Brain Insulin Resistance in Neurodegenerative Disorders and Its Treatments
A Special Issue of Cells (ISSN 2073-4409) belonging to the section "Cellular Neuroscience".
Deadline for manuscript submissions: 30 November 2026 | Viewed by 1330
Editor
Special Issue Information
Dear Colleagues,
Insulin signaling plays many vital roles in the brain, including promotion of neuronal development, inhibition of apoptosis and autophagy, facilitation of protein synthesis, and regulation of food intake, energy metabolism, synaptic plasticity, and cognition. Reduced responsiveness to insulin in the brain, a condition called brain insulin resistance, can thus have serious consequences. Indeed, evidence of brain insulin resistance has been reported in five neurodegenerative disorders—Alzheimer’s disease, Down syndrome, Parkinson’s disease dementia, Pick’s disease, and multiple system atrophy—as well as in traumatic brain injury, a risk factor for Alzheimer’s and Parkinson’s disease. The same may be true for other neurodegenerative disorders in which systemic, but not brain, insulin resistance has been tested and found (i.e., amyotrophic lateral sclerosis, dementia with Lewy bodies, frontotemporal dementia, Huntington’s disease, and multiple sclerosis). This suggests that brain insulin resistance could be a common therapeutic target in diverse neurodegenerative disorders, all of which still lack fully effective disease-modifying treatments.
This Special Issue will offer reviews and original research on the etiology, mechanisms, and effects of brain insulin resistance in neurodegenerative disorders and on treatments being developed for them. This Special Issue welcomes reviews and original research articles that work on cells and animal model studies.
Dr. Konrad Talbot
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- Alzheimer’s disease
- brain insulin resistance
- Down syndrome
- incretin receptor agonist
- insulin
- insulin resistance
- multiple system atrophy
- neurodegenerative disease
- Parkinson’s disease
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
