Cell Signaling in Neurodegeneration Disease

Dear Colleagues,

Neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, frontotemporal dementia, amyotrophic lateral sclerosis (ALS), Huntington’s disease, and many others represent a growing global health burden. Despite decades of research, the underlying molecular mechanisms remain incompletely understood, and effective disease-modifying treatments are still limited. Emerging evidence highlights that dysregulation of cell signaling pathways plays a central role in the onset and progression of these diseases, impacting neuronal survival, synaptic plasticity, mitochondrial function, neuroinflammation, post-translational modifications and protein homeostasis.

This Special Issue, titled “Cell Signaling in Neurodegeneration Disease”, aims to provide a comprehensive overview of the dynamic signaling networks involved in neurodegeneration. We invite original research articles, reviews, and perspectives that focus on the identification and functional analysis of signaling pathways implicated in neurodegenerative conditions. Of particular interest are studies investigating biomarkers, pathway-specific mechanisms, glial-neuronal interactions, intercellular communication, and novel therapeutic strategies.

We welcome interdisciplinary contributions utilizing a variety of experimental models and methodologies, including human-derived samples, neuroimaging, iPSCs, transcriptomics, proteomics, animal models, computational modeling, and drug screening platforms. By integrating insights across molecular, cellular, and system-level neuroscience, this Special Issue seeks to advance both our basic understanding and translational applications.

We look forward to your contributions to this exciting and timely Special Issue.

Dr. Rijwan Uddin Ahammad
Dr. Yasuhiro Funahashi
Guest Editors

Dr. Akira Sobue
Dr. Xinjian Zhang
Dr. Md-nadim Hossain
Co-Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.