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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Role of T Cells in Immune Disease Treatment

edited by

Ilan Bank

submission deadline 15 Jul 2026 | 1 articles | Viewed by 1706 | Submission Open

Keywords: autoimmunity; autoimmune diseases; immunotherapy; immune diseases; T cells; B cells; natural killer T cells

(This special issue belongs to the Section Cellular Immunology)

Phytofactories: From Lab to Applications

edited by

and

submission deadline 15 Jul 2026 | 1 articles | Viewed by 1556 | Submission Open

Keywords: plant cell suspension cultures; phytofactories; bioprocess; specialty molecules; metabolic engineering; germplasm preservation

(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)

Role of Ras-Regulated Signal Pathways

edited by

Takayuki Tsukuba

submission deadline 15 Jul 2026 | Viewed by 522 | Submission Open

Keywords: Ras-regulated signaling pathway; MAPK/ERK pathway; PI3K/AKT pathway; Ral-GDS pathway

(This special issue belongs to the Section Cell Signaling)

Functions of Cilia

edited by

Raj Luxmi

submission deadline 15 Jul 2026 | Viewed by 441 | Submission Open

Keywords: cilia; cilia-derived vesicles; ciliopathies; neuronal cilia; motile cilia; primary cilia; ciliary secretion; peptidergic signaling; ectosomes

MET: Signaling, Regulation, and Biological Roles

edited by Abdulhameed Al-Ghabkari and William W. Lockwood

submission deadline 15 Jul 2026 | Viewed by 253 | Submission Open

Keywords: MET; HGF (hepatocyte growth factor); MET signaling; receptor tyrosine kinase (RTK); cancer; tumor progression; receptor activation; MET-targeted therapy

(This special issue belongs to the Section Cell Signaling)

Role of Hippo Signaling in Cancer

edited by

Dimpi Mukhopadhyay

and

Alessio D'Alessio

submission deadline 15 Jul 2026 | Viewed by 235 | Submission Open

Keywords: angiogenesis; cancer metabolism; cancer stemness; chemoresistance; endothelial cell plasticity; epithelial-to-mesenchymal transition (EMT); hippo signaling pathway; immunotherapy; mechanotransduction; targeted cancer therapy; TEAD transcription factors; therapeutic resistance; tumor microenvironment; tumorigenesis; YAP/TAZ; new therapeutic modalities to target YAP/TAZ-driven tumors including ferroptosis

(This special issue belongs to the Section Cell Signaling)

Skeletal Muscle Plasticity in Health, Aging and Disease

edited by

Junaith S. Mohamed

submission deadline 15 Jul 2026 | Viewed by 172 | Submission Open

Keywords: skeletal muscle; muscle plasticity; muscle regeneration; muscle atrophy; mitochondria; autophagy; non-coding RNAs

(This special issue belongs to the Section Cellular Aging)

Molecular and Cellular Mechanisms of Inherited Retinal Diseases

edited by Holly Yu Chen

submission deadline 15 Jul 2026 | Viewed by 118 | Submission Open

Keywords: inherited retinal diseases; retinal degeneration; retinal organoids; mü ller glia; retinal pigment epithelium

(This special issue belongs to the Section Cellular Pathology)

Select Topics in Molecular and Cellular Mechanisms of Mammalian Reproduction

edited by Zhengui Zheng,

Brent M. Bany

and Liang Ma

submission deadline 20 Jul 2026 | 7 articles | Viewed by 18466 | Submission Open

Keywords: reproductive organ development; sexual differentiation; reproductive tract function; fertilization; implantation; placentation; parturition; lactation

(This special issue belongs to the Section Reproductive Cells and Development)

The Roles of the Extracellular Matrix in Cardiac Structure and Function: A Commemorative Issue in Honor of Dr. Thomas K. Borg

edited by

Wayne Carver

and Edie Goldsmith

submission deadline 20 Jul 2026 | 9 articles | Viewed by 14482 | Submission Open

Keywords: collagen; integrin; extracellular matrix; cardiomyocyte; fibroblast; heart bioengineering

(This special issue belongs to the Section Cell Microenvironment)

Insights into the Pathophysiology of NeuroCOVID: Current Topics

edited by

Christian Barbato

Antonio Minni

and

Carla Petrella

submission deadline 20 Jul 2026 | 4 articles | Viewed by 7520 | Submission Open

Keywords: neuroCOVID; longCOVID; neurocognitive; cellular and molecular neurobiology; brain fog; anxiety; depression; biomarkers; translational biomedicine; neurodegenerative diseases

(This special issue belongs to the Section Cellular Pathology)

Mitochondria at the Crossroad of Health and Disease—Second Edition

edited by

Nickolay Brustovetsky

submission deadline 20 Jul 2026 | 6 articles | Viewed by 7006 | Submission Open

Keywords: mitochondria; oxidative phosphorylation; mitochondrial ion transport; permeability transition pore; mitochondrial ROS generation; mitochondrial quality control; mitochondrial traffic; mitochondrial morphology; mitochondrial dynamics; mitophagy

(This special issue belongs to the Section Cellular Aging)

Second Edition of Advances in Adipose Tissue Biology

edited by

Melvin K. S. Leow

submission deadline 20 Jul 2026 | 2 articles | Viewed by 5785 | Submission Open

Keywords: adipocyte differentiation; progenitors; and stem cells; adipokines; myokines; hepatokines; cytokines; cellular signaling; and molecular crosstalk; white adipose tissue (WAT) and brown adipose tissue (BAT); beige fat and browning of WAT; research techniques and methodologies; diagnostics and therapeutics; genomics; metabolomics; other ‘ omics’ technologies; metabolic syndrome; obesity; insulin resistance; cancer

(This special issue belongs to the Section Tissues and Organs)

Cancer and Immune System Interactions

edited by

Hong-Jian Zhu

and

Bradley Creamer

submission deadline 20 Jul 2026 | 2 articles | Viewed by 1819 | Submission Open

Keywords: cancer immunology; tumor microenvironment; immune evasion; immunotherapy; tumor– immune interactions; immune checkpoint regulation; translational oncology

(This special issue belongs to the Section Cell Microenvironment)

Impact of Chronic Substance Exposure on Hematopoiesis and Immunity

edited by

Mary Mohrin

and

Hami Hemati

submission deadline 20 Jul 2026 | Viewed by 333 | Submission Open

Keywords: Substance Use Alcohol Immunity Inflammation Hematopoietic stem and progenitor cells Monocytes Neutrophils Macrophages T cells

Clockwork Cells: Decoding the Language of Cell Cycle Regulators

edited by

Guanxiong Yan

, Kyung-sang Lee,

Richard W. Wong

and

Gary S. Stein

submission deadline 20 Jul 2026 | Viewed by 324 | Submission Open

Keywords: cyclins; cyclin-dependent kinases (CDKs); checkpoints; cell proliferation; mitosis; meiosis

(This special issue belongs to the Section Cell Proliferation and Division)

Cellular and Molecular Research of Plant-Derived Exosomes

edited by Mukesh Kumar Sriwastva

submission deadline 20 Jul 2026 | Viewed by 224 | Submission Open

Keywords: plant-derived exosomes; extracellular vesicles; exosome isolation and characterization; cross-kingdom communication; therapeutic applications; biomolecule cargo (proteins; RNAs; lipids); plant exosome-like nanoparticles; drug delivery systems

(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)

Cellular Signaling and Metabolic Adaptations in the Tumor Microenvironment

edited by Shashi Anand

submission deadline 20 Jul 2026 | Viewed by 200 | Submission Open

Keywords: cancer metabolic plasticity; tumor microenvironment; metabolic vulnerabilities; oncogenic signaling pathways; hypoxia and nutrient stress; therapeutic resistance

(This special issue belongs to the Section Cellular Metabolism)

Epigenetic and Metabolic Regulation of Cancer—2nd Edition

edited by

Jung-Hyun Kim

and

Ming Tan

submission deadline 20 Jul 2026 | Viewed by 191 | Submission Open

Keywords: cancer; epigenetic; transcription; chromatin; tumor metabolism; immunometabolism

(This special issue belongs to the Section Cellular Metabolism)

Molecular Mechanisms and Targeting Strategies of the Blood–Brain Barrier

edited by Kasandra Bélanger

submission deadline 20 Jul 2026 | Viewed by 182 | Submission Open

Keywords: blood– brain barrier; homeostasis; neurovascular unit; drug delivery; neurorological disorders; BBB integrity; permeability; molecular pathways

(This special issue belongs to the Section Cellular Neuroscience)

Bioactive Compounds in the Management of Neurodegenerative Diseases

edited by Melania Ruggiero and

Maria Antonietta

submission deadline 20 Jul 2026 | Viewed by 177 | Submission Open

Keywords: bioactive compounds; neurodegenerative diseases; neuroprotection; neuroinflammation; oxidative stress; neurogenesis; astrocytes reprogramming

(This special issue belongs to the Section Cellular Neuroscience)

Applications of Nanotechnology and Molecular Imaging in Cancer

edited by

Zheng-Rong Lu

and Victoria Laney

submission deadline 20 Jul 2026 | Viewed by 157 | Submission Open

Keywords: contrast agents and mechanisms; probes; molecular imaging; longitudinal imaging; tumor microenvironment; nanomaterials; cell signaling; cancer therapy; intracellular pathways; imaging-guided treatment

Novel Molecular Targets for the Treatment of Sleep Disorders

edited by

Dae-Wui Yoon

submission deadline 25 Jul 2026 | Viewed by 446 | Submission Open

Keywords: sleep disorders; molecular targets; glymphatic system; neuroinflammation; circadian rhythms; microbiome; biomarkers; pharmacological therapy; gene therapy; neurodegeneration

A New Frontier for Cancer Diagnosis and Therapy

edited by

Concettina La Motta

Md Manirujjaman

and

A.S.M. Waliullah

submission deadline 25 Jul 2026 | Viewed by 361 | Submission Open

Keywords: cancer diagnosis; precision oncology; liquid biopsy; molecular biomarkers; immunotherapy; targeted therapy; nanomedicine; multi-omics; artificial intelligence; tumor heterogeneity

(This special issue belongs to the Section Cellular Immunology)

Molecular Regulation of Trophoblast Invasion in Placental Function and Pregnancy Disorders

edited by Mirjana Nacka-Aleksić

submission deadline 25 Jul 2026 | Viewed by 175 | Submission Open

Keywords: trophoblast invasion; preeclampsia; placenta accreta; human trophoblast stem cells

(This special issue belongs to the Section Reproductive Cells and Development)

Harnessing the Immune System: Emerging Therapeutic Strategies in Cancer

edited by Kishan Shamjibhai Italiya

submission deadline 25 Jul 2026 | Viewed by 154 | Submission Open

Keywords: cancer immunotherapy; tumor microenvironment; immune checkpoint inhibitors; adoptive cell therapy; cancer vaccines; T cell therapy; immuno-oncology; tumor immune evasion; immune modulation; antitumor immunity

(This special issue belongs to the Section Cellular Immunology)

Applications of Proteomics in Human Diseases and Treatments

edited by

Giovanni Cuda

and

Marco Gaspari

submission deadline 30 Jul 2026 | 2 articles | Viewed by 3213 | Submission Open

Keywords: biomarkers; clinical proteomics; single-cell proteomics; next-generation proteomics; biofluids; high-throughput proteomics

(This special issue belongs to the Section Cell Methods)

Osteoporosis Treatment: Targeting Osteoclast and Osteoblast Function with microRNA Therapeutics

edited by

Aijaz Ahmad John Bhat

submission deadline 30 Jul 2026 | 1 articles | Viewed by 2355 | Submission Open

Keywords: osteoporosis; microRNA; osteoblasts; osteoclasts; osteocytes; fracture; bone remodeling

(This special issue belongs to the Section Tissues and Organs)

Toxicology in Cells: Cellular Mechanisms, Molecular Responses, and Modern Models

edited by Maria Jurczuk and

Patrice X. Petit

submission deadline 30 Jul 2026 | 2 articles | Viewed by 1538 | Submission Open

Keywords: cellular toxicology; oxidative stress; apoptosis; autophagy; biomarkers; nanotoxicology; organ-on-chip; toxicogenomics; epigenetic regulation; mitochondrial dysfunction

Mitochondria in Cancer Immune Evasion and Immunotherapy

edited by Loredana Moro and

Flora Guerra

submission deadline 30 Jul 2026 | 2 articles | Viewed by 1092 | Submission Open

Keywords: mitochondria; mtDNA; immunity; cancer immune evasion; tumor microenvironment; immune tolerance; lymphocytes; inflammation; immune response

(This special issue belongs to the Section Cellular Immunology)

New Advances in Immunomodulation Using Biomaterials

edited by

Gundula Schulze-Tanzil

and Vaishali Inamdar

submission deadline 30 Jul 2026 | 1 articles | Viewed by 915 | Submission Open

Keywords: immunomodulation; biomaterials; cell– material interactions; biocompatibility; immune system

In Vitro Models for Assessing Toxicity and Cellular Effects

edited by

Anna Bassi

Sara Tirendi

Alice Zoso

and Camilla Paoletti

submission deadline 30 Jul 2026 | Viewed by 249 | Submission Open

Keywords: alternative testing; NAMs; 3D in vitro models; organ-on-chip; millifluidic cultures; toxicity; biomaterials; 3Rs; organoids

Cancer Cytopathology: Structural Features and Intracellular Events in Malignancy

edited by

Toshimichi Onuma

and

Jianjun Wei

submission deadline 30 Jul 2026 | Viewed by 208 | Submission Open

Keywords: cancer cells; cytopathology; tumor microenvironment; cell culture; biopsies

(This special issue belongs to the Section Cellular Pathology)

Targeted Therapy and Immunotherapy in Breast Cancer: Molecular Mechanisms and Translational Advances

edited by Saranya Chumsri, Hatem H. Soliman and

Aixa Elena Soyano

submission deadline 30 Jul 2026 | Viewed by 206 | Submission Open

Keywords: breast cancer; targeted therapy; immunotherapy; biomarkers of response; therapeutic resistance

(This special issue belongs to the Section Cellular Immunology)

Cellular Mechanisms of Anti-Cancer Therapies

edited by Ilgen Mender and

Kazuyuki Kitatani

submission deadline 31 Jul 2026 | 8 articles | Viewed by 29500 | Submission Open

Keywords: anti-cancer therapies; innovative treatment strategies; cellular mechanisms; drug resistance; personalized medicine

(This special issue belongs to the Section Cellular Pathology)

How Can We Optimise Cancer Therapy? Tumour Microenvironment and Immune Evasion Strategies

edited by

Agnieszka Bojarska-Junak

and

Michal Zarobkiewicz

submission deadline 31 Jul 2026 | 6 articles | Viewed by 16684 | Submission Open

Keywords: immunosurveillance; immune evasion in cancer; tumour microenvironment; immune suppression; immunotherapy; immune checkpoints; cancer immunity; drug intervention

(This special issue belongs to the Section Cell Microenvironment)

Advances in the Cellular and Molecular Mechanisms of Cardiovascular Diseases

edited by

Timothy Martin Palmer

and Katie S. Wraith

submission deadline 31 Jul 2026 | 7 articles | Viewed by 11061 | Submission Open

Keywords: thrombosis; smooth muscle; endothelium; atherosclerosis; inflammation

(This special issue belongs to the Section Cells of the Cardiovascular System)

Cellular and Molecular Mechanisms of Vascular-Related Diseases

edited by

Bingmei Fu

and

Ye Zeng

submission deadline 31 Jul 2026 | 8 articles | Viewed by 10914 | Submission Open

Keywords: cellular and molecular mechanisms; cardiovascular disease; cerebrovascular disease; vascular signaling; vascular dysfunctions in cns disorders; vascular dysfunctions in diabetes; vascular dysfunction in chronic kidney disease; tumor metastasis via vascular system

(This special issue belongs to the Section Cellular Pathology)

Advances in the Discovery of Retinal Degeneration

edited by

Ram Prasad

and

Yvonne Adu-Rutledge

submission deadline 31 Jul 2026 | 6 articles | Viewed by 10396 | Submission Open

Keywords: retinal cell biology; photoreceptors; oxidative stress; inflammation; blood– retinal barriers; diabetic retinopathy; clinical eye research; inherited retinal diseases; ocular immunology

(This special issue belongs to the Section Cellular Pathology)

Mechanisms of Lung Growth and Regeneration

edited by

Saverio Bellusci

and

Yuanlin Song

submission deadline 31 Jul 2026 | 4 articles | Viewed by 8944 | Submission Open

Keywords: stem cells; niche; aging; growth factors; extracellular matrix; organoids; fibrosis; single-cell RNAseq

(This special issue belongs to the Section Cell Microenvironment)

Adipose Tissue Functioning in Health and Diseases

edited by Richard C Chang

submission deadline 31 Jul 2026 | 4 articles | Viewed by 7689 | Submission Open

Keywords: adipose tissue biology; adipogenesis; lipolysis; adipose tissue inflammation; diet-induced obesity; non-coding RNA in metabolism; PPARγ signaling; metabolic health and disease; obesogens; epigenetics and chromatin regulation; transgenerational inheritance

(This special issue belongs to the Section Tissues and Organs)

Osteoblasts, Osteoclasts and Bone Diseases: Cellular Crosstalk and Therapeutic Opportunities

edited by

Thomas Nicholson

submission deadline 31 Jul 2026 | 3 articles | Viewed by 6501 | Submission Open

Keywords: osteoblasts; osteoclasts; bone remodelling; osteoporosis; skeletal diseases; bone homeostasis; bone interactions; bone crosstalk; targeted therapies

(This special issue belongs to the Section Cellular Pathology)

Cellular and Molecular Mechanisms in Neuropsychiatric and Neurological Disorders

edited by Irina Balan

submission deadline 31 Jul 2026 | 4 articles | Viewed by 5974 | Submission Open

Keywords: cellular mechanisms; molecular mechanisms; neuropsychiatric disorders; neurological disorders; neuroinflammation; neuronal signaling; gene expression; synaptic function; glial cells; peripheral factors

(This special issue belongs to the Section Cellular Pathology)

Emerging Mechanisms and Therapeutic Strategies in Head and Neck Cancer

edited by

Madalina Anca Moldovan

and

Ciprian Tomuleasa

submission deadline 31 Jul 2026 | 5 articles | Viewed by 5077 | Submission Open

Keywords: tumor microenvironment; epithelial– mesenchymal transition (EMT); tumor– stroma interaction; treatment resistance; radiotherapy sensitization; targeted therapy; precision oncology

Cellular and Molecular Mechanisms of Heart Diseases

edited by

Sumita Mishra

submission deadline 31 Jul 2026 | 2 articles | Viewed by 4732 | Submission Open

Keywords: heart failure; HFrEF; HFpEF; molecular signaling; therapeutic interventions; ejection fraction; fibrosis; metabolism; mitochondrial dysfunction; cardiovascular therapies

(This special issue belongs to the Section Cellular Pathology)

The Role of Pancreatic Beta-Cells in Obesity and Type 2 Diabetes

edited by Mayur Doke, Juan Domínguez-Bendala and Oscar Alcazar

submission deadline 31 Jul 2026 | 3 articles | Viewed by 4664 | Submission Open

Keywords: pancreatic beta-cells; GLP-1; obesity; type 2 diabetes; islet biology; beta-cell regeneration; insulin resistance; incretin therapies; single-cell transcriptomics; metabolic stress

Cellular and Molecular Mechanisms in Immune Regulation—Second Edition

edited by Fábio Rinaldo Santori and Natalia B. Ivanova

submission deadline 31 Jul 2026 | 5 articles | Viewed by 4523 | Submission Open

Keywords: innate immunity; dendritic cells; macrophages; T cells; B cells; cytokines; immunotherapy

(This special issue belongs to the Section Cellular Pathology)

Advances in Smart and Innovative Nanoparticles for Precision Tumor Therapy: Design, Delivery, Immune Modulation, and Clinical Translation

edited by Hari Krishnareddy Rachamala and

Naga Malleswara Rao Nakka

submission deadline 31 Jul 2026 | 2 articles | Viewed by 4138 | Submission Open

Keywords: smart nanoparticles; tumor-targeted drug delivery; immune modulation; stimuli-responsive nanocarriers; clinical translation in oncology

(This special issue belongs to the Section Cell Methods)

Genetic Mechanisms in Cellular Genomics and Therapeutics

edited by Elaine T. Lim and Yingleong Chan

submission deadline 31 Jul 2026 | 1 articles | Viewed by 4007 | Submission Open

Keywords: genetics of human diseases; functional genomics; cellular mechanisms; genomics or stem cell technologies; therapeutics research and development for human diseases

Integrated Approaches Between Metabolomics and Cellular Aging

edited by Maria Nikolaou and

Nikolaos Theodorakis

submission deadline 31 Jul 2026 | 2 articles | Viewed by 3980 | Submission Open

Keywords: metabolomics; cellular aging; senescence; mitochondrial dysfunction; DNA damage; biomarkers; metabolism

(This special issue belongs to the Section Cellular Aging)

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