Proteomic Applications in Ageing and Neurodegenerative Conditions
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Methods".
Deadline for manuscript submissions: 20 January 2025 | Viewed by 13082
Special Issue Editors
Interests: neurodegeneration; synapse; comparative pathology; proteomics; pathway mapping
Interests: neurodegeneration; synapses; systems biology; proteomics
Interests: proteomics; mass spectrometry; post-translational modifications; redox proteomics and proteostasis
Special Issue Information
Dear Colleagues,
Advances in mass spectrometric technologies, separation sciences and associated informatics over the last decade have ushered proteomics technologies to a position where we can address questions at the level of the effector molecule with sensitivity and precision greater than ever before. Probing thousands of proteins from clinical and biofluid samples or in tissues in the context of cellular and subcellular localisations and their post-translational variants now offer unprecedented opportunities in characterising complex disease phenotypes. The sheer breadth of data potentially generated by these advanced MS technologies encompasses analyte subsets ranging from lipids, metabolites, peptides, proteins and post-translational modifications. Each technique harbours its own merits and challenges, from experimental design to sample processing and data handling. This Special Issue will comprise new manuscripts describing the limitations and considerations required for effective -omics experimentation and novel research demonstrating the importance of MS-based -omics to our understanding of the molecular underpinnings of processes informing on and/or regulating ageing and/or neurodegeneration.
Prof. Dr. Thomas Wishart
Dr. Rachel A. Kline
Dr. Dominic Kurian
Guest Editors
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