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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Mitochondria at the Crossroad of Health and Disease—Second Edition

edited by

Nickolay Brustovetsky

submission deadline 20 Jul 2026 | 6 articles | Viewed by 7285 | Submission Open

Keywords: mitochondria; oxidative phosphorylation; mitochondrial ion transport; permeability transition pore; mitochondrial ROS generation; mitochondrial quality control; mitochondrial traffic; mitochondrial morphology; mitochondrial dynamics; mitophagy

(This special issue belongs to the Section Cellular Aging)

Second Edition of Advances in Adipose Tissue Biology

edited by

Melvin K. S. Leow

submission deadline 20 Jul 2026 | 2 articles | Viewed by 5826 | Submission Open

Keywords: adipocyte differentiation; progenitors; and stem cells; adipokines; myokines; hepatokines; cytokines; cellular signaling; and molecular crosstalk; white adipose tissue (WAT) and brown adipose tissue (BAT); beige fat and browning of WAT; research techniques and methodologies; diagnostics and therapeutics; genomics; metabolomics; other ‘ omics’ technologies; metabolic syndrome; obesity; insulin resistance; cancer

(This special issue belongs to the Section Tissues and Organs)

Cancer and Immune System Interactions

edited by

Hong-Jian Zhu

and

Bradley Creamer

submission deadline 20 Jul 2026 | 2 articles | Viewed by 1883 | Submission Open

Keywords: cancer immunology; tumor microenvironment; immune evasion; immunotherapy; tumor– immune interactions; immune checkpoint regulation; translational oncology

(This special issue belongs to the Section Cell Microenvironment)

Cellular Signaling and Metabolic Adaptations in the Tumor Microenvironment

edited by Shashi Anand

submission deadline 20 Jul 2026 | 1 articles | Viewed by 441 | Submission Open

Keywords: cancer metabolic plasticity; tumor microenvironment; metabolic vulnerabilities; oncogenic signaling pathways; hypoxia and nutrient stress; therapeutic resistance

(This special issue belongs to the Section Cellular Metabolism)

Impact of Chronic Substance Exposure on Hematopoiesis and Immunity

edited by

Mary Mohrin

and

Hami Hemati

submission deadline 20 Jul 2026 | Viewed by 344 | Submission Open

Keywords: Substance Use Alcohol Immunity Inflammation Hematopoietic stem and progenitor cells Monocytes Neutrophils Macrophages T cells

Clockwork Cells: Decoding the Language of Cell Cycle Regulators

edited by

Guanxiong Yan

, Kyung-sang Lee,

Richard W. Wong

and

Gary S. Stein

submission deadline 20 Jul 2026 | Viewed by 328 | Submission Open

Keywords: cyclins; cyclin-dependent kinases (CDKs); checkpoints; cell proliferation; mitosis; meiosis

(This special issue belongs to the Section Cell Proliferation and Division)

Cellular and Molecular Research of Plant-Derived Exosomes

edited by Mukesh Kumar Sriwastva

submission deadline 20 Jul 2026 | Viewed by 225 | Submission Open

Keywords: plant-derived exosomes; extracellular vesicles; exosome isolation and characterization; cross-kingdom communication; therapeutic applications; biomolecule cargo (proteins; RNAs; lipids); plant exosome-like nanoparticles; drug delivery systems

(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)

Epigenetic and Metabolic Regulation of Cancer—2nd Edition

edited by

Jung-Hyun Kim

and

Ming Tan

submission deadline 20 Jul 2026 | Viewed by 195 | Submission Open

Keywords: cancer; epigenetic; transcription; chromatin; tumor metabolism; immunometabolism

(This special issue belongs to the Section Cellular Metabolism)

Molecular Mechanisms and Targeting Strategies of the Blood–Brain Barrier

edited by Kasandra Bélanger

submission deadline 20 Jul 2026 | Viewed by 186 | Submission Open

Keywords: blood– brain barrier; homeostasis; neurovascular unit; drug delivery; neurorological disorders; BBB integrity; permeability; molecular pathways

(This special issue belongs to the Section Cellular Neuroscience)

Bioactive Compounds in the Management of Neurodegenerative Diseases

edited by Melania Ruggiero and

Maria Antonietta

submission deadline 20 Jul 2026 | Viewed by 183 | Submission Open

Keywords: bioactive compounds; neurodegenerative diseases; neuroprotection; neuroinflammation; oxidative stress; neurogenesis; astrocytes reprogramming

(This special issue belongs to the Section Cellular Neuroscience)

Applications of Nanotechnology and Molecular Imaging in Cancer

edited by

Zheng-Rong Lu

and Victoria Laney

submission deadline 20 Jul 2026 | Viewed by 160 | Submission Open

Keywords: contrast agents and mechanisms; probes; molecular imaging; longitudinal imaging; tumor microenvironment; nanomaterials; cell signaling; cancer therapy; intracellular pathways; imaging-guided treatment

Novel Molecular Targets for the Treatment of Sleep Disorders

edited by

Dae-Wui Yoon

submission deadline 25 Jul 2026 | Viewed by 453 | Submission Open

Keywords: sleep disorders; molecular targets; glymphatic system; neuroinflammation; circadian rhythms; microbiome; biomarkers; pharmacological therapy; gene therapy; neurodegeneration

A New Frontier for Cancer Diagnosis and Therapy

edited by

Concettina La Motta

Md Manirujjaman

and

A.S.M. Waliullah

submission deadline 25 Jul 2026 | Viewed by 365 | Submission Open

Keywords: cancer diagnosis; precision oncology; liquid biopsy; molecular biomarkers; immunotherapy; targeted therapy; nanomedicine; multi-omics; artificial intelligence; tumor heterogeneity

(This special issue belongs to the Section Cellular Immunology)

Molecular Regulation of Trophoblast Invasion in Placental Function and Pregnancy Disorders

edited by Mirjana Nacka-Aleksić

submission deadline 25 Jul 2026 | Viewed by 182 | Submission Open

Keywords: trophoblast invasion; preeclampsia; placenta accreta; human trophoblast stem cells

(This special issue belongs to the Section Reproductive Cells and Development)

Harnessing the Immune System: Emerging Therapeutic Strategies in Cancer

edited by Kishan Shamjibhai Italiya

submission deadline 25 Jul 2026 | Viewed by 157 | Submission Open

Keywords: cancer immunotherapy; tumor microenvironment; immune checkpoint inhibitors; adoptive cell therapy; cancer vaccines; T cell therapy; immuno-oncology; tumor immune evasion; immune modulation; antitumor immunity

(This special issue belongs to the Section Cellular Immunology)

Applications of Proteomics in Human Diseases and Treatments

edited by

Giovanni Cuda

and

Marco Gaspari

submission deadline 30 Jul 2026 | 2 articles | Viewed by 3276 | Submission Open

Keywords: biomarkers; clinical proteomics; single-cell proteomics; next-generation proteomics; biofluids; high-throughput proteomics

(This special issue belongs to the Section Cell Methods)

Osteoporosis Treatment: Targeting Osteoclast and Osteoblast Function with microRNA Therapeutics

edited by

Aijaz Ahmad John Bhat

submission deadline 30 Jul 2026 | 1 articles | Viewed by 2404 | Submission Open

Keywords: osteoporosis; microRNA; osteoblasts; osteoclasts; osteocytes; fracture; bone remodeling

(This special issue belongs to the Section Tissues and Organs)

Toxicology in Cells: Cellular Mechanisms, Molecular Responses, and Modern Models

edited by Maria Jurczuk and

Patrice X. Petit

submission deadline 30 Jul 2026 | 2 articles | Viewed by 1590 | Submission Open

Keywords: cellular toxicology; oxidative stress; apoptosis; autophagy; biomarkers; nanotoxicology; organ-on-chip; toxicogenomics; epigenetic regulation; mitochondrial dysfunction

Mitochondria in Cancer Immune Evasion and Immunotherapy

edited by Loredana Moro and

Flora Guerra

submission deadline 30 Jul 2026 | 2 articles | Viewed by 1439 | Submission Open

Keywords: mitochondria; mtDNA; immunity; cancer immune evasion; tumor microenvironment; immune tolerance; lymphocytes; inflammation; immune response

(This special issue belongs to the Section Cellular Immunology)

New Advances in Immunomodulation Using Biomaterials

edited by

Gundula Schulze-Tanzil

and Vaishali Inamdar

submission deadline 30 Jul 2026 | 1 articles | Viewed by 955 | Submission Open

Keywords: immunomodulation; biomaterials; cell– material interactions; biocompatibility; immune system

In Vitro Models for Assessing Toxicity and Cellular Effects

edited by

Anna Bassi

Sara Tirendi

Alice Zoso

and Camilla Paoletti

submission deadline 30 Jul 2026 | Viewed by 253 | Submission Open

Keywords: alternative testing; NAMs; 3D in vitro models; organ-on-chip; millifluidic cultures; toxicity; biomaterials; 3Rs; organoids

Targeted Therapy and Immunotherapy in Breast Cancer: Molecular Mechanisms and Translational Advances

edited by Saranya Chumsri, Hatem H. Soliman and

Aixa Elena Soyano

submission deadline 30 Jul 2026 | Viewed by 213 | Submission Open

Keywords: breast cancer; targeted therapy; immunotherapy; biomarkers of response; therapeutic resistance

(This special issue belongs to the Section Cellular Immunology)

Cancer Cytopathology: Structural Features and Intracellular Events in Malignancy

edited by

Toshimichi Onuma

and

Jianjun Wei

submission deadline 30 Jul 2026 | Viewed by 210 | Submission Open

Keywords: cancer cells; cytopathology; tumor microenvironment; cell culture; biopsies

(This special issue belongs to the Section Cellular Pathology)

Cellular Mechanisms of Anti-Cancer Therapies

edited by Ilgen Mender and

Kazuyuki Kitatani

submission deadline 31 Jul 2026 | 8 articles | Viewed by 30012 | Submission Open

Keywords: anti-cancer therapies; innovative treatment strategies; cellular mechanisms; drug resistance; personalized medicine

(This special issue belongs to the Section Cellular Pathology)

How Can We Optimise Cancer Therapy? Tumour Microenvironment and Immune Evasion Strategies

edited by

Agnieszka Bojarska-Junak

and

Michal Zarobkiewicz

submission deadline 31 Jul 2026 | 6 articles | Viewed by 16944 | Submission Open

Keywords: immunosurveillance; immune evasion in cancer; tumour microenvironment; immune suppression; immunotherapy; immune checkpoints; cancer immunity; drug intervention

(This special issue belongs to the Section Cell Microenvironment)

Advances in the Cellular and Molecular Mechanisms of Cardiovascular Diseases

edited by

Timothy Martin Palmer

and Katie S. Wraith

submission deadline 31 Jul 2026 | 7 articles | Viewed by 11316 | Submission Open

Keywords: thrombosis; smooth muscle; endothelium; atherosclerosis; inflammation

(This special issue belongs to the Section Cells of the Cardiovascular System)

Cellular and Molecular Mechanisms of Vascular-Related Diseases

edited by

Bingmei Fu

and

Ye Zeng

submission deadline 31 Jul 2026 | 8 articles | Viewed by 11161 | Submission Open

Keywords: cellular and molecular mechanisms; cardiovascular disease; cerebrovascular disease; vascular signaling; vascular dysfunctions in cns disorders; vascular dysfunctions in diabetes; vascular dysfunction in chronic kidney disease; tumor metastasis via vascular system

(This special issue belongs to the Section Cellular Pathology)

Advances in the Discovery of Retinal Degeneration

edited by

Ram Prasad

and

Yvonne Adu-Rutledge

submission deadline 31 Jul 2026 | 6 articles | Viewed by 10533 | Submission Open

Keywords: retinal cell biology; photoreceptors; oxidative stress; inflammation; blood– retinal barriers; diabetic retinopathy; clinical eye research; inherited retinal diseases; ocular immunology

(This special issue belongs to the Section Cellular Pathology)

Mechanisms of Lung Growth and Regeneration

edited by

Saverio Bellusci

and

Yuanlin Song

submission deadline 31 Jul 2026 | 5 articles | Viewed by 9099 | Submission Open

Keywords: stem cells; niche; aging; growth factors; extracellular matrix; organoids; fibrosis; single-cell RNAseq

(This special issue belongs to the Section Cell Microenvironment)

Adipose Tissue Functioning in Health and Diseases

edited by Richard C Chang

submission deadline 31 Jul 2026 | 5 articles | Viewed by 7962 | Submission Open

Keywords: adipose tissue biology; adipogenesis; lipolysis; adipose tissue inflammation; diet-induced obesity; non-coding RNA in metabolism; PPARγ signaling; metabolic health and disease; obesogens; epigenetics and chromatin regulation; transgenerational inheritance

(This special issue belongs to the Section Tissues and Organs)

Osteoblasts, Osteoclasts and Bone Diseases: Cellular Crosstalk and Therapeutic Opportunities

edited by

Thomas Nicholson

submission deadline 31 Jul 2026 | 3 articles | Viewed by 6540 | Submission Open

Keywords: osteoblasts; osteoclasts; bone remodelling; osteoporosis; skeletal diseases; bone homeostasis; bone interactions; bone crosstalk; targeted therapies

(This special issue belongs to the Section Cellular Pathology)

Cellular and Molecular Mechanisms in Neuropsychiatric and Neurological Disorders

edited by Irina Balan

submission deadline 31 Jul 2026 | 4 articles | Viewed by 6095 | Submission Open

Keywords: cellular mechanisms; molecular mechanisms; neuropsychiatric disorders; neurological disorders; neuroinflammation; neuronal signaling; gene expression; synaptic function; glial cells; peripheral factors

(This special issue belongs to the Section Cellular Pathology)

Emerging Mechanisms and Therapeutic Strategies in Head and Neck Cancer

edited by

Madalina Anca Moldovan

and

Ciprian Tomuleasa

submission deadline 31 Jul 2026 | 5 articles | Viewed by 5522 | Submission Open

Keywords: tumor microenvironment; epithelial– mesenchymal transition (EMT); tumor– stroma interaction; treatment resistance; radiotherapy sensitization; targeted therapy; precision oncology

Cellular and Molecular Mechanisms in Immune Regulation—Second Edition

edited by Fábio Rinaldo Santori and Natalia B. Ivanova

submission deadline 31 Jul 2026 | 6 articles | Viewed by 4932 | Submission Open

Keywords: innate immunity; dendritic cells; macrophages; T cells; B cells; cytokines; immunotherapy

(This special issue belongs to the Section Cellular Pathology)

Cellular and Molecular Mechanisms of Heart Diseases

edited by

Sumita Mishra

submission deadline 31 Jul 2026 | 2 articles | Viewed by 4892 | Submission Open

Keywords: heart failure; HFrEF; HFpEF; molecular signaling; therapeutic interventions; ejection fraction; fibrosis; metabolism; mitochondrial dysfunction; cardiovascular therapies

(This special issue belongs to the Section Cellular Pathology)

The Role of Pancreatic Beta-Cells in Obesity and Type 2 Diabetes

edited by Mayur Doke, Juan Domínguez-Bendala and Oscar Alcazar

submission deadline 31 Jul 2026 | 3 articles | Viewed by 4815 | Submission Open

Keywords: pancreatic beta-cells; GLP-1; obesity; type 2 diabetes; islet biology; beta-cell regeneration; insulin resistance; incretin therapies; single-cell transcriptomics; metabolic stress

Advances in Smart and Innovative Nanoparticles for Precision Tumor Therapy: Design, Delivery, Immune Modulation, and Clinical Translation

edited by Hari Krishnareddy Rachamala and

Naga Malleswara Rao Nakka

submission deadline 31 Jul 2026 | 2 articles | Viewed by 4173 | Submission Open

Keywords: smart nanoparticles; tumor-targeted drug delivery; immune modulation; stimuli-responsive nanocarriers; clinical translation in oncology

(This special issue belongs to the Section Cell Methods)

Integrated Approaches Between Metabolomics and Cellular Aging

edited by Maria Nikolaou and

Nikolaos Theodorakis

submission deadline 31 Jul 2026 | 2 articles | Viewed by 4042 | Submission Open

Keywords: metabolomics; cellular aging; senescence; mitochondrial dysfunction; DNA damage; biomarkers; metabolism

(This special issue belongs to the Section Cellular Aging)

Genetic Mechanisms in Cellular Genomics and Therapeutics

edited by Elaine T. Lim and Yingleong Chan

submission deadline 31 Jul 2026 | 1 articles | Viewed by 4038 | Submission Open

Keywords: genetics of human diseases; functional genomics; cellular mechanisms; genomics or stem cell technologies; therapeutics research and development for human diseases

Epigenetic Mechanisms of Tumorigenesis

edited by

Hengbin Wang

submission deadline 31 Jul 2026 | 2 articles | Viewed by 3526 | Submission Open

Keywords: epigenetics; tumorigenesis; gene expression; cell identity; precise medicine

Standardization and Metrological Advancements in Cellular and Genomic Diagnostics for Cancer

edited by

Jessica Petiti

and Marika Fava

submission deadline 31 Jul 2026 | 1 articles | Viewed by 3192 | Submission Open

Keywords: cancer diagnostics; cellular analysis; genomic profiling; precision medicine; metrology in diagnostics; next generation sequencing (NGS); reference measurement systems (RMSs); quality assurance (QA); IVDR compliance; SI-traceable standards

Regulation of Ca²⁺ Signals in Human Disease

edited by Yandong Zhou

submission deadline 31 Jul 2026 | 2 articles | Viewed by 2533 | Submission Open

Keywords: calcium signaling; cellular homeostasis; disease mechanisms; calcium channels; therapeutic targets

(This special issue belongs to the Section Cell Signaling)

Cellular and Molecular Mechanisms of Neurotoxicity

edited by

Anna Andrioli

Idris Azeez

, Tiziana Cotrufo and

Olumayowa Igado

submission deadline 31 Jul 2026 | 2 articles | Viewed by 2436 | Submission Open

Keywords: neurotoxicity; neurodegeneration; neuronal cell death; neurodegenerative disorders; nerve regeneration; heavy metals; air pollution; endogenous neurotoxins; oxidative stress; glutamate

Advances in Adipocyte Biology Research and Their Relevance to Metabolic Health

edited by

Aaron C. Brown

submission deadline 31 Jul 2026 | 2 articles | Viewed by 2206 | Submission Open

Keywords: adipose tissue; obesity; inflammation; thermogenesis; adipokines

The Language of Neural Cells: Decoding Molecular Signaling in Neurodevelopmental and Neuro-Oncological Disorders

edited by

Marilena Briglia

Alice Foti

and Adriana C. E. Graziano

submission deadline 31 Jul 2026 | 2 articles | Viewed by 2135 | Submission Open

Keywords: neural cells; molecular signaling; neurodevelopmental disorders; neuro-oncological disorders; transcriptional dysregulation

(This special issue belongs to the Section Cellular Neuroscience)

Biochemical Mechanisms and Physiological Implication of Stem Cell Differentiation

edited by

Giuliana Mannino

and

Floriana D'Angeli

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1838 | Submission Open

Keywords: stem cells; differentiation; 3D cultures; co-cultures; biochemistry; physiology; epigenetics

(This special issue belongs to the Section Stem Cells)

The Role of Cell Signaling Pathway Starvation Therapy for Cancer

edited by

Niramol Savaraj

and Min You

submission deadline 31 Jul 2026 | 2 articles | Viewed by 1720 | Submission Open

Keywords: signaling pathways; nutrient deprivation; starvation therapy; metabolic reprogramming; metabolic pathways

(This special issue belongs to the Section Cell Signaling)

Molecular Research in Osteoporosis

edited by

Virginia Visconti

Annalisa Botta

and

Umberto Tarantino

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1514 | Submission Open

Keywords: osteoporosis; osteosarcopenia; bone– muscle crosstalk; genetics; epigenetics; transcriptomics; biomarkers; therapeutic strategy

(This special issue belongs to the Section Cellular Pathology)

Rho Family Small GTPases in Health and Diseases

edited by

Katalin Szászi

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1247 | Submission Open

Keywords: Rho signalling; Rho guanine nucleotide exchange factor; Rho GTPase-activating protein; Rho effector; dysregulation of Rho GTPases; Rho pathway inhibitors

(This special issue belongs to the Section Cell Signaling)

Aquaporins at the Crossroads of Human Health and Disease

edited by

Anna Patrizia Gena

submission deadline 31 Jul 2026 | 1 articles | Viewed by 938 | Submission Open

Keywords: aquaporins; membrane molecular transport; channels proteins in health and disease; novel drug targets; cellular biophysics

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