Mitochondria Beyond Energy: Signaling, Immunity, and Cell Fate

Dear Colleagues,

Mitochondria are increasingly recognized as central regulators of cell identity and function, with their activities extending far beyond their classical role in energy production.

In embryogenesis, adult stem cells, and induced pluripotent stem cells (iPSCs), mitochondrial dynamics, and metabolism orchestrate the transition from pluripotent or multipotent progenitor states to lineage commitment and terminal differentiation.

Mitochondrial functions include cell signaling, epigenetic remodeling, and transcriptional programs that collectively define cell fate.

This Special Issue will bring together studies exploring how mitochondrial function, communication, fission, fusion, and transfer influence differentiation, regeneration, and disease. From developmental and stem cell biology to metabolism and tissue engineering perspectives, this Special Issue will advance our understanding of how mitochondrial signaling governs stem cell differentiation and regenerative potential.

We welcome original research articles and reviews addressing mitochondrial regulation in induced pluripotent stem cells (iPSCs) and mesenchymal stem cells (MSCs), organogenesis, and their roles in chondrogenesis, immunometabolism, and regenerative medicine. We particularly encourage submissions addressing how mitochondrial signaling networks guide stem cell fate decisions and contribute to regenerative medicine applications.

Topics of interest include, but are not limited to, the following:

• Mitochondrial dynamics;
• Metabolic reprogramming;
• Mitochondria and cell fate;
• Mitochondrial transfer;
• Mitochondria and disease models;
• Developmental lineage control;
• Translational studies bridging mitochondrial signaling and regeneration.

Dr. Martha E Diaz-Hernandez
Guest Editor

Manuscript Submission Information

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