs delivery; engineered extracellular vesicles; EVs therapeutic applications

Mechanisms That Link Olfactory Perception with Aging in Drosophila

edited by

Tuhin Subhra Chakraborty

, Anindya Ganguly and Jordan A. Munroe

submission deadline 31 Jan 2026 | Viewed by 287 | Submission Open

Keywords: olfaction; aging; neuroscience

(This special issue belongs to the Section Cellular Aging)

Autophagy and Neurodegeneration: Unveiling Cellular Pathways in ALS and Beyond

edited by Valeria Gerbino

submission deadline 31 Jan 2026 | Viewed by 201 | Submission Open

Keywords: autophagy; neurodegeneration; amyotrophic lateral sclerosis (ALS); protein aggregation; cellular homeostasis; lysosomal dysfunction; neuronal health; therapeutic targets; molecular pathways; neuroprotective strategies

(This special issue belongs to the Section Cells of the Nervous System)

Gastrointestinal Disorders: Immunity and Inflammation

edited by Faizan Ahmed and

Aditi Bhargava

submission deadline 31 Jan 2026 | Viewed by 186 | Submission Open

Keywords: gastrointestinal disorders; immunity; inflammation; immune system; microbiota; gastroenterology; biomarkers; pathways

Cellular and Molecular Mechanisms in Immune Regulation—Second Edition

edited by Fábio Rinaldo Santori and Natalia B. Ivanova

submission deadline 31 Jan 2026 | Viewed by 179 | Submission Open

Keywords: innate immunity; dendritic cells; macrophages; T cells; B cells; cytokines; immunotherapy

(This special issue belongs to the Section Cellular Pathology)

Displaying special issue 201-250 on page 5 of 13.

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