Molecular Mechanisms of Drug Delivery in Ophthalmology
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Tissues and Organs".
Deadline for manuscript submissions: 30 November 2025 | Viewed by 40
Special Issue Editors
Interests: design and evaluation of novel drug delivery systems; preformulation studies; solid-state characterization of drugs and dosage forms; pharmaceutical analysis utilizing the following techniques: HPLC, GC, GC-MS, thermoanalytical methods, IR, powder X-ray diffraction and scanning electron microscopy; evaluation and design of dosage forms for nutraceuticals
Special Issues, Collections and Topics in MDPI journals
Interests: neurodegenerative diseases; mechanism of neurite outgrowth; novel drug delivery; ocular drug delivery; ocular gene delivery; brain delivery; ocular pharmacokinetics
Special Issue Information
Dear Colleagues,
Even in the face of all developmental progress, overcoming one of the critical factors in drug delivery to the eye—the genuine uniqueness of the eye's anatomical and physiological barriers—remains a major challenge. The corneal epithelium, blood–aqueous barrier, and blood–retinal barrier, together with the physiological clearance process, serve as defense mechanisms, leading to low drug concentrations and high accumulation in other parts of the eye. Therefore, in search of solutions to these problems, researchers' goal is to develop new methods, such as nanocarriers, hydrogel systems, and targeted delivery systems. The knowledge of molecular mechanisms involved in drug transport, retention, and cellular interactions in the modification of these treatment methods is of primary importance for ophthalmic treatment progress and improved therapeutic effects.
This Special Issue is planned to provide not only a comprehensive probe into the molecular and biophysical aspects of ophthalmological drug transport but also its experimental cytology. Topics of interest include the following:
- Molecular interactions in ocular drug delivery;
- Nanotechnology-based drug carriers for ophthalmic applications;
- Transport mechanisms across ocular barriers;
- Biophysical properties affecting drug absorption and distribution;
- Strategies to enhance drug retention and bioavailability;
- Advances in targeted drug delivery at the molecular level;
- Advances in gene delivery in the eye.
We welcome original research and review articles that provide new insights into these processes and on their potential impacts on future ophthalmic therapies.
Prof. Dr. Alekha K. Dash
Dr. Surabhi Shukla
Guest Editors
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Keywords
- drug delivery
- ophthalmology
- nanocarriers
- ocular barriers
- molecular transport
- targeted therapy
- ocular gene delivery
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