Cellular and Molecular Mechanisms of Liver Diseases
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 1913
Special Issue Editor
Special Issue Information
Dear Colleagues,
The liver is the largest internal organ and gland in the human body. It performs many vital functions to keep the body pure from toxins and harmful substances; thus, it is considered a central organ for metabolic homeostasis. Liver diseases account for two million deaths annually. The major risk factors include prolonged excessive alcohol consumption, chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections, autoimmune hepatitis, drug-induced liver injury, diabetes mellitus, obesity, and other metabolic diseases.
Liver injury induced by these risk factors is often reversible at early stages since normally quiescent hepatocytes can proliferate and restore normal liver mass and functions. However, persistent injury increases cellular damage, oxidative stress, and inflammation, which can lead to liver fibrosis, progress to cirrhosis, and may ultimately result in liver cancer. In addition, genetic and epigenetic alterations are involved in the development and progression of liver diseases.
This Special Issue will publish original articles and review articles in basic, translational research concerning Cellular and Molecular Mechanisms of all aspects of liver diseases.
Dr. Jieyun Jiang
Guest Editor
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Keywords
- liver
- alcoholic liver disease (ALD)
- viral hepatitis
- metabolic associated steatotic liver disease (MASLD)
- autoimmune hepatitis
- drug-induced liver injury
- liver fibrosis and cirrhosis
- liver cancer
- cellular and molecular mechanisms
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