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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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New Insights into Astrocytes in Health and Disease

edited by

Tao Tao

submission deadline 20 Nov 2025 | Viewed by 72 | Submission Open

Keywords: astrocytes heterogeneity; blood-brain barrier (BBB); synaptic modulation; metabolic support; neuroinflammation; ageing; neurodegenerative disorders; neurodevelopmental disorders; stress response

(This special issue belongs to the Section Cells of the Nervous System)

Atherosclerosis and Thrombosis: Molecular and Pathological Research Advance

edited by

Tijana Subotički

Olivera Mitrović Ajtić

and

Vladan P. Čokić

submission deadline 20 Nov 2025 | Viewed by 70 | Submission Open

Keywords: atherosclerosis; thrombosis; molecular mechanisms; translational research; precision medicine

(This special issue belongs to the Section Cellular Pathology)

Transient Receptor Potential (TRP) Channels and Health and Disease

edited by Hiroki Kittaka and Makoto Tominaga

submission deadline 20 Nov 2025 | Viewed by 68 | Submission Open

Keywords: Transient Receptor Potential (TRP) channels; cell signaling; cell physiology

The Metabolic Interactions and Pathways in Cancers

edited by Mohamed Elgendy

submission deadline 20 Nov 2025 | Viewed by 57 | Submission Open

Keywords: cancer metabolism; metastasis; drug resistance; oncometabolites; metabolic plasticity; diet; bioenergetics; metabolic crosstalk; immunotherapy

Targeting Tumor Metabolism and Epigenetics: Mechanisms and Therapeutic Strategies

edited by

Jorge Mata-Garrido

Raquel Francés

and Íñigo Casafont

submission deadline 22 Nov 2025 | Viewed by 188 | Submission Open

Keywords: tumor metabolism; epigenetics; metabolic reprogramming; DNA methylation; histone modification; warburg effect; glycolysis inhibitors; fatty acid synthesis; chromatin remodeling; cancer therapy

(This special issue belongs to the Section Cellular Metabolism)

Cellular and Molecular Basis in Chronic Kidney Disease

edited by

Prabhatchandra Dube

submission deadline 25 Nov 2025 | 8 articles | Viewed by 17318 | Submission Open

Keywords: CKD; renal inflammation; renal fibrosis; RAAS; aldosterone; TGF-B1; uremic toxins; hypertension; GFR; albuminuria

(This special issue belongs to the Section Cellular Pathology)

Glial Cells in Aging Neuroscience

edited by

Renato Socodato

submission deadline 25 Nov 2025 | 1 articles | Viewed by 4699 | Submission Open

Keywords: glial cells; aging; neuroinflammation; neurodegeneration; glial– neuronal interactions; glial– glial crosstalk; astrocytes; oligodendrocytes; microglia; ependymal cells

(This special issue belongs to the Section Cellular Aging)

Biomolecular Condensates in Oncology and Immunology

edited by

Andrzej Mackiewicz

Pravin B. Sehgal

and

Mariusz Kaczmarek

submission deadline 25 Nov 2025 | 1 articles | Viewed by 1033 | Submission Open

Keywords: liquid-liquid phase separation (LLPS); biomolecular condensates; pro-oncogenic signaling; innate and adaptive immunity; transcriptional regulation; epigenetic regulation; condensate targeting; antiviral mechanisms; intercellular adhesion; cell migration and metastasis

(This special issue belongs to the Section Cellular Immunology)

Cell Signaling in Neurodegeneration Disease

edited by

Rijwan Uddin Ahammad

, Yasuhiro Funahashi,

Akira Sobue

Xinjian Zhang

and Md-nadim Hossain

submission deadline 25 Nov 2025 | Viewed by 161 | Submission Open

Keywords: neurodegeneration; cell signaling; biomarkers; synaptic dysfunction; neuroinflammation; protein aggregation; IPSC and animal models; mitochondrial dysfunction; therapeutic targets; translational neuroscience

(This special issue belongs to the Section Cells of the Nervous System)

CAR T Cells in Human Cancers

edited by

Tabish H. Khan

and

Naoshad Muhammad

submission deadline 25 Nov 2025 | Viewed by 102 | Submission Open

Keywords: CAR T cells; engineered immune cell therapies; CAR T cell engineering

Pathology and Treatments of Amyotrophic Lateral Sclerosis (ALS)

edited by Laxman Gangwani

submission deadline 28 Nov 2025 | 1 articles | Viewed by 1024 | Submission Open

Keywords: amyotrophic lateral sclerosis (ALS); pathology; molecular mechanisms; treatments; symptom management; biological mechanisms; risk factors; innovative treatments

(This special issue belongs to the Section Cellular Pathology)

Cellular Senescence and Senotherapies in the Aging Retina

edited by

Bhavana Chhunchha

submission deadline 28 Nov 2025 | Viewed by 287 | Submission Open

Keywords: retina; senescence; aging; inflammasome; oxidative stress; antioxidant; gene therapy; senotherapies; glaucoma; diabetic retinopathy

(This special issue belongs to the Section Cellular Aging)

Cell-to-Cell Crosstalk as a Target of Therapies

edited by

Agnieszka Gizak

and

Dominika Drulis-Fajdasz

submission deadline 30 Nov 2025 | 2 articles | Viewed by 8259 | Submission Open

Keywords: cell-to-cell crosstalk; cellular communication; microenvironment; extracellular vesicles; diagnostic tools; membrane nanotubes; pathogenesis; therapy; cell metabolism; homeostasis

(This special issue belongs to the Section Cell Microenvironment)

Emerging Insights into Natural Killer Cell Immunity in Infection and Cancer

edited by Sumit Sen Santara,

Engin Berber

, Weshely Kujur and Sachin Mulik

submission deadline 30 Nov 2025 | 4 articles | Viewed by 5365 | Submission Open

Keywords: CAR NK cells; cancer immunotherapy; cell therapy; viral infection; memory NK cells; NK cell targeted therapies; NK-immune cell crosstalk; exosomes

(This special issue belongs to the Section Cellular Immunology)

Recent Advances in Metabolism and Oxidative Stress in Human Diseases: 2nd Edition

edited by

Isabella Panfoli

and Vanessa Cossu

submission deadline 30 Nov 2025 | 3 articles | Viewed by 5087 | Submission Open

Keywords: antioxidant responses; redox balance; ROS; hematologic oncology; solid tumors; immune response; ATP; cancer cells; mitochondria-ER interactions; endoplasmic reticulum; glucose metabolism; inflammation; mitochondria; mitochondrial dynamics; autophagy; mitophagy; metabolic plasticity; metabolism

(This special issue belongs to the Section Cellular Metabolism)

Harnessing the Tumor Microenvironment and Signaling Pathways for Precision Cancer Therapy

edited by Behzad M. Toosi and

Andrew Freywald

submission deadline 30 Nov 2025 | 2 articles | Viewed by 4293 | Submission Open

Keywords: tumor microenvironment (TME); signaling pathways; precision cancer therapy; immune evasion; metabolic pathways; tumor– stroma interactions; therapeutic targets; personalized medicine; cancer metastasis; molecular oncology

(This special issue belongs to the Section Cell Microenvironment)

Gastrointestinal Cancer: From Cellular and Molecular Mechanisms to Therapeutic Opportunities

edited by

Federica Laudisi

and

Carmine Stolfi

submission deadline 30 Nov 2025 | 4 articles | Viewed by 4226 | Submission Open

Keywords: colorectal cancer; gastric cancer; liver cancer; pancreatic cancer; tumor microenvironment; cytokines; epigenetic; checkpoint inhibitors; biomarkers; immunotherapy

(This special issue belongs to the Section Cellular Pathology)

Advances in Muscle Research in Health and Disease—2nd Edition

edited by

Wan Lee

submission deadline 30 Nov 2025 | 3 articles | Viewed by 3859 | Submission Open

Keywords: skeletal muscle; cardiac muscle; smooth muscle; myocyte; vascular smooth muscle cell; stem cell; development; homeostasis; regeneration; biomarker; therapeutic target

(This special issue belongs to the Section Tissues and Organs)

Advances in Musculoskeletal Tissue Regeneration Using Mesenchymal Stromal/Stem Cells, Biomaterials, and Signaling Molecules: Second Edition

edited by

Dimitrios Kouroupis

and

Thomas M. Best

submission deadline 30 Nov 2025 | 2 articles | Viewed by 2948 | Submission Open

Keywords: mesenchymal stromal/stem cells; extracellular vesicles; biomaterials; signalling molecules; microphysiological systems; musculoskeletal regeneration; immunomodulation; cell therapy; tissue engineering

(This special issue belongs to the Section Stem Cells)

Retinal Pigment Epithelium in Degenerative Retinal Diseases

edited by Jian Liu and Shintaro Horie

submission deadline 30 Nov 2025 | 3 articles | Viewed by 2744 | Submission Open

Keywords: RPE; degenerative retinal diseases; macular degeneration; diabetic retinopathy; glaucoma; photoreceptor; vascular endothelium; microglia; macrophage; inflammation; oxidative stress; autophagy; mitochondria; lipid metabolism; senescence; neuropeptide; therapeutics; biomarkers

(This special issue belongs to the Section Cellular Pathology)

Cellular Mechanisms in Mitochondrial Function and Calcium Signaling

edited by Sergio De la Fuente and Jaime Santo-Domingo

submission deadline 30 Nov 2025 | 2 articles | Viewed by 2582 | Submission Open

Keywords: mitochondria; calcium; MCU; uniporter; NCLX; energy metabolism; disease; MAMs; signaling

(This special issue belongs to the Section Cellular Metabolism)

Molecular and Cellular Research on Spinal Cord Injury

edited by

Vinnitsa Buzoianu-Anguiano

and

Jörg Mey

submission deadline 30 Nov 2025 | 1 articles | Viewed by 2060 | Submission Open

Keywords: spinal cord injury; growth inhibitory factors; axonal regeneration; neuroprotection; combined therapies; cell trasnplants; regenerative medicine; inhibition scar formation; extracellular matrix molecules

(This special issue belongs to the Section Cellular Pathology)

Neuroinflammation in Developmental Brain Diseases

edited by

Evelyne Gozal

Jun Cai

and

Gregory Neal Barnes

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1925 | Submission Open

Keywords: neuroinflammation; endothelial injury; blood brain barrier; microglia; immune dysfunction; oxidative stress; autism spectrum disorders; epilepsy; cerebral palsy; schizophrenia; neurodevelopment; neurovascular brain signaling; inflammatory cytokines; immune cells

(This special issue belongs to the Section Cells of the Nervous System)

Genetic and Cellular Basis of Autoimmune Diseases

edited by

Christian Sadik

submission deadline 30 Nov 2025 | 2 articles | Viewed by 1743 | Submission Open

Keywords: autoimmune disease; break of tolerance; effector cells; immunodysregulation; risk genes

(This special issue belongs to the Section Cellular Immunology)

New Research on Immunity and Inflammation in Cardiovascular Disease

edited by Pavel Poredoš

submission deadline 30 Nov 2025 | 2 articles | Viewed by 1517 | Submission Open

Keywords: inflammation; atherosclerosis; coronary artery disease; peripheral arterial disease; cerebrovascular disease; venous thromboembolic disease; circulating biomarkers; anti-innflammatory treatment of cardiovascular disease

(This special issue belongs to the Section Cells of the Cardiovascular System)

Aging and Neurodegeneration: Molecular Insights and Emerging Strategies

edited by

Piotr Paweł Chmielewski

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1505 | Submission Open

Keywords: Alzheimer’ s disease; biomarkers; endolysosomal pathway; extracellular vesicles; inflammation; mitophagy; neurodegeneration; neuroinflammation; Parkinson’ s disease; translational research

(This special issue belongs to the Section Cellular Aging)

Emerging Advances in Neurodegeneration: Innovations in Stem Cell and Organoid Research

edited by

Elena Coccia

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1466 | Submission Open

Keywords: neurodegeneration; stem cells; induced pluripotent stem cells (iPSCs); brain organoids; disease modeling; therapeutic strategies; personalized medicine

(This special issue belongs to the Section Stem Cells)

Modulation of Senescence and Differentiation in Human Mesenchymal Stem Cells

edited by

Federica Facchin

and

Silvia Canaider

submission deadline 30 Nov 2025 | Viewed by 1406 | Submission Open

Keywords: tissue-specific mesenchymal stem cells; cell senescence; cell differentiation; natural and synthetic molecules; tissue engineering; regenerative medicine

(This special issue belongs to the Section Stem Cells)

Human Immunodeficiency Virus/Simian Immunodeficiency Virus and Host Interactions

edited by

Nongthombam Boby

and Susanta Pahari

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1373 | Submission Open

Keywords: HIV/SIV/SHIV infection; rhesus macaques; host immunity; chronic inflammation; mucosal immunity; immune evasion; therapeutic intervention; immune checkpoints; microbiota; substance use

(This special issue belongs to the Section Cellular Immunology)

Updates of Stem Cell Applications in Bone Tissue Engineering

edited by Fahad Karim Kidwai

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1136 | Submission Open

Keywords: stem cells; bone tissue engineering; bone diseases; bone repair; bone defect; bone healing; bone regeneration; osteogenic progenitor cells

(This special issue belongs to the Section Stem Cells)

Epigenetic Regulatory Networks in Cancer: Understanding the Mechanisms of Disease Progression

edited by

Anand Singh

and Sudheer Kumar Gara

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1090 | Submission Open

Keywords: cancer; epigenetics; miRNAs; BAP1; DNMTs; tumor suppressor; oncogenes; histone modification; chromatin remodeling

(This special issue belongs to the Section Cellular Pathology)

CRISPR-Based Genome Editing Approaches in Cancer Therapy

edited by Martin Pal

submission deadline 30 Nov 2025 | 1 articles | Viewed by 922 | Submission Open

Keywords: CRISPR; genome editing; cancer therapy; precision medicine

(This special issue belongs to the Section Cell and Gene Therapy)

Non-Coding RNAs as Regulators of Cellular Function and Disease

edited by

Lucia Natarelli

submission deadline 30 Nov 2025 | 1 articles | Viewed by 806 | Submission Open

Keywords: non-coding RNAs; gene regulation; disease mechanisms; therapeutic targets; molecular mechanisms

Role of Calpains in Health and Diseases

edited by

Michel Baudry

and Peter A. Greer

submission deadline 30 Nov 2025 | 1 articles | Viewed by 805 | Submission Open

Keywords: calpain; physiology; biochemistry; disease; mutation; target; inhibitor

(This special issue belongs to the Section Cellular Pathology)

Adipose-Derived Stem Cells for Tissue Regeneration

edited by

Lukas Prantl, MD, PhD, MHBA, FACS

submission deadline 30 Nov 2025 | 1 articles | Viewed by 518 | Submission Open

Keywords: adipose stem cells (ASCs); stromal vascular fraction (SVF); cell enriched lipotransfer (CELT and CELT-PLUS); extracellular vesicles (EVs); tissue processing; basic biology; mechanisms of action; regenerative medicine; cell-bases therapies

(This special issue belongs to the Section Tissues and Organs)

G Protein-Coupled Receptors and Diseases

edited by

Yongqiang Chen

submission deadline 30 Nov 2025 | Viewed by 477 | Submission Open

Keywords: G protein-coupled receptor; taste receptor; microbiome; cancer; aging; neurodegenerative disease; cardiovascular disease; pulmonary hypertension; cell survival; cell death; apoptosis; autophagy; necroptosis; ferroptosis; proliferation

Osteoblasts, Osteoclasts and Bone Diseases: Cellular Crosstalk and Therapeutic Opportunities

edited by

Thomas Nicholson

submission deadline 30 Nov 2025 | 1 articles | Viewed by 429 | Submission Open

Keywords: osteoblasts; osteoclasts; bone remodelling; osteoporosis; skeletal diseases; bone homeostasis; bone interactions; bone crosstalk; targeted therapies

(This special issue belongs to the Section Cellular Pathology)

Molecular and Cellular Mechanisms of Brain Development and Neurodevelopmental Disorders

edited by

Mojgan Rastegar

submission deadline 30 Nov 2025 | 1 articles | Viewed by 397 | Submission Open

Keywords: brain development; neural stem cells; neurodevelopmental disorders; brain diseases; cellular and molecular mechanisms; embryonic and adult brain

(This special issue belongs to the Section Cellular Pathology)

Hypoxia Pathway Proteins in the Immune System: Regulation, Disease, and Therapeutics

edited by Ben Wielockx

submission deadline 30 Nov 2025 | Viewed by 325 | Submission Open

Keywords: hypoxia; oxygen sensors; immune system; HIF; disease mechanisms; therapeutics; inflammation; autoimmunity; cancer immunology

(This special issue belongs to the Section Cellular Immunology)

Drug Resistance in Breast and Ovarian Cancers

edited by

Tuula Kallunki

submission deadline 30 Nov 2025 | Viewed by 308 | Submission Open

Keywords: breast cancer; endocrine resistance; ESR1 mutations; Trop-2; ovarian cancer; drug resistance; predictive biomarkers; personalized medicine

Brain Organoids for Disease Modeling

edited by

Jonghun Kim

submission deadline 30 Nov 2025 | Viewed by 217 | Submission Open

Keywords: brain organoids; induced pluripotent stem cells (iPSCs); neurodevelopmental disorders; neurodegenerative diseases; neuronal activity; organoid-based drug screening

(This special issue belongs to the Section Stem Cells)

Exploring Morphological Changes and Diversity in Cancer

edited by

Mustapha Kandouz

submission deadline 30 Nov 2025 | Viewed by 205 | Submission Open

Keywords: morphology; heterogeneity; cancer; phenotype; shape

Exploring the Structural and Functional Diversity of Proteins: Foundations of Life and Biological Complexity

edited by Jiabei Lin

submission deadline 30 Nov 2025 | Viewed by 185 | Submission Open

Keywords: AAA+ protein; RNA-binding protein; protein kinase; PTMs; protein structure; function; and diseases; protein and RNA homeostasis; neurodegeneration; cancer

Myocardial Ischemia/Reperfusion Injury: Mechanisms and New Directions in Cardioprotection

edited by Sauri Hernandez-Resendiz

submission deadline 30 Nov 2025 | Viewed by 143 | Submission Open

Keywords: myocardial infarction; heart failure; ischemia/reperfusion injury; no-reflow phenomenon; oxidative stress; cell death; cardiac metabolism; mitochondrial quality control; inflammation; cardioprotection

(This special issue belongs to the Section Tissues and Organs)

Crossroad Between Oxidative Stress and DNA Damage and Repair in Stroke

edited by

William James Antonisamy

Zahoor Shah

and Moorthi Ponnusamy

submission deadline 30 Nov 2025 | Viewed by 115 | Submission Open

Keywords: oxidative stress; DNA damage; DNA repair; stroke; ischemic stroke; neuroinflamamtion; intracranial hemorrhagic stroke; neuronal death

(This special issue belongs to the Section Cells of the Nervous System)

ROS in Atherosclerosis and Cardiometabolic Disorders

edited by

Weibin Shi

submission deadline 30 Nov 2025 | Viewed by 108 | Submission Open

Keywords: reactive oxygen/nitrogen species; oxidative stress; atherosclerosis; cardiovascular; inflammation; endothelial dysfunction; obesity; dyslipidemia

(This special issue belongs to the Section Tissues and Organs)

Molecular Research in Osteoporosis

edited by

Virginia Visconti

Annalisa Botta

and

Umberto Tarantino

submission deadline 30 Nov 2025 | Viewed by 100 | Submission Open

Keywords: osteoporosis; osteosarcopenia; bone– muscle crosstalk; genetics; epigenetics; transcriptomics; biomarkers; therapeutic strategy

(This special issue belongs to the Section Cellular Pathology)

Molecular Mechanisms of Drug Delivery in Ophthalmology

edited by Alekha K. Dash and Surabhi Shukla

submission deadline 30 Nov 2025 | Viewed by 94 | Submission Open

Keywords: drug delivery; ophthalmology; nanocarriers; ocular barriers; molecular transport; targeted therapy; ocular gene delivery

(This special issue belongs to the Section Tissues and Organs)

Redox Regulation by Nrf2 in Health and Disease

edited by Pandu Gangula

submission deadline 30 Nov 2025 | Viewed by 92 | Submission Open

Keywords: Nrf2; redox; cellular stress response; antioxidant gene regulation; signaling pathway crosstalk; oxidative stress response

The Cellular and Molecular Basis of Lifestyle Factors in Cancer Progression and Prevention

edited by Vivek Kumar Kashyap and Himanshu Narayan Singh

submission deadline 30 Nov 2025 | Viewed by 81 | Submission Open

Keywords: lifestyle factors; smoking; alcohol consumption; cancer risk; cancer prevention recommendations; modifiable risk factors

(This special issue belongs to the Section Cellular Pathology)

Displaying special issue 201-250 on page 5 of 12.

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