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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Membrane Trafficking Components and Mechanisms in Bacterial, Viral or Fungal Infections

edited by

Bor Luen Tang

submission deadline 31 Mar 2026 | Viewed by 335 | Submission Open

Keywords: bacterial intracellular infections; bacterial intracellular sanctuaries; viral infection; viral hijacking of host trafficking machinery; membrane trafficking; Rab; secretory pathway; endocytic pathway; viral replication

Cellular and Molecular Insights into Gynecologic Tumors

edited by

Mladen Anđić

and

Jianjun Wei

submission deadline 31 Mar 2026 | Viewed by 329 | Submission Open

Keywords: gynecologic cancers; cervical cancer; endometrial cancer; ovarian tumors; tumor microenvironment; molecular biomarkers; genetic mutations; targeted therapies

Organelle Crosstalk: New Insights into Intracellular Communication and Dynamics

edited by

Jonathan Barra

submission deadline 31 Mar 2026 | Viewed by 323 | Submission Open

Keywords: organelle contact sites; membrane contact sites; intracellular communication; early endosomes; recycling endosomes; Golgi; mitochondrial dynamics; ER stress; mitophagy; autophagy; lysosome; calcium signaling; lipid transfer; proteostasis

PI3K/AKT/mTOR Signaling Network in Human Health and Diseases, 3rd Edition

edited by

Jean Christopher Chamcheu

Claudia Bürger

and

Shile Huang

submission deadline 31 Mar 2026 | Viewed by 287 | Submission Open

Keywords: acne; ageing; Akt; Alzheimer’ s disease; autophagy; autoimmunity; PI3K; mTOR; cancer; cardiovascular diseases; diabetes; growth; hamartoma; hypertrophy; inflammation; neurologic; tuberous sclerosis; systemic sclerosis; obesity; Parkinson’ s disease; psoriasis; atopic dermatitis; burns/wound healing; targeted therapy; natural products; biologics

Molecular and Cellular Drivers of Parkinson's Disease

edited by

Fatema Currim

and

Jason Cannon

submission deadline 31 Mar 2026 | Viewed by 268 | Submission Open

Keywords: Parkinson’ s disease; neurodegeneration; mitochondrial dysfunction; α -synuclein aggregation; neurotoxicity; neuroinflammation; oxidative stress; environmental factors; gene– environment interactions; cell death

(This special issue belongs to the Section Cellular Neuroscience)

Neurodevelopmental Factors of Autism Spectrum Disorder: Etiology to Therapy

edited by

George Ayoub

submission deadline 31 Mar 2026 | Viewed by 265 | Submission Open

Keywords: autism spectrum disorder; developmental factors; genetic contributions; environmental influences; gene– environment interactions; developing therapies

Ubiquitin Ligases: Key Regulators in Cellular Homeostasis and Disease

edited by Praveen Koganti and

Michal Goldberg

submission deadline 31 Mar 2026 | Viewed by 265 | Submission Open

Keywords: ubiquitin ligases; protein ubiquitination; cellular homeostasis; proteasome pathway

Current Research on Immunotherapy for Glioblastoma

edited by Markella Zannikou

submission deadline 31 Mar 2026 | Viewed by 259 | Submission Open

Keywords: GBM; tumor microenvironment; cancer vaccines; TIL (tumor-infiltrating lymphocytes) therapy; combination therapy; BiTEs; immune checkpoint therapy; CAR T-cell therapy; peptide/dendritic vaccines; tumor-associated antigens; oncolytic virotherapy

(This special issue belongs to the Section Cellular Immunology)

Neurodegenerative Diseases and Related Proteins

edited by Tian Liu

submission deadline 31 Mar 2026 | Viewed by 253 | Submission Open

Keywords: protein misfolding and aggregation; proteostasis and quality control; neuroinflammation; autophagy and mitophagy; molecular chaperones; Amyloid-β and tau; α -synuclein and TDP-43; multi-omics biomarkers; structural biology; therapeutic targets; mitochondrial– ER crosstalk; genetic and epigenetic regulation

Advances in CAR Cell Therapies and Manufacturing

edited by William J. Kelly and Madhuresh C. Sumit

submission deadline 31 Mar 2026 | Viewed by 239 | Submission Open

Keywords: CAR cells; autologous; allogeneic; crispr; lentivirus; expansion; cryopreservation; isolation; biomarker; cytokines

Multi-Omics Technologies in Immunity Within Tumors

edited by

Muhammad A. Alsherbiny

and

Anas M. Abdel Rahman

submission deadline 31 Mar 2026 | Viewed by 238 | Submission Open

Keywords: multi-omics; proteomics; metabolomics; lipidomics; genomics and epigenomics; synergistic combinations for cancer; AI applications in multi-omics integrations; tumor microenvironment (TME); cancer immunotherapy; immuno-oncology; integrative analysis of multi-omics; biomarkers; precision medicine; tumor heterogeneity

Novel Biomarkers and Dose-Response Modifiers in Radiation Oncology and Nuclear Medicine: Molecular Insights for Personalized Therapy and Precision Medicine

edited by

Wolfgang Sauerwein

and Andrea Wittig

submission deadline 31 Mar 2026 | Viewed by 227 | Submission Open

Keywords: targeted therapies; predictive essays; radiosensitizers; radioprotectors; theranostics; BNCT; alpha-immunotherapy; biological response modifiers; biomarkers

GABA_A Receptor Dynamics: From Cellular Quality Control to Disease Mechanisms

edited by Tingwei Mu and Yajuan Wang

submission deadline 31 Mar 2026 | Viewed by 212 | Submission Open

Keywords: GABAA receptors; trafficking; biogenesis; proteostasis; structure and function; gating; neurotransmission; neurological diseases; disease mechanisms

Stem Cells and Endometrium

edited by Shiying Jin

submission deadline 31 Mar 2026 | Viewed by 203 | Submission Open

Keywords: stem cell; homeostasis; regeneration; endometrium

(This special issue belongs to the Section Stem Cells)

Cell Death and Apoptosis

edited by

Marianna Pap

and

Judit Varga

submission deadline 31 Mar 2026 | Viewed by 199 | Submission Open

Keywords: apoptosis; necroptosis; pyroptosis; ferroptosis; regulated cell death; signaling pathways; tumor biology; resistance mechanisms

(This special issue belongs to the Section Cellular Pathology)

Next-Generation CAR-T Cell Therapy: From Bench to Bedside

edited by

Ping Zhang

and

Yasushi Akahori

submission deadline 31 Mar 2026 | Viewed by 192 | Submission Open

Keywords: chimeric antigen receptor T cells; cytokine release syndrome; immune effector cell-associated neurotoxicity syndrome (ICANS); immunotoxicity; T cell exhaustion; antigen discovery; CAR engineering; mouse models

(This special issue belongs to the Section Cellular Immunology)

Regulation of Ca²⁺ Signals in Human Disease

edited by Yandong Zhou

submission deadline 31 Mar 2026 | Viewed by 174 | Submission Open

Keywords: calcium signaling; cellular homeostasis; disease mechanisms; calcium channels; therapeutic targets

(This special issue belongs to the Section Cell Signaling)

Lung Diseases: From Cellular and Molecular Mechanisms to Targeted Therapies

edited by

Christoph Beisswenger

and Daniela Yildiz

submission deadline 31 Mar 2026 | Viewed by 161 | Submission Open

Keywords: lung diseases; cellular and molecular mechanisms; targeted therapies; OMICS; single-cell sequencing

From Liver Transplantation to Gene Therapy: A Therapeutic Revolution in Argininosuccinic Aciduria

edited by Sonam Gurung

submission deadline 31 Mar 2026 | Viewed by 159 | Submission Open

Keywords: urea cycle disorder; argininosuccinic aciduria; gene therapies; mRNA therapies; liver transplantation; arginosuccinate lyase (ASL)

Cellular and Molecular Mechanisms in Aging

edited by Michel Satya Naslavsky and Mateus Vidigal

submission deadline 1 Apr 2026 | 2 articles | Viewed by 2781 | Submission Open

Keywords: cellular senescence; aging models; DNA repair; neurodegeneration; elderly

(This special issue belongs to the Section Cellular Aging)

Glycolysis in Tumorigenesis: Mechanisms and Therapeutic Implications

edited by

Fabrizio Marcucci

, Shibo Wei and

Marco Cordani

submission deadline 1 Apr 2026 | Viewed by 240 | Submission Open

Keywords: glycolysis; tumorigenesis; moonlighting functions; Warburg effect; metabolic reprogramming; tumor microenvironment; therapeutic targets; cancer metabolism

Evolution, Structure, and Functions of Apolipoproteins L

edited by Etienne Pays

submission deadline 10 Apr 2026 | 4 articles | Viewed by 9699 | Submission Open

Keywords: APOL1 nephropathy; APOL1 risk variants; membrane traffic; membrane fission; membrane fusion; membrane dynamics; autophagy; mitophagy; viral replication; lipid droplets; pathogen resistance; inflammation

Novel and Experimental Strategies for the Treatment of Neurodegenerative Diseases

edited by

Morten Meyer

and Justyna Okarmus

submission deadline 10 Apr 2026 | 3 articles | Viewed by 8010 | Submission Open

Keywords: neurodegenerative diseases; experimental treatments; stem cell transplantation; immunotherapy; gene therapy; focused ultrasound; neuroprotective agents; Parkinson's disease; Alzheimer's disease; Huntington’ s disease; amyotrophic lateral sclerosis

(This special issue belongs to the Section Cellular Neuroscience)

Galectins in Cancer, Fibrosis and Immune Modulation: Mechanisms, Therapeutic Strategies and Translational Advances

edited by Tsung-Chieh Shih

submission deadline 10 Apr 2026 | 3 articles | Viewed by 6245 | Submission Open

Keywords: Galectin; tumor microenvironment; immunosuppression; fibrosis; epithelial– mesenchymal transition (EMT); cancer metastasis; immune evasion; therapy resistance; myeloid-derived suppressor cells (MDSCs); tumor-associated macrophages (TAMs); extracellular matrix remodeling; Galectin-targeted therapy; combination immunotherapy; fibroblast activation; chronic inflammation; tumor– stroma interactions; novel inhibitors of Galectins

(This special issue belongs to the Section Cellular Immunology)

New Tools to Address Old Challenges in Tolerogenic Cellular Therapies

edited by Konstantinos Mengrelis and

Nina Pilat

submission deadline 10 Apr 2026 | Viewed by 216 | Submission Open

Keywords: tolerogenic strategies; immune tolerance; allogeneic cellular therapies; autoimmunity; allergy; systems immunology; artificial intelligence; biomarkers; immune regulation

Cellular Mechanisms of Testosterone in Metabolic Disorders

edited by Daniel M. Kelly

submission deadline 13 Apr 2026 | Viewed by 178 | Submission Open

Keywords: testosterone; metabolism; type 2 diabetes; obesity; metabolic syndrome; MASLD; skeletal muscle; adipose tissue; insulin resistance; endocrine signalling

Modeling Developmental Processes and Disorders in Zebrafish

edited by

Natascia Tiso

and

Francesco Argenton

submission deadline 15 Apr 2026 | 13 articles | Viewed by 60218 | Submission Open

(This special issue belongs to the Section Cellular Biophysics)

Pathogenic Mechanisms of Chronic Inflammation-Associated Cancer

edited by Emiko Mizoguchi

submission deadline 15 Apr 2026 | 5 articles | Viewed by 29993 | Submission Open

Keywords: chronic inflammation; dysplasia; neoplasia; oncogene; cytokine; colitis-associated cancer

(This special issue belongs to the Section Cellular Pathology)

Role of Thyroid Hormone in Neurodegenerative and Neurodevelopmental Disorders

edited by Janaína Sena de Souza

submission deadline 15 Apr 2026 | 5 articles | Viewed by 12858 | Submission Open

Keywords: thyroid hormones; neurodevelopmental and neurodegenerative disorders; central nervous system

(This special issue belongs to the Section Cellular Neuroscience)

Advances in Zebrafish Disease Models

edited by

Natalia Kasica

and

Jaroslaw Widelski

submission deadline 15 Apr 2026 | 4 articles | Viewed by 8105 | Submission Open

Keywords: zebrafish; human disease models; experimental disease models; novel drugs and therapies; organic diseases; functional disorders

Mast Cells in Health and Disease: Current Insights and Future Perspectives on Development, Activation, Functional Roles, and Therapeutic Strategies

edited by

Aida Paivandy

submission deadline 15 Apr 2026 | 3 articles | Viewed by 3599 | Submission Open

Keywords: mast cell granules; mast cell mediators; mast cell development; mast cell survival; mast cell activation; mast cell activating and inhibitory receptors; receptor signaling; allergic and non-allergic pathologies; immunity and host defense; mast cell-directed therapeutic approaches

(This special issue belongs to the Section Cellular Immunology)

Increasing Incidence of Retinal Disorders: Addressing Preclinical Studies with Appropriate Animal Models and Advanced Methodologies

edited by

Paola Bagnoli

and

Maurizio Cammalleri

submission deadline 15 Apr 2026 | 3 articles | Viewed by 3326 | Submission Open

Keywords: hypoxia; oxidative stress; angiogenic markers; HIF-1/VEGF axis; retinal diseases; β -adrenoceptors; electroretinographic responses

(This special issue belongs to the Section Tissues and Organs)

Epigenetic Regulatory Networks in Cancer: Understanding the Mechanisms of Disease Progression

edited by

Anand Singh

and Sudheer Kumar Gara

submission deadline 15 Apr 2026 | 1 articles | Viewed by 2747 | Submission Open

Keywords: cancer; epigenetics; miRNAs; BAP1; DNMTs; tumor suppressor; oncogenes; histone modification; chromatin remodeling

(This special issue belongs to the Section Cellular Pathology)

Molecular Mechanisms and Pathophysiology of Diabetic Retinopathy

edited by

Siddharth Sunilkumar

, Stephanie L. Grillo and

Sandeep M. Subrahmanian

submission deadline 15 Apr 2026 | 1 articles | Viewed by 2191 | Submission Open

Keywords: diabetic retinopathy; retina; retinal neurodegeneration; diabetic macular edema; pathophysiology of diabetic retinopathy; proliferative and non-proliferative diabetic retinopathy; molecular mediators of diabetic retinopathy; cell-based therapies for diabetic retinopathy

(This special issue belongs to the Section Cellular Pathology)

Translational Aspects of Cell Signaling

edited by

Marc D. Basson

submission deadline 15 Apr 2026 | 2 articles | Viewed by 1971 | Submission Open

Keywords: cell signaling; drug development; prognostic markers; bioinformatics; translational research

Recent Advances in the Molecular Mechanisms of Neurodegenerative Diseases: Current Progress and Future Directions for Disease-Modifying Therapies

edited by

Rengasamy Balakrishnan

and

Balamuralikrishnan Balasubramanian

submission deadline 15 Apr 2026 | 1 articles | Viewed by 1880 | Submission Open

Keywords: neuroprotection; new drug development; natural products; blood– brain barrier; molecular mechanisms; neuronal signaling; neuroinflammation; microglial cells; neurotoxicity; neurodegenerative diseases

(This special issue belongs to the Section Cellular Aging)

Decoding Cancer Metabolism: Recent Insights and Future Directions

edited by Parash Prasad and Snehasis R. Mishra

submission deadline 15 Apr 2026 | 1 articles | Viewed by 1362 | Submission Open

Keywords: glutamine metabolism; Warburg effect; anaplerosis; fatty acid metabolism; ferroptosis; oncometabolites; hypoxia; mitochondrial dynamics; reactive oxygen species; glutathione synthesis; nutrient sensing

Cellular Metabolism and Hormonal Signaling in Colorectal Cancer: Biomarkers and Therapeutic Opportunities

edited by Jibran Sualeh Muhammad

submission deadline 15 Apr 2026 | 1 articles | Viewed by 540 | Submission Open

Keywords: colorectal cancer; metabolic reprogramming; gut microbiome– metabolite interactions; therapy resistance; hormonal signaling

Yeast Stress Responses and Cell Death Regulation

edited by

Maria João Sousa

Manuela Côrte-Real

and

Susana R. Chaves

submission deadline 15 Apr 2026 | Viewed by 487 | Submission Open

Keywords: yeast stress responses; environmental stresses; signalling pathways; cell death

Gut Dysbiosis in Inflammatory Diseases

edited by Weiwei Liu

submission deadline 15 Apr 2026 | Viewed by 474 | Submission Open

Keywords: gut microbiota; innate and adaptive immunity; dysbiosis; metabolism; inflammatory bowel diseases; autoimmune diseases; metabolic disorders; fecal microbiota transplantation

(This special issue belongs to the Section Cellular Pathology)

Cell Biology of the Eye: Development, Disorders, and Repair

edited by

Meha Kabra

Praveen Joseph Susaimanickam

and

Alessandra Micera

submission deadline 15 Apr 2026 | Viewed by 246 | Submission Open

Keywords: eye development; ocular homeostasis; degenerative eye disorders; stem cells; Regenerative medicine; ocular imaging; disease modeling; cellular senescence; gene therapy; ophthalmology therapeutics

Extracellular Vesicles in Chronic Obstructive Pulmonary Disease: A 2025 Update

edited by

Tommaso Neri

and

Erica Bazzan

submission deadline 15 Apr 2026 | Viewed by 218 | Submission Open

Keywords: extracellular vesicles (EVs); chronic obstructive pulmonary disease (COPD); inflammation; epithelial barrier; cellular senescence; tissue remodeling; biomarkers; exacerbations; microbiota; therapeutic targets

Advances in Annexin Biology

edited by

Raffaella Belvedere

Antonello Petrella

and Nunzia Novizio

submission deadline 15 Apr 2026 | Viewed by 201 | Submission Open

Keywords: annexin family; calcium-dependent membrane binding; cell signaling; inflammation and immune response; membrane repair; cancer biology; cell motility; cell differentiation; tumor microenvironment; diagnostic/prognostic biomarkers; therapeutic targets

Cellular and Molecular Mechanisms of Cell Death in Neurodegenerative Diseases

edited by

Nikolaos Patikas

and Emmanouil Metzakopian

submission deadline 15 Apr 2026 | Viewed by 185 | Submission Open

Keywords: cell death; neurodegenerative diseases; molecular biology; genomics; neuroinflammation; protein aggregation; neurobiology; mitochondria dysfunction

Cellular and Molecular Studies of the Adrenal Gland

edited by Wen-Jun Shen,

Fredric B. Kraemer

and Salman Azhar

submission deadline 15 Apr 2026 | Viewed by 161 | Submission Open

Keywords: adrenal zonation; steroid hormones; steroidogenesis; congenital adrenal hyperplasia; hyperaldosteronism; Cushing’ s syndrome

Neurobiology of Sleep

edited by

Henna-Kaisa Wigren

submission deadline 15 Apr 2026 | Viewed by 146 | Submission Open

Keywords: sleep-wake regulation; neural circuits; glial biology; neurometabolism; sleep disorders; aging; neuropathology; astrocytes; GABAergic neurons

(This special issue belongs to the Section Cellular Neuroscience)

Novel Therapeutic Targets and Approaches, Genetic Markers and Signaling Pathways in Neoplasms

edited by

Daria Chudakova

and

Kazuyuki Kitatani

submission deadline 20 Apr 2026 | 11 articles | Viewed by 36848 | Submission Open

Keywords: cancer; neoplasms; personalized medicine; genetic markers; next-generation sequencing (NGS); whole-genome sequencing; signaling pathways in cancer; novel therapeutic targets; drug development

(This special issue belongs to the Section Cell and Gene Therapy)

Molecular Mechanisms of Tumor Pathogenesis

edited by

Saverio Candido

and

Alessandro Lavoro

submission deadline 20 Apr 2026 | 9 articles | Viewed by 28613 | Submission Open

Keywords: cancer; therapeutic targets; biomarkers; epigenetics; DNA methylation; microRNAs; somatic mutations; germline mutations; chromatin remodeling; histone modifications

(This special issue belongs to the Section Cellular Pathology)

Recent Advances in Novel Cell and Gene Therapies for the Treatment of Immune Diseases

edited by Qingdong Guan

submission deadline 20 Apr 2026 | 2 articles | Viewed by 10448 | Submission Open

Keywords: cell therapy; gene therapy; chimeric antigen receptor T cells; T cell receptor-engineered T cells; tumor-infiltrating lymphocytes; hematopoietic stem cells; chimeric antigen receptor NK cells; induced pluripotent stem cells; mesenchymal stem/stromal cells; immune regulatory cells

(This special issue belongs to the Section Cellular Immunology)

Chromosomal Instability in Health and Disease

edited by Anna V. Roschke

submission deadline 20 Apr 2026 | 3 articles | Viewed by 7614 | Submission Open

Keywords: chromosomal instability; aneuploidy; polyploidy; cancer evolution; chromosomal instability and aneuploidy in embryonic development; chromosomal instability and polyploidy in evolutionary process; somatic aneuploidy in senescence and ageing

(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)

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