Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Spatial Biology: Decoding Cellular Complexity in Tissues submission deadline 30 Sep 2025 | Viewed by 145 | Submission Open
Keywords: spatial biology; spatial tissue profiling; proteomics; transcriptomics; cell and tissue
(This special issue belongs to the Section Tissues and Organs)
Novel Insights into Mechanism and Treatment of Degenerative Disc Disease
edited by Yejia Zhang
submission deadline 30 Sep 2025 | Viewed by 133 | Submission Open
Keywords: intervertebral disc (IVD) degeneration; back pain; age; genetics; injury
(This special issue belongs to the Section Cellular Pathology)
Mechanisms and Dynamics in Cellular Adhesion in Development and Disease
edited by
submission deadline 30 Sep 2025 | Viewed by 130 | Submission Open
Keywords: actin; integrin; cell adhesion; signalling; mechanotransduction
Biomarkers and Therapeutic Targets in Insulin Resistance
edited by
submission deadline 30 Sep 2025 | Viewed by 119 | Submission Open
Keywords: insulin resistance; biomarkers; therapeutic targets; type 2 diabetes; metabolic syndrome; obesity; molecular mechanisms; pharmacologic treatments; precision medicine; cardiovascular diseases
(This special issue belongs to the Section Cellular Pathology)
Mitochondria and Peroxisomes–Individual Roles and Delicate Balance of Redox Organelles
edited by
submission deadline 30 Sep 2025 | Viewed by 88 | Submission Open
Keywords: mitochondria; peroxisomes; redox organelles; oxidative stress; ROS; organelles; neurodegeneration; autophagy; aging; metabolism
Novel Molecular Insight into Congenital Disorders of N-Linked Glycosylation
edited by
submission deadline 30 Sep 2025 | Viewed by 78 | Submission Open
Keywords: N-linked glycosylation; CDG; animal models; genetic variants; glycomics; glycoproteomics; pathophysiology
Psilocybe Mushrooms Constituents—Therapeutic Implications
edited by and Janet Schloss
submission deadline 30 Sep 2025 | Viewed by 70 | Submission Open
Keywords: Psilocybe mushrooms; psilocybin; pre-clinical research; neurodegeneration
Function of Stress Granules in Normal Cells and in Alzheimer’s Disease
edited by and Benjamin Wolozin
submission deadline 30 Sep 2025 | Viewed by 65 | Submission Open
Keywords: stress granules; Alzheimer's disease; neurodegenerative diseases
(This special issue belongs to the Section Cellular Aging)
Novel Insights into Molecular Mechanisms and Therapy of Myeloma
edited by and
submission deadline 5 Oct 2025 | 3 articles | Viewed by 3705 | Submission Open
Keywords: multiple myeloma; CAR-T therapy; relapse; methylation; drug resistance; treatment strategy; molecular mechanism; novel target; biomarker
(This special issue belongs to the Section Cellular Pathology)
The Interplay of G-Protein-Coupled Receptor Signaling between Humans and Diseases
edited by Victor Garcia
submission deadline 10 Oct 2025 | 1 articles | Viewed by 5958 | Submission Open
Keywords: G-proteins; G-protein-coupled receptors; G-protein-independent signaling; cAMP signals
Study on Immune Activity of Natural Products
edited by Xiu-Min Li
submission deadline 10 Oct 2025 | Viewed by 81 | Submission Open
Keywords: natural products; bioactive compounds; immune activity; immunomodulation; inflammation; autoimmune diseases; immunotherapy; therapeutic potential
Ras Family of Genes and Proteins: Structure, Function and Regulation
edited by , and Rosula Garcia-Navas
submission deadline 15 Oct 2025 | 2 articles | Viewed by 2139 | Submission Open
Keywords: HRAS; NRAS; KRAS; RAS-driven tumors; rasopathies; RAS signaling; RAS inhibitors; GAP; GEF; SOS; GRF
Non-Traditional Roles of Protein Ubiquitination in Cellular Processes and Health
edited by
submission deadline 15 Oct 2025 | 2 articles | Viewed by 1694 | Submission Open
Keywords: Protein Ubiquitination; ; Ubiquitin chain; ; k63-linked ubiquitination;   ; linear ubiquitination; ; ubiquitin-binding proteins; ; deubiquitinases; ; NF-kB; ; autophagy; ; inflammation; ; immunodeficiency; ; neurodegenerative diseases.
(This special issue belongs to the Section Cellular Pathology)
Advances in Understanding Inflammation in Atherosclerosis: From Mechanisms to Therapeutic Targets
edited by Yaw Asare and Michael Lacy
submission deadline 15 Oct 2025 | Viewed by 612 | Submission Open
Keywords: atherosclerosis; inflammatory pathways; monocytes/macrophages; endothelial cells; innate immunity; inflammasome; IL-1β ; cytokines and chemokines; neutrophils; epigenetic mechanisms; adaptive immunity; small-molecule inhibitors; T cells; B cells
(This special issue belongs to the Section Cellular Pathology)
Regulation of the Subcellular Compartmentalization of Signaling Pathways by Post-Translational Modifications
edited by Jürgen Fritsch
submission deadline 15 Oct 2025 | 1 articles | Viewed by 577 | Submission Open
Keywords: phosphorylation; ubiquitination; acetylation; acylation; methylation; sumoylation; glycosylation; neddylation; ribosylation; oxidation; proteolysis
LPS-Induced Inflammatory Diseases
edited by and
submission deadline 15 Oct 2025 | Viewed by 260 | Submission Open
Keywords: lipopolysaccharide (LPS); endotoxemia; inflammation; LPS signaling; acute lung injury; inflammatory cytokines; therapeutic targets
(This special issue belongs to the Section Cellular Pathology)
The Multifaceted Role of Molecular Chaperones in Cancer: Pro-Tumoral or Therapeutic Function submission deadline 15 Oct 2025 | Viewed by 218 | Submission Open
Keywords: molecular chaperones; cancer biology; carcinogenesis; tumor progression; diagnostic/prognostic biomarkers; anti-tumor therapeutic strategies; in vitro/in vivo experimental approaches; in silico computational approaches
Molecular and Cellular Mechanisms of Type 1 Diabetes (T1D)
edited by Robert Sharp and
submission deadline 15 Oct 2025 | Viewed by 200 | Submission Open
Keywords: T1D; autoimmunity; type 1 diabetes; single-nucleotide polymorphisms (SNPs); viral/bacterial pathogens; T-cell biology; inflammation; pancreatic beta cells; immunoregulatory; molecular biology; cellular biology
(This special issue belongs to the Section Cellular Pathology)
AI, CRISPR, and Molecular Mechanisms in Precision Medicine
edited by Karim Daliri
submission deadline 15 Oct 2025 | Viewed by 92 | Submission Open
Keywords: CRISPR; gene therapy; precision medicine
(This special issue belongs to the Section Cell Methods)
Advances in Adipocyte Biology Research and Their Relevance to Metabolic Health
edited by
submission deadline 15 Oct 2025 | Viewed by 80 | Submission Open
Keywords: adipose tissue; obesity; inflammation; thermogenesis; adipokines
Membrane Trafficking Components and Mechanisms in Bacterial, Viral or Fungal Infections
edited by
submission deadline 15 Oct 2025 | Viewed by 74 | Submission Open
Keywords: bacterial intracellular infections; bacterial intracellular sanctuaries; viral infection; viral hijacking of host trafficking machinery; membrane trafficking; Rab; secretory pathway; endocytic pathway; viral replication
Extracellular Vesicles and Exosomes: Novel Insight and Therapeutic Applications in Cancer
edited by Giusi Alberti and
submission deadline 16 Oct 2025 | Viewed by 112 | Submission Open
Keywords: extracellular vesicles (EVs); exosomes (Exos); proteins and miRNA; 2D-EVs and Exos; 3D-EVs and Exos; precision therapy; molecular mechanism; cancer physiology; oncology research
Understanding Spinal Cord Injury and Repair: From Molecules to Neurocircuits and Multimodal Prostheses
edited by
submission deadline 20 Oct 2025 | 9 articles | Viewed by 19031 | Submission Open
(This special issue belongs to the Section Cells of the Nervous System)
Molecular Mechanisms of Autism Spectrum Disorder
edited by Tanya Gandhi and
submission deadline 20 Oct 2025 | 6 articles | Viewed by 10839 | Submission Open
Keywords: autism spectrum disorder; neurodevelopmental disorders; molecular mechanisms; cellular-molecular mechanisms; neurobiological mechanisms; neural mechanisms; intervention approaches; treatment strategies
(This special issue belongs to the Section Cells of the Nervous System)
Therapeutic Targets in Glioblastoma
edited by Candice Mazewski and
submission deadline 20 Oct 2025 | 5 articles | Viewed by 7710 | Submission Open
Keywords: glioblastoma; signaling targets; blood-brain-barrier; complementary and alternative medicine; combination therapy; glioma stem cells; progression; resistance; nutrient-sensing
(This special issue belongs to the Section Cells of the Nervous System)
New Trends and Advances in Diagnosis and Prognosis of Head and Neck Cancer from Carcinogenesis to Future Molecular Targeted Therapies: 2nd Edition submission deadline 20 Oct 2025 | 4 articles | Viewed by 5074 | Submission Open
Keywords: head and neck cancer; oral cancer; biomarker; prognosis; carcinogenesis; oral premalignant lesions; cancer stem cells; signaling pathways; molecular targeted therapy
(This special issue belongs to the Section Cellular Pathology)
Sperm Biology and Reproductive Health—Second Edition
edited by and
submission deadline 20 Oct 2025 | 2 articles | Viewed by 1852 | Submission Open
Keywords: spermatogenesis; differentiation of spermatogonial stem cells in vitro; mitosis; meiosis; sperm formation
Experimental Systems to Model Aging Processes
edited by , and Ralf Dahm
submission deadline 20 Oct 2025 | 1 articles | Viewed by 1338 | Submission Open
Keywords: aging; ageing; age-related; longevity; model; animal; signalling pathway; mechanism; in vitro; in vivo; cell culture; marker
(This special issue belongs to the Section Cellular Aging)
Mechanism of Cell Signaling During Eye Development and Diseases—Second Edition submission deadline 20 Oct 2025 | 1 articles | Viewed by 426 | Submission Open
Keywords: cell signaling; ocular; eye disorders; Wnt signaling; TGF-β
(This special issue belongs to the Section Cell Signaling)
Cell Therapy for Retinal Diseases submission deadline 20 Oct 2025 | Viewed by 292 | Submission Open
Keywords: retinal diseases; cell therapy; stem cells; retinal regeneration; cell transplantation; gene editing in retinal therapy; tissue engineering; retinal organoids; vision restoration; clinical translation of cell therapy; future directions in retinal regeneration
(This special issue belongs to the Section Tissues and Organs)
Immune Response in HIV Infection, Pathogenesis and Persistence
edited by Suvadip Mallick
submission deadline 20 Oct 2025 | Viewed by 138 | Submission Open
Keywords: HIV infection; immune response; chronic inflammation; immune activation; antiretroviral therapy (ART); immune reconstitution; immune checkpoints
(This special issue belongs to the Section Cellular Immunology)
New Molecular Insights into Hepatitis and Hepatic Cancer
edited by
submission deadline 20 Oct 2025 | Viewed by 116 | Submission Open
Keywords: hepatitis; alcoholic and non-alcoholic steatohepatitis; HBV and HCV; hepatic Cancer; hepatocellular carcinoma; chronic liver disease; cellular and molecular basis; signaling pathways; antiviral therapies; immunotherapy; therapeutic advances
(This special issue belongs to the Section Cellular Pathology)
Autophagy in Neurological Disorders submission deadline 20 Oct 2025 | Viewed by 103 | Submission Open
Keywords: autophagy; selective autophagy; neurodegeneration; proteostasis; lysosomes; aging; oxidative stress; aging; biomarkers; pharmacological agents
(This special issue belongs to the Section Cells of the Nervous System)
New Advances in Anticancer Therapy
edited by
submission deadline 20 Oct 2025 | Viewed by 94 | Submission Open
Keywords: antibody-based immunotherapy; cell therapy; personalized anticancer therapy; RNA vaccines; nanotechnology
(This special issue belongs to the Section Cellular Pathology)
Cell Death and Its Clearance in Health and Disease
edited by
submission deadline 20 Oct 2025 | Viewed by 94 | Submission Open
Keywords: cell death; phagocytosis; immune homeostasis; inflammation
(This special issue belongs to the Section Cellular Pathology)
The Cellular and Molecular Mechanisms of Immunity to Infectious Viruses submission deadline 20 Oct 2025 | Viewed by 86 | Submission Open
Keywords: viral infections; immune cell biology; gene expression programs; epigenetics; chromatin architecture; cis-regulatory elements; functional genomics; computational biology applications
(This special issue belongs to the Section Cellular Pathology)
Unraveling Protein–Protein Interactions for Innovative Therapeutics and Nanodelivery
edited by Roberta Montanari and
submission deadline 20 Oct 2025 | Viewed by 58 | Submission Open
Keywords: protein– protein interactions; PPI modulators; nanodelivery; molecular mechanisms
(This special issue belongs to the Section Cellular Biophysics)
Recent Advances in Regenerative Dentistry—Second Edition
edited by
submission deadline 25 Oct 2025 | 5 articles | Viewed by 9848 | Submission Open
Keywords: oral stem cells; oral tissue regeneration; bioengineering; dental materials; stem cell banking
(This special issue belongs to the Section Tissues and Organs)
Adult Stem Cells in Human Disease
edited by Esther Wolfs, Tim Vangansewinkel and
submission deadline 25 Oct 2025 | 1 articles | Viewed by 2438 | Submission Open
Keywords: dental pulp stem cells; disease; regenerative medicine; disease modeling
(This special issue belongs to the Section Stem Cells)
3D Cultures and Organ-on-a-Chip in Cell and Tissue Cultures submission deadline 25 Oct 2025 | 1 articles | Viewed by 1157 | Submission Open
Keywords: three-dimensional cell culture; organ-on-a-chip; tissue engineering; regenerative medicine; drug testing; microfluidics; in vitro models; personalized medicine; cellular interaction; disease modeling
(This special issue belongs to the Section Cell Methods)
Beyond Bystanders: The Emerging Roles of Glia in Brain Health and Disease
edited by
submission deadline 25 Oct 2025 | Viewed by 153 | Submission Open
Keywords: astrocytes; microglia; oligodendrocytes; neuroinflammation; neuroimmunology; synaptic plasticity; blood– brain barrier; neuropsychiatric disorders
(This special issue belongs to the Section Cells of the Nervous System)
Molecular Anatomy and Function of Sensory Organs and Sensory Tissues
edited by
submission deadline 25 Oct 2025 | Viewed by 117 | Submission Open
Keywords: sensory organ; sensory tissue; vision; hearing; skin; sensory structures of internal organs
(This special issue belongs to the Section Tissues and Organs)
Regenerating Poorly Vascularized Tissues
edited by Simone Pacini
submission deadline 25 Oct 2025 | Viewed by 114 | Submission Open
Keywords: regenerative medicine; avascular tissue; angiogenesis; vasculogenesis; cell-based medicinal products; bioengineered materials; cell transplantation
(This special issue belongs to the Section Tissues and Organs)
Therapeutic Targeting of MicroRNAs in Human Cancer
edited by
submission deadline 28 Oct 2025 | Viewed by 90 | Submission Open
Keywords: microRNAs; nanoparticle platforms; spatial miRNomics; combination therapeutic strategies
(This special issue belongs to the Section Cell and Gene Therapy)
Immunoregulatory Functions of Mesenchymal Stem Cells (MSCs)
edited by
submission deadline 30 Oct 2025 | 1 articles | Viewed by 448 | Submission Open
Keywords: mesenchymal stem cells; MSCs; immunoregulation; immunosuppression
(This special issue belongs to the Section Stem Cells)
Emerging Topics in Smooth Muscle Cell Fate and Plasticity in Atherosclerosis submission deadline 30 Oct 2025 | 1 articles | Viewed by 363 | Submission Open
Keywords: vascular smooth muscle cells; lineage tracing; fate mapping; VSMC plasticity; (single cell) (spatial) omics; vascular heterogeneity; atherosclerosis
(This special issue belongs to the Section Cellular Pathology)
Advances in Cellular and Molecular Treatment of Autoimmune Diseases—Second Edition submission deadline 30 Oct 2025 | Viewed by 207 | Submission Open
Keywords: autoimmune diseases; disease activity; TNFa inhibitors; tocilizumab; infliximab; golimumab; etanercept; JAK inhibitors; cellular targets; molecular targets
(This special issue belongs to the Section Cellular Immunology)
Thirty plus Years’ Journey—Painting the Molecular Picture of E-C Coupling
edited by Jianjie Ma, Long-Sheng Song, and
submission deadline 30 Oct 2025 | Viewed by 109 | Submission Open
Keywords: E-C coupling; calcium signaling; muscle physiology; cardiovascular disease
New Advances in Cancer Cell Biology: Biomarkers and Therapeutic Targets
edited by
submission deadline 30 Oct 2025 | Viewed by 86 | Submission Open
Keywords: cancer; biomarkers; therapeutic targets
(This special issue belongs to the Section Cellular Immunology)
Molecular Cell Biology of T Cells in Cancer and Infectious Diseases
edited by and João Viola
submission deadline 30 Oct 2025 | Viewed by 84 | Submission Open
Keywords: T cells; cancer; infectious diseases; genomics; proteomics; metabolomics; metabolism
(This special issue belongs to the Section Cellular Immunology)
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